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Envelope-to: mykhaylo.dubrovka@saraya.co.in
Delivery-date: Thu, 18 May 2023 09:08:08 +0800
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Date: Wed, 17 May 2023 21:07:17 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
Subject: Vaccine development in the post-COVID era
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Accelerating research with structure-specific and full length transmembrane=
 viral antigens and related antibodies. Upcoming Events View in Browser =EF=
=BB=BFResources Products Insights News Support Decades in the Making | Hera=
lding the Next Vaccine Revolution =E2=80=8A The Next Target for mRNA Vaccin=
es: HIV? HIV antigens and antibodies Utilizing the same mRNA technology fro=
m their COVID vaccines, Moderna is now entering Phase 1 clinical trials for=
 their mRNA-based HIV vaccine. Earlier in 2021, this vaccine was shown to t=
rigger the production of neutralizing antibodies against HIV-like viruses i=
n monkeys, focusing on surface-bound glycoproteins, gp41 and gp120. Further=
 research around these surface glycoprotein subunits has been shown to indu=
ce the production of antibodies that can neutralize over 80% of the virus. =
=E2=80=8A A New Era of Structure-based Vaccine Design? The journey in devel=
oping an RSV vaccine is nearing the end with the FDA's approval of GSK=E2=
=80=99s AREXVY. From the 1960s, RSV vaccine research was put at a standstil=
l until the identification of a different protein conformation, the pre-fus=
ion form. Focusing on the pre-fusion RSV F protein, vaccine design was impr=
oved significantly. Of course, this brings bigger hope not only to combat R=
SV but also to other vaccines, highlighting the role of protein structure i=
n vaccine design.  RSV antigens and antibodies =E2=80=8A =E2=80=8A Product =
Spotlight SARS-CoV-2 Mutant Antigens, Antibodies and Kits   =E2=80=8A MHC C=
ustom Services =E2=80=8A =E2=80=8A Explore ViruStop =E2=80=8A Learn more ab=
out RSV structural conformation analytical methods by downloading our appli=
cation note! =E2=80=8A Awards & Certifications ACROBiosystems | 1 Innovatio=
n Way, Newark, DE 19711 Unsubscribe mykhaylo.dubrovka@saraya.co.in Update P=
rofile | Our Privacy Policy | Constant Contact Data Notice Sent by acrobio.=
apac@outlook.com
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lOaTl1c_8TbRTCCdOXt1gdl1FtHFJvcvGBOT-sfnE2pP-Cti7YJNyF3OeSnPDBOpa90BDuqkRDJ=
C7Qy8ezjvRc-x6Uzykzp6HiDqOFpa4UoMeUzsBCcyFF8fNR5MhXRIL9smXJjN00_iS01n1AjIsM=
4fFf6Y2QbahDORdCtqn15pA2iqjZSqp4Mcnk_FnR23vE6V-owvVqVz6bMttO7ij5zidFjM4zFjC=
pWmMbTP3Wvyzc1l3c=3D&c=3D2L_5ls1o5ZmchXqqpAlfGOWnaTMC77rfb4CQa7oJbEWWgitB_w=
u1IA=3D=3D&ch=3DQzBJwgVWk9wgNIKYnKo-B1Xm_X-hxRHuuMTb448c65Jbcpc4_aJubg=3D=
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mal; text-decoration: none;">News</a></p></td> </tr> </table> </td>  <td cl=
ass=3D"column column--5 scale stack" style=3D"width: 20%;" align=3D"center"=
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<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
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reak-word; padding: 10px 40px 10px 0px;" align=3D"center" valign=3D"top"><p=
 style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001fzhPJ3kI=
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zQFNKxmgEEND6Jt3422FZiR0QNu0So3wKpFGiiP-vQ-EYgsx1khv2oTJO-iRdAhjn6WVmvcroTY=
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rfb4CQa7oJbEWWgitB_wu1IA=3D=3D&ch=3DQzBJwgVWk9wgNIKYnKo-B1Xm_X-hxRHuuMTb448=
c65Jbcpc4_aJubg=3D=3D" target=3D"_blank" style=3D"color: rgb(255, 255, 255)=
; font-weight: normal; text-decoration: none;">Support</a></p></td> </tr> <=
/table> </td> </tr> </table> <table class=3D"layout layout--heading layout-=
-1-column" style=3D"background-color: #c03e30; table-layout: fixed;" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#c03e=
30"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;"=
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<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif;=
 color: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; pa=
dding: 10px 40px;" align=3D"center" valign=3D"top"><h1 style=3D"font-family=
: Tahoma,Geneva,sans-serif; color: #3E3E3E; font-size: 24px; font-weight: b=
old; margin: 0;">
<span style=3D"font-size: 16px; font-family: Verdana, Geneva, sans-serif; f=
ont-weight: bold; color: rgb(255, 255, 255);">Decades in the Making | </spa=
n><span style=3D"font-family: Verdana, Geneva, sans-serif; font-size: 16px;=
 color: rgb(255, 255, 255);">Heralding the Next Vaccine Revolution</span>
</h1></td> </tr> </table> </td> </tr> </table> <table class=3D"layout layou=
t--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cel=
lpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale =
stack" style=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D=
"spacer" style=3D"line-height: 15px; height: 15px;">&#x200a;</div></td> </t=
r> </table> <table class=3D"layout layout--1-column" style=3D"table-layout:=
 fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <=
tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=
=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; c=
olor: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cent=
er; margin: 0;" align=3D"center"><span style=3D"color: rgb(52, 51, 50); fon=
t-family: Verdana, Geneva, sans-serif; font-weight: bold; font-size: 16px;"=
>The Next Target for mRNA Vaccines: HIV? </span></p></td> </tr> </table> </=
td> </tr> </table> <table class=3D"layout-margin" style=3D"" width=3D"100%"=
 border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"layout=
-margin_cell" style=3D"padding: 0px 40px;" align=3D"center" valign=3D"top">=
 <table class=3D"layout-border layout-border--solid" style=3D"" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"lay=
out-border_cell" style=3D"background-color: #ffffff; padding: 3px;" align=
=3D"center" valign=3D"top" bgcolor=3D"#ffffff">
<table class=3D"layout layout--2-column" style=3D"table-layout: fixed; back=
ground-color: #ffffff;" width=3D"100%" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" bgcolor=3D"#ffffff"> <tr> <td class=3D"column column--1 scale =
stack" style=3D"width: 45%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container" align=3D"center" valign=3D"top"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001fzhPJ3kIRi1Sio9rUDUQb8ZDHKWWsiBhzX5qL5vf8lBq7h7_3dHBK8ohqN=
6myhlHLeoTwklOz9icY80rGy_qRrhlUC_oP4ZugB-fZLDDfNMpiwckZF1jBAotV4ThbzYzcZVYx=
P5bUpM_qfdHuRjZ16_YOnhGuOCN19Ms3oRrytpXvjLEtiQVjd2d4FuCx6bomYGQB2cooyUJQJ5a=
BVurLMJasmjaKo8fH4N5LczUpaawxS2QA1uPXpgaUGCyvP1gSX1whNXG2I0y3pF5bosee3VWbNq=
Jd9mbMdqFYcAsRL7_lhO8Nq53VO5UBZPZmIDmA0q9MoqD1vja3E6ItkBn56C80TJe8Ohn&c=3D2=
L_5ls1o5ZmchXqqpAlfGOWnaTMC77rfb4CQa7oJbEWWgitB_wu1IA=3D=3D&ch=3DQzBJwgVWk9=
wgNIKYnKo-B1Xm_X-hxRHuuMTb448c65Jbcpc4_aJubg=3D=3D" data-trackable=3D"true"=
><img data-image-content class=3D"image_content" width=3D"267" src=3D"https=
://files.constantcontact.com/5f3d0cf9401/1f1608c7-be18-4823-af27-b5093af46d=
61.png" alt=3D"" style=3D"display: block; height: auto; max-width: 100%;"><=
/a> </td> </tr> </table>  <table class=3D"button button--padding-vertical" =
width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"ta=
ble-layout: fixed;"> <tr> <td class=3D"button_container content-padding-hor=
izontal" align=3D"center" style=3D"padding: 10px 10px 10px 20px;">    <tabl=
e class=3D"button_content-row" style=3D"border-radius: 3px; width: inherit;=
 border-spacing: 0; background-color: #c60c0c; border: none;" border=3D"0" =
cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#c60c0c"> <tr> <td class=3D"=
button_content-cell" style=3D"padding: 10px 15px;" align=3D"center"> <a cla=
ss=3D"button_link" href=3D"https://r20.rs6.net/tn.jsp?f=3D001fzhPJ3kIRi1Sio=
9rUDUQb8ZDHKWWsiBhzX5qL5vf8lBq7h7_3dHBK8ohqN6myhlHLeoTwklOz9icY80rGy_qRrhlU=
C_oP4ZugB-fZLDDfNMpiwckZF1jBAotV4ThbzYzcZVYxP5bUpM_qfdHuRjZ16_YOnhGuOCN19Ms=
3oRrytpXvjLEtiQVjd2d4FuCx6bomYGQB2cooyUJQJ5aBVurLMJasmjaKo8fH4N5LczUpaawxS2=
QA1uPXpgaUGCyvP1gSX1whNXG2I0y3pF5bosee3VWbNqJd9mbMdqFYcAsRL7_lhO8Nq53VO5UBZ=
PZmIDmA0q9MoqD1vja3E6ItkBn56C80TJe8Ohn&c=3D2L_5ls1o5ZmchXqqpAlfGOWnaTMC77rf=
b4CQa7oJbEWWgitB_wu1IA=3D=3D&ch=3DQzBJwgVWk9wgNIKYnKo-B1Xm_X-hxRHuuMTb448c6=
5Jbcpc4_aJubg=3D=3D" data-trackable=3D"true" style=3D"font-family: Verdana,=
Geneva,sans-serif; font-size: 14px; font-weight: normal; color: #FFFFFF; wo=
rd-wrap: break-word; text-decoration: none;">HIV antigens and antibodies</a=
> </td> </tr> </table>    </td> </tr> </table>   </td>  <td class=3D"column=
 column--2 scale stack" style=3D"width: 55%;" align=3D"center" valign=3D"to=
p">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: b=
reak-word; padding: 10px 20px 10px 10px;" align=3D"left" valign=3D"top"><p =
class=3D"indent-0" style=3D"text-align: justify; margin: 0;" align=3D"justi=
fy"><span style=3D"font-size: 14px; font-family: Arial, Verdana, Helvetica,=
 sans-serif;">Utilizing the same mRNA technology from their COVID vaccines,=
 Moderna is now entering Phase 1 clinical trials for their mRNA-based HIV v=
accine. Earlier in 2021, this vaccine was shown to trigger the production o=
f neutralizing antibodies against HIV-like viruses in monkeys, focusing on =
surface-bound glycoproteins, </span><a href=3D"https://r20.rs6.net/tn.jsp?f=
=3D001fzhPJ3kIRi1Sio9rUDUQb8ZDHKWWsiBhzX5qL5vf8lBq7h7_3dHBK-yAbsdLNrgPy_O2b=
t16b6KzxjcxB21mi1hIdrnZnys-MF7Z8BSMRjdWBQfIwlad7H5CXobSDUr-Wl-CQyCwFI3HIwhj=
kNq7F4TwdJf2g8EBW3uniIV53piIeUbFMVRsTkLII399Mcl1nBvv0cYY1nYJSbNFOiGwr43IxH3=
BCtofzPTj38OQweAxEBAhLKfSthxNZMcuBojt_IJJgaUNuAagZmdqcCs6zH9nUdX3O6BSc9e1_Q=
_jj4_OUXgYhifB3833dBKkZluK-WmYRnHHm34_flT5Pf4PCD-65Hf-4KX-0OZyyA_bXExunJgOG=
FsNdz9VUipG_17B&c=3D2L_5ls1o5ZmchXqqpAlfGOWnaTMC77rfb4CQa7oJbEWWgitB_wu1IA=
=3D=3D&ch=3DQzBJwgVWk9wgNIKYnKo-B1Xm_X-hxRHuuMTb448c65Jbcpc4_aJubg=3D=3D" t=
arget=3D"_blank" style=3D"font-size: 14px; font-family: Arial, Verdana, Hel=
vetica, sans-serif; color: rgb(77, 77, 77); text-decoration: underline; fon=
t-weight: bold;">gp41</a><span style=3D"font-family: Arial, Verdana, Helvet=
ica, sans-serif; font-size: 14px;"> and </span><a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001fzhPJ3kIRi1Sio9rUDUQb8ZDHKWWsiBhzX5qL5vf8lBq7h7_3dHBK-yAbs=
dLNrgPj_z9QzouF_dihxKUzTK_OLh9gyeIopPyd8ACqnMGL6qLmAW2IdwCFwpN8Nv2sPtsFpRWC=
fyGhCb_mpE-EpotaLMg4CHg6n5pnh6SV6eXvBY5PvaYh9s5p0fHj6xc_AwqIHbFvDhvMcS28E9C=
QwzxpNnR9OsD6NBSz060XkwqUWTmG08cyAJh-NULxCNjKQrtE1wEzgUz62DP5GJ6pFstlZYtQYp=
Q8KPaKJk8Vng1M46NkmqXx5SXF6_Vc_5RyIbpUI-jLh7GdWB3FNkjTNZtC0UDzB-R6Mhd9coKmo=
Y6TBL0ey-ih-nzhQc2t_LeZ-e9&c=3D2L_5ls1o5ZmchXqqpAlfGOWnaTMC77rfb4CQa7oJbEWW=
gitB_wu1IA=3D=3D&ch=3DQzBJwgVWk9wgNIKYnKo-B1Xm_X-hxRHuuMTb448c65Jbcpc4_aJub=
g=3D=3D" target=3D"_blank" style=3D"font-size: 14px; font-family: Arial, Ve=
rdana, Helvetica, sans-serif; color: rgb(77, 77, 77); text-decoration: unde=
rline; font-weight: bold;">gp120</a><span style=3D"font-size: 14px; font-fa=
mily: Arial, Verdana, Helvetica, sans-serif;">. Further research around the=
se surface glycoprotein subunits has been shown to induce the production of=
 antibodies that can neutralize over 80% of the virus. </span></p></td> </t=
r> </table> </td> </tr> </table> </td> </tr> </table>  </td> </tr> </table>=
 <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;" wi=
dth=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td cla=
ss=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center"=
 valign=3D"top"><div class=3D"spacer" style=3D"height: 30px; line-height: 3=
0px;">&#x200a;</div></td> </tr> </table> <table class=3D"layout layout--1-c=
olumn" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpaddi=
ng=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack"=
 style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; c=
olor: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cent=
er; margin: 0;" align=3D"center"><span style=3D"font-size: 16px; color: rgb=
(52, 51, 50); font-weight: bold;">A New Era of Structure-based Vaccine Desi=
gn?</span></p></td> </tr> </table> </td> </tr> </table> <table class=3D"lay=
out-margin" style=3D"" width=3D"100%" border=3D"0" cellpadding=3D"0" cellsp=
acing=3D"0"> <tr> <td class=3D"layout-margin_cell" style=3D"padding: 0px 40=
px;" align=3D"center" valign=3D"top"> <table class=3D"layout-border layout-=
border--solid" style=3D"" width=3D"100%" border=3D"0" cellpadding=3D"0" cel=
lspacing=3D"0"> <tr> <td class=3D"layout-border_cell" style=3D"background-c=
olor: #ffffff; padding: 3px;" align=3D"center" valign=3D"top" bgcolor=3D"#f=
fffff">
<table class=3D"layout layout--2-column" style=3D"table-layout: fixed; back=
ground-color: #ffffff;" width=3D"100%" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" bgcolor=3D"#ffffff"> <tr> <td class=3D"column column--1 scale =
stack" style=3D"width: 55%;" align=3D"center" valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: b=
reak-word; padding: 10px 10px 10px 20px;" align=3D"left" valign=3D"top"><p =
style=3D"margin: 0;"><span style=3D"font-size: 14px; font-family: Arial, Ve=
rdana, Helvetica, sans-serif;">The journey in developing an RSV vaccine is =
nearing the end with the FDA's approval of GSK&#x2019;s AREXVY. From the 19=
60s, RSV vaccine research was put at a standstill until the identification =
of a different protein conformation, the pre-fusion form. </span><span styl=
e=3D"font-size: 14px; color: black; font-family: Arial, Verdana, Helvetica,=
 sans-serif;">Focusing </span><span style=3D"font-size: 14px; font-family: =
Arial, Verdana, Helvetica, sans-serif;">on the</span><span style=3D"font-si=
ze: 14px; font-weight: bold; font-family: Arial, Verdana, Helvetica, sans-s=
erif;"> </span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001fzhPJ3kIRi1Sio9=
rUDUQb8ZDHKWWsiBhzX5qL5vf8lBq7h7_3dHBK-yAbsdLNrgPhxQAEt8Nctkl7A4BRMbmvNlun_=
vHLfu_3XEfD7pO3UVqBcyAEOgjYZHFB2dZRmWmhYZVw9Ql_gm6W6SpLb2_EI9QzIS8eEvdrY4rY=
NxWyqxkyc_rpDkzYTuyX47dHT8q1jI8pfS5hGGQz0it8T974HkwlIdiI6QDjO6UK9zqGzPKm18X=
O7dghm6-uC4925cSVX4fY2YgIVt7EQIY-dEeKR_kvMcU6i4bLxYr-hNI-6q7sdGO2xFruuDcK40=
kpjMa7z-tdnkLiN7U2b9RNUX3SYTNy5KkHtQeJDngLgvBqpZKSmeQRMR2dPYwxheuCiCdlPPdYq=
2aSK8CzixV8xsJBbobDNYRhVnR&c=3D2L_5ls1o5ZmchXqqpAlfGOWnaTMC77rfb4CQa7oJbEWW=
gitB_wu1IA=3D=3D&ch=3DQzBJwgVWk9wgNIKYnKo-B1Xm_X-hxRHuuMTb448c65Jbcpc4_aJub=
g=3D=3D" target=3D"_blank" style=3D"font-size: 14px; font-weight: bold; col=
or: rgb(77, 77, 77); text-decoration: underline; font-family: Arial, Verdan=
a, Helvetica, sans-serif;">pre-fusion RSV F protein</a><span style=3D"font-=
size: 14px; font-family: Arial, Verdana, Helvetica, sans-serif;">, vaccine =
design was improved significantly. Of course, this brings bigger hope not o=
nly to combat RSV but also to other vaccines, highlighting the role of prot=
ein structure in vaccine design.&#xa0;</span></p></td> </tr> </table> </td>=
  <td class=3D"column column--2 scale stack" style=3D"width: 45%;" align=3D=
"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 20px 10px 10px;"> <a href=3D"h=
ttps://r20.rs6.net/tn.jsp?f=3D001fzhPJ3kIRi1Sio9rUDUQb8ZDHKWWsiBhzX5qL5vf8l=
Bq7h7_3dHBK8ohqN6myhlHLeoTwklOz9icY80rGy_qRrhlUC_oP4ZugB-fZLDDfNMpiwckZF1jB=
AotV4ThbzYzcZVYxP5bUpM_qfdHuRjZ16_YOnhGuOCN19Ms3oRrytpXvjLEtiQVjd2d4FuCx6bo=
mYGQB2cooyUJQJ5aBVurLMJasmjaKo8fH4N5LczUpaawxS2QA1uPXpgaUGCyvP1gSX1whNXG2I0=
y3pF5bosee3VWbNqJd9mbMdqFYcAsRL7_lhO8Nq53VO5UBZPZmIDmA0q9MoqD1vja3E6ItkBn56=
C80TJe8Ohn&c=3D2L_5ls1o5ZmchXqqpAlfGOWnaTMC77rfb4CQa7oJbEWWgitB_wu1IA=3D=3D=
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