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https://www.agilent.com/

Ignite Genomics Insights
Targeted NGS panels for epigenetics research
Hero Image

Targeted next-generation sequencing for population epigenetic studies

Optimally assay systemic interindividual epigenetic variation (CoRSIV) and=
 discover associations with human diseases in large population studies usi=
ng the Agilent SureSelect CD Baylor Human CoRSIV panel. By multiplexing at=
 the capture step=2C this capture protocol provides a cost-effective solut=
ion=2C enabling genome-scale=2C deep bisulfite sequencing data at a price=
 competitive with commercial methylation arrays.

Developed by the Waterland team at the Baylor College of Medicine=2C Houst=
on=2C Texas=2C this new SureSelect CD Baylor Human CoRSIV panel incorporat=
es baits targeting 9=2C926 CoRSIVs=2C allowing comprehensive NGS profiling=
 of these regions.

The key advantages of targeted NGS for CoRSIV analysis include:
* Flexibility to design probes over any region of interest
* Ability to assay regions unavailable to microarray analysis due to known=
 array hybridization artifacts such as transposable elements
* Capacity to detect more methylation quantitative trait loci (mQTL) over=
 a smaller number of CpG sites
* Power of a cost-effective NGS analysis through a multiplex workflow

Explore the panel (https://www.agilent.com/en/product/next-generation-sequ=
encing/community-designs-ngs/designs-for-epigenetics-research-536211?utm_s=
ource=3DLabRoots&utm_medium=3Demail_3rdparty&utm_campaign=3DDGG_23_CommDe_=
EP-01&utm_content=3Dwebpage)

Agilent has not performed verification and validation of these panels.

For Research Use Only. Not for use in diagnostic procedures.

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                 <td colspan=3D"1" style=3D"text-align: left; padding: 0px=
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geted NGS panels for epigenetics research</td>
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                             <td style=3D"padding: 0px 20px 0px 20px; font=
-size: 1.3em; font-family: Helvetica=2C Arial=2C sans-serif; color: #00000=
0;">Targeted next-generation sequencing for population epigenetic studies<=
/td>
                           </tr>
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                             <td style=3D"padding: 0px 20px 0px 20px; font=
-size: .9em; font-family: Helvetica=2C Arial=2C sans-serif; line-height: 1=
=2E5em; color: #53565a;"><p>Optimally assay systemic interindividual epigene=
tic variation (CoRSIV) and discover associations with human diseases in la=
rge population studies using the Agilent SureSelect CD Baylor Human CoRSIV=
 panel. By multiplexing at the capture step=2C this capture protocol provi=
des a cost-effective solution=2C enabling genome-scale=2C deep bisulfite s=
equencing data at a price competitive with commercial methylation arrays.&=
nbsp;</p>
<p>Developed by the Waterland team at the Baylor College of Medicine=2C Ho=
uston=2C Texas=2C this new SureSelect CD Baylor Human CoRSIV panel incorpo=
rates baits targeting 9=2C926 CoRSIVs=2C allowing comprehensive NGS profil=
ing of these regions.&nbsp;</p>
<p>The key advantages of targeted NGS for CoRSIV analysis include:</p>
<ul>
<li>Flexibility to design probes over any region of interest</li>
<li>Ability to assay regions unavailable to microarray analysis due to kno=
wn array hybridization artifacts such as transposable elements</li>
<li>Capacity to detect more methylation quantitative trait loci (mQTL) ove=
r a smaller number of CpG sites</li>
<li>Power of a cost-effective NGS analysis through a multiplex workflow</l=
i>
</ul>
</td>
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