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Date: Wed, 10 May 2023 20:55:24 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: daisuke@saraya.co.in
Subject: =?utf-8?Q?=E3=80=90Aneuro_New_Product_Launched=E3=80=91_Ta?=
 =?utf-8?Q?u-441_PFFs_Assist_in_AD_Modeling?=
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Proteins for Neuroscience View as Webpage Products Support Insights Resourc=
es About Us =E2=80=8A =E3=80=90Aneuro New Product Launched=E3=80=91 Tau-441=
 PFFs Assist in AD Modeling >>News Express Eli Lilly recently announced pos=
itive clinical results from a Phase 3 clinical study of Donanemab, which wa=
s stratified by brain Tau protein deposition levels and showed that Donanem=
ab slowed clinical and functional decline by 35% in patients with Alzheimer=
's disease (AD). Based on these results, Lilly will proceed with global sub=
mission as soon as possible and expects to submit a marketing application t=
o the FDA within this quarter. AD is a complex neurodegenerative disease, i=
ts pathology has not yet been defined. As the brand of ACROBiosystems that =
focused on neuroscience, Aneuro offers a range of PFFs to support and accel=
erate the establishment of reliable neurodegenerative models. Based on stab=
le, quantifiable characterization and validation of reproducible protocols,=
 the structural features and mechanisms of activity of PFFs in disease mode=
ls will be better defined, allowing for their application in large-scale dr=
ug screening and testing. >>Explore More Verification Data   PFFs activity =
(ThT assay) Thioflavin T emission curves show increased fluorescence (corre=
lated to tau aggregation) over time when tau wild-type monomers (Cat. No. T=
AU-H5117) are combined with tau wild-type Pre-formed Fibrils (Cat. No. TAU-=
H5115) (QC tested). Request for Protocol  PFFs morphology (electron microsc=
opy) Transmission electron microscopy (TEM) of Tau-441 preformed fibrils (C=
at. No. TAU-H5115). Fibril structure is visible on negative stain TEM image=
s of TAU-H5115 (Routinely tested). PFFs bioactivity (cell-base assay) Confo=
cal image of 4% Paraformaldehyde-fixed, 0.1% TritonX-100 permeabilized SH-S=
Y5Y cells previously treated with 10 =CE=BCg/mL Tau-H5115 showed cytoplasmi=
c aggregation of Tau PFFs. Tau-PFFs was stained by thioflavin S (Green). Th=
e Nuclear counterstain was DAPI (Blue) (Routinely tested). =E2=80=8A >> Lea=
rn more about neural factors =E2=80=8A =EF=BB=BFTo receive the latest indus=
try news and updates from ACROBiosystems, =EF=BB=BFvisit our website & foll=
ow us on our social media!=EF=BB=BF =E2=80=8A Visit our Website =E2=80=8A =
=E2=80=8A       ACROBiosystems | 1 Innovation Way, Newark, DE 19711 Unsubsc=
ribe daisuke@saraya.co.in Update Profile | Our Privacy Policy | Constant Co=
ntact Data Notice Sent by acrobio.apac@outlook.com
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<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
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a,sans-serif; color: #3E3E3E; font-size: 14px; display: block; word-wrap: b=
reak-word; padding: 10px 40px;" align=3D"center" valign=3D"top"><p style=3D=
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6.net/tn.jsp?f=3D001uUac3YGWWTAI7OeI3SLQF6_HxnTLNo2PZx3uIO5J4J89AF8fboHFWWz=
rVRwZ1sZv4yqekcL5xluNhy_SDhulCZ6U2rY6wWZ9ovs7QY92uyGFInnl_eCjKAaWucxEqxlArA=
2tWeSmjwigvNsgCebwAtJBWImtVgMRu623i2oXppoQOhuhjr6re5-CKuKStfBzdtj5B8hWA1a98=
RTPMpuaZkaMzwKcV9P6tg6YxesKZwpaQpMe1EcYI0DLZXHJYfvrmPnF7vXi1NDX6UMnpyyfDfCt=
6ezk-Yn0lXn4ajuzvtSYSHMxrXS0oTOrXuRIhm2cBStfuYsPs6vFuDxvi8LN4ePQ_I5QFmeGX3Z=
Wdvj7J_l_SS3GKetbb51Ko7JYJZKo-69ML6ML-BUJw13DROPyTDoP7blIpkIjr0u4SXC4xw2CW2=
GaRKiDzQ=3D=3D&c=3DmEucWcGKZVkNfQ0mtegJ58dLHgrdwPxWsAPJUb58agBsHZAcnPtqnQ=
=3D=3D&ch=3DSouZSwsAz4r4-R_UDScopCz-GfrI2A-9cVztHJCKqKD5PxzS5IinGQ=3D=3D" t=
arget=3D"_blank" style=3D"font-size: 16px; color: rgb(192, 0, 0); font-weig=
ht: bold; text-decoration: none;">&#x3010;Aneuro New Product Launched&#x301=
1; Tau-441 PFFs Assist in AD Modeling</a></p></td> </tr> </table> </td> </t=
r> </table> <table class=3D"layout-margin" style=3D"" width=3D"100%" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"layout-margin=
_cell" style=3D"padding: 0px 40px;" align=3D"center" valign=3D"top"> <table=
 class=3D"layout-border layout-border--dashed" style=3D"border: 3px dashed =
#cccccc;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> =
<tr> <td class=3D"layout-border_cell" style=3D"" align=3D"center" valign=3D=
"top">
<table class=3D"layout layout--coupon layout--1-column" style=3D"table-layo=
ut: fixed; background-color: #ffffff;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0" bgcolor=3D"#ffffff"> <tr> <td class=3D"column c=
olumn--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top=
">
<table class=3D"text text--coupon text--padding-vertical" width=3D"100%" bo=
rder=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed=
;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 2; text-align: center; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #3E3E3E; font-size: 18px; display: block; word-wrap: b=
reak-word; padding: 10px 20px;" align=3D"center" valign=3D"top">
<p style=3D"text-align: left; margin: 0;" align=3D"left"><span style=3D"fon=
t-size: 14px;">&gt;&gt;News Express</span></p>
<p style=3D"text-align: left; margin: 0;" align=3D"left"><span style=3D"fon=
t-size: 14px; font-family: Arial, Verdana, Helvetica, sans-serif; color: rg=
b(51, 51, 51);">Eli </span><span style=3D"font-size: 14px;">Lilly recently =
announced positive clinical results from a Phase 3 clinical study of Donane=
mab, which was stratified by brain Tau protein deposition levels and showed=
 that Donanemab slowed clinical and functional decline by 35% in patients w=
ith Alzheimer's disease (AD). Based on these results, Lilly will proceed wi=
th global submission as soon as possible and expects to submit a marketing =
application to the FDA within this quarter.</span></p>
</td> </tr> </table> </td> </tr> </table> </td> </tr> </table>  </td> </tr>=
 </table> <table class=3D"layout layout--1-column" style=3D"table-layout: f=
ixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr=
> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=
=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: justify; margin: 0;" align=3D"justify">AD is a comp=
lex neurodegenerative disease, its pathology has not yet been defined. As t=
he brand of ACROBiosystems that focused on neuroscience, Aneuro offers a ra=
nge of PFFs to support and accelerate the establishment of reliable neurode=
generative models. Based on stable, quantifiable characterization and valid=
ation of reproducible protocols, the structural features and mechanisms of =
activity of PFFs in disease models will be better defined, allowing for the=
ir application in large-scale drug screening and testing.</p>
<p style=3D"text-align: right; margin: 0;" align=3D"right"><a href=3D"https=
://r20.rs6.net/tn.jsp?f=3D001uUac3YGWWTAI7OeI3SLQF6_HxnTLNo2PZx3uIO5J4J89AF=
8fboHFWVfZPlnLjeEOdDY-a25yflGjQmJBgIUm6Y1-cyaFelCEXvUIw0WmPPZW1wmoDIyLni12W=
PFn1pwfIbvMvmoffIcbVGiTZn0ieTtc2OFD6U4dlR9sbZUw2QSLk8-BMbeID9TCo8rHwWo2Sfyu=
bFBgglrnhCgEwaEUXZW4guaML9aSKT5-HX7dHRdC-hM8tJxfDV-VnZiNlX02Isk968B-jwya_y5=
dRrzvWEE-nlFyeJYvHy_JDnN6l2x7vpG9EwEa8USKAOZAogqCbMh9q1B_lOFsOzKtZlhcMwZGpT=
Oi2QCPVmC8ovHrVKp7pfhBLFW9mg=3D=3D&c=3DmEucWcGKZVkNfQ0mtegJ58dLHgrdwPxWsAPJ=
Ub58agBsHZAcnPtqnQ=3D=3D&ch=3DSouZSwsAz4r4-R_UDScopCz-GfrI2A-9cVztHJCKqKD5P=
xzS5IinGQ=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 0, 0); font-wei=
ght: bold; text-decoration: underline;">&gt;&gt;Explore More</a></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-weight: bold; font-size: 16px;">Verification Data</span></p>
<ul><li>
<span style=3D'font-family: Georgia, "Times New Roman", Times, serif; font-=
weight: bold;'>&#xa0;</span><span style=3D"font-weight: bold;">&#xa0;PFFs a=
ctivity (ThT assay)</span>
</li></ul>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 40px;"> <img data-image-conten=
t class=3D"image_content" width=3D"449" src=3D"https://files.constantcontac=
t.com/5f3d0cf9401/7d34bd03-d20c-4f39-961e-b9b4f91d5d49.jpg" alt=3D"" style=
=3D"display: block; height: auto; max-width: 100%;"> </td> </tr> </table> <=
table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" cel=
lpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td c=
lass=3D"text_content-cell content-padding-horizontal" style=3D"text-align: =
left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font=
-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; paddi=
ng: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><span=
 style=3D"font-size: 11px; color: black; font-style: italic;">Thioflavin T =
emission curves show increased fluorescence (correlated to tau aggregation)=
 over time when tau wild-type monomers (Cat. No.</span><a href=3D"https://r=
20.rs6.net/tn.jsp?f=3D001uUac3YGWWTAI7OeI3SLQF6_HxnTLNo2PZx3uIO5J4J89AF8fbo=
HFWSTdcjCNaJ1DL1WFvIBqHib80TmNhC0Q8T2y5q1GEpn4goQ8h_G9DaFnGckoDcTP_PC6NAKCM=
XwinLC7T7AUr-hJyb1gqdtAgFw127nhL5WMHkjHf1U0jTkIs_7yNG5zkSIu_l2vcFi6qqDunadD=
cGGGxonQ8-ZodtacX-cgV7YrCNlGI1zS9ZX5xFtiJDVsQgl3uIkC8hQw81hA3MfsAOfNRn2rQHV=
Q7g_L1am27ucnYo4hgfMqX8OQjNLqMI0bla_l0sk1kQDmA25mS1KfB_L_HpSZlES_m5hCDhV3-7=
-AEji5vYjUoXqDMsPptYbDs3G2GbSYFpT2KzkUbeOBPGy8eD-Y8mzw4l0rHwQVSW4p&c=3DmEuc=
WcGKZVkNfQ0mtegJ58dLHgrdwPxWsAPJUb58agBsHZAcnPtqnQ=3D=3D&ch=3DSouZSwsAz4r4-=
R_UDScopCz-GfrI2A-9cVztHJCKqKD5PxzS5IinGQ=3D=3D" target=3D"_blank" style=3D=
"font-size: 11px; color: rgb(192, 0, 0); font-style: italic; text-decoratio=
n: underline; font-weight: bold;"> TAU-H5117</a><span style=3D"font-size: 1=
1px; color: black; font-style: italic;">) are combined with tau wild-type P=
re-formed Fibrils (Cat. No. </span><a href=3D"https://r20.rs6.net/tn.jsp?f=
=3D001uUac3YGWWTAI7OeI3SLQF6_HxnTLNo2PZx3uIO5J4J89AF8fboHFWWzrVRwZ1sZv4yqek=
cL5xluNhy_SDhulCZ6U2rY6wWZ9ovs7QY92uyGFInnl_eCjKAaWucxEqxlArA2tWeSmjwigvNsg=
CebwAtJBWImtVgMRu623i2oXppoQOhuhjr6re5-CKuKStfBzdtj5B8hWA1a98RTPMpuaZkaMzwK=
cV9P6tg6YxesKZwpaQpMe1EcYI0DLZXHJYfvrmPnF7vXi1NDX6UMnpyyfDfCt6ezk-Yn0lXn4aj=
uzvtSYSHMxrXS0oTOrXuRIhm2cBStfuYsPs6vFuDxvi8LN4ePQ_I5QFmeGX3ZWdvj7J_l_SS3GK=
etbb51Ko7JYJZKo-69ML6ML-BUJw13DROPyTDoP7blIpkIjr0u4SXC4xw2CW2GaRKiDzQ=3D=3D=
&c=3DmEucWcGKZVkNfQ0mtegJ58dLHgrdwPxWsAPJUb58agBsHZAcnPtqnQ=3D=3D&ch=3DSouZ=
SwsAz4r4-R_UDScopCz-GfrI2A-9cVztHJCKqKD5PxzS5IinGQ=3D=3D" target=3D"_blank"=
 style=3D"font-size: 11px; color: rgb(192, 0, 0); font-style: italic; text-=
decoration: underline; font-weight: bold;">TAU-H5115</a><span style=3D"font=
-size: 11px; color: black; font-style: italic;">) (QC tested).</span></p></=
td> </tr> </table>  <table class=3D"button button--padding-vertical" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-l=
ayout: fixed;"> <tr> <td class=3D"button_container content-padding-horizont=
al" align=3D"center" style=3D"padding: 10px 40px;">    <table class=3D"butt=
on_content-row" style=3D"background-color: #c03e30; width: inherit; border-=
radius: 7px; border-spacing: 0; border: none;" border=3D"0" cellpadding=3D"=
0" cellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"button_content-=
cell" style=3D"padding: 10px 15px;" align=3D"center"> <a class=3D"button_li=
nk" href=3D"https://r20.rs6.net/tn.jsp?f=3D001uUac3YGWWTAI7OeI3SLQF6_HxnTLN=
o2PZx3uIO5J4J89AF8fboHFWR6ji0pWHrwncZv28kZCInGeo5IPKDu-r8kTCjZ2W1JQ62cCNQg3=
1SVxjvAmCXHGJD-vSbJI_gFCRXKTGSfzcEiBakCB6onKq00rfrhY9maUIZ9wh5Z_oFTiCntvgde=
IQgIFfw2LIuKDljJA-w-gtDqUPnT1wR_vexzza-wUKfEgcKpb1KR3TPAjx2ATS43x9XvCI2dUvt=
BCNZxHdXPMDTYflPmBdWJ-ClUGgOk1czizqN3O1LFx-Ljs3QacLnt_ea70E-8uY-N9X4Ef3Tnbb=
wxB0OnnxYdjfoMeXDnLyn_s05rWLxnTqldVqa-b0Hvy3QWcnGsht7XP&c=3DmEucWcGKZVkNfQ0=
mtegJ58dLHgrdwPxWsAPJUb58agBsHZAcnPtqnQ=3D=3D&ch=3DSouZSwsAz4r4-R_UDScopCz-=
GfrI2A-9cVztHJCKqKD5PxzS5IinGQ=3D=3D" data-trackable=3D"true" style=3D"colo=
r: #FFFFFF; font-family: Arial,Verdana,Helvetica,sans-serif; font-size: 16p=
x; word-wrap: break-word; font-weight: bold; text-decoration: none;">Reques=
t for Protocol</a> </td> </tr> </table>    </td> </tr> </table>   <table cl=
ass=3D"text text--padding-vertical" width=3D"100%" border=3D"0" cellpadding=
=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"=
text_content-cell content-padding-horizontal" style=3D"text-align: left; fo=
nt-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: 1=
4px; line-height: 1.2; display: block; word-wrap: break-word; padding: 10px=
 40px;" align=3D"left" valign=3D"top"><ul><li>
<span style=3D'font-family: Georgia, "Times New Roman", Times, serif; font-=
weight: bold;'>&#xa0;</span><span style=3D"font-weight: bold;">PFFs morphol=
ogy (electron microscopy)</span>
</li></ul></td> </tr> </table> <table class=3D"image image--padding-vertica=
l image--mobile-scale image--mobile-center" width=3D"100%" border=3D"0" cel=
lpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"image_container content=
-padding-horizontal" align=3D"center" valign=3D"top" style=3D"padding: 10px=
 40px;"> <img data-image-content class=3D"image_content" width=3D"503" src=
=3D"https://files.constantcontact.com/5f3d0cf9401/bfb326d4-b2f5-4ab8-9a45-7=
09ca91374d8.jpg" alt=3D"" style=3D"display: block; height: auto; max-width:=
 100%;"> </td> </tr> </table> </td> </tr> </table> <table class=3D"layout l=
ayout--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0"=
 cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 sc=
ale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><spa=
n style=3D"font-size: 11px; color: black; font-style: italic;">Transmission=
 electron microscopy (TEM) of Tau-441 preformed fibrils (Cat. No.</span><a =
href=3D"https://r20.rs6.net/tn.jsp?f=3D001uUac3YGWWTAI7OeI3SLQF6_HxnTLNo2PZ=
x3uIO5J4J89AF8fboHFWSTdcjCNaJ1DL1WFvIBqHib80TmNhC0Q8T2y5q1GEpn4goQ8h_G9DaFn=
GckoDcTP_PC6NAKCMXwinLC7T7AUr-hJyb1gqdtAgFw127nhL5WMHkjHf1U0jTkIs_7yNG5zkSI=
u_l2vcFi6qqDunadDcGGGxonQ8-ZodtacX-cgV7YrCNlGI1zS9ZX5xFtiJDVsQgl3uIkC8hQw81=
hA3MfsAOfNRn2rQHVQ7g_L1am27ucnYo4hgfMqX8OQjNLqMI0bla_l0sk1kQDmA25mS1KfB_L_H=
pSZlES_m5hCDhV3-7-AEji5vYjUoXqDMsPptYbDs3G2GbSYFpT2KzkUbeOBPGy8eD-Y8mzw4l0r=
HwQVSW4p&c=3DmEucWcGKZVkNfQ0mtegJ58dLHgrdwPxWsAPJUb58agBsHZAcnPtqnQ=3D=3D&c=
h=3DSouZSwsAz4r4-R_UDScopCz-GfrI2A-9cVztHJCKqKD5PxzS5IinGQ=3D=3D" target=3D=
"_blank" style=3D"font-size: 11px; color: rgb(192, 62, 48); font-style: ita=
lic; font-weight: bold; text-decoration: underline;"> TAU-H5115</a><span st=
yle=3D"font-size: 11px; color: black; font-style: italic;">). Fibril struct=
ure is visible on negative stain TEM images of</span><span style=3D"font-si=
ze: 11px; color: rgb(192, 0, 0); font-style: italic;"> </span><a href=3D"ht=
tps://r20.rs6.net/tn.jsp?f=3D001uUac3YGWWTAI7OeI3SLQF6_HxnTLNo2PZx3uIO5J4J8=
9AF8fboHFWSTdcjCNaJ1DL1WFvIBqHib80TmNhC0Q8T2y5q1GEpn4goQ8h_G9DaFnGckoDcTP_P=
C6NAKCMXwinLC7T7AUr-hJyb1gqdtAgFw127nhL5WMHkjHf1U0jTkIs_7yNG5zkSIu_l2vcFi6q=
qDunadDcGGGxonQ8-ZodtacX-cgV7YrCNlGI1zS9ZX5xFtiJDVsQgl3uIkC8hQw81hA3MfsAOfN=
Rn2rQHVQ7g_L1am27ucnYo4hgfMqX8OQjNLqMI0bla_l0sk1kQDmA25mS1KfB_L_HpSZlES_m5h=
CDhV3-7-AEji5vYjUoXqDMsPptYbDs3G2GbSYFpT2KzkUbeOBPGy8eD-Y8mzw4l0rHwQVSW4p&c=
=3DmEucWcGKZVkNfQ0mtegJ58dLHgrdwPxWsAPJUb58agBsHZAcnPtqnQ=3D=3D&ch=3DSouZSw=
sAz4r4-R_UDScopCz-GfrI2A-9cVztHJCKqKD5PxzS5IinGQ=3D=3D" target=3D"_blank" s=
tyle=3D"font-size: 11px; color: rgb(192, 0, 0); font-style: italic; font-we=
ight: bold; text-decoration: underline;">TAU-H5115</a><span style=3D"font-s=
ize: 11px; color: black; font-style: italic;"> (Routinely tested).</span></=
p></td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--=
1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpa=
dding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale sta=
ck" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><ul><li><span style=3D"font-=
weight: bold;">PFFs bioactivity (cell-base assay)</span></li></ul></td> </t=
r> </table> </td> </tr> </table> <table class=3D"layout layout--1-column" s=
tyle=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0"=
 cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=
=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 40px;"> <img data-image-conten=
t class=3D"image_content" width=3D"522" src=3D"https://files.constantcontac=
t.com/5f3d0cf9401/6619ba27-248c-4028-a90f-97168f49054a.jpg" alt=3D"" style=
=3D"display: block; height: auto; max-width: 100%;"> </td> </tr> </table> <=
/td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"table=
-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100=
%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><spa=
n style=3D"font-size: 11px; color: black; font-style: italic;">Confocal ima=
ge of 4% Paraformaldehyde-fixed, 0.1% TritonX-100 permeabilized SH-SY5Y cel=
ls previously treated with 10 &#x3bc;g/mL</span><a href=3D"https://r20.rs6.=
net/tn.jsp?f=3D001uUac3YGWWTAI7OeI3SLQF6_HxnTLNo2PZx3uIO5J4J89AF8fboHFWSTdc=
jCNaJ1DL1WFvIBqHib80TmNhC0Q8T2y5q1GEpn4goQ8h_G9DaFnGckoDcTP_PC6NAKCMXwinLC7=
T7AUr-hJyb1gqdtAgFw127nhL5WMHkjHf1U0jTkIs_7yNG5zkSIu_l2vcFi6qqDunadDcGGGxon=
Q8-ZodtacX-cgV7YrCNlGI1zS9ZX5xFtiJDVsQgl3uIkC8hQw81hA3MfsAOfNRn2rQHVQ7g_L1a=
m27ucnYo4hgfMqX8OQjNLqMI0bla_l0sk1kQDmA25mS1KfB_L_HpSZlES_m5hCDhV3-7-AEji5v=
YjUoXqDMsPptYbDs3G2GbSYFpT2KzkUbeOBPGy8eD-Y8mzw4l0rHwQVSW4p&c=3DmEucWcGKZVk=
NfQ0mtegJ58dLHgrdwPxWsAPJUb58agBsHZAcnPtqnQ=3D=3D&ch=3DSouZSwsAz4r4-R_UDSco=
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ize: 11px; color: rgb(192, 62, 48); font-style: italic; text-decoration: un=
derline; font-weight: bold;"> Tau-H5115</a><span style=3D"font-size: 11px; =
color: black; font-style: italic;"> showed cytoplasmic aggregation of Tau P=
FFs. Tau-PFFs was stained by thioflavin S (Green). The Nuclear counterstain=
 was DAPI (Blue) (Routinely tested).</span></p></td> </tr> </table> </td> <=
/tr> </table> <table class=3D"layout layout--1-column" style=3D"table-layou=
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