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Envelope-to: tfujikawa@saraya.co.in
Delivery-date: Thu, 20 Jul 2023 08:31:14 +0800
Message-ID: <1140406074560.1119371711477.1205581575.0.412030JL.2002@synd.ccsend.com>
Date: Wed, 19 Jul 2023 20:30:24 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: tfujikawa@saraya.co.in
Subject: Developing ADCs Part 1: Inspiring Antibody Targets
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Reagents to help develop your antibody drug conjugate View as Webpage Devel=
oping ADCs Part 1: Targeting cancer with inspiring antibody targets  Antibo=
dies are arguably the main part of antibody-drug conjugates (ADCs), providi=
ng the =E2=80=98homing=E2=80=99 component to precisely target tumors throug=
hout the body. To combat specific tumors, the antibody must also be specifi=
c and accurate against an antigen expressed only on the target tissue type.=
 As such, finding innovative targets is the first step towards developing A=
DCs.   Here=E2=80=99s some inspiring ADC targets we have found in our lates=
t research:   Leucine-rich Repeat-containing Protein 15 (LRRC15) Cell surfa=
ce protein that plays a role in cell-to-cell and cell-matrix interactions. =
=C2=B7 Expression: Overexpressed on mesenchymal stem cells & fibroblasts =
=C2=B7 Relevant Diseases: Breast, head, neck, lung, pancreatic cancers. =C2=
=B7 Status: Promising results from preclinical studies.  Explore our LRRC15=
 Products Cadherin 6 (CDH6) Transmembrane protein expressed during embryoni=
c development. =C2=B7  Expression: Upregulated in certain cancers.  =C2=B7 =
 Relevant Diseases: Renal cell carcinoma and ovarian cancer. =C2=B7  Status=
: Promising results from preclinical studies (DS-6000a, Daiichi Sankyo)  Ex=
plore our CDH6 Products Are you interested in other =E2=80=98inspiring targ=
ets=E2=80=99 or other ADC solutions? Explore our products designed to help =
you develop your own novel ADCs. Find your ADC Reagents Spotlight products =
for you Peptide Linker Proteases AGLink=C2=AE ADC site-specific conjugation=
 kit Tools for ADCs PK analysis =E2=80=8A =EF=BB=BFTo receive the latest in=
dustry news and updates from ACROBiosystems, =EF=BB=BFvisit our website & f=
ollow us on our social media!=EF=BB=BF Visit our Website =E2=80=8A       AC=
ROBiosystems | 1 Innovation Way, Newark, DE 19711 Unsubscribe tfujikawa@sar=
aya.co.in Update Profile | Our Privacy Policy | Constant Contact Data Notic=
e Sent by acrobio.apac@outlook.com
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out: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" a=
lign=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-family: Tahoma, Geneva, sans-serif; font-weight: bold; font-size: 16p=
x;">Developing ADCs Part 1: </span><span style=3D"font-family: Tahoma, Gene=
va, sans-serif; font-weight: bold; font-style: italic; font-size: 16px;">Ta=
rgeting cancer with inspiring antibody targets&#xa0;</span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-family: Arial, Verdana, Helvetica, sans-serif;">Antibodies are arguab=
ly the main part of antibody-drug conjugates (ADCs), providing the &#x2018;=
homing&#x2019; component to precisely target tumors throughout the body. To=
 combat specific tumors, the antibody must also be specific and accurate ag=
ainst an antigen expressed only on the target tissue type. As such, finding=
 innovative targets is the first step towards developing ADCs. </span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-family: Arial, Verdana, Helvetica, sans-serif;">&#xa0;</span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-family: Arial, Verdana, Helvetica, sans-serif;">Here&#x2019;s some in=
spiring ADC targets we have found in our latest research:&#xa0;&#xa0;</span=
></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--2-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 65%;" align=3D"center" valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.2; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: b=
reak-word; padding: 10px 20px 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"font-size: 14px; font-family: Arial,=
 Verdana, Helvetica, sans-serif; font-weight: bold;">Leucine-rich Repeat-co=
ntaining Protein 15 (LRRC15)</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 14px; font-family: Arial,=
 Verdana, Helvetica, sans-serif;">Cell surface protein that plays a role in=
 cell-to-cell and cell-matrix interactions. </span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 14px; font-family: Arial,=
 Verdana, Helvetica, sans-serif;">&#xb7;&#xa0;</span><span style=3D"font-si=
ze: 14px; font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: =
bold;">Expression: </span><span style=3D"font-size: 14px; font-family: Aria=
l, Verdana, Helvetica, sans-serif;">Overexpressed on</span><span style=3D"f=
ont-size: 14px; font-family: Arial, Verdana, Helvetica, sans-serif; font-we=
ight: bold;"> </span><span style=3D"font-size: 14px; font-family: Arial, Ve=
rdana, Helvetica, sans-serif;">mesenchymal stem cells &amp; fibroblasts</sp=
an></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 14px; font-family: Arial,=
 Verdana, Helvetica, sans-serif;">&#xb7;&#xa0;</span><span style=3D"font-si=
ze: 14px; font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: =
bold;">Relevant Diseases:</span><span style=3D"font-size: 14px; font-family=
: Arial, Verdana, Helvetica, sans-serif;"> Breast, head, neck, lung, pancre=
atic cancers.</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 14px; font-family: Arial,=
 Verdana, Helvetica, sans-serif;">&#xb7;&#xa0;</span><span style=3D"font-si=
ze: 14px; font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: =
bold;">Status: </span><span style=3D"font-size: 14px; font-family: Arial, V=
erdana, Helvetica, sans-serif;">Promising results from preclinical studies.=
&#xa0;</span></p>
</td> </tr> </table>  <table class=3D"button button--padding-vertical" widt=
h=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-=
layout: fixed;"> <tr> <td class=3D"button_container content-padding-horizon=
tal" align=3D"center" style=3D"padding: 10px 20px 10px 40px;">    <table cl=
ass=3D"button_content-row" style=3D"background-color: #c03e30; width: inher=
it; border-radius: 7px; border-spacing: 0; border: none;" border=3D"0" cell=
padding=3D"0" cellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"butt=
on_content-cell" style=3D"padding: 10px 15px;" align=3D"center"> <a class=
=3D"button_link" href=3D"https://r20.rs6.net/tn.jsp?f=3D001L7GElZaSkqZ4tt9q=
AdGi9CdkxUgP1iHivHeQbUYi9JdmIApvJmyO821aKnQws1jAB6x2B1lZA1YQirfZoy7xps-qeNr=
oqtzz7bYelkdEprdozv1iE32itjlLlrLxbhT0U7tIZgOBVxYYE9YO_kbPwCA0CTcXPRHtpaqNWF=
j0bXwkwFl90cY_Y5o8bfLPSyigcJSGau6BGFh_nKA_9Atz0I5vFZ-LOHAGfIoIdXMuPfnq7F5WN=
7YhRMxe9C9IlKnSVM-pnNQ6_apCHp9fIqU8ZcBlctG-W1VFVLd8B1Vxu5um6it_KqBT4Kk-NCKV=
-9a06JvQPsLwJ_5XDSxkvagcL_U-BJt5tQsX&c=3DAUvYLkoUej7xmo7XVyMo8rI-v8KZ9z88vk=
J8P0cBs7KryCcva_vSaA=3D=3D&ch=3DlaON_Fzvhz7vZHG--2vraW55GiG9UnojWCDIfWgvmaS=
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 #FFFFFF; font-family: Arial,Verdana,Helvetica,sans-serif; word-wrap: break=
-word; font-weight: bold; text-decoration: none;">Explore our LRRC15 Produc=
ts</a> </td> </tr> </table>    </td> </tr> </table>   </td>  <td class=3D"c=
olumn column--2 scale stack" style=3D"width: 35%;" align=3D"center" valign=
=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 40px 10px 20px;"> <img data-im=
age-content class=3D"image_content" width=3D"200" src=3D"https://files.cons=
tantcontact.com/5f3d0cf9401/eefb67a9-abb4-420c-984b-787eb3351e22.png" alt=
=3D"" style=3D"display: block; height: auto; max-width: 100%;"> </td> </tr>=
 </table> </td> </tr> </table> <table class=3D"layout layout--2-column" sty=
le=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" c=
ellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"=
width: 65%;" align=3D"center" valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.2; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: b=
reak-word; padding: 10px 20px 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"font-weight: bold; font-family: Aria=
l, Verdana, Helvetica, sans-serif; font-size: 14px;">Cadherin 6 (CDH6)</spa=
n></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif; font-size: 14px;">Transmembrane protein expressed during em=
bryonic development.</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 14px; font-family: Arial,=
 Verdana, Helvetica, sans-serif;">&#xb7;&#xa0;&#xa0;</span><span style=3D"f=
ont-size: 14px; font-weight: bold; font-family: Arial, Verdana, Helvetica, =
sans-serif;">Expression: </span><span style=3D"font-size: 14px; font-family=
: Arial, Verdana, Helvetica, sans-serif;">Upregulated in certain cancers.&#=
xa0;</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 14px; font-family: Arial,=
 Verdana, Helvetica, sans-serif;">&#xb7;&#xa0;&#xa0;</span><span style=3D"f=
ont-size: 14px; font-weight: bold; font-family: Arial, Verdana, Helvetica, =
sans-serif;">Relevant Diseases:</span><span style=3D"font-size: 14px; font-=
family: Arial, Verdana, Helvetica, sans-serif;"> Renal cell carcinoma and o=
varian cancer.</span></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif; font-size: 14px;">&#xb7;&#xa0;&#xa0;</span><span style=3D"f=
ont-size: 14px; font-weight: bold; font-family: Arial, Verdana, Helvetica, =
sans-serif;">Status: </span><span style=3D"font-size: 14px; font-family: Ar=
ial, Verdana, Helvetica, sans-serif;">Promising results from preclinical st=
udies (DS-6000a, Daiichi Sankyo)&#xa0;</span></p>
</td> </tr> </table>  <table class=3D"button button--padding-vertical" widt=
h=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-=
layout: fixed;"> <tr> <td class=3D"button_container content-padding-horizon=
tal" align=3D"center" style=3D"padding: 10px 20px 10px 40px;">    <table cl=
ass=3D"button_content-row" style=3D"background-color: #c03e30; width: inher=
it; border-radius: 7px; border-spacing: 0; border: none;" border=3D"0" cell=
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AdGi9CdkxUgP1iHivHeQbUYi9JdmIApvJmyO821aKnQws1jA4oM9mkhuRs_AOveos92TC5CIeyE=
z_KJaCiMF_XAyIjNMCLbrODx4acyZuwKsa5hMJgT4FQRGmY6lorLfGat21CfpqfwWo2kLYiWhp2=
dwRSjYbFK_sdLTVRFQ6v6I-qfFAbNaDbGGcjfNgiNn7ME9_t7HHliEnIWHdnxb52hsarU24sHmd=
K2LmvMkXOB_xgv7Q5xb2aia1zoN803LMzzcX1We5mcUBfrCRuk6Y1GXhaa9r2_9faWv8AsM0gbx=
TNuond5ulZMRpIqjtBczNUnVRnu7bZC31WqS&c=3DAUvYLkoUej7xmo7XVyMo8rI-v8KZ9z88vk=
J8P0cBs7KryCcva_vSaA=3D=3D&ch=3DlaON_Fzvhz7vZHG--2vraW55GiG9UnojWCDIfWgvmaS=
GAkY2Cg68bw=3D=3D" data-trackable=3D"true" style=3D"font-size: 14px; color:=
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n style=3D"font-family: Tahoma, Geneva, sans-serif; font-weight: normal;">A=
re you interested in other &#x2018;inspiring targets&#x2019; or other ADC s=
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td class=3D"button_container content-padding-horizontal" align=3D"center" s=
tyle=3D"padding: 10px 40px;">    <table class=3D"button_content-row" style=
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g: 10px 15px;" align=3D"center"> <a class=3D"button_link" href=3D"https://r=
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ont-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: =
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