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편집 파일: 1687831939.M947013P24909.server.saraya-global.com,S=50922,W=51716:2,

Envelope-to: mykhaylo.dubrovka@saraya.co.in
Delivery-date: Tue, 27 Jun 2023 10:12:19 +0800
Message-ID: <1140331344496.1119371711477.1404958413.0.402208JL.2002@synd.ccsend.com>
Date: Mon, 26 Jun 2023 22:11:30 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
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BBQ7duZlTDrEUuP0e1FUuquL-Fd1KUKLI3nBsKKLSpH07pHMxyG0svdflyKf57yWzEtIJM7qoFK=
uMEpC-VY93IZC4MrI=3D&c=3DLzLx06hXiFj4te9NC9Ln7osQDI40jdTmUmHiwnVL3Awk9c3hY_=
CPwg=3D=3D&ch=3DwYPpzEmDYldf8PNGdFCD06sItZhkG6u-63XOpMhY-WwllNsSUYKVSg=3D=
=3D" target=3D"_blank" style=3D"color: rgb(192, 62, 48); text-decoration: u=
nderline; font-size: 13px; font-weight: bold;">&#x30a4;&#x30f3;&#x30b5;&#x3=
0a4;&#x30c8;</a></p></td> </tr> </table> </td>  <td class=3D"column column-=
-4 scale stack" style=3D"width: 20%;" align=3D"center" valign=3D"middle">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
 break-word; padding: 10px 20px;" align=3D"center" valign=3D"top"><p style=
=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001IWPW5Pv4EDqOEg=
XhPo4_3OIM7HogQbptus00pWFolk0brkwNCZ2TX_cRDMO_26FiDkEquwvT7WHN76xFcso8KtumW=
KgLfXaEQE_fACGWtu79nS7wNyxSlAkd-oUiLuryxZ9yD3q6C0_-dK40sOFnG3pYH540SVPHdX5H=
B3oFkqqsYna76-9F0gsoS5dY-8ASYVe9aRwQr1qocjkfj4j9-aVXNJKuOsNxcpsFd5p9ZZZogFs=
Wr0llE_ffeikaWQcCZAOTXBkiPf5rPbv4-9GYM_c_tkFDCeCwWBnv5S5b1cWIV5xth7qrOkOSdX=
4q5L9LWX7h-MZmjPzHMWHpUJfTmA=3D=3D&c=3DLzLx06hXiFj4te9NC9Ln7osQDI40jdTmUmHi=
wnVL3Awk9c3hY_CPwg=3D=3D&ch=3DwYPpzEmDYldf8PNGdFCD06sItZhkG6u-63XOpMhY-Wwll=
NsSUYKVSg=3D=3D" target=3D"_blank" style=3D'color: rgb(192, 62, 48); text-d=
ecoration: underline; font-family: "Arial Black", Gadget, sans-serif; font-=
size: 13px; font-weight: bold;'>&#x30ea;&#x30bd;&#x30fc;&#x30b9;</a></p></t=
d> </tr> </table> </td>  <td class=3D"column column--5 scale stack" style=
=3D"width: 20%;" align=3D"center" valign=3D"middle">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
 break-word; padding: 10px 40px 10px 0px;" align=3D"center" valign=3D"top">=
<p style=3D"text-align: right; margin: 0;" align=3D"right"><a href=3D"https=
://r20.rs6.net/tn.jsp?f=3D001IWPW5Pv4EDqOEgXhPo4_3OIM7HogQbptus00pWFolk0brk=
wNCZ2TX4wsmOwEHGYcm9iIa7oJ02ql3nmsCGzZUcl61Ha19TLzngVOblpkqXlR-9hK9zUNFXTyP=
kBccZF5fIgb1Z-DfMMTIv7kzEihKF8nH54vLoWEwtxWN91mFgCliUTjKMDfkKHi3Ij9frFOtizb=
QzGJUg5H8YKjuyBlHrdrDBrOB8zkQBcfwth2UauUmtirq7-5-zSZ-XmPEcAP7TRY-CWB6NtzDic=
P4zNQvaClYExbbLhfZ9W5UfWB2_HrsjagM0GtdhK3yMGlZDz6-8b7FNpojShTTg-OBETAf2LYe4=
Y0wqXs&c=3DLzLx06hXiFj4te9NC9Ln7osQDI40jdTmUmHiwnVL3Awk9c3hY_CPwg=3D=3D&ch=
=3DwYPpzEmDYldf8PNGdFCD06sItZhkG6u-63XOpMhY-WwllNsSUYKVSg=3D=3D" target=3D"=
_blank" style=3D"color: rgb(192, 62, 48); text-decoration: underline; font-=
size: 13px; font-weight: bold;">&#x4f1a;&#x793e;&#x6982;&#x8981;</a></p></t=
d> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-col=
umn" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=
=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" s=
tyle=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D"spacer"=
 style=3D"line-height: 10px; height: 10px;">&#x200a;</div></td> </tr> </tab=
le> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;"=
 width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td =
class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"cent=
er" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1; text-align: center; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #3E3E3E; font-size: 14px; display: block; word-wrap: b=
reak-word; padding: 10px 40px;" align=3D"center" valign=3D"top"><p style=3D=
"text-align: center; margin: 0;" align=3D"center"><span style=3D"font-size:=
 18px; font-weight: bold;">&#x30d2;&#x30c8; GLP-1R (Luc) HEK293 &#x30ec;&#x=
30dd;&#x30fc;&#x30bf;&#x30fc;&#x7d30;&#x80de;: &#x7d30;&#x80de;&#x30ec;&#x3=
0d9;&#x30eb;&#x3067;&#x306e;&#x691c;&#x8a3c;</span></p></td> </tr> </table>=
 </td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"tab=
le-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacin=
g=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 10=
0%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; c=
olor: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"color: black;">&#x4eba;&#x3005;&#x30=
6e;&#x751f;&#x6d3b;&#x3084;&#x98df;&#x751f;&#x6d3b;&#x306e;&#x5909;&#x5316;=
&#x3001;&#x9ad8;&#x9f62;&#x5316;&#x306b;&#x4f34;&#x3044;&#x3001;II&#x578b;&=
#x7cd6;&#x5c3f;&#x75c5;&#xff08;T2DM&#xff09;&#x3068;&#x80a5;&#x6e80;&#x306e;=
&#x6709;&#x75c5;&#x7387;&#x304c;&#x6025;&#x901f;&#x306b;&#x5897;&#x52a0;&#x=
3057;&#x3066;&#x304a;&#x308a;&#x3001;&#x4e16;&#x754c;&#x4e2d;&#x3067;&#x516=
c;&#x8846;&#x885b;&#x751f;&#x4e0a;&#x306e;&#x554f;&#x984c;&#x3068;&#x306a;&=
#x3063;&#x3066;&#x3044;&#x307e;&#x3059;&#x3002;</span></p>
<p style=3D"margin: 0;">&#x7cd6;&#x5c3f;&#x75c5;&#x306f;&#x3001;&#x81b5;&#x=
81d3;&#x304c;&#x5341;&#x5206;&#x306a;&#x30a4;&#x30f3;&#x30b9;&#x30ea;&#x30f=
3;&#x3092;&#x751f;&#x6210;&#x3057;&#x306a;&#x3044;&#x5834;&#x5408;&#x3001;&=
#x307e;&#x305f;&#x306f;&#x751f;&#x6210;&#x3055;&#x308c;&#x305f;&#x30a4;&#x3=
0f3;&#x30b9;&#x30ea;&#x30f3;&#x3092;&#x4f53;&#x304c;&#x52b9;&#x679c;&#x7684=
;&#x306b;&#x4f7f;&#x7528;&#x3067;&#x304d;&#x306a;&#x3044;&#x5834;&#x5408;&#=
x306b;&#x767a;&#x751f;&#x3059;&#x308b;&#x6162;&#x6027;&#x75be;&#x60a3;&#x30=
67;&#x3059;&#x3002; GLP-1 (&#x30b0;&#x30eb;&#x30ab;&#x30b4;&#x30f3;&#x69d8;=
&#x30da;&#x30d7;&#x30c1;&#x30c9;-1&#x3001;&#x30b0;&#x30eb;&#x30ab;&#x30b4;&=
#x30f3;&#x69d8;&#x30da;&#x30d7;&#x30c1;&#x30c9; 1) &#x306f;&#x3001;&#x56de;=
&#x8178;&#x304a;&#x3088;&#x3073;&#x7d50;&#x8178; L &#x7d30;&#x80de;&#x306b;=
&#x3088;&#x3063;&#x3066;&#x5206;&#x6ccc;&#x3055;&#x308c;&#x308b;&#x30dd;&#x=
30ea;&#x30da;&#x30d7;&#x30c1;&#x30c9; &#x30db;&#x30eb;&#x30e2;&#x30f3;&#x30=
67;&#x3059;&#x3002; &#x305d;&#x306e;&#x53d7;&#x5bb9;&#x4f53;&#x3067;&#x3042=
;&#x308b; GLP-1R &#x306f;&#x3001;&#x81b5;&#x81d3;&#x7d44;&#x7e54;&#x3001;&#=
x80c3;&#x3001;&#x5c0f;&#x8178;&#x3001;&#x5fc3;&#x81d3;&#x3001;&#x814e;&#x81=
d3;&#x3001;&#x80ba;&#x3001;&#x8133;&#x306e;&#x81b5;&#x81d3; &#x3b2; &#x7d30=
;&#x80de;&#x306b;&#x5e83;&#x304f;&#x767a;&#x73fe;&#x3057;&#x3066;&#x3044;&#=
x307e;&#x3059;&#x3002;</p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container content-padding-horizontal" align=3D"center" valign=3D"top" st=
yle=3D"padding-left: 40px; padding-right: 40px;"> <a href=3D"https://r20.rs=
6.net/tn.jsp?f=3D001IWPW5Pv4EDqOEgXhPo4_3OIM7HogQbptus00pWFolk0brkwNCZ2TX7H=
YAVNfQj1LEKjywIC7Glafagr_2TVzEGi-h_K4LqH3o5E1EA8_ECRRjldSFjffHvo8r8sT2qbrIQ=
4LXgv1uUSmxPWoZWHPwnnsd183BEMqwitKFEQmU5-zccfTIzQz_7vT7J9bOIMNObByUZbDmGUxw=
VUcjgxInWcI6sQLfkhmf2kmZBwRmJwXTx0au5y6QdEYgTnG242h64cSPs9DELqkeOGj6hUj8J8h=
yqXPJ3b7Qmd8NN1Qoa-G08nAA6YNRA18lJyQhMxKkMLGfRkyjVk2y8XyMo_6jRmvjK7OOIOaTW1=
BVYJLHRNQxfwl7h1im4zLNRNsYIHk&c=3DLzLx06hXiFj4te9NC9Ln7osQDI40jdTmUmHiwnVL3=
Awk9c3hY_CPwg=3D=3D&ch=3DwYPpzEmDYldf8PNGdFCD06sItZhkG6u-63XOpMhY-WwllNsSUY=
KVSg=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"image_=
content" width=3D"600" src=3D"https://files.constantcontact.com/5f3d0cf9401=
/e8f9bc12-aefd-4207-a859-49eca29006f9.png" alt=3D"" style=3D"display: block=
; height: auto; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </t=
able> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed=
;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <t=
d class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"ce=
nter" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; c=
olor: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-size: 13px; color: black;">Schematic representation of the GLP-1R rep=
orter cell line</span></p>
<p style=3D"margin: 0;"><br></p>
<p style=3D"margin: 0;">GLP-1 &#x306f; GLP-1R &#x306b;&#x7d50;&#x5408;&#x30=
57;&#x3001;mTOR &#x4f9d;&#x5b58;&#x6027; HIF-1 &#x3b1; &#x306e;&#x6d3b;&#x6=
027;&#x5316;&#x3092;&#x901a;&#x3058;&#x3066;&#x81b5;&#x5cf6; &#x3b2; &#x7d3=
0;&#x80de;&#x306e;&#x30b0;&#x30eb;&#x30b3;&#x30fc;&#x30b9;&#x4ee3;&#x8b1d;&=
#x3092;&#x4fc3;&#x9032;&#x3057;&#x307e;&#x3059;&#x3002; GLP-1 &#x53d7;&#x5b=
b9;&#x4f53;&#x30a2;&#x30b4;&#x30cb;&#x30b9;&#x30c8; (GLP-1RA) &#x306f;&#x30=
01;GLP-1 &#x53d7;&#x5bb9;&#x4f53;&#x3092;&#x523a;&#x6fc0;&#x3059;&#x308b;&#=
x3053;&#x3068;&#x3067;&#x30a4;&#x30f3;&#x30af;&#x30ec;&#x30c1;&#x30f3;&#x30=
6e;&#x7523;&#x751f;&#x3068;&#x4f53;&#x91cd;&#x6e1b;&#x5c11;&#x3092;&#x4fc3;=
&#x9032;&#x3057;&#x307e;&#x3059;&#x3002;</p>
<p style=3D"margin: 0;">GPL-1R &#x30a2;&#x30b4;&#x30cb;&#x30b9;&#x30c8;&#x3=
06e;&#x533b;&#x85ac;&#x54c1;&#x958b;&#x767a;&#x30cb;&#x30fc;&#x30ba;&#x3092=
;&#x6e80;&#x305f;&#x3059;&#x305f;&#x3081;&#x306b;&#x3001;ACROBiosystems &#x=
306f;&#x3001;GLP-1R &#x95a2;&#x9023;&#x30b7;&#x30b0;&#x30ca;&#x30eb;&#x4f1d=
;&#x9054;&#x6a5f;&#x69cb;&#x306b;&#x57fa;&#x3065;&#x3044;&#x305f; HEK293 &#=
x7d30;&#x80de;&#x3092;&#x4f7f;&#x7528;&#x3057;&#x3066;&#x3001;&#x9ad8;&#x54=
c1;&#x8cea;&#x306a;<a href=3D"https://r20.rs6.net/tn.jsp?f=3D001IWPW5Pv4EDq=
OEgXhPo4_3OIM7HogQbptus00pWFolk0brkwNCZ2TX7HYAVNfQj1LEKjywIC7Glafagr_2TVzEG=
i-h_K4LqH3o5E1EA8_ECRRjldSFjffHvo8r8sT2qbrIQ4LXgv1uUSmxPWoZWHPwnnsd183BEMqw=
itKFEQmU5-zccfTIzQz_7vT7J9bOIMNObByUZbDmGUxwVUcjgxInWcI6sQLfkhmf2kmZBwRmJwX=
Tx0au5y6QdEYgTnG242h64cSPs9DELqkeOGj6hUj8J8hyqXPJ3b7Qmd8NN1Qoa-G08nAA6YNRA1=
8lJyQhMxKkMLGfRkyjVk2y8XyMo_6jRmvjK7OOIOaTW1BVYJLHRNQxfwl7h1im4zLNRNsYIHk&c=
=3DLzLx06hXiFj4te9NC9Ln7osQDI40jdTmUmHiwnVL3Awk9c3hY_CPwg=3D=3D&ch=3DwYPpzE=
mDYldf8PNGdFCD06sItZhkG6u-63XOpMhY-WwllNsSUYKVSg=3D=3D" target=3D"_blank" s=
tyle=3D"color: rgb(192, 62, 48); font-weight: bold; text-decoration: underl=
ine;">&#x30d2;&#x30c8; GLP-1R (Luc) HEK293 &#x30ec;&#x30dd;&#x30fc;&#x30bf;=
&#x30fc;&#x7d30;&#x80de;&#x682a;&#x88fd;&#x54c1;</a>&#x3092;&#x958b;&#x767a=
;&#x3057;&#x307e;&#x3057;&#x305f;&#x3002;</p>
<p style=3D"margin: 0;"><br></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-weight: bold;">&#x30d2;&#x30c8; GLP-1R (Luc) HEK293&#x30ec;&#x30dd;&#=
x30fc;&#x30bf;&#x30fc;&#x7d30;&#x80de;&#x88fd;&#x54c1;&#x4e00;&#x89a7;</spa=
n></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container content-padding-horizontal" align=3D"center" valign=3D"top" st=
yle=3D"padding-left: 40px; padding-right: 40px;"> <a href=3D"https://r20.rs=
6.net/tn.jsp?f=3D001IWPW5Pv4EDqOEgXhPo4_3OIM7HogQbptus00pWFolk0brkwNCZ2TX7H=
YAVNfQj1LEKjywIC7Glafagr_2TVzEGi-h_K4LqH3o5E1EA8_ECRRjldSFjffHvo8r8sT2qbrIQ=
4LXgv1uUSmxPWoZWHPwnnsd183BEMqwitKFEQmU5-zccfTIzQz_7vT7J9bOIMNObByUZbDmGUxw=
VUcjgxInWcI6sQLfkhmf2kmZBwRmJwXTx0au5y6QdEYgTnG242h64cSPs9DELqkeOGj6hUj8J8h=
yqXPJ3b7Qmd8NN1Qoa-G08nAA6YNRA18lJyQhMxKkMLGfRkyjVk2y8XyMo_6jRmvjK7OOIOaTW1=
BVYJLHRNQxfwl7h1im4zLNRNsYIHk&c=3DLzLx06hXiFj4te9NC9Ln7osQDI40jdTmUmHiwnVL3=
Awk9c3hY_CPwg=3D=3D&ch=3DwYPpzEmDYldf8PNGdFCD06sItZhkG6u-63XOpMhY-WwllNsSUY=
KVSg=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"image_=
content" width=3D"600" src=3D"https://files.constantcontact.com/5f3d0cf9401=
/2b991d44-e1c6-4320-9f2c-e9cc9bd3aed8.png" alt=3D"" style=3D"display: block=
; height: auto; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </t=
able> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed=
;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <t=
d class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"ce=
nter" valign=3D"top">
<table class=3D"divider divider--dashed" width=3D"100%" cellpadding=3D"0" c=
ellspacing=3D"0" border=3D"0"> <tr> <td class=3D"divider_container content-=
padding-horizontal" style=3D"padding: 10px 40px;" width=3D"100%" align=3D"c=
enter" valign=3D"top"> <table class=3D"divider_content-row" style=3D"height=
: 1px; width: 100%;" cellpadding=3D"0" cellspacing=3D"0" border=3D"0"> <tr>=
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px; border-bottom-style: dashed; border-bottom-color: #4d4d4d;" height=3D"1=
" align=3D"center" bgcolor=3D"transparent"> <img alt=3D"" width=3D"5" heigh=
t=3D"1" border=3D"0" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.consta=
ntcontact.com/letters/images/1101116784221/S.gif" style=3D"display: block; =
height: 1px; width: 5px;"> </td> </tr> </table> </td> </tr> </table> </td> =
</tr> </table> <table class=3D"layout layout--1-column" style=3D"table-layo=
ut: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"=
> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" al=
ign=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
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