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Envelope-to: daisuke@saraya.co.in
Delivery-date: Tue, 04 Jul 2023 08:21:13 +0800
Message-ID: <1140358583150.1119371711477.1237888709.0.562020JL.2002@synd.ccsend.com>
Date: Mon, 3 Jul 2023 20:20:24 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: daisuke@saraya.co.in
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=3D'color: black; font-family: Georgia, "Times New Roman", Times, serif; fo=
nt-style: italic;'>:</span></p>
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ew Roman", Times, serif; font-style: italic;'>?</span></p>
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ca, sans-serif;">&#x514d;&#x75ab;&#x30a2;&#x30b4;&#x30cb;&#x30b9;&#x30c8;&#=
x6297;&#x4f53;&#xff08;IAA&#xff09;&#x306f;&#x3001;&#x5c06;&#x6765;&#x304c;&#=
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6a;&#x8981;&#x7d20;&#x306b;&#x306a;&#x308b;&#x53ef;&#x80fd;&#x6027;&#x3092;=
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1;&#x7406;&#x306a;&#x3069;&#x306e;&#x8ab2;&#x984c;&#x306b;&#x5bfe;&#x51e6;&=
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002;</span></p>
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ca, sans-serif;">&#x3053;&#x3061;&#x3089;&#x306e;&#x8ad6;&#x6587;&#x3067;&#=
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e3;&#x66ff;&#x6226;&#x7565;&#x3068;&#x3057;&#x3066;&#x306e;IAA&#x306e;&#x69=
82;&#x8981;&#x3068;&#x3001;IAA&#x306e;3&#x3064;&#x306e;&#x7279;&#x7570;&#x7=
684;&#x6a19;&#x7684;&#xff08;CD40&#x3001;OX40&#x3001;4-1BB&#xff09;&#x306e;&#=
x4f5c;&#x7528;&#x6a5f;&#x5e8f;&#x3001;&#x8ab2;&#x984c;&#x3001;&#x30dd;&#x30=
c6;&#x30f3;&#x30b7;&#x30e3;&#x30eb;&#x306b;&#x3064;&#x3044;&#x3066;&#x8ad6;=
&#x3058;&#x3089;&#x308c;&#x307e;&#x3057;&#x305f;&#x3002;</span></p>
</td> </tr> </table>  <table class=3D"button button--padding-vertical" widt=
h=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-=
layout: fixed;"> <tr> <td class=3D"button_container content-padding-horizon=
tal" align=3D"center" style=3D"padding: 10px 40px;">    <table class=3D"but=
ton_content-row" style=3D"background-color: #c03e30; width: inherit; border=
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"0" cellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"button_content=
-cell" style=3D"padding: 10px 15px;" align=3D"center"> <a class=3D"button_l=
ink" href=3D"https://r20.rs6.net/tn.jsp?f=3D001WmhhqksTWgp-siLuzi4xpWU077mC=
9igPn0cp5vLv-ERCT_b9M_r9zQWYGIKCfRHabiR0oGsc9QWkFOUwqBtlRbMTri-KkgPGhD2_ZGI=
PBcLWyoWmljBTkrkRCnMV1Y7N4rW-oCpUm-iCv4sWmDhKNRXBtbjIR7xJ39O8UwR4kyQmv_QOVM=
fggTdmE642PUu8MtjEOt6Fl59z9_Ptc8Guk07NY3SSYBLXetB8v4es-ukNvGkHNkHrCi5k22-8H=
BOZGovaIOpV1V95jCcoOfL7sPXFGPdorrUw_NFNZomWD4sKsNza1cJaUYXuC-k8P0F9dQ3zwSbb=
NTeA97j1QLP5TmJQiDLzWkFwGgfawvK6t3c=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW-CWX=
4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9p5I5=
esJjpwGbzd-BA=3D=3D" data-trackable=3D"true" style=3D"color: #FFFFFF; font-=
family: Arial,Verdana,Helvetica,sans-serif; font-size: 16px; word-wrap: bre=
ak-word; font-weight: bold; text-decoration: none;">&#x8a73;&#x3057;&#x304f=
;&#x306f;&#x3053;&#x3061;&#x3089;</a> </td> </tr> </table>    </td> </tr> <=
/table>   </td> </tr> </table> <table class=3D"layout layout--1-column" sty=
le=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" c=
ellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"=
width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top">
<table class=3D"image image--float-right scale image--mobile-scale image--m=
obile-center" align=3D"right" border=3D"0" cellpadding=3D"0" cellspacing=3D=
"0" style=3D"mso-table-lspace: 5.75pt;"> <tr> <td class=3D"image_spacer hid=
e" width=3D"15" height=3D"1" align=3D"center" valign=3D"top" style=3D"heigh=
t: 1px; line-height: 1px; padding: 0px;"> <img alt=3D"" width=3D"15" height=
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tcontact.com/letters/images/sys/S.gif"> </td> <td class=3D"image_container =
scale stack" align=3D"right" valign=3D"" style=3D"padding-top: 0px; padding=
-bottom: 10px;"> <a href=3D"https://r20.rs6.net/tn.jsp?f=3D001WmhhqksTWgp-s=
iLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r9zQWYGIKCfRHaxI5pw3ZCU9BOMwqlVvFW3s5c=
mjZM4C_GrtKV7x_rOgZLfIALc8hPWRQyCd4Bh4CV3KehTgHvs-d0EzLURWCz3ERuLANiqf_ZCaQ=
nf-inEYIcCPqiSi3TVUdkQIQu0MrGjV9_0NEqGv1f1W-QT7at-osOBOlyHW7Ry63rxQjXndy1uZ=
aDIIXa1qHGBulhqq4ewu7C1SfboRYg_fddBXYPK3xBRPwUpgMU1yy9qsLn9Vn4YJMYhcVilICOw=
DKLWywP8m4QRrXfI8k8IRAdt50oN4lw9H0m_I2q&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW-CW=
X4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9p5I=
5esJjpwGbzd-BA=3D=3D" data-trackable=3D"true" style=3D"color: #4d4d4d; font=
-weight: bold; text-decoration: underline;"><img data-image-content class=
=3D"image_content" width=3D"232" src=3D"https://files.constantcontact.com/5=
f3d0cf9401/e83679e9-b202-455b-af85-a4998f58abd1.png" alt=3D"" style=3D"disp=
lay: block; height: auto; max-width: 100%;"></a> </td> </tr> </table> <p st=
yle=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D"font=
-family: Arial, Verdana, Helvetica, sans-serif; font-weight: bold;">B7&#x81=
9c;&#x30bf;&#x30f3;&#x30d1;&#x30af;&#x8cea;&#x30d5;&#x30a1;&#x30df;&#x30ea;=
&#x30fc;</span></p>
<p style=3D"margin: 0;"><br></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(54, 54, 54);">&#x79c1;&#x=
305f;&#x3061;&#x306e;&#x81ea;&#x7136;&#x514d;&#x75ab;&#x30b7;&#x30b9;&#x30c=
6;&#x30e0;&#x306f;&#x3001;&#x591a;&#x6570;&#x306e;&#x6b63;&#x307e;&#x305f;&=
#x306f;&#x8ca0;&#x306e;&#x5171;&#x523a;&#x6fc0;&#x5206;&#x5b50;&#x3092;&#x7=
d44;&#x307f;&#x8fbc;&#x3093;&#x3060;&#x8907;&#x96d1;&#x306a;&#x30c1;&#x30a7=
;&#x30c3;&#x30af;</span><span style=3D'font-family: Georgia, "Times New Rom=
an", Times, serif; color: rgb(54, 54, 54);'> </span><span style=3D"color: r=
gb(54, 54, 54);">&#xff06;&#x30d0;&#x30e9;&#x30f3;&#x30b9;&#x306e;&#x30b7;&#=
x30b9;&#x30c6;&#x30e0;&#x3067;&#x3059;&#x3002;</span><span style=3D'font-fa=
mily: Georgia, "Times New Roman", Times, serif; color: rgb(54, 54, 54);'> <=
/span><span style=3D"color: rgb(54, 54, 54);">&#x7279;&#x306b;&#x3001;</spa=
n><span style=3D'font-family: Georgia, "Times New Roman", Times, serif; col=
or: rgb(54, 54, 54);'>B7 </span><span style=3D"color: rgb(54, 54, 54);">&#x=
819c;&#x30bf;&#x30f3;&#x30d1;&#x30af;&#x8cea;&#x30d5;&#x30a1;&#x30df;&#x30e=
a;&#x30fc;&#x306f;&#x3001;</span><span style=3D'font-family: Georgia, "Time=
s New Roman", Times, serif; color: rgb(54, 54, 54);'>T </span><span style=
=3D"color: rgb(54, 54, 54);">&#x7d30;&#x80de;&#x5fdc;&#x7b54;&#x306e;&#x523=
6;&#x5fa1;&#x306b;&#x304a;&#x3044;&#x3066;&#x5354;&#x8abf;&#x7684;&#x306a;&=
#x5f79;&#x5272;&#x3092;&#x679c;&#x305f;&#x3059;&#x3053;&#x3068;&#x304c;&#x7=
93a;&#x3055;&#x308c;&#x3066;&#x304a;&#x308a;&#x3001;</span><span style=3D'f=
ont-family: Georgia, "Times New Roman", Times, serif; color: rgb(54, 54, 54=
);'>CD28 </span><span style=3D"color: rgb(54, 54, 54);">&#x307e;&#x305f;&#x=
306f;</span><span style=3D'font-family: Georgia, "Times New Roman", Times, =
serif; color: rgb(54, 54, 54);'> CTLA-4 </span><span style=3D"color: rgb(54=
, 54, 54);">&#x3068;&#x4e26;&#x884c;&#x3057;&#x3066;&#x300c;&#x7b2c;&#x4e8c=
;&#x306e;&#x30b7;&#x30b0;&#x30ca;&#x30eb;&#x300d;&#x3092;&#x4f1d;&#x9054;&#=
x3057;&#x3066;&#x3001;</span><span style=3D'font-family: Georgia, "Times Ne=
w Roman", Times, serif; color: rgb(54, 54, 54);'>T </span><span style=3D"co=
lor: rgb(54, 54, 54);">&#x7d30;&#x80de;&#x306e;&#x5897;&#x6b96;&#x3001;</sp=
an><span style=3D'font-family: Georgia, "Times New Roman", Times, serif; co=
lor: rgb(54, 54, 54);'>T </span><span style=3D"color: rgb(54, 54, 54);">&#x=
7d30;&#x80de;&#x306e;&#x5206;&#x5316;&#x3092;&#x523a;&#x6fc0;&#x3057;&#x300=
1;&#x514d;&#x75ab;&#x5fdc;&#x7b54;&#x3092;&#x963b;&#x5bb3;&#x3057;&#x307e;&=
#x3059;&#x3002;</span><span style=3D'font-family: Georgia, "Times New Roman=
", Times, serif; color: rgb(54, 54, 54);'> </span><span style=3D"color: rgb=
(54, 54, 54);">&#x307e;&#x305f;&#x306f;&#x6297;&#x539f;&#x5bdb;&#x5bb9;&#x3=
082;&#x8a98;&#x5c0e;&#x3057;&#x307e;&#x3059;&#x3002;</span><span style=3D'f=
ont-family: Georgia, "Times New Roman", Times, serif; color: rgb(54, 54, 54=
);'> </span><span style=3D"color: rgb(54, 54, 54);">&#x53d7;&#x5bb9;&#x4f53=
;&#x306e;&#x76f8;&#x4e92;&#x4f5c;&#x7528;&#x306b;&#x5fdc;&#x3058;&#x3066;&#=
x3001;</span><span style=3D'font-family: Georgia, "Times New Roman", Times,=
 serif; color: rgb(54, 54, 54);'>T </span><span style=3D"color: rgb(54, 54,=
 54);">&#x30ea;&#x30f3;&#x30d1;&#x7403;&#x5a92;&#x4ecb;&#x514d;&#x75ab;&#x5=
fdc;&#x7b54;&#x304c;&#x963b;&#x5bb3;&#x307e;&#x305f;&#x306f;&#x523a;&#x6fc0=
;&#x3055;&#x308c;&#x307e;&#x3059;&#x3002;</span></p>
</td> </tr> </table> <table class=3D"text text--padding-vertical" width=3D"=
100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layou=
t: fixed;"> <tr> <td class=3D"text_content-cell content-padding-horizontal"=
 style=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif=
; color: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-w=
rap: break-word; padding: 10px 40px;" align=3D"left" valign=3D"top"><p styl=
e=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D"font-f=
amily: Arial, Verdana, Helvetica, sans-serif; font-weight: bold;">B7 &#x819=
c;&#x30bf;&#x30f3;&#x30d1;&#x30af;&#x8cea;&#x30d5;&#x30a1;&#x30df;&#x30ea;&=
#x306e;11 &#x306e;&#x30e1;&#x30f3;&#x30d0;&#x30fc;&#x3092;&#x63d0;&#x4f9b;&=
#x53ef;&#x80fd;&#x3067;&#x3059;.</span></p></td> </tr> </table> </td> </tr>=
 </table> <table class=3D"layout layout--1-column" style=3D"table-layout: f=
ixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr=
> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=
=3D"center" valign=3D"top">
<table class=3D"text text--dataTable text--padding-vertical" width=3D"100%"=
 border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fi=
xed;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" styl=
e=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap: =
break-word; padding: 10px 40px;" align=3D"left" valign=3D"top" data-purpose=
=3D"dataTable"><div class=3D"dataTable dataTable--outerBorder dataTable--in=
nerBorder"> <table class=3D"dataTable_content" style=3D"background-color: #=
ffffff; width: 100%; min-width: 100%; border-collapse: collapse; font-famil=
y: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: 14px; bor=
der: 1px solid #a6a6a6;" width=3D"100%" border=3D"0" cellpadding=3D"0" cell=
spacing=3D"0" bgcolor=3D"#ffffff">  <tr>  <td class=3D"dataTable_content-ce=
ll" style=3D"background-color: #c03e30; text-align: center; vertical-align:=
 top; padding: 10px; border: 1px solid #a6a6a6;" align=3D"center" bgcolor=
=3D"#c03e30" valign=3D"top"> <p style=3D"margin: 0;"><span style=3D"color: =
rgb(255, 255, 255); font-weight: bold;">Name</span></p> </td>  <td class=3D=
"dataTable_content-cell" style=3D"background-color: #c03e30; text-align: ce=
nter; vertical-align: top; padding: 10px; border: 1px solid #a6a6a6;" align=
=3D"center" bgcolor=3D"#c03e30" valign=3D"top"> <p style=3D"margin: 0;"><sp=
an style=3D"color: rgb(255, 255, 255); font-weight: bold;">Alt. Name</span>=
</p> </td>  <td class=3D"dataTable_content-cell" style=3D"background-color:=
 #c03e30; text-align: center; vertical-align: top; padding: 10px; border: 1=
px solid #a6a6a6;" align=3D"center" bgcolor=3D"#c03e30" valign=3D"top"> <p =
style=3D"margin: 0;"><span style=3D"color: rgb(255, 255, 255); font-weight:=
 bold;">Binds to</span></p> </td>  </tr>  <tr>  <td class=3D"dataTable_cont=
ent-cell" style=3D"text-align: center; vertical-align: top; padding: 10px; =
border: 1px solid #a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"ma=
rgin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001WmhhqksTWgp-siLuzi4x=
pWU077mC9igPn0cp5vLv-ERCT_b9M_r9zQWYGIKCfRHaZ7hhtqOydxX_9nxEgjYZmOlpXSAIzXI=
R6aLo4IxJN2j1Nl6IkG9dwOl9ekUz4GUGvRN_IHLreM6hTo8oYzxU8kEv4dlyJIVeCrEHQqS0aW=
bTy9S2CmTV-BBKqrYxFLvYOayRSHm45Jg9vcj-sBA-JCFVH3Qrr-2cxMCUS6fcHnCiWC5g01X-_=
trA66f3PNzefIINtCTute3JRVxK6_5RoFJ3yR8pRi71JoZOmgxU0H93k0ZoqhN-vlp25ndk1aPq=
diZmNybp-77Q6SQGEIt1vw=3D=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW-CWX4d0h0SI5Tq=
JRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9p5I5esJjpwGbzd=
-BA=3D=3D" target=3D"_blank" style=3D"color: rgb(54, 54, 54); font-weight: =
bold; text-decoration: underline;">B7-1</a></p> </td>  <td class=3D"dataTab=
le_content-cell" style=3D"text-align: center; vertical-align: top; padding:=
 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"top"> <p styl=
e=3D"margin: 0;"><span style=3D"color: rgb(54, 54, 54);">CD80</span></p> </=
td>  <td class=3D"dataTable_content-cell" style=3D"text-align: center; vert=
ical-align: top; padding: 10px; border: 1px solid #a6a6a6;" align=3D"center=
" valign=3D"top"> <p style=3D"margin: 0;"><span style=3D"color: rgb(54, 54,=
 54);">CD28, CTLA-4, PD-L1</span></p> </td>  </tr>  <tr>  <td class=3D"data=
Table_content-cell" style=3D"text-align: center; vertical-align: top; paddi=
ng: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"top"> <p s=
tyle=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001WmhhqksTWg=
p-siLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r9zQWYGIKCfRHai9kkjud6yPDEqUGkJnShg=
jeoxA3zKEkxEbHz5RVQlhrj6ceRg2llrP66uHcNoYLrceOOIT-5oFGjiWrVHvyp_Mq3lD0G6Qsr=
sBL_UYVAxTAAl4BkelO_UI658uy-e5xtstIJK4WszLhqeLzQkYkvYDjosn__KhaQFzuBh6KP27Y=
KeRguQ9AkZo2rsnvqLR_MIfL3DWpIfPL1Ocl2KiVdqKJBfPBuewKr1WWCGNPeqSAYOef_7ix7bx=
r665JabK0TGDmEadv0KTtGYG4DDVjt5w=3D=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW-CWX=
4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9p5I5=
esJjpwGbzd-BA=3D=3D" target=3D"_blank" style=3D"color: rgb(54, 54, 54); fon=
t-weight: bold; text-decoration: underline;">B7-2</a></p> </td>  <td class=
=3D"dataTable_content-cell" style=3D"text-align: center; vertical-align: to=
p; padding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"to=
p"> <p style=3D"margin: 0;"><span style=3D"color: rgb(54, 54, 54);">CD86</s=
pan></p> </td>  <td class=3D"dataTable_content-cell" style=3D"text-align: c=
enter; vertical-align: top; padding: 10px; border: 1px solid #a6a6a6;" alig=
n=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><span style=3D"color: =
rgb(54, 54, 54);">CD28, CTLA-4</span></p> </td>  </tr>  <tr>  <td class=3D"=
dataTable_content-cell" style=3D"text-align: center; vertical-align: top; p=
adding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"top"> =
<p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001Wmhhqk=
sTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r9zQWYGIKCfRHayyJBD4YKq65xi6ctB=
XGE8kjyryhWkwQU6-0Z6BpqnZHwcfKlsaLFGn07YA7QdfhKi_UTijmFLzFwXYCqQW4KWe02g9Jj=
1q-7xJkXbG35jr121DmYC2Fca2pyV5T2u7P_sUR_l8CgCXaciO44OAJQ_tUQUc8d5vZDWXIdGDa=
jlRHxWRVmxf_Ezk-l4hpCbUtbSvKnNJ5--7kHLtFXBkyDMQq7wLnyoJ9pRDs22q8ba5HHySw6N9=
mspgXhvnXX9og5Mr0JSXEWO1TaftJik6ac9Q=3D=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW=
-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9=
p5I5esJjpwGbzd-BA=3D=3D" target=3D"_blank" style=3D"color: rgb(54, 54, 54);=
 font-weight: bold; text-decoration: underline;">B7-DC</a></p> </td>  <td c=
lass=3D"dataTable_content-cell" style=3D"text-align: center; vertical-align=
: top; padding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=
=3D"top"> <p style=3D"margin: 0;"><span style=3D"color: rgb(54, 54, 54);">P=
D-L2, CD273</span></p> </td>  <td class=3D"dataTable_content-cell" style=3D=
"text-align: center; vertical-align: top; padding: 10px; border: 1px solid =
#a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><span st=
yle=3D"color: rgb(54, 54, 54);">PD-1</span></p> </td>  </tr>  <tr>  <td cla=
ss=3D"dataTable_content-cell" style=3D"text-align: center; vertical-align: =
top; padding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"=
top"> <p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001=
WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r9zQWYGIKCfRHaf1C_T70m_Hw=
wtMk0Kh40afj3CFNdHSWSDvdGQsYvtyYm0e0j4P6juqCRAZHM_pn2gO7gmXNc0C9KpNuyS6kAEI=
vmPlGQmu97VnImUavX7R5XUlnhIUhjlvnXGpJA8T2-5bUYd5q0sV3-oUpk2AUtxyWru0545mLGb=
PUGd-uEXcRSO5l7rQo-MGIDA1yFtBZ4ONhJ72EFxNcbfY3vRSsUyCQaFMy2psJqFSf5TuGrjl3g=
5HYKsvejwDndz4KM0MEVSAk9fPDdArIHbkgLAlGDOg=3D=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2=
Ryv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPn=
ELraz9p5I5esJjpwGbzd-BA=3D=3D" target=3D"_blank" style=3D"color: rgb(54, 54=
, 54); font-weight: bold; text-decoration: underline;">B7-H1</a></p> </td> =
 <td class=3D"dataTable_content-cell" style=3D"text-align: center; vertical=
-align: top; padding: 10px; border: 1px solid #a6a6a6;" align=3D"center" va=
lign=3D"top"> <p style=3D"margin: 0;"><span style=3D"color: rgb(54, 54, 54)=
;">PD-L1, CD274</span></p> </td>  <td class=3D"dataTable_content-cell" styl=
e=3D"text-align: center; vertical-align: top; padding: 10px; border: 1px so=
lid #a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><spa=
n style=3D"color: rgb(54, 54, 54);">PD-1</span></p> </td>  </tr>  <tr>  <td=
 class=3D"dataTable_content-cell" style=3D"text-align: center; vertical-ali=
gn: top; padding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=
=3D"top"> <p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=
=3D001WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r9zQWYGIKCfRHamltNT=
Ixi87fAaeS0l_ESFFtiwL-0hI-l041cpbXBuAJ456SDlahgGkz7HvfEMqmjt6ah4zX9UqWiB-tM=
8u56XCRjJ4jcASNiFOgzymZNJHk79ZhFeESZLrBIrmaQj0k-yeoBbzVPuFXiCKQfmV2NsX_ULi-=
AkDUAR-d1kLEKbsIeEG5i7TP9WUV6kmjPKS9qVDv0YyRKFEosaOiKTpyGKZi9UBghasWNVmM6DY=
lnZ6npi3ZD7lugd9He26iyX3sKSJVRACMEbUsgdhHXoFQ-PA=3D=3D&c=3DyFB4KsQ3SOcjieUx=
lYVGQ2Ryv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjib=
VDoPPnELraz9p5I5esJjpwGbzd-BA=3D=3D" target=3D"_blank" style=3D"color: rgb(=
54, 54, 54); font-weight: bold; text-decoration: underline;">B7-H2</a></p> =
</td>  <td class=3D"dataTable_content-cell" style=3D"text-align: center; ve=
rtical-align: top; padding: 10px; border: 1px solid #a6a6a6;" align=3D"cent=
er" valign=3D"top"> <p style=3D"margin: 0;"><span style=3D"color: rgb(54, 5=
4, 54);">ICOSLG, CD275</span></p> </td>  <td class=3D"dataTable_content-cel=
l" style=3D"text-align: center; vertical-align: top; padding: 10px; border:=
 1px solid #a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0=
;"><span style=3D"color: rgb(54, 54, 54);">ICOS</span></p> </td>  </tr>  <t=
r>  <td class=3D"dataTable_content-cell" style=3D"text-align: center; verti=
cal-align: top; padding: 10px; border: 1px solid #a6a6a6;" align=3D"center"=
 valign=3D"top"> <p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.=
jsp?f=3D001WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r9zWAOhsQUGsF7=
btIBLKrUm2iuDXPCC0NI3kN2o99WqiY6OtL7821Dlt1HXVfDX7BU7rsUzMlRpR3YbgcHPgOzGCt=
TDxrlzxBzxn0wuEA8jH6FbXPN-g-92nUjZ5DvO9zX0bJ2RVvlpx3IvAVQxSPcsimVUz3Mltij6b=
nKbjAvGRwX-7gk3zCnB_oCNcvwP7SlZUlyfRfOhrRkZ3KBr6teWOaCtVP54QJ4W_eldHeUDV4Oi=
BjtWxkdji6e4yNMVdpDK600lZbxbSY403_rLxqWi4BYOPvUObYQWg=3D=3D&c=3DyFB4KsQ3SOc=
jieUxlYVGQ2Ryv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqT=
hLjibVDoPPnELraz9p5I5esJjpwGbzd-BA=3D=3D" target=3D"_blank" style=3D"color:=
 rgb(54, 54, 54); font-weight: bold; text-decoration: underline;">B7-H3</a>=
</p> </td>  <td class=3D"dataTable_content-cell" style=3D"text-align: cente=
r; vertical-align: top; padding: 10px; border: 1px solid #a6a6a6;" align=3D=
"center" valign=3D"top"> <p style=3D"margin: 0;"><span style=3D"color: rgb(=
54, 54, 54);">CD2765</span></p> </td>  <td class=3D"dataTable_content-cell"=
 style=3D"text-align: center; vertical-align: top; padding: 10px; border: 1=
px solid #a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"=
>
</p> </td>  </tr>  <tr>  <td class=3D"dataTable_content-cell" style=3D"text=
-align: center; vertical-align: top; padding: 10px; border: 1px solid #a6a6=
a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><a href=3D"ht=
tps://r20.rs6.net/tn.jsp?f=3D001WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ER=
CT_b9M_r9zWAOhsQUGsF7-B95urLhb8wCx7YqbupYQPE3w8DUrChNxzNop6-eiihJ-R3pVk9_OD=
BRpQK1tZ3HvHvdSoJSQ8_w6GrhnE4DxNcN4fIKtoGHndsXjnbvUKPjaNDnmb9bz0COAadVTNFUP=
LzFh3yDkz5eEh0gAgj_A4NpR8eN05qYPviIIK9qe4BEaRXntd4LI5DMig8vJ3KyrD_9tgOiu6rx=
rLl09G8pWkc87iiZKCtTdPoexFipOf-t-bFSzyV0wlqTGpgKqlDFMOn37bSUNXeHMbcWshBjqQ=
=3D=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=
=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9p5I5esJjpwGbzd-BA=3D=3D" target=3D"=
_blank" style=3D"color: rgb(54, 54, 54); font-weight: bold; text-decoration=
: underline;">B7-H4</a></p> </td>  <td class=3D"dataTable_content-cell" sty=
le=3D"text-align: center; vertical-align: top; padding: 10px; border: 1px s=
olid #a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><sp=
an style=3D"color: rgb(54, 54, 54);">VTCN1</span></p> </td>  <td class=3D"d=
ataTable_content-cell" style=3D"text-align: center; vertical-align: top; pa=
dding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"top"> <=
p style=3D"margin: 0;">
</p> </td>  </tr>  <tr>  <td class=3D"dataTable_content-cell" style=3D"text=
-align: center; vertical-align: top; padding: 10px; border: 1px solid #a6a6=
a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><a href=3D"ht=
tps://r20.rs6.net/tn.jsp?f=3D001WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ER=
CT_b9M_r9zQWYGIKCfRHaXTk55AzGXv3c_6KUyhW7z3RLJZ0tUs2kloyC1RYvDvf-YJPzTNZpab=
qUSCYuGNpvh_jhXZnsUNYw31I2fparGbbMPpU-AoNuKHuFTi7rLD0-tb-9PzHRt2tgu8RQah91x=
4dEMl3Tl-E1lw7Glf5RapRz-QTgAiycISL3oSPivujqEjga2hdJ14E_Td00a0c38YZAWJXmp5kE=
MCdWTHXNrBRkGeDFumNg-TvG14WyCcbfaCOQJHmKFMetvjHqQM0A9cwfjvLT6fxQ5iDfqjltEg=
=3D=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=
=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9p5I5esJjpwGbzd-BA=3D=3D" target=3D"=
_blank" style=3D"color: rgb(54, 54, 54); font-weight: bold; text-decoration=
: underline;">B7-H5</a></p> </td>  <td class=3D"dataTable_content-cell" sty=
le=3D"text-align: center; vertical-align: top; padding: 10px; border: 1px s=
olid #a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><sp=
an style=3D"color: rgb(54, 54, 54);">VISTA</span></p> </td>  <td class=3D"d=
ataTable_content-cell" style=3D"text-align: center; vertical-align: top; pa=
dding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"top"> <=
p style=3D"margin: 0;">
</p> </td>  </tr>  <tr>  <td class=3D"dataTable_content-cell" style=3D"text=
-align: center; vertical-align: top; padding: 10px; border: 1px solid #a6a6=
a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><a href=3D"ht=
tps://r20.rs6.net/tn.jsp?f=3D001WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ER=
CT_b9M_r9zQWYGIKCfRHaeuz6bbGAvEhPCsjgjHcWO-DXvYiHjPxu7urWtFnXk7xifbQerVTSNl=
Fkxfe_UUy64kgORVANpLUxEx8kmjbR2rSgNnGQ9bH_YfO0ndXi6HgUfVdJBF4Z-Kie-Ou_7S8Jo=
sv5oQDSBO_ewO2K9KcTZxZzj3lvZn5aM9W6yXlHKD_cLZSXTwFTr9_ctLeIXtgGAq3btWF0HoL-=
I-u6DBxxGDUIYnUvm4r_qaIjiGmZnZcuJm_bB93KlE87W36Hu89Y-D29Mxt1W1ZVNsRlLKUlXQ=
=3D=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=
=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9p5I5esJjpwGbzd-BA=3D=3D" target=3D"=
_blank" style=3D"color: rgb(54, 54, 54); font-weight: bold; text-decoration=
: underline;">B7-H6</a></p> </td>  <td class=3D"dataTable_content-cell" sty=
le=3D"text-align: center; vertical-align: top; padding: 10px; border: 1px s=
olid #a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><sp=
an style=3D"color: rgb(54, 54, 54);">NCR3LG1</span></p> </td>  <td class=3D=
"dataTable_content-cell" style=3D"text-align: center; vertical-align: top; =
padding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"top">=
 <p style=3D"margin: 0;"><span style=3D"color: rgb(54, 54, 54);">NKp30</spa=
n></p> </td>  </tr>  <tr>  <td class=3D"dataTable_content-cell" style=3D"te=
xt-align: center; vertical-align: top; padding: 10px; border: 1px solid #a6=
a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><a href=3D"=
https://r20.rs6.net/tn.jsp?f=3D001WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-=
ERCT_b9M_r9zQWYGIKCfRHaTOxCqooFBBpp36wAmphouYCK6TWv-8JICFqCgo4K9pG8X4uGodgz=
HqVrnih8uaKHW2hIruTGQot5kX8Cm-PmE-VVCjrqA6pyex7_k5zqvYwayFcMcX_oQ0e7qatzXru=
XizQqfPIeGre98z7hqg9nTUPjQZUxcWBlmp3-4GrrWPkfLGFQF85iomNCh0aGi251GINO8qy_CU=
om2qSdwvggEMPMTC8Ufrk7N7ScIEEk41gIwDwVdtV55yRiMTzIJg_lTvlOmDDkln01y6LHr28Br=
g=3D=3D&c=3DyFB4KsQ3SOcjieUxlYVGQ2Ryv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=
=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnELraz9p5I5esJjpwGbzd-BA=3D=3D" target=3D"=
_blank" style=3D"color: rgb(54, 54, 54); font-weight: bold; text-decoration=
: underline;">B7-H7</a></p> </td>  <td class=3D"dataTable_content-cell" sty=
le=3D"text-align: center; vertical-align: top; padding: 10px; border: 1px s=
olid #a6a6a6;" align=3D"center" valign=3D"top"> <p style=3D"margin: 0;"><sp=
an style=3D"color: rgb(54, 54, 54);">HHLA2</span></p> </td>  <td class=3D"d=
ataTable_content-cell" style=3D"text-align: center; vertical-align: top; pa=
dding: 10px; border: 1px solid #a6a6a6;" align=3D"center" valign=3D"top"> <=
p style=3D"margin: 0;"><span style=3D"color: rgb(54, 54, 54);">CD28H</span>=
</p> </td>  </tr>  </table> </div></td> </tr> </table> </td> </tr> </table>=
 <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;" wi=
dth=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td cla=
ss=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center"=
 valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cent=
er; margin: 0;" align=3D"center"><span style=3D"font-weight: bold; font-fam=
ily: Arial, Verdana, Helvetica, sans-serif;">ACROBiosystems &#x304b;&#x3089=
;&#x306e;&#x3055;&#x3089;&#x306b;&#x591a;&#x304f;&#x306e; B7 &#x30d5;&#x30a=
1;&#x30df;&#x30ea;&#x30fc;&#x5206;&#x5b50;&#x3068;&#x30a2;&#x30c3;&#x30bb;&=
#x30a4;&#x30c7;&#x30fc;&#x30bf;&#x3092;&#x304a;&#x63a2;&#x3057;&#x306e;&#x6=
5b9;&#x306f;</span></p></td> </tr> </table>  <table class=3D"button button-=
-padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacin=
g=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"button_container =
content-padding-horizontal" align=3D"center" style=3D"padding: 10px 40px;">=
    <table class=3D"button_content-row" style=3D"background-color: #c03e30;=
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er=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td =
class=3D"button_content-cell" style=3D"padding: 10px 15px;" align=3D"center=
"> <a class=3D"button_link" href=3D"https://r20.rs6.net/tn.jsp?f=3D001Wmhhq=
ksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r9zQWYGIKCfRHaxI5pw3ZCU9BOMwql=
VvFW3s5cmjZM4C_GrtKV7x_rOgZLfIALc8hPWRQyCd4Bh4CV3KehTgHvs-d0EzLURWCz3ERuLAN=
iqf_ZCaQnf-inEYIcCPqiSi3TVUdkQIQu0MrGjV9_0NEqGv1f1W-QT7at-osOBOlyHW7Ry63rxQ=
jXndy1uZaDIIXa1qHGBulhqq4ewu7C1SfboRYg_fddBXYPK3xBRPwUpgMU1yy9qsLn9Vn4YJMYh=
cVilICOwDKLWywP8m4QRrXfI8k8IRAdt50oN4lw9H0m_I2q&c=3DyFB4KsQ3SOcjieUxlYVGQ2R=
yv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnE=
Lraz9p5I5esJjpwGbzd-BA=3D=3D" data-trackable=3D"true" style=3D"font-size: 1=
4px; color: #FFFFFF; font-family: Arial,Verdana,Helvetica,sans-serif; word-=
wrap: break-word; font-weight: bold; text-decoration: none;">&#x3053;&#x306=
1;&#x3089;&#x304b;&#x3089;&#x3054;&#x89a7;&#x304f;&#x3060;&#x3055;&#x3044;<=
/a> </td> </tr> </table>    </td> </tr> </table>   </td> </tr> </table> <ta=
ble class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=
=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center" v=
align=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cent=
er; margin: 0;" align=3D"center"><span style=3D"color: black; font-size: 16=
px; font-weight: bold;">&#x30bb;&#x30eb;&#x30d9;&#x30fc;&#x30b9;&#x30a2;&#x=
30c3;&#x30bb;&#x30a4;&#x691c;&#x8a3c;&#x30c7;&#x30fc;&#x30bf;</span><span s=
tyle=3D'font-family: Georgia, "Times New Roman", Times, serif; color: black=
; font-size: 16px; font-weight: bold;'>:</span></p></td> </tr> </table> <ta=
ble class=3D"image image--mobile-scale image--mobile-center" width=3D"100%"=
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container content-padding-horizontal" align=3D"center" valign=3D"top" style=
=3D"padding-left: 40px; padding-right: 40px;"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r9zQWYGI=
KCfRHafOI7hGDXClkQCSZGD09s3SaLUhb8nGUaCd-KnP8LIySsDZ0j11ZZeCr-9KkVFWhzgbQIj=
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o; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </table> <table =
class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"1=
00%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"co=
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<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
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class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><spa=
n style=3D"font-size: 13px; color: black; font-family: Arial, Verdana, Helv=
etica, sans-serif; font-style: italic;">Flow Cytometry assay shows that Bio=
tinylated Human B7-1, Fc,Avitag (Cat. No.&#xa0;</span><a href=3D"https://r2=
0.rs6.net/tn.jsp?f=3D001WmhhqksTWgp-siLuzi4xpWU077mC9igPn0cp5vLv-ERCT_b9M_r=
9zQWYGIKCfRHa7ZrdPMfoRCVdyxoT5qrEW2bXhT-FYOWg3jlmdsB5fD65hi7hVxDnC94ZfafJBD=
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yv5tW-CWX4d0h0SI5TqJRDBb0vJ0b6w=3D=3D&ch=3DMxdZq1rRx6aaM8mThgqThLjibVDoPPnE=
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olor: black; font-family: Arial, Verdana, Helvetica, sans-serif; font-style=
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n style=3D"font-size: 13px; color: black; font-family: Arial, Verdana, Helv=
etica, sans-serif; font-style: italic;">) can bind to 293 cell overexpressi=
ng human CTLA-4. The concentration of Human B7-1 is 0.3 &#x3bc;g/mL (Routin=
ely tested).</span></p></td> </tr> </table>  <table class=3D"button button-=
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