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Delivery-date: Thu, 22 Jun 2023 08:34:23 +0800
Message-ID: <1140315092347.1119371711477.1404958413.0.592030JL.2002@synd.ccsend.com>
Date: Wed, 21 Jun 2023 20:30:56 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
Subject: =?utf-8?Q?ASCO_2023=EF=BC=9ANew_Hope_for_TIGIT_Cancer_Immunotherapies?=
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ASCO 2023: TIGIT lives again with Roche and Gilead data View as Webpage =E2=
=80=8A =E2=80=8A Products Support Insights Resources About Us =E2=80=8A Now=
 that ASCO has ended (for those who couldn=E2=80=99t attend, we hope to see=
 you at ACROBiosystems=E2=80=99 booth next year!!). A year ago, enthusiasm =
for a new generation of cancer immunotherapies targeting TIGIT started to w=
ane, after Roche=E2=80=99s Tiragolumab was hit by two failed studies in lun=
g cancer. However, the year=E2=80=99s ASCO congress brought new hope for TI=
GIT cancer immunotherapies, as top pharmaceutical companies, presented prom=
ising clinical data. o Roche=E2=80=99s Tiragolumab: Adding Tiragolumab to s=
tandard-of-care atezolizumab plus bevacizumab improved tumor responses comp=
ared with the atezolizumab/bevacizumab doublet as first-line treatment in p=
atients with unresectable, locally advanced, or metastatic hepatocellular c=
arcinoma (HCC). o  Arcus/Gilead=E2=80=99s Arc-7: The new data presented fro=
m the phase 2 study of Domvanalimab in combination with PD-1 inhibitor Zimb=
erelimab as a first-line therapy for non-small cell lung cancer (NSCLC) sho=
wed that Domvanalimab continues to demonstrate consistent improvement in pr=
ogression-free survival compared to Zimberelimab monotherapy. TIGIT Related=
 Products from ACROBiosystems o Proteins lVarious tags & species (Human/Mou=
se, Cynomolgus/Rhesus macaque/Rabbit/Rat/Canine). lHomogeneous structure an=
d high purity verified by SEC-MALS. lHigh bioactivity validated by ELISA/SP=
R/BLI/FACS o Inhibitor screening kits=EF=BC=9A ACROBiosystems has developed=
 a TIGIT: CD155 [Biotinylated] inhibitor screening kit (Cat.No. EP-131) bas=
ed on the sandwich ELISA method, which can be used for early screening and =
QC release. Assay Data TIGIT Homodimer structure and purity (=EF=BC=9E90%) =
verified by SELC-MALS The purity of Human TIGIT, Fc Tag (Cat. No. TIT-H5254=
) is more than 90% and the molecular weight of this protein is around 85-10=
0 kDa verified by SEC-MALS.    Binding activity between TIGIT and antibody =
verified by ELISA Anti-hTIGIT antibody captured on CM5 chip via Anti-mouse =
antibodies surface can bind Human TIGIT, His Tag (Cat. No. TIT-H52H5) with =
an affinity constant of 1.28 nM as determined in a SPR assay (Biacore 8K) (=
Routinely tested). Request a Protocol Spotlight product CD155 Proteins CD22=
6 Proteins PVRIG Proteins >>>Click to learn more immune checkpoint proteins=
  =EF=BB=BFTo receive the latest industry news and updates from ACROBiosyst=
ems, =EF=BB=BFvisit our website & follow us on our social media!=EF=BB=BF V=
isit our Website =E2=80=8A       ACROBiosystems | 1 Innovation Way, Newark,=
 DE 19711 Unsubscribe mykhaylo.dubrovka@saraya.co.in Update Profile | Our P=
rivacy Policy | Constant Contact Data Notice Sent by acrobio.apac@outlook.c=
om
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nderline; font-weight: bold; font-family: "Arial Black", Gadget, sans-serif=
;'>Resources</a></p></td> </tr> </table> </td>  <td class=3D"column column-=
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1evD3DjiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvpTb6Vqt=
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lor: rgb(192, 62, 48); text-decoration: underline; font-family: "Arial Blac=
k", Gadget, sans-serif; font-weight: bold;'>About Us</a></p></td> </tr> </t=
able> </td> </tr> </table> <table class=3D"layout layout--1-column" style=
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dth: 100%;" align=3D"center" valign=3D"top"><div class=3D"spacer" style=3D"=
line-height: 10px; height: 10px;">&#x200a;</div></td> </tr> </table> <table=
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100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"c=
olumn column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=
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<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container" align=3D"center" valign=3D"top"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClgsgsS=
melNDPVhjBQmSV6963VAAL3PY-NJ5O-Q7xtHdX9lQ1tyGFxDC8FLtscAOeR5g_23wHV1HOdi_OC=
k3LhaIYRvtPwixF3Ojr5YHJiBhl57uePgLPGJEtmzmezEo_xukyO4dcT4wVKsZYGsBnt-jwBsrm=
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uJ_3Z9QaVSOLoWKwF6pfXZZHqMLfHMrVoVkgRCZu2FagDN2JXuheh_4vgFsZivIk0Nabp&c=3Do=
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><img data-image-content class=3D"image_content" width=3D"506" src=3D"https=
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93.png" alt=3D"" style=3D"display: block; height: auto; max-width: 100%;"><=
/a> </td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout=
--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cell=
padding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale s=
tack" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top">
<table class=3D"image image--float-right scale image--mobile-scale image--m=
obile-center" align=3D"right" border=3D"0" cellpadding=3D"0" cellspacing=3D=
"0" style=3D"mso-table-lspace: 5.75pt;"> <tr> <td class=3D"image_spacer hid=
e" width=3D"15" height=3D"1" align=3D"center" valign=3D"top" style=3D"heigh=
t: 1px; line-height: 1px; padding: 0px;"> <img alt=3D"" width=3D"15" height=
=3D"1" border=3D"0" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.constan=
tcontact.com/letters/images/sys/S.gif"> </td> <td class=3D"image_container =
scale stack" align=3D"right" valign=3D"" style=3D"padding-top: 0px; padding=
-bottom: 10px;"> <img data-image-content class=3D"image_content" width=3D"2=
00" src=3D"https://files.constantcontact.com/5f3d0cf9401/12f16804-0d56-48e4=
-8acc-79cfa1c8bff5.jpg" alt=3D"" style=3D"display: block; height: auto; max=
-width: 100%;"> </td> </tr> </table> <p style=3D"margin: 0;"><span style=3D=
"color: black; font-family: Arial, Verdana, Helvetica, sans-serif;">Now tha=
t ASCO has ended (for those who couldn&#x2019;t attend, we hope to see you =
at ACROBiosystems&#x2019; booth next year!!).</span><span style=3D"font-fam=
ily: Arial, Verdana, Helvetica, sans-serif;"> </span><span style=3D"color: =
black; font-family: Arial, Verdana, Helvetica, sans-serif;">A year ago, ent=
husiasm for a new generation of cancer immunotherapies targeting </span><a =
href=3D"https://r20.rs6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4m=
WkBn5ynInBXVamCXuGClgsgsSmelNDPVhjBQmSV6963VAAL3PY-NJ5O-Q7xtHdX9lQ1tyGFxDC8=
FLtscAOeR5g_23wHV1HOdi_OCk3LhaIYRvtPwixF3Ojr5YHJiBhl57uePgLPGJEtmzmezEo_xuk=
yO4dcT4wVKsZYGsBnt-jwBsrmhqjbH3kwhPUV4ignU_VWsmdb10bimF59tVu6P__u7f91Ju1WdW=
-0YL6kR00CdkOz-aSG9--qqq9uJ_3Z9QaVSOLoWKwF6pfXZZHqMLfHMrVoVkgRCZu2FagDN2IZu=
sWuBdqvIPq9TRkA1lR_&c=3DonxdsVd1evD3DjiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr=
1BA=3D=3D&ch=3D43iYx4CFvpTb6Vqtr0BFDLoEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D=
" target=3D"_blank" style=3D"color: rgb(192, 0, 0); font-family: Arial, Ver=
dana, Helvetica, sans-serif; text-decoration: underline; font-weight: bold;=
">TIGIT</a><span style=3D"color: black; font-family: Arial, Verdana, Helvet=
ica, sans-serif;"> started to wane, after Roche&#x2019;s Tiragolumab was hi=
t by two failed studies in lung cancer. However, the year&#x2019;s ASCO con=
gress brought new hope for TIGIT cancer immunotherapies, as top pharmaceuti=
cal companies, presented promising clinical data.</span></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif;">o&#xa0;</span><span style=3D"font-family: Arial, Verdana, =
Helvetica, sans-serif; font-weight: bold;">Roche&#x2019;s Tiragolumab: </sp=
an><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif;">Addi=
ng Tiragolumab to standard-of-care atezolizumab plus bevacizumab improved t=
umor responses compared with the atezolizumab/bevacizumab doublet as first-=
line treatment in patients with unresectable, locally advanced, or metastat=
ic hepatocellular carcinoma (HCC).</span></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif;">o&#xa0;&#xa0;</span><span style=3D"font-family: Arial, Ver=
dana, Helvetica, sans-serif; font-weight: bold;">Arcus/Gilead&#x2019;s Arc-=
7: </span><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif=
;">The new data presented from the phase 2 study of Domvanalimab in combina=
tion with PD-1 inhibitor Zimberelimab as a first-line therapy for non-small=
 cell lung cancer (NSCLC) showed that Domvanalimab continues to demonstrate=
 consistent improvement in progression-free survival compared to Zimberelim=
ab monotherapy.</span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: bold; fon=
t-size: 16px;">TIGIT Related Products from ACROBiosystems</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--2-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 55%;" align=3D"center" valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: b=
reak-word; padding: 10px 20px 10px 40px;" align=3D"left" valign=3D"top">
<h3 style=3D"font-family: Franklin Gothic Medium,Arial,Helvetica,sans-serif=
; color: #3E3E3E; font-size: 18px; font-weight: bold; margin: 0;">
<span style=3D"font-size: 14px; color: rgb(62, 62, 62); font-family: Arial,=
 Verdana, Helvetica, sans-serif;">o&#xa0;</span><span style=3D"font-size: 1=
4px; font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: bold;=
">Proteins</span>
</h3>
<ul>
<li style=3D"font-size: 14px;"><span style=3D"font-size: 14px; font-family:=
 Arial, Verdana, Helvetica, sans-serif;">lVarious tags &amp; species (Human=
/Mouse, Cynomolgus/Rhesus macaque/Rabbit/Rat/Canine).</span></li>
<li style=3D"font-size: 14px;"><span style=3D"font-size: 14px; font-family:=
 Arial, Verdana, Helvetica, sans-serif;">lHomogeneous structure&#xa0;and&#x=
a0;high purity&#xa0;verified by SEC-MALS. </span></li>
<li style=3D"font-size: 14px;"><span style=3D"font-size: 14px; font-family:=
 Arial, Verdana, Helvetica, sans-serif;">lHigh&#xa0;bioactivity&#xa0;valida=
ted by ELISA/SPR/BLI/FACS</span></li>
</ul>
</td> </tr> </table> </td>  <td class=3D"column column--2 scale stack" styl=
e=3D"width: 45%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container content-padding-horizontal" align=3D"center" valign=3D"top" st=
yle=3D"padding-left: 20px; padding-right: 40px;"> <img data-image-content c=
lass=3D"image_content" width=3D"238" src=3D"https://files.constantcontact.c=
om/5f3d0cf9401/de6ef4d0-1b5f-466b-96ec-ccfa1ceece8a.png" alt=3D"" style=3D"=
display: block; height: auto; max-width: 100%;"> </td> </tr> </table> </td>=
 </tr> </table> <table class=3D"layout layout--1-column" style=3D"table-lay=
out: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" a=
lign=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; c=
olor: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif; font-weight: bold;">o</span><span style=3D"font-family: Ari=
al, Verdana, Helvetica, sans-serif; font-size: 9px; font-weight: bold;">&#x=
a0;</span><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif=
; font-weight: bold;">Inhibitor screening kits&#xff1a;</span></p>
<p style=3D"margin: 0;"><span style=3D"color: black; font-family: Arial, Ve=
rdana, Helvetica, sans-serif; font-weight: normal;">ACROBiosystems has deve=
loped a TIGIT: CD155 [Biotinylated] inhibitor screening kit (Cat.No. </span=
><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWU=
Wf4mWkBn5ynInBXVamCXuGClgsgsSmelNDPjVWW0CFZOxYVt2anSB5qzsCZF2nRf8EaF6I6x-bx=
sRfUwA4nYHtPyReGFh4ya3zdT9EDevSwiB-jZayoF7sdFL25HiHNNMI_TtNc2jWhZSF2tCxHi4v=
QKnCuNDelRUceBT2tY8mokWqC7BwOBFFHgUrh_IPBIsn9uRqpLGPWAmGn6Y10ynjgb5fenTK7Xq=
Dl59rxlN5WAoGxYdktYRWvkjMBs_WHWObxfBjdVuwciVNTpD81Dp-jjnbAQNBjhb_0DrQhULvQb=
yayimAqX7clwSRBLT3GKSujgHAdSYhUMrCi60OuPOUiLy3LUVzToOBIw828BK2OCOClEgVTsCo9=
lVogGxb0q1JoMEvaa-lThWonfyQXE-UZRA=3D=3D&c=3DonxdsVd1evD3DjiJLXmmCrctDesWrv=
j1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvpTb6Vqtr0BFDLoEfqZJUrXXfOPeo4B=
iInvbOBEpHmrMsw=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 0, 0); fo=
nt-family: Arial, Verdana, Helvetica, sans-serif; font-weight: normal; text=
-decoration: underline;">EP-131</a><span style=3D"color: black; font-family=
: Arial, Verdana, Helvetica, sans-serif; font-weight: normal;">) based on t=
he sandwich ELISA method, which can be used for early screening and QC rele=
ase.</span></p>
</td> </tr> </table> <table class=3D"text text--padding-vertical" width=3D"=
100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layou=
t: fixed;"> <tr> <td class=3D"text_content-cell content-padding-horizontal"=
 style=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,He=
lvetica,sans-serif; color: #3E3E3E; font-size: 14px; display: block; word-w=
rap: break-word; padding: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"color: black; font-weight: bold; font-family: Arial, Verdana, Helvetica, s=
ans-serif; font-size: 16px;">Assay Data</span></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif; font-weight: bold;">TIGIT Homodimer structure and purity (&=
#xff1e;90%) verified by SELC-MALS</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container content-padding-horizontal" align=3D"center" valign=3D"top" st=
yle=3D"padding-left: 40px; padding-right: 40px;"> <a href=3D"https://r20.rs=
6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClgs=
gsSmelNDPI4mqLplwRnAmmtDsVOusAO3Xu-vPDsw45FbCk-FMcBR3DfdVnw8B1HBp_k2mI5anKc=
SLfVPHmou7ICfw70U1KJtoUBoz0L1Q8TY5xyWkLTio-8qIWTRTub_6REICvTRhKg0pruFcgnuSr=
25IWfECUdWnJb0pR-3gPHIP1hbbiGjSBBLj3Kq8zWRHkJFgA9P3zFw8j2K25PFRhdw4rXUxa8CG=
xaB2Ypne_Tx5gGEmK4QA_q1BqBkutx483tflPvSdeluF4kHAtbhdlOH-q0a7uDvXbO4rtq9xnSb=
WvPVb6IgjfNmRkt_VZykb2V60r2kAa2zOX2w6XDCJLGwCczQVlg=3D=3D&c=3DonxdsVd1evD3D=
jiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvpTb6Vqtr0BFDL=
oEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D" data-trackable=3D"true"><img data-i=
mage-content class=3D"image_content" width=3D"600" src=3D"https://files.con=
stantcontact.com/5f3d0cf9401/883ef485-206f-4c59-9854-a720e474cc34.png" alt=
=3D"" style=3D"display: block; height: auto; max-width: 100%;"></a> </td> <=
/tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-column"=
 style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"=
0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=
=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container content-padding-horizontal" align=3D"center" valign=3D"top" st=
yle=3D"padding-left: 40px; padding-right: 40px;"> <a href=3D"https://r20.rs=
6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClqR=
32yr9vVUfxk5VootHCswsYxau2FSsxBGKyJGjtK8F3ZQQzY1Ek9hg5a_7GnUUN3F_tnVToL3e2H=
rVJc8b2XHEIgKEnOL5z5HKEKt5xLAC5wfcOfMMUGjGg84jshGW70bTFtiA4Zew5OPd8kk7gJ1L3=
QWgTOe5AV3pqBFwBECfGKhhWo1obewOfc5JBD_7dDlRjxccUYnxTqBJSbBMSNAtfAkikbJrDlVv=
VufXuLdj1wQox0mfe7ut9a7gd5cV0LlzwYjPpayRUQH4vXd1Axm6gkrAFgOZKfLob7zTHqKJzLV=
JwkPUjzwfc7zOLnLzHB-QwVEt-jFwNLIncKNpbxg=3D&c=3DonxdsVd1evD3DjiJLXmmCrctDes=
Wrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvpTb6Vqtr0BFDLoEfqZJUrXXfOPe=
o4BiInvbOBEpHmrMsw=3D=3D" data-trackable=3D"true"><img data-image-content c=
lass=3D"image_content" width=3D"600" src=3D"https://files.constantcontact.c=
om/5f3d0cf9401/88b7cf36-f111-4c61-8cac-8347f7ec991e.png" alt=3D"" style=3D"=
display: block; height: auto; max-width: 100%;"></a> </td> </tr> </table> <=
/td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"table=
-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100=
%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; c=
olor: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"color: black; font-family: Arial, Ve=
rdana, Helvetica, sans-serif; font-style: italic;">The purity of Human TIGI=
T, Fc Tag (Cat. No. </span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001954=
T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClgsgsSmelNDPI4mqLplwRnAmmt=
DsVOusAO3Xu-vPDsw45FbCk-FMcBR3DfdVnw8B1HBp_k2mI5anKcSLfVPHmou7ICfw70U1KJtoU=
Boz0L1Q8TY5xyWkLTio-8qIWTRTub_6REICvTRhKg0pruFcgnuSr25IWfECUdWnJb0pR-3gPHIP=
1hbbiGjSBBLj3Kq8zWRHkJFgA9P3zFw8j2K25PFRhdw4rXUxa8CGxaB2Ypne_Tx5gGEmK4QA_q1=
BqBkutx483tflPvSdeluF4kHAtbhdlOH-q0a7uDvXbO4rtq9xnSbWvPVb6IgjfNmRkt_VZykb2V=
60r2kAa2zOX2w6XDCJLGwCczQVlg=3D=3D&c=3DonxdsVd1evD3DjiJLXmmCrctDesWrvj1cb5s=
0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvpTb6Vqtr0BFDLoEfqZJUrXXfOPeo4BiInvbO=
BEpHmrMsw=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 0, 0); font-fam=
ily: Arial, Verdana, Helvetica, sans-serif; font-style: italic; font-weight=
: bold; text-decoration: underline;">TIT-H5254</a><span style=3D"color: bla=
ck; font-family: Arial, Verdana, Helvetica, sans-serif; font-style: italic;=
">) is more than 90% and the molecular weight of this protein is around 85-=
100 kDa verified by SEC-MALS.</span></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(85, 85, 85); font-family:=
 Arial, Verdana, Helvetica, sans-serif;">&#xa0;</span></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif;">&#xa0;</span><span style=3D"color: black; font-weight: bol=
d; font-family: Arial, Verdana, Helvetica, sans-serif;">Binding activity be=
tween TIGIT and antibody verified by ELISA</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container content-padding-horizontal" align=3D"center" valign=3D"top" st=
yle=3D"padding-left: 40px; padding-right: 40px;"> <a href=3D"https://r20.rs=
6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClgs=
gsSmelNDPUZVHzy1aR_vUzC-jDPEP2MycuRdzD4uBLmZN2dc0BnFblxn6y4KO2V9UV0bEGWQ7Is=
f8rcZ2P7KpM7EXuizO5pMm9HVtPQJ6VQTD7jL0aNgV6kK9o3ekgonoX59EG07g4D0Gnz_qrBCdZ=
mtgtLe7Rj6PMNkxjQwJvwQJn6caN74zHXYw0BFT18zsmYFi-2W7jGeWfi75ARR6gRXVNbUXtdGc=
5Uq5RM8as3rIbkh1o4ieXU1NUgdiAi7uxWumvdBgZD1BizojQtW9b5TR_jeLsuojPucq-g7Sw5t=
b-5p3sCkQUPeOpJlB0XKKQ6eLDY6eQClXyzKv5BDEneJd1bgpPg=3D=3D&c=3DonxdsVd1evD3D=
jiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvpTb6Vqtr0BFDL=
oEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D" data-trackable=3D"true"><img data-i=
mage-content class=3D"image_content" width=3D"564" src=3D"https://files.con=
stantcontact.com/5f3d0cf9401/094fbfdd-7132-42fc-84a5-b81b277758a9.jpg" alt=
=3D"" style=3D"display: block; height: auto; max-width: 100%;"></a> </td> <=
/tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-column"=
 style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"=
0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=
=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><spa=
n style=3D"font-style: italic; font-family: Arial, Verdana, Helvetica, sans=
-serif; color: black;">Anti-hTIGIT antibody captured on CM5 chip via Anti-m=
ouse antibodies surface can bind Human TIGIT, His Tag (Cat. No. </span><a h=
ref=3D"https://r20.rs6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mW=
kBn5ynInBXVamCXuGClgsgsSmelNDPUZVHzy1aR_vUzC-jDPEP2MycuRdzD4uBLmZN2dc0BnFbl=
xn6y4KO2V9UV0bEGWQ7Isf8rcZ2P7KpM7EXuizO5pMm9HVtPQJ6VQTD7jL0aNgV6kK9o3ekgono=
X59EG07g4D0Gnz_qrBCdZmtgtLe7Rj6PMNkxjQwJvwQJn6caN74zHXYw0BFT18zsmYFi-2W7jGe=
Wfi75ARR6gRXVNbUXtdGc5Uq5RM8as3rIbkh1o4ieXU1NUgdiAi7uxWumvdBgZD1BizojQtW9b5=
TR_jeLsuojPucq-g7Sw5tb-5p3sCkQUPeOpJlB0XKKQ6eLDY6eQClXyzKv5BDEneJd1bgpPg=3D=
=3D&c=3DonxdsVd1evD3DjiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D4=
3iYx4CFvpTb6Vqtr0BFDLoEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D" target=3D"_bla=
nk" style=3D"font-style: italic; font-family: Arial, Verdana, Helvetica, sa=
ns-serif; color: rgb(192, 0, 0); font-weight: bold; text-decoration: underl=
ine;">TIT-H52H5</a><span style=3D"font-style: italic; font-family: Arial, V=
erdana, Helvetica, sans-serif; color: black;">) with an affinity constant o=
f 1.28 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).</sp=
an></p></td> </tr> </table> </td> </tr> </table> <table class=3D"layout lay=
out--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" c=
ellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scal=
e stack" style=3D"width: 100%;" align=3D"center" valign=3D"top"> <table cla=
ss=3D"button button--padding-vertical" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=
=3D"button_container content-padding-horizontal" align=3D"center" style=3D"=
padding: 10px 40px;">    <table class=3D"button_content-row" style=3D"backg=
round-color: #c03e30; width: inherit; border-radius: 7px; border-spacing: 0=
; border: none;" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=
=3D"#c03e30"> <tr> <td class=3D"button_content-cell" style=3D"padding: 10px=
 15px;" align=3D"center"> <a class=3D"button_link" href=3D"https://r20.rs6.=
net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClgsgs=
SmelNDPVWFocFm1PWzm4OU_yKlsaJKMkbUfg3eMksx8WT9VzkCHuzzTX5khEVG4uC9jqPjPhc7g=
5ffgZI5s38NXhsV77v2OtpCpdbP1Z0hRvzqVp4d-i0afz82i5F6Zh0JKUha89aX8Pif0_awo3yl=
yfaH8avTqtZiKkFmIRmPYEMuWn21PB_sZvKyvxfuf48gurWrO4Fim9ruOYhPinzLtI9LAO3NkJX=
fq3DbrGbSmzL2YjQfFl6Cth_5XdqqCO8pUvrImiRyzzsjPkXJBpZxcjX71ycfhv8jhlI6zsXwqq=
MxBuVXzc00vNyZvJsKHW9027R7NHVySdbjvyP8=3D&c=3DonxdsVd1evD3DjiJLXmmCrctDesWr=
vj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvpTb6Vqtr0BFDLoEfqZJUrXXfOPeo4=
BiInvbOBEpHmrMsw=3D=3D" data-trackable=3D"true" style=3D"color: #FFFFFF; fo=
nt-family: Arial,Verdana,Helvetica,sans-serif; font-size: 16px; word-wrap: =
break-word; font-weight: bold; text-decoration: none;">Request a Protocol</=
a> </td> </tr> </table>    </td> </tr> </table>   </td> </tr> </table> <tab=
le class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=
=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center" v=
align=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cent=
er; margin: 0;" align=3D"center"><span style=3D"font-weight: bold; font-fam=
ily: Arial, Verdana, Helvetica, sans-serif; font-size: 16px;">Spotlight pro=
duct</span></p></td> </tr> </table> </td> </tr> </table> <table class=3D"la=
yout layout--3-column" style=3D"table-layout: fixed;" width=3D"100%" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column=
--1 scale stack" style=3D"width: 33%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container" align=3D"center" valign=3D"top"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClgsgsS=
melNDPVhjBQmSV6963VAAL3PY-NJ5O-Q7xtHdX9lQ1tyGFxDC8FLtscAOeR5g_23wHV1HOdi_OC=
k3LhaIYRvtPwixF3Ojr5YHJiBhl57uePgLPGJEtmzmezEo_xukyO4dcT4wVKsZYGsBnt-jwBsrm=
hqjbH3kwhPUV4ignU_VWsmdb10bimF59tVu6P__u7f91Ju1WdW-0YL6kR00CdkOz-aSG9--qqq9=
uJ_3Z9QaVSOLoWKwF6pfXZZHqMLfHMrVoVkgRCZu2FagDN2JXuheh_4vgFsZivIk0Nabp&c=3Do=
nxdsVd1evD3DjiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvp=
Tb6Vqtr0BFDLoEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D" data-trackable=3D"true"=
><img data-image-content class=3D"image_content" width=3D"217" src=3D"https=
://files.constantcontact.com/5f3d0cf9401/00d727c7-d922-482a-b1e0-c769f3a639=
3f.jpg" alt=3D"" style=3D"display: block; height: auto; max-width: 100%;"><=
/a> </td> </tr> </table> <table class=3D"text text--padding-vertical" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-l=
ayout: fixed;"> <tr> <td class=3D"text_content-cell content-padding-horizon=
tal" style=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-s=
erif; color: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; wo=
rd-wrap: break-word; padding: 10px 0px 10px 40px;" align=3D"left" valign=3D=
"top"><p style=3D"text-align: center; margin: 0;" align=3D"center"><a href=
=3D"https://r20.rs6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn=
5ynInBXVamCXuGClgsgsSmelNDPVhjBQmSV6963VAAL3PY-NJ5O-Q7xtHdX9lQ1tyGFxDC8FLts=
cAOeR5g_23wHV1HOdi_OCk3LhaIYRvtPwixF3Ojr5YHJiBhl57uePgLPGJEtmzmezEo_xukyO4d=
cT4wVKsZYGsBnt-jwBsrmhqjbH3kwhPUV4ignU_VWsmdb10bimF59tVu6P__u7f91Ju1WdW-0YL=
6kR00CdkOz-aSG9--qqq9uJ_3Z9QaVSOLoWKwF6pfXZZHqMLfHMrVoVkgRCZu2FagDN2JXuheh_=
4vgFsZivIk0Nabp&c=3DonxdsVd1evD3DjiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=
=3D=3D&ch=3D43iYx4CFvpTb6Vqtr0BFDLoEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D" t=
arget=3D"_blank" style=3D"font-family: Arial, Verdana, Helvetica, sans-seri=
f; color: rgb(192, 0, 0); font-weight: bold; text-decoration: underline;">C=
D155 Proteins</a></p></td> </tr> </table> </td>  <td class=3D"column column=
--2 scale stack" style=3D"width: 33%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container" align=3D"center" valign=3D"top"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClgsgsS=
melNDP38tyiyC3CFZwo4TIaW9ZoMr0uGjxUzoXPJZLq5MpOyXJWO3V7GbgWItFbRtxvq9_TYdCZ=
tQqXIvolSK4PBbg5mBM2CW7Rtkd_EoVVfb7nOcSirEpJHvI5tSf8VZapNPhrg9R3Oa34AomGItY=
-NnrJ68VNl0HhBZ21IiH6_M2eXpp1dv4N3xhxvWKuWJyk1AIVbISGOiDJLHk7Ez_r8FHLVIIkMB=
w9EAKq8P0tvwwnp8slRFfTE1twAZ7HhACNSLG1M3WvRONdkUdfPk5eRCznB-zMI-iERXL&c=3Do=
nxdsVd1evD3DjiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvp=
Tb6Vqtr0BFDLoEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D" data-trackable=3D"true"=
><img data-image-content class=3D"image_content" width=3D"217" src=3D"https=
://files.constantcontact.com/5f3d0cf9401/3768e44a-4f30-44e7-ad42-5e25d72217=
87.jpg" alt=3D"" style=3D"display: block; height: auto; max-width: 100%;"><=
/a> </td> </tr> </table> <table class=3D"text text--padding-vertical" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-l=
ayout: fixed;"> <tr> <td class=3D"text_content-cell content-padding-horizon=
tal" style=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-s=
erif; color: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; wo=
rd-wrap: break-word; padding: 10px 20px;" align=3D"left" valign=3D"top"><p =
style=3D"text-align: center; margin: 0;" align=3D"center"><a href=3D"https:=
//r20.rs6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVam=
CXuGClgsgsSmelNDP38tyiyC3CFZwo4TIaW9ZoMr0uGjxUzoXPJZLq5MpOyXJWO3V7GbgWItFbR=
txvq9_TYdCZtQqXIvolSK4PBbg5mBM2CW7Rtkd_EoVVfb7nOcSirEpJHvI5tSf8VZapNPhrg9R3=
Oa34AomGItY-NnrJ68VNl0HhBZ21IiH6_M2eXpp1dv4N3xhxvWKuWJyk1AIVbISGOiDJLHk7Ez_=
r8FHLVIIkMBw9EAKq8P0tvwwnp8slRFfTE1twAZ7HhACNSLG1M3WvRONdkUdfPk5eRCznB-zMI-=
iERXL&c=3DonxdsVd1evD3DjiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=
=3D43iYx4CFvpTb6Vqtr0BFDLoEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D" target=3D"=
_blank" style=3D"font-family: Arial, Verdana, Helvetica, sans-serif; color:=
 rgb(192, 0, 0); font-weight: bold; text-decoration: underline;">CD226 Prot=
eins</a></p></td> </tr> </table> </td>  <td class=3D"column column--3 scale=
 stack" style=3D"width: 33%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container" align=3D"center" valign=3D"top"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn5ynInBXVamCXuGClgsgsS=
melNDPW0nT5MatfyVO7wlGKj1Qe6lheTZHky35QQY3H2E7YnzsPl8-NXPit4ES4P7VESy2jAr5q=
rZJjZ6uz2qyVoEzJhNrYqGiaEBluK-LTJGomedIPg8HZ6_m-TrMeBbpsRrM_HSvlGOA-QhJ7RXS=
-kS2UGNoVLyifm72uLpc9lAVBtw2M9vlhtwcoaguc1tvZ6rbwAOTIP4iXnTiMFvVuiLKXoBEGfk=
TgH8KAhiePuvj0JmOerx2niGIMbwkgA1yS5bC0WlS1sBv7hxyGsLyQI_XVVO45-acxycI&c=3Do=
nxdsVd1evD3DjiJLXmmCrctDesWrvj1cb5s0DJZK8WaZXRhaEr1BA=3D=3D&ch=3D43iYx4CFvp=
Tb6Vqtr0BFDLoEfqZJUrXXfOPeo4BiInvbOBEpHmrMsw=3D=3D" data-trackable=3D"true"=
><img data-image-content class=3D"image_content" width=3D"212" src=3D"https=
://files.constantcontact.com/5f3d0cf9401/e1bf33f6-faa9-4e89-ac38-5ab2b48923=
14.jpg" alt=3D"" style=3D"display: block; height: auto; max-width: 100%;"><=
/a> </td> </tr> </table> <table class=3D"text text--padding-vertical" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-l=
ayout: fixed;"> <tr> <td class=3D"text_content-cell content-padding-horizon=
tal" style=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-s=
erif; color: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; wo=
rd-wrap: break-word; padding: 10px 40px 10px 0px;" align=3D"left" valign=3D=
"top"><p style=3D"text-align: center; margin: 0;" align=3D"center"><a href=
=3D"https://r20.rs6.net/tn.jsp?f=3D001954T2cC0ymCfNNnX45XM3NL4wRGWUWf4mWkBn=
5ynInBXVamCXuGClgsgsSmelNDPW0nT5MatfyVO7wlGKj1Qe6lheTZHky35QQY3H2E7YnzsPl8-=
NXPit4ES4P7VESy2jAr5qrZJjZ6uz2qyVoEzJhNrYqGiaEBluK-LTJGomedIPg8HZ6_m-TrMeBb=
psRrM_HSvlGOA-QhJ7RXS-kS2UGNoVLyifm72uLpc9lAVBtw2M9vlhtwcoaguc1tvZ6rbwAOTIP=
4iXnTiMFvVuiLKXoBEGfkTgH8KAhiePuvj0JmOerx2niGIMbwkgA1yS5bC0WlS1sBv7hxyGsLyQ=
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