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Date: Wed, 18 Oct 2023 21:45:26 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
Subject: Drug Evaluation: A Key Component in Biopharmaceutical Development
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Essential Evaluation Tools: Pre-formed Fibrils (PFFs) Upcoming Events | Vie=
w as Webpage Unleashing the Potential of Drugs through Empowered Drug Evalu=
ation Drug evaluation results have a significant impact on decision-making =
in biopharmaceutical development. By employing various methodologies and ex=
perimental models, drug evaluation helps identify promising drug candidates=
, optimize potential drugs, and prioritize the most viable candidates for f=
urther development. The integration of comprehensive drug evaluation during=
 early drug discovery and preclinical phases accelerates the drug developme=
nt process, increases the chances of successful clinical outcomes, and ulti=
mately contributes to improving patient healthcare. ACROBiosystems offers i=
nnovative solutions, Pre-formed Fibrils (PFFs), researchers can enhance the=
ir understanding of drug behavior, optimize drug candidates, and make infor=
med decisions during early drug discovery and preclinical evaluation. Pre-f=
ormed Fibrils (PFFs) for Disease Modeling Pre-formed Fibrils (PFFs) are imp=
ortant in modeling neurodegenerative diseases. They are intermediate struct=
ures formed during protein misfolding and aggregation. PFFs-based disease m=
odels offer improved drug evaluation by recapitulating disease pathology, p=
roviding reproducible experimental conditions, targeting disease-specific p=
athways, assessing drug effects on aggregation kinetics and cellular toxici=
ty, and facilitating high-throughput screening. Explore Our PFFs Products >=
> =E2=80=8A Tau-441 PFFs Tau-H5115 | Tau-H5146 Alpha-Synuclein PFFs ALN-H51=
H4 Tau-441 K18 PFFsNew Activity (ThT assay) Thioflavin T emission curves sh=
ow increased fluorescence (correlated to tau aggregation) over time when ta=
u K18 monomers are combined with Human Tau-441 K18 Pre-formed Fibrils Prote=
in, His Tag (Cat. No. TAU-H5146) (QC tested). Request for Protocol Event An=
nouncement Awards & Certifications =E2=80=8A =E2=80=8A =E2=80=8A =E2=80=8A =
ACROBiosystems | 1 Innovation Way, Newark, DE 19711 Unsubscribe mykhaylo.du=
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rif; color: #ffffff; font-size: 14px; display: block; word-wrap: break-word=
; padding: 10px 40px;" align=3D"center" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-size: 18px; color: rgb(0, 0, 0); font-weight: bold;">Unleashing the P=
otential of Drugs through Empowered Drug Evaluation</span></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(0, 0, 0);">Drug evaluatio=
n results have a significant impact on decision-making in biopharmaceutical=
 development. By employing various methodologies and experimental models, d=
rug evaluation helps identify promising drug candidates, optimize potential=
 drugs, and prioritize the most viable candidates for further development. =
The integration of comprehensive drug evaluation during early drug discover=
y and preclinical phases accelerates the drug development process, increase=
s the chances of successful clinical outcomes, and ultimately contributes t=
o improving patient healthcare.</span></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(0, 0, 0);">ACROBiosystems=
 offers innovative solutions, </span><a href=3D"https://r20.rs6.net/tn.jsp?=
f=3D001mDuumIr5PkhKAZT-soue4nUQsKlubYVAaxhtd-7xX11xwfmOUL6Q62eQhIm6exPL2img=
IW9qKyzxy7bl01D5UCKgJeRgeDJCKR6qADVIhElE6Hq3nyHwy_6CgC0lNGpl_iXSrXhzA99ZyrB=
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P28y4i3HkuirtYAlBhjdWlvUwbIuPmoyo085gS0S4aKVoqdA=3D=3D" target=3D"_blank" s=
tyle=3D"color: rgb(0, 0, 0); font-weight: bold; text-decoration: none;">Pre=
-formed Fibrils (PFFs)</a><span style=3D"color: rgb(0, 0, 0);">, researcher=
s can enhance their understanding of drug behavior, optimize drug candidate=
s, and make informed decisions during early drug discovery and preclinical =
evaluation.</span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"color: rgb(0, 0, 0); font-weight: bold;">Pre-formed Fibrils (PFFs) for Dis=
ease Modeling</span></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(0, 0, 0);">Pre-formed Fib=
rils (PFFs) are important in modeling neurodegenerative diseases. They are =
intermediate structures formed during protein misfolding and aggregation. P=
FFs-based disease models offer improved drug evaluation by recapitulating d=
isease pathology, providing reproducible experimental conditions, targeting=
 disease-specific pathways, assessing drug effects on aggregation kinetics =
and cellular toxicity, and facilitating high-throughput screening.</span></=
p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
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utton button--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"=
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on_container content-padding-horizontal" align=3D"center" style=3D"padding:=
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rBOCUI9GvOwHRgNWXtP5V3gdjpQ3JFQrr4MNnutdrr2V4vF09xUymSjmp2IHBHbHWejHso50Em8=
l2Z_quIKjfgICFebIlwsVqLobFwIUjero26cwOkq0MDNqCqil4dG5QQbPv-Fa4D-jn4qFd3Uc5P=
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t-size: 14px; font-weight: normal; color: #FFFFFF; word-wrap: break-word; t=
ext-decoration: none;">Explore Our PFFs Products &gt;&gt;</a> </td> </tr> <=
/table>    </td> </tr> </table>   </td> </tr> </table> <table class=3D"layo=
ut layout--1-column" style=3D"background-color: #fafafa; table-layout: fixe=
d;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=
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h: 100%;" align=3D"center" valign=3D"top"><div class=3D"spacer" style=3D"he=
ight: 30px; line-height: 30px;">&#x200a;</div></td> </tr> </table> <table c=
lass=3D"layout layout--2-column" style=3D"background-color: #ffffff; table-=
layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
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<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Verdana,Geneva,sans-serif; color: #3E3E3E; font-size: 1=
4px; line-height: 1.2; display: block; word-wrap: break-word; padding: 10px=
 20px 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cen=
ter; margin: 0;" align=3D"center"><a href=3D"https://r20.rs6.net/tn.jsp?f=
=3D001mDuumIr5PkhKAZT-soue4nUQsKlubYVAaxhtd-7xX11xwfmOUL6Q6-5j5yztVrJ-bRoif=
Z0atF71mv_WvW59PB3PrUQIl5ntItTeRgg6NMeAP9_AJKSyawp_ldqgmCl9KtoQ9LEIjV5IbBVu=
QK-5r8V1qn-s0dwuWzmZwz6_tvA14EFQc0IEfC4U3FveCmX9koQY-D0mvPJlKnNCy0CgDHhXeT6=
ra6zDnEX0pUOpU_X5b8vjAhj8GHTk-E7aYjqa_pA7pWNrtOBNzQUlYVKk3F3IP5qWB4Q82Oo321=
umO4iGAjyVfbr6lIbzrtCmd3BUb_1lcp1yGLGrFlOmRKpUDg=3D=3D&c=3D2TxifS3seKmvf5eG=
Cy5lwlUCt8zJgprNWL-nAX6-c2CEAz_fCjKRJA=3D=3D&ch=3DH598q1P28y4i3HkuirtYAlBhj=
dWlvUwbIuPmoyo085gS0S4aKVoqdA=3D=3D" target=3D"_blank" style=3D'font-family=
: "Franklin Gothic Medium", Arial, Helvetica, sans-serif; color: #4d4d4d; f=
ont-weight: bold; text-decoration: none;'>  Tau-441 PFFs</a></p></td> </tr>=
 </table> <table class=3D"image image--mobile-scale image--mobile-center" w=
idth=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td cl=
ass=3D"image_container content-padding-horizontal" align=3D"center" valign=
=3D"top" style=3D"padding-left: 40px; padding-right: 20px;"> <a href=3D"htt=
ps://r20.rs6.net/tn.jsp?f=3D001mDuumIr5PkhKAZT-soue4nUQsKlubYVAaxhtd-7xX11x=
wfmOUL6Q6-5j5yztVrJ-bRoifZ0atF71mv_WvW59PB3PrUQIl5ntItTeRgg6NMeAP9_AJKSyawp=
_ldqgmCl9KtoQ9LEIjV5IbBVuQK-5r8V1qn-s0dwuWzmZwz6_tvA14EFQc0IEfC4U3FveCmX9ko=
QY-D0mvPJlKnNCy0CgDHhXeT6ra6zDnEX0pUOpU_X5b8vjAhj8GHTk-E7aYjqa_pA7pWNrtOBNz=
QUlYVKk3F3IP5qWB4Q82Oo321umO4iGAjyVfbr6lIbzrtCmd3BUb_1lcp1yGLGrFlOmRKpUDg=
=3D=3D&c=3D2TxifS3seKmvf5eGCy5lwlUCt8zJgprNWL-nAX6-c2CEAz_fCjKRJA=3D=3D&ch=
=3DH598q1P28y4i3HkuirtYAlBhjdWlvUwbIuPmoyo085gS0S4aKVoqdA=3D=3D" data-track=
able=3D"true"><img data-image-content class=3D"image_content" width=3D"197"=
 src=3D"https://files.constantcontact.com/5f3d0cf9401/0ec27b34-3b6f-4506-be=
d6-5187286281f6.png" alt=3D"" style=3D"display: block; height: auto; max-wi=
dth: 100%;"></a> </td> </tr> </table> <table class=3D"text text--padding-ve=
rtical" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" sty=
le=3D"table-layout: fixed;"> <tr> <td class=3D"text_content-cell content-pa=
dding-horizontal" style=3D"text-align: left; font-family: Verdana,Geneva,sa=
ns-serif; color: #3E3E3E; font-size: 14px; line-height: 1.2; display: block=
; word-wrap: break-word; padding: 10px 20px 10px 40px;" align=3D"left" vali=
gn=3D"top"><p style=3D"text-align: center; margin: 0;" align=3D"center"><a =
href=3D"https://r20.rs6.net/tn.jsp?f=3D001mDuumIr5PkhKAZT-soue4nUQsKlubYVAa=
xhtd-7xX11xwfmOUL6Q69iJvTdSc-jqC0ppIVeVhx1louqhmNie4tRyCbqgKjqKf6GZkkoIH10u=
IfbWxafVJSFXXaWogoTX6DQRMSceY0RD2iNFNBGyE6mrLn-v8MH2gKaGxlvbu_I8XCuftY40t83=
xQ58PV1zOigIo6HBOMy-bKDZQxUyKVa72ZETOsNmSGmaa8T3_QF-rMMGRIseEQnLFRdQ6xh6Of_=
O0cQrptiNCp4xiIcic-J4qEqO1l8RtVMJQuYF4JoLSQI1SF44ft0y7jlYKVPsUCwM8SA9tjmTfm=
LtTBEFvETx1XP2tf9YWIwUXVoun6DbLhsDYqKA4jp2cV20w3uZfE3xl-s8ZvogWf981yc5PosK5=
Y3g_dflIR-8JE8LDoQqM4iuGp7NtaQ=3D=3D&c=3D2TxifS3seKmvf5eGCy5lwlUCt8zJgprNWL=
-nAX6-c2CEAz_fCjKRJA=3D=3D&ch=3DH598q1P28y4i3HkuirtYAlBhjdWlvUwbIuPmoyo085g=
S0S4aKVoqdA=3D=3D" target=3D"_blank" style=3D'color: rgb(192, 0, 0); font-w=
eight: bold; font-family: "Franklin Gothic Medium", Arial, Helvetica, sans-=
serif; text-decoration: none;'>Tau-H5115</a><span style=3D'color: rgb(192, =
0, 0); font-weight: bold; font-family: "Franklin Gothic Medium", Arial, Hel=
vetica, sans-serif;'> |  </span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D0=
01mDuumIr5PkhKAZT-soue4nUQsKlubYVAaxhtd-7xX11xwfmOUL6Q6-YZVEXEiKm-o8a6P97_Q=
3YC356L7enPhnzwfmDMb0ZLJXZumxk-Z_1ZkmgbNnGIuzFwxUqHiSdo-_OTTnCArQbZCiN_Cn-C=
nmKmR3mMGzlJ-Ai_Qt6iLv23NeSPmFSXHqALZah2lo964SUVUMwLRblhOkBa_e-w2i2puBBoZtJ=
7XsxJYYiOQLlhVV73ic-9KBiQudwfndalNsCHnBWknj4qtamGe6aL8Ibyc1UwzLJ_xDlcAeUdoz=
VsKdk_VYkhXb2VeNABM53wYUQhQw632Rq8m2wVSsHDSWdeHz0dgUwyXQ8YGU_OAwDKFwo9j33hY=
D-TJbATSGaZo-DEzpmuO9tHWMoCxtPfPTQM9L9mplMy23y1i_yWoTE=3D&c=3D2TxifS3seKmvf=
5eGCy5lwlUCt8zJgprNWL-nAX6-c2CEAz_fCjKRJA=3D=3D&ch=3DH598q1P28y4i3HkuirtYAl=
BhjdWlvUwbIuPmoyo085gS0S4aKVoqdA=3D=3D" target=3D"_blank" style=3D'color: r=
gb(192, 0, 0); font-weight: bold; font-family: "Franklin Gothic Medium", Ar=
ial, Helvetica, sans-serif; text-decoration: none;'>Tau-H5146</a></p></td> =
</tr> </table> </td>  <td class=3D"column column--2 scale stack" style=3D"w=
idth: 50%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Verdana,Geneva,sans-serif; color: #3E3E3E; font-size: 1=
4px; line-height: 1.2; display: block; word-wrap: break-word; padding: 10px=
 40px 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cen=
ter; margin: 0;" align=3D"center"><a href=3D"https://r20.rs6.net/tn.jsp?f=
=3D001mDuumIr5PkhKAZT-soue4nUQsKlubYVAaxhtd-7xX11xwfmOUL6Q628YrtQByTOQT_-Yb=
m9l7rZ6fFKiOaQ_lA0AxQVKBYCJhOg1rUFQnSeq0IFmBS6n5dpZ2Rojtj4Lt8-LRp4MTK2nQB7Q=
HeqzxugC5yoynk6X_zoP3mAI0hHPhw1SRRgqNnxzlw7WBdo45EosAIlDyssDYEzVBRRwMk2RmBu=
Rsbj_LSfLWW_i-WrQDot0wcF1AjrYxiSqGzOKliWtv_DwOyTs48RX8L4FYshHdNXUbKSZFCnrKs=
mwKzVWcxuS8rmwqp7XYufXX6Y0T1ZRRzXRj5gvseW8GVQvTxYi9mrstYYb&c=3D2TxifS3seKmv=
f5eGCy5lwlUCt8zJgprNWL-nAX6-c2CEAz_fCjKRJA=3D=3D&ch=3DH598q1P28y4i3HkuirtYA=
lBhjdWlvUwbIuPmoyo085gS0S4aKVoqdA=3D=3D" target=3D"_blank" style=3D'font-fa=
mily: "Franklin Gothic Medium", Arial, Helvetica, sans-serif; color: #4d4d4=
d; font-weight: bold; text-decoration: none;'>  Alpha-Synuclein PFFs</a></p=
></td> </tr> </table> <table class=3D"image image--mobile-scale image--mobi=
le-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0">=
 <tr> <td class=3D"image_container content-padding-horizontal" align=3D"cen=
ter" valign=3D"top" style=3D"padding-left: 20px; padding-right: 40px;"> <a =
href=3D"https://r20.rs6.net/tn.jsp?f=3D001mDuumIr5PkhKAZT-soue4nUQsKlubYVAa=
xhtd-7xX11xwfmOUL6Q628YrtQByTOQT_-Ybm9l7rZ6fFKiOaQ_lA0AxQVKBYCJhOg1rUFQnSeq=
0IFmBS6n5dpZ2Rojtj4Lt8-LRp4MTK2nQB7QHeqzxugC5yoynk6X_zoP3mAI0hHPhw1SRRgqNnx=
zlw7WBdo45EosAIlDyssDYEzVBRRwMk2RmBuRsbj_LSfLWW_i-WrQDot0wcF1AjrYxiSqGzOKli=
Wtv_DwOyTs48RX8L4FYshHdNXUbKSZFCnrKsmwKzVWcxuS8rmwqp7XYufXX6Y0T1ZRRzXRj5gvs=
eW8GVQvTxYi9mrstYYb&c=3D2TxifS3seKmvf5eGCy5lwlUCt8zJgprNWL-nAX6-c2CEAz_fCjK=
RJA=3D=3D&ch=3DH598q1P28y4i3HkuirtYAlBhjdWlvUwbIuPmoyo085gS0S4aKVoqdA=3D=3D=
" data-trackable=3D"true"><img data-image-content class=3D"image_content" w=
idth=3D"169" src=3D"https://files.constantcontact.com/5f3d0cf9401/a71f27c2-=
b311-4bdc-aba9-b24324d1c8ab.png" alt=3D"" style=3D"display: block; height: =
auto; max-width: 100%;"></a> </td> </tr> </table> <table class=3D"text text=
--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspaci=
ng=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_content-cel=
l content-padding-horizontal" style=3D"text-align: left; font-family: Verda=
na,Geneva,sans-serif; color: #3E3E3E; font-size: 14px; line-height: 1.2; di=
splay: block; word-wrap: break-word; padding: 10px 40px 10px 20px;" align=
=3D"left" valign=3D"top"><p style=3D"text-align: center; margin: 0;" align=
=3D"center"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001mDuumIr5PkhKAZT-so=
ue4nUQsKlubYVAaxhtd-7xX11xwfmOUL6Q67S78aIeIHI5GC3Mw60GpuVel6MOaQObHvo01xQYu=
Mrya_QiLl0yxmdmsrLefvNJ54-yHrwXYddUFE1l55m-g7CQUQBkX5-ZL1UjK4GgOKDnxLADnPwd=
wssdcdCsQxp-MzoiGjj3xvKNSNSbP9RP6jEdg1PqZVd8hIFLpiBPJsBtYyfYBilTtGK2XJZSqqH=
K1u6YrGFP2SJerr90178Hc6p46iF4rEEnw4wHIaVwnhXXOdE96H2op30LlN9GGIdVVg9l8w5h_6=
5pszZdU_qbbarvfa0IKep0e12K5WnwtCYjKCumWn1IrMxDCDZ-kRlJDnT2GoTcQ3WOhZgyFtKKY=
SrFHC2dmdNBt-R7N0hMIZAg-jXqBRjYlu08qhaOKr6P3g=3D=3D&c=3D2TxifS3seKmvf5eGCy5=
lwlUCt8zJgprNWL-nAX6-c2CEAz_fCjKRJA=3D=3D&ch=3DH598q1P28y4i3HkuirtYAlBhjdWl=
vUwbIuPmoyo085gS0S4aKVoqdA=3D=3D" target=3D"_blank" style=3D'color: rgb(192=
, 0, 0); font-weight: bold; font-family: "Franklin Gothic Medium", Arial, H=
elvetica, sans-serif; text-decoration: none;'>ALN-H51H4</a></p></td> </tr> =
</table> </td> </tr> </table> <table class=3D"layout layout--1-column" styl=
e=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" ce=
llspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"w=
idth: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Verdana,Geneva,sans-serif; color: #3E3E3E; font-size: 1=
4px; line-height: 1.2; display: block; word-wrap: break-word; padding: 10px=
 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: center; margi=
n: 0;" align=3D"center"><span style=3D'font-weight: bold; font-family: "Fra=
nklin Gothic Medium", Arial, Helvetica, sans-serif; font-size: 16px;'>Tau-4=
41 K18 PFFs</span><sup style=3D'font-weight: bold; font-style: italic; font=
-family: "Franklin Gothic Medium", Arial, Helvetica, sans-serif; color: rgb=
(192, 0, 0); font-size: 16px;'>New</sup><span style=3D'font-weight: bold; f=
ont-family: "Franklin Gothic Medium", Arial, Helvetica, sans-serif; font-si=
ze: 16px;'> Activity (ThT assay)</span></p></td> </tr> </table> </td> </tr>=
 </table> <table class=3D"layout layout--1-column" style=3D"table-layout: f=
ixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr=
> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=
=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container" align=3D"center" valign=3D"top"> <img data-image-content clas=
s=3D"image_content" width=3D"421" src=3D"https://files.constantcontact.com/=
5f3d0cf9401/57781ff5-f40d-4878-aea8-99c310799395.jpg" alt=3D"" style=3D"dis=
play: block; height: auto; max-width: 100%;"> </td> </tr> </table> </td> </=
tr> </table> <table class=3D"layout layout--1-column" style=3D"table-layout=
: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> =
<tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" alig=
n=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Verdana,Geneva,sans-serif; color: #3E3E3E; font-size: 1=
4px; line-height: 1.2; display: block; word-wrap: break-word; padding: 10px=
 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: center; margi=
n: 0;" align=3D"center"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif; font-size: 10px; font-style: italic;">Thioflavin T emission=
 curves show increased fluorescence (correlated to tau aggregation) over ti=
me when tau K18 monomers are combined with Human Tau-441 K18 Pre-formed Fib=
rils Protein, His Tag (Cat. No.</span><span style=3D"font-family: Arial, Ve=
rdana, Helvetica, sans-serif; font-size: 10px; color: rgb(192, 0, 0); font-=
style: italic;"> </span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001mDuumI=
r5PkhKAZT-soue4nUQsKlubYVAaxhtd-7xX11xwfmOUL6Q6-YZVEXEiKm-o8a6P97_Q3YC356L7=
enPhnzwfmDMb0ZLJXZumxk-Z_1ZkmgbNnGIuzFwxUqHiSdo-_OTTnCArQbZCiN_Cn-CnmKmR3mM=
GzlJ-Ai_Qt6iLv23NeSPmFSXHqALZah2lo964SUVUMwLRblhOkBa_e-w2i2puBBoZtJ7XsxJYYi=
OQLlhVV73ic-9KBiQudwfndalNsCHnBWknj4qtamGe6aL8Ibyc1UwzLJ_xDlcAeUdozVsKdk_VY=
khXb2VeNABM53wYUQhQw632Rq8m2wVSsHDSWdeHz0dgUwyXQ8YGU_OAwDKFwo9j33hYD-TJbATS=
GaZo-DEzpmuO9tHWMoCxtPfPTQM9L9mplMy23y1i_yWoTE=3D&c=3D2TxifS3seKmvf5eGCy5lw=
lUCt8zJgprNWL-nAX6-c2CEAz_fCjKRJA=3D=3D&ch=3DH598q1P28y4i3HkuirtYAlBhjdWlvU=
wbIuPmoyo085gS0S4aKVoqdA=3D=3D" target=3D"_blank" style=3D"font-family: Ari=
al, Verdana, Helvetica, sans-serif; font-size: 10px; color: rgb(192, 0, 0);=
 font-style: italic; font-weight: bold; text-decoration: none;">TAU-H5146</=
a><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif; font-s=
ize: 10px; font-style: italic;">) (QC tested).</span></p></td> </tr> </tabl=
e> </td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"t=
able-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspac=
ing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: =
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0" style=3D"table-layout: fixed;"> <tr> <td class=3D"button_container conte=
nt-padding-horizontal" align=3D"center" style=3D"padding: 10px 40px;">    <=
table class=3D"button_content-row" style=3D"width: inherit; border-radius: =
8px; border-spacing: 0; background-color: #c60c0c; border: none;" border=3D=
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hKAZT-soue4nUQsKlubYVAaxhtd-7xX11xwfmOUL6Q64FXLWUR69dOA_XFOLu7lZ-EIrumqkILf=
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true" style=3D"font-size: 14px; color: #FFFFFF; font-family: Arial,Verdana,=
Helvetica,sans-serif; word-wrap: break-word; font-weight: bold; text-decora=
tion: none;">Request for Protocol</a> </td> </tr> </table>    </td> </tr> <=
/table>   </td> </tr> </table> <table class=3D"layout layout--1-column" sty=
le=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" c=
ellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"=
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o; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </table> <table =
class=3D"layout layout--1-column" style=3D"background-color: #fafafa; table=
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llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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4px; line-height: 1.2; display: block; word-wrap: break-word; padding: 10px=
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n: 0;" align=3D"center"><span style=3D'font-size: 20px; font-family: "Frank=
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bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
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; height: auto; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </t=
able> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed=
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d class=3D"column column--1 scale stack" style=3D"width: 37.5%;" align=3D"c=
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llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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4px; line-height: 1.2; display: block; word-wrap: break-word; padding: 10px=
 40px;" align=3D"left" valign=3D"top"><h3 style=3D"text-align: right; font-=
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ight: bold; margin: 0;" align=3D"right"><span style=3D"font-weight: normal;=
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out: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
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