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편집 파일: 1683595487.M11779P10030.server.saraya-global.com,S=64925,W=65902:2,

Envelope-to: mykhaylo.dubrovka@saraya.co.in
Delivery-date: Tue, 09 May 2023 09:24:47 +0800
Message-ID: <1140172155034.1119371711477.1404958413.0.522121JL.2002@synd.ccsend.com>
Date: Mon, 8 May 2023 21:23:57 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
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=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
 break-word; padding: 10px 20px;" align=3D"center" valign=3D"top"><p style=
=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RDJMZZRlUw4oEb=
U27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdm-NI6I5z1SV36gClNL4tqyAV68aw_ZgV8km5=
Ah45ecU6aZs0cEIx8gA7oc4GbXdY-dc8SsQ77ZFS4dvBg_74ZOgdt_GCwmL6NHBebV1odwsswig=
EgyIaKqiciwnTDMbhq4Oo582v0lsiS2pjtP03I_r4eP1dVFYZN3FxjudxwX6XRqIDjF-rHNXPR1=
Rw2m8NkmdJCBWtj3z_dup9EVcEnx_TDVrq7J_EInRVG58etOqtWCBKdVFIk97SS-aiwdSgMOlxf=
hgJpbX2uitShaI8DIq71PtQ76S0A=3D=3D&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0eBSD=
sqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephznLsY=
bJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 62, 48); text-d=
ecoration: underline; font-size: 13px; font-weight: bold;">&#x30ea;&#x30bd;=
&#x30fc;&#x30b9;</a></p></td> </tr> </table> </td>  <td class=3D"column col=
umn--4 scale stack" style=3D"width: 25%;" align=3D"center" valign=3D"middle=
">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
 break-word; padding: 10px 40px 10px 0px;" align=3D"center" valign=3D"top">=
<p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RDJMZZ=
RlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdm-NI6I5z1SV_rE2QNI5oikUDI4f2=
EUP7fe0WH5yZ3uaCs1qsskwTPQft8ho7r3_hPbM10l8SQp9pW39EW22blinxSf81-CBHtkF-Lzr=
3ZgCpz3roOc8ldYFDI7oohs8kVynYN4EeW8x9egm7OYK5wJFeORonEDUWU4LUTQGaoGwfHWvhQj=
sFScGk5Ilpofe-0D3P1LoYHfLD5CTzxzLNwXUr1PFXkCC2jcY8vSuc_gJm-wXOKMFOzZcA9p-g6=
y7zAwKEymG4FsKWZLk-z-cIp4=3D&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0eBSDsqT-57=
_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephznLsYbJk7AJ=
7kw=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 62, 48); text-decorat=
ion: underline; font-size: 13px; font-weight: bold;">&#x30a4;&#x30f3;&#x30b=
5;&#x30a4;&#x30c8;</a></p></td> </tr> </table> </td> </tr> </table> <table =
class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"1=
00%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"co=
lumn column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=
=3D"top"><div class=3D"spacer" style=3D"line-height: 10px; height: 10px;">&=
#x200a;</div></td> </tr> </table> <table class=3D"layout layout--1-column" =
style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0=
" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=
=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: center; font-family: Arial,Verdana,Helvet=
ica,sans-serif; color: #3E3E3E; font-size: 14px; display: block; word-wrap:=
 break-word; padding: 10px 40px;" align=3D"center" valign=3D"top"><p style=
=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D"color: =
rgb(25, 25, 25); font-weight: bold; font-size: 18px;">AACR2023&#x901f;&#x58=
31; : &#x65b0;&#x305f;&#x306a;&#x85ac;&#x7269;&#x8907;&#x5408;&#x4f53;&#x30=
4c;&#x51fa;&#x73fe;</span></p></td> </tr> </table> </td> </tr> </table> <ta=
ble class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=
=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center" v=
align=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"text-align: justif=
y; margin: 0;" align=3D"justify"><span style=3D"color: rgb(25, 25, 25);">&#=
x5148;&#x65e5;&#x3001;&#x7c73;&#x56fd;&#x30d5;&#x30ed;&#x30ea;&#x30c0;&#x5d=
de;&#x30aa;&#x30fc;&#x30e9;&#x30f3;&#x30c9;&#x3067;&#x7b2c;114&#x56de;&#x7c=
73;&#x56fd;&#x764c;&#x5b66;&#x4f1a;&#xff08;AACR&#xff09;&#x5b66;&#x8853;&#x7=
dcf;&#x4f1a;&#x304c;&#x958b;&#x50ac;&#x3055;&#x308c;&#x307e;&#x3057;&#x305f=
;&#x3002; &#x4eca;&#x3001;&#x6700;&#x3082;&#x958b;&#x767a;&#x3055;&#x308c;&=
#x3066;&#x3044;&#x308b;ADC&#x306f;&#x3001;&#x4e16;&#x754c;&#x4e2d;&#x306e;&=
#x88fd;&#x85ac;&#x4f1a;&#x793e;&#x306e;&#x8e8d;&#x9032;&#x304c;&#x7d9a;&#x3=
04d;&#x3001;AACR&#x3067;ADC&#x85ac;&#x306e;&#x5206;&#x91ce;&#x306b;&#x3064;=
&#x3044;&#x3066;&#x591a;&#x304f;&#x306e;&#x91cd;&#x8981;&#x306a;&#x9032;&#x=
5c55;&#x304c;&#x5171;&#x306b;&#x7d39;&#x4ecb;&#x3055;&#x308c;&#x307e;&#x305=
7;&#x305f;&#x3002; &#x5f93;&#x6765;&#x306e;ADC&#x85ac;&#x306b;&#x52a0;&#x30=
48;&#x3001;&#x65b0;&#x898f;&#x306e;&#x85ac;&#x7269;&#x8907;&#x5408;&#x4f53;=
&#x306b;&#x3082;&#x6709;&#x671b;&#x306a;&#x5c55;&#x958b;&#x304c;&#x591a;&#x=
304f;&#x898b;&#x3089;&#x308c;&#x307e;&#x3059;&#x3002;</span></p></td> </tr>=
 </table> </td> </tr> </table> <table class=3D"layout layout--1-column" sty=
le=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" c=
ellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"=
width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"font-size: 15px; color: rgb(25, 25, =
25); font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: bold;=
">&#xb7; YH013</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 15px; color: rgb(25, 25, =
25); font-family: Arial, Verdana, Helvetica, sans-serif;">YH013 &#x306f;&#x=
3001;Biocytogen&#x793e;&#x304c;&#x72ec;&#x81ea;&#x306e;&#x5171;&#x901a;&#x8=
efd;&#x9396; RenLite&#x30de;&#x30a6;&#x30b9;&#x30d7;&#x30e9;&#x30c3;&#x30c8=
;&#x30d5;&#x30a9;&#x30fc;&#x30e0;&#x3068; KIH (knobs-into-holes) &#x6280;&#=
x8853;&#x3092;&#x4f7f;&#x7528;&#x3057;&#x3066;&#x958b;&#x767a;&#x3057;&#x30=
5f;&#x30d2;&#x30c8; EGFR/Met BsADC &#x3067;&#x3042;&#x308a;&#x3001;&#x4e2d;=
&#x56fd;&#x521d;&#x306e; </span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D0=
01RDJMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdjMS9E0Vf8D34es37OPuz=
mAy37Pu-ZHsRA3WMo-FHs70JMtqrRXBStN1a0RBobT1qDjFaSt6_20sgAC9MluU1InlOitAsERJ=
ZLRWYZPUTvFcSUg-5G1xEJIphzBYnjljDiOhLhXjAKGScGrzfsX_HXoo-dUH_EaAxGbOqZCOI2M=
JF71buVOlaa218OjdeEqIrmppJoQ_Znd76Td50SRIm9C5E9V-7qAzqFpBr6WigZEL7QkDR0-yzw=
Tm9fVDX_LdnC0gw_QAmF8L7juNLizDtXLJ3e87AlZDnLr18M9EYfHd&c=3DQuY-0bnbmMfLnvkD=
9KftThHRtv5XrgW0eBSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi=
7jcsDESyxchOephznLsYbJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"font-size: =
15px; color: rgb(192, 62, 48); font-family: Arial, Verdana, Helvetica, sans=
-serif; font-weight: bold; text-decoration: underline;">EGFR x MET</a><span=
 style=3D"font-size: 15px; color: rgb(25, 25, 25); font-family: Arial, Verd=
ana, Helvetica, sans-serif;"> ADC &#x3067;&#x3059;&#x3002;&#x30e2;&#x30ce;&=
#x30e1;&#x30c1;&#x30eb;&#x30a2;&#x30a6;&#x30ea;&#x30b9;&#x30bf;&#x30c1;&#x3=
0f3; E (MMAE) &#x306f;&#x3001;NCI-H1975 &#x3068;NCI-H292 &#x7d30;&#x80de;&#=
x682a;&#x7531;&#x6765;&#x306e;&#x7570;&#x7a2e;&#x79fb;&#x690d;&#x30e2;&#x30=
c7;&#x30eb;&#x306b;&#x304a;&#x3044;&#x3066;&#x3001;&#x89aa;&#x6297;&#x4f53;=
&#x3084;&#x4e00;&#x4fa1;&#x6297;&#x4f53;&#x3088;&#x308a;&#x3082;&#x816b;&#x=
760d;&#x7d30;&#x80de;&#x306b;&#x7d50;&#x5408;&#x3059;&#x308b;&#x3053;&#x306=
8;&#x304c;&#x793a;&#x3055;&#x308c;&#x3001;&#x7528;&#x91cf;&#x4f9d;&#x5b58;&=
#x7684;&#x306a;&#x6297;&#x816b;&#x760d;&#x52b9;&#x679c;&#x304c;&#x9855;&#x8=
457;&#x3067;&#x3057;&#x305f;&#x3002;</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 15px; color: rgb(25, 25, =
25); font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: bold;=
">&#xb7;</span><span style=3D"font-size: 9px; color: rgb(25, 25, 25); font-=
family: Arial, Verdana, Helvetica, sans-serif; font-weight: bold;">&#xa0;</=
span><span style=3D"font-size: 15px; color: rgb(25, 25, 25); font-family: A=
rial, Verdana, Helvetica, sans-serif; font-weight: bold;">DB-1303</span></p=
>
<p style=3D"margin: 0;"><span style=3D"font-size: 15px; color: rgb(25, 25, =
25); font-family: Arial, Verdana, Helvetica, sans-serif;">DB-1303 &#x306f;&=
#x3001;DualityBio&#x793e;&#x304c; DITAC &#x6280;&#x8853;&#x306b;&#x57fa;&#x=
3065;&#x3044;&#x3066;&#x958b;&#x767a;&#x3057;&#x305f; HER2 ADC &#x88fd;&#x5=
4c1;&#x3067;&#x3042;&#x308a;&#x3001;&#x65b0;&#x898f;&#x306e;&#x30c8;&#x30dd=
;&#x30a4;&#x30bd;&#x30e1;&#x30e9;&#x30fc;&#x30bc; 1 &#x963b;&#x5bb3;&#x5264=
; (P1003) &#x3068;&#x7d50;&#x5408;&#x3057;&#x305f; </span><a href=3D"https:=
//r20.rs6.net/tn.jsp?f=3D001RDJMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfBy=
ujZSkdjMS9E0Vf8D3Qjd65lGqdPqfgUJT0l8Pgmjxgg4E0aPJRQrZ0lC4g6oeoAznphXt7wqHoj=
jIi4iICnd85aC8050SJbQlcdAVKNgBNMNHWyrgto04_Jks27NE8olEjoC-Q45flQcRkd9klDHHB=
aGnOR4YgWdFjYYJxoMLBjx1xu9C7QDIZfm4e9RmK93EvSY6OR4KNfEI8FPF2Q3aqhHYESwcq-QD=
FSPCuKKx2fOsYGhoSQxdwiG9ympWRahhuX__H2BpjMkd_wsWvam1bSJqrn5b0jzG95aiqA=3D=
=3D&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0eBSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl=
2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephznLsYbJk7AJ7kw=3D=3D" target=3D"_bla=
nk" style=3D"font-size: 15px; color: rgb(192, 62, 48); font-family: Arial, =
Verdana, Helvetica, sans-serif; font-weight: bold; text-decoration: underli=
ne;">HER2</a><span style=3D"font-size: 15px; color: rgb(192, 62, 48); font-=
family: Arial, Verdana, Helvetica, sans-serif;"> </span><span style=3D"font=
-size: 15px; color: rgb(25, 25, 25); font-family: Arial, Verdana, Helvetica=
, sans-serif;">&#x3092;&#x6a19;&#x7684;&#x3068;&#x3059;&#x308b;&#x30e2;&#x3=
0ce;&#x30af;&#x30ed;&#x30fc;&#x30ca;&#x30eb;&#x6297;&#x4f53;&#x3067;&#x69cb=
;&#x6210;&#x3055;&#x308c;&#x3066;&#x3044;&#x307e;&#x3059;&#x3002; &#x4ee5;&=
#x524d;&#x516c;&#x958b;&#x3055;&#x308c;&#x305f;&#x30c7;&#x30fc;&#x30bf;&#x3=
06b;&#x3088;&#x308a;&#x3001;P1003 &#x304c;&#x30d0;&#x30a4;&#x30b9;&#x30bf;&=
#x30f3;&#x30c0;&#x30fc;&#x52b9;&#x679c;&#x3068;&#x8fc5;&#x901f;&#x306a;&#x3=
0af;&#x30ea;&#x30a2;&#x30e9;&#x30f3;&#x30b9;&#x7279;&#x6027;&#x3092;&#x6301=
;&#x3063;&#x3066;&#x3044;&#x307e;&#x3059;&#x3002; &#x4eca;&#x56de;&#x306e;A=
ACR &#x4f1a;&#x8b70;&#x3067;DB-1303 &#x306b;&#x95a2;&#x3059;&#x308b;&#x7814=
;&#x7a76;&#x30c7;&#x30fc;&#x30bf;&#x304c;&#x66f4;&#x65b0;&#x3055;&#x308c;&#=
x3001;DS-8201 &#x3088;&#x308a;&#x3082;&#x524d;&#x81e8;&#x5e8a;&#x3067;&#x51=
2a;&#x308c;&#x3066;&#x3044;&#x308b;&#x3053;&#x3068;&#x3092;&#x793a;&#x3057;=
&#x3066;&#x3044;&#x307e;&#x3059;&#x3002;</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 15px; color: rgb(25, 25, =
25); font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: bold;=
">&#xb7;</span><span style=3D"font-size: 9px; color: rgb(25, 25, 25); font-=
family: Arial, Verdana, Helvetica, sans-serif; font-weight: bold;">&#xa0;</=
span><span style=3D"font-size: 15px; color: rgb(25, 25, 25); font-family: A=
rial, Verdana, Helvetica, sans-serif; font-weight: bold;">TAK-500</span></p=
>
<p style=3D"margin: 0;"><span style=3D"font-size: 15px; color: rgb(25, 25, =
25); font-family: Arial, Verdana, Helvetica, sans-serif;">TAK-500&#x306f;&#=
x3001;&#x6b66;&#x7530;&#x85ac;&#x54c1;&#x5de5;&#x696d;&#x304c;&#x958b;&#x76=
7a;&#x3057;&#x305f;&#x65b0;&#x898f;ISAC&#x3067;&#x3001;IgG1&#x6297;CCR2&#x6=
297;&#x4f53;&#x3068;STING&#x30a2;&#x30b4;&#x30cb;&#x30b9;&#x30c8;&#xff08;TA=
K-676&#x3092;&#x30d9;&#x30fc;&#x30b9;&#xff09;&#x304c;&#x5207;&#x65ad;&#x53e=
f;&#x80fd;&#x306a;&#x30de;&#x30ec;&#x30a4;&#x30df;&#x30c9;&#x578b;&#x30ea;&=
#x30f3;&#x30ab;&#x30fc;&#x3067;&#x7d50;&#x5408;&#x3055;&#x308c;&#x3066;&#x3=
044;&#x307e;&#x3059;&#x3002;AACR 2023&#x3067;&#x6b66;&#x7530;&#x85ac;&#x54c=
1;&#x5de5;&#x696d;&#x304c;&#x521d;&#x3081;&#x3066;&#x767a;&#x8868;&#x3057;&=
#x305f;&#x524d;&#x81e8;&#x5e8a;&#x8a66;&#x9a13;&#x306e;&#x7d50;&#x679c;&#x3=
06b;&#x3088;&#x308a;&#x3001;CCR2&#x306e;&#x767a;&#x73fe;&#x30ec;&#x30d9;&#x=
30eb;&#x306f;&#x3001;&#x4ed6;&#x306e;&#x304c;&#x3093;&#x7a2e;&#xff08;CRC&#x=
3084;PDAC&#xff09;&#x306b;&#x6bd4;&#x3079;&#x3066;NSCLC&#x3067;&#x6709;&#x61=
0f;&#x5dee;&#x304c;&#x3042;&#x308b;&#x3068;&#x3044;&#x3046;&#x3053;&#x3068;=
&#x304c;&#x793a;&#x3055;&#x308c;&#x307e;&#x3057;&#x305f;&#x3002;&#x816b;&#x=
760d;&#x5185;&#x9aa8;&#x9ac4;&#x7d30;&#x80de;&#x306b;&#x304a;&#x3051;&#x308=
b;CCR2&#x30ec;&#x30d9;&#x30eb;&#x306e;&#x4e0a;&#x6607;&#x306f;&#x3001;&#x30=
57;&#x3070;&#x3057;&#x3070;EGFR/KRAS&#x6d3b;&#x6027;&#x5316;&#x5909;&#x7570=
;&#x3084;PD-L1&#x767a;&#x73fe;&#x3068;&#x95a2;&#x9023;&#x3057;&#x3066;&#x30=
44;&#x307e;&#x3057;&#x305f;&#x3002; &#x30de;&#x30a6;&#x30b9;&#x30e2;&#x30c7=
;&#x30eb;&#x3067;&#x306f;&#x3001;mTAK-500&#x306f;CD8+T&#x7d30;&#x80de;&#x30=
6e;&#x84c4;&#x7a4d;&#x3068;&#x6d3b;&#x6027;&#x5316;&#x3092;&#x53ef;&#x80fd;=
&#x306b;&#x3057;&#x3001;&#x6297;&#x816b;&#x760d;&#x6d3b;&#x6027;&#x3092;&#x=
3082;&#x305f;&#x3089;&#x3057;&#x307e;&#x3059;&#x3002; CCR2&#x3092;&#x767a;&=
#x73fe;&#x3057;&#x3066;&#x3044;&#x308b;mMDSC&#x306e;&#x30d9;&#x30fc;&#x30b9=
;&#x30e9;&#x30a4;&#x30f3;&#x30ec;&#x30d9;&#x30eb;&#x306f;&#x3001;&#x6297;&#=
x816b;&#x760d;&#x30ec;&#x30d9;&#x30eb;&#x3068;&#x95a2;&#x9023;&#x3057;&#x30=
66;&#x3044;&#x307e;&#x3059;&#x3002;</span></p>
<p style=3D"margin: 0;"><br></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-weight: bold; color: rgb(25, 25, 25); font-size: 16px;">&#x6ce8;&#x76=
ee;&#x306e;ADC&#x85ac;&#x7269;&#x8907;&#x5408;&#x4f53;&#x30bf;&#x30fc;&#x30=
b2;&#x30c3;&#x30c8;</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--dataTable text--padding-vertical" width=3D"100%"=
 border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fi=
xed;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" styl=
e=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap: =
break-word; padding: 10px 40px;" align=3D"left" valign=3D"top" data-purpose=
=3D"dataTable"><div class=3D"dataTable dataTable--outerBorder dataTable--in=
nerBorder"> <table class=3D"dataTable_content" style=3D"background-color: #=
ffffff; width: 100%; min-width: 100%; border-collapse: collapse; font-famil=
y: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: 14px; bor=
der: 1px solid #b3b3b3;" width=3D"100%" border=3D"0" cellpadding=3D"0" cell=
spacing=3D"0" bgcolor=3D"#ffffff">  <tr>  <td class=3D"dataTable_content-ce=
ll" style=3D"text-align: center; vertical-align: top; padding: 10px; border=
: 1px solid #b3b3b3;" align=3D"center" valign=3D"top"> <p style=3D"margin: =
0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RDJMZZRlUw4oEbU27xIPFW1pzf=
6VgJ1I6-BTnN-aAjcCfByujZSkdkS4UlNeyODvf1bCHKp0ULKrLY765V0YwOJxuSAosGmxYu5u0=
vPNvoM91RlqwM4mn0S1GlwHlm-7z9SOmLUX9weCmUND_tT6tnlt9kcX-6DFqL9DJ9UrtxeTCtEY=
jdsE5efT-BuvUuJbihqSY-24vHsrMIRZNOo-tRn25AEI3oSlNlQ3mMuq9QCzyDOo1tz0BxnJoNn=
IuOX3w7I9cER63VLWPmLBeEISRPbpK8OC3ACn_3cACfffH9Tv17gj2eNyFoMweEA8B4s1hGgFek=
JThvB18Bl97uX5xg=3D=3D&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0eBSDsqT-57_f6yBm=
-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephznLsYbJk7AJ7kw=3D=
=3D" target=3D"_blank" style=3D"color: #4d4d4d; font-weight: bold; text-dec=
oration: underline;">FR&#x3b1;</a></p> </td>  <td class=3D"dataTable_conten=
t-cell" style=3D"text-align: center; vertical-align: top; padding: 10px; bo=
rder: 1px solid #b3b3b3;" align=3D"center" valign=3D"top"> <p style=3D"marg=
in: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RDJMZZRlUw4oEbU27xIPFW=
1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdjMS9E0Vf8D34es37OPuzmAy37Pu-ZHsRA3WMo-FHs70J=
MtqrRXBStN1a0RBobT1qDjFaSt6_20sgAC9MluU1InlOitAsERJZLRWYZPUTvFcSUg-5G1xEJIp=
hzBYnjljDiOhLhXjAKGScGrzfsX_HXoo-dUH_EaAxGbOqZCOI2MJF71buVOlaa218OjdeEqIrmp=
pJoQ_Znd76Td50SRIm9C5E9V-7qAzqFpBr6WigZEL7QkDR0-yzwTm9fVDX_LdnC0gw_QAmF8L7j=
uNLizDtXLJ3e87AlZDnLr18M9EYfHd&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0eBSDsqT-=
57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephznLsYbJk7=
AJ7kw=3D=3D" target=3D"_blank" style=3D"color: #4d4d4d; font-weight: bold; =
text-decoration: underline;">EGFR</a></p> </td>  <td class=3D"dataTable_con=
tent-cell" style=3D"text-align: center; vertical-align: top; padding: 10px;=
 border: 1px solid #b3b3b3;" align=3D"center" valign=3D"top"> <p style=3D"m=
argin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RDJMZZRlUw4oEbU27xI=
PFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdkS4UlNeyODvcx_xt0FNR68Pfb5QT2OXXs36Y1sFbY=
ACubgHDSIRMiJnobd90Yimhb6mpR99Ltfd9Qgx_D11wzMCNkYt-hExy1C1von8xPEH2Twn0N-k7=
b60wtAGZTIoIR_92ZsgFaZ6e0drs65FZlI18lwADtgjSjdFitN52g_A8Wnr2i7wGdwtZAIr7pV3=
HmumxKsVWA02DFcg0uku-x-sJFFharpNfGe3HuuFwqlY7oN5Y7FjP6PF7SR-wOJcoH352asbrsh=
YNtyuIOzfEi3R0EvLCYutLnNI3ew8OKOx&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0eBSDs=
qT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephznLsYb=
Jk7AJ7kw=3D=3D" target=3D"_blank" style=3D"color: #4d4d4d; font-weight: bol=
d; text-decoration: underline;">c-Met</a></p> </td>  <td class=3D"dataTable=
_content-cell" style=3D"text-align: center; vertical-align: top; padding: 1=
0px; border: 1px solid #b3b3b3;" align=3D"center" valign=3D"top"> <p style=
=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RDJMZZRlUw4oEb=
U27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdkS4UlNeyODvJ5kkOMcHVUJJGdrtOv8sp7K_0=
xtaPsQ7Dq2VLmT9wabokVYV6NUjzU3ZKC5rvO2d-65C-3paYInPhuw97l4SjNM8XdWzU5CGFOFw=
QJVdjPlpEylerw4G0utxEC-lX6FxyAWWaYEc5epyzfZZz4N_zll2iTN2MXAQrMRWNs1Q5eNyo_N=
53nMFPFjzihO9j0FhqsJJzWC9V5yLKkmkcwHjc_1mq8r0C4RT7xAglvIUxTIaajLM3NZYsxSPAb=
ENVcNF-OkVN8Gu9NC2R0vfYp-6Ww=3D=3D&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0eBSD=
sqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephznLsY=
bJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"color: #4d4d4d; font-weight: bo=
ld; text-decoration: underline;">B7-H3</a></p> </td>  </tr>  <tr>  <td clas=
s=3D"dataTable_content-cell" style=3D"text-align: center; vertical-align: t=
op; padding: 10px; border: 1px solid #b3b3b3;" align=3D"center" valign=3D"t=
op"> <p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001R=
DJMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdkS4UlNeyODval78HOwx6oId=
JL2qeQ87WS05obQaf8V1M6ky2vPfsnqJ9-5S0mvVwZRLZdB-J5kuqwtEH3ojP5QAKXP9W-D2Gee=
m4jaxQ6QmgzVivawRPUwCRJeQye6ep8ay-LYMymFEh4HNKRbp47J2N4qq8nn6Nf_20RYBlj-E4R=
9WxWAgQoGaGmCkxF45JZQZfLNPzkg21sy5AaVBVOdFEspEpixyYc6pseUWqK5oaHI3-5ibjufxN=
bV3x1G8h4mBytIzsmN8941VyBMbRw3fejoUYnuOow=3D=3D&c=3DQuY-0bnbmMfLnvkD9KftThH=
Rtv5XrgW0eBSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDES=
yxchOephznLsYbJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"color: #4d4d4d; fo=
nt-weight: bold; text-decoration: underline;">B7-H4</a></p> </td>  <td clas=
s=3D"dataTable_content-cell" style=3D"text-align: center; vertical-align: t=
op; padding: 10px; border: 1px solid #b3b3b3;" align=3D"center" valign=3D"t=
op"> <p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001R=
DJMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdjMS9E0Vf8D3Qjd65lGqdPqf=
gUJT0l8Pgmjxgg4E0aPJRQrZ0lC4g6oeoAznphXt7wqHojjIi4iICnd85aC8050SJbQlcdAVKNg=
BNMNHWyrgto04_Jks27NE8olEjoC-Q45flQcRkd9klDHHBaGnOR4YgWdFjYYJxoMLBjx1xu9C7Q=
DIZfm4e9RmK93EvSY6OR4KNfEI8FPF2Q3aqhHYESwcq-QDFSPCuKKx2fOsYGhoSQxdwiG9ympWR=
ahhuX__H2BpjMkd_wsWvam1bSJqrn5b0jzG95aiqA=3D=3D&c=3DQuY-0bnbmMfLnvkD9KftThH=
Rtv5XrgW0eBSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDES=
yxchOephznLsYbJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"color: #4d4d4d; fo=
nt-weight: bold; text-decoration: underline;">Her2</a></p> </td>  <td class=
=3D"dataTable_content-cell" style=3D"text-align: center; vertical-align: to=
p; padding: 10px; border: 1px solid #b3b3b3;" align=3D"center" valign=3D"to=
p"> <p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RD=
JMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdkS4UlNeyODvhInu0vK6SbtCD=
i8fQXpGi7DK16TiIfA2IRGraMWYOydgPAxpxbeosvYYhVlqifO8Wn0xQzb9rWTOWDVlE_VqlXFJ=
-wDsg9xD9qTtR-axG7T4fXgTqT00bEzQt18HTXjEcTBOR46pYOdYv7XNBuTsfTMiIWF8rkrmiwZ=
S2m9JI0gHZo5kT8lglNexJhwgyQ8q_Ji6llGQPXoOkTCyaBdmdmQnTKoBGZn53k6BClv8IORxtn=
Y7mgJLsNZQriJQGhXP2D7EpEsgzECWhTQ1yUHoAw=3D=3D&c=3DQuY-0bnbmMfLnvkD9KftThHR=
tv5XrgW0eBSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESy=
xchOephznLsYbJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"color: #4d4d4d; fon=
t-weight: bold; text-decoration: underline;">ROR1</a></p> </td>  <td class=
=3D"dataTable_content-cell" style=3D"text-align: center; vertical-align: to=
p; padding: 10px; border: 1px solid #b3b3b3;" align=3D"center" valign=3D"to=
p"> <p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RD=
JMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkdjMS9E0Vf8D3sVFOvVnNVcc1X=
AiyXsZ_WQjTtoBkFgI2t1aCpvUrtxaFxMr2OIWkJsqUW9rPtcHqs20JgGd8neD-3vfOR9SeSjdD=
CeYBArPM7d3RO420HAdo923KcdoxfOH9aFkVhgrlIxl4AUEntYZAcYg9WxZQ2LM17tYkzqzewqe=
AKEi6VP3F2OWLNGPWMxKxrYQuwM_z0b_eB00aY2xD-8_1viC3kK1MVr8iHq_7NqeHVElNBoppDp=
xF84c4rsWHuPao1RgoQmUwOLIMdbel0IWQoQA7EA=3D=3D&c=3DQuY-0bnbmMfLnvkD9KftThHR=
tv5XrgW0eBSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESy=
xchOephznLsYbJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"color: #4d4d4d; fon=
t-weight: bold; text-decoration: underline;">HER3</a></p> </td>  </tr>  </t=
able> </div></td> </tr> </table> </td> </tr> </table> <table class=3D"layou=
t layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D=
"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1=
 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top"><div c=
lass=3D"spacer" style=3D"line-height: 14px; height: 14px;">&#x200a;</div></=
td> </tr> </table> <table class=3D"layout layout--3-column" style=3D"table-=
layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 31.=
666666666666668%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 0px 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"text-al=
ign: justify; margin: 0;" align=3D"justify"><a href=3D"https://r20.rs6.net/=
tn.jsp?f=3D001RDJMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkduJSnacvG=
ICHHBSK-ZRdb3s_4IbY71-e_32RBX_jjipy-rZJoxZbIemNISMtTFoGS2L2gtHZPVamiEw8vdU8=
hYPiEEW35pRN38EmQ_B4lSE7UV8yfEDRnQBIhxk-bDPw_mg6ukhCwYmbxbg-7SF_L_6vFP4x04u=
GQ6Du6PefGr7_mh9EVKIU1lZosFBVAI1S41pog_XMNipJkw0xUNWFCHfHLypXJHNEUC_sw1X2Pe=
JAeWxtBSzI5OlkIrHOFGReF0U3jaUH0WcLFaM8PGxR4gSI95EhQnwgBBTukIdhPENaf57BPRCX-=
MEkn8e18GBtxDR4fAAswiy5n-ZQiPagDS0=3D&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0e=
BSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephzn=
LsYbJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"color: black; font-weight: n=
ormal; text-decoration: underline;">Proteases for peptide linker</a></p></t=
d> </tr> </table> <div class=3D"spacer" style=3D"line-height: 10px; height:=
 10px;">&#x200a;</div>
<div class=3D"spacer" style=3D"line-height: 18px; height: 18px;">&#x200a;</=
div>
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container" align=3D"center" valign=3D"top"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001RDJMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkduJSna=
cvGICHHBSK-ZRdb3s_4IbY71-e_32RBX_jjipy-rZJoxZbIemNISMtTFoGS2L2gtHZPVamiEw8v=
dU8hYPiEEW35pRN38EmQ_B4lSE7UV8yfEDRnQBIhxk-bDPw_mg6ukhCwYmbxbg-7SF_L_6vFP4x=
04uGQ6Du6PefGr7_mh9EVKIU1lZosFBVAI1S41pog_XMNipJkw0xUNWFCHfHLypXJHNEUC_sw1X=
2PeJAeWxtBSzI5OlkIrHOFGReF0U3jaUH0WcLFaM8PGxR4gSI95EhQnwgBBTukIdhPENaf57BPR=
CX-MEkn8e18GBtxDR4fAAswiy5n-ZQiPagDS0=3D&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5Xrg=
W0eBSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOep=
hznLsYbJk7AJ7kw=3D=3D" data-trackable=3D"true"><img data-image-content clas=
s=3D"image_content" width=3D"172" src=3D"https://files.constantcontact.com/=
5f3d0cf9401/9eb41053-f163-4aef-9896-1bf51337afd7.jpg" alt=3D"" style=3D"dis=
play: block; height: auto; max-width: 100%;"></a> </td> </tr> </table> </td=
>  <td class=3D"column column--2 scale stack" style=3D"width: 35%;" align=
=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><a h=
ref=3D"https://r20.rs6.net/tn.jsp?f=3D001RDJMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-=
BTnN-aAjcCfByujZSkduJSnacvGICHHBSK-ZRdb3s_4IbY71-e_32RBX_jjipy-rZJoxZbIemNI=
SMtTFoGS2L2gtHZPVamiEw8vdU8hYPiEEW35pRN38EmQ_B4lSE7UV8yfEDRnQBIhxk-bDPw_mg6=
ukhCwYmbxbg-7SF_L_6vFP4x04uGQ6Du6PefGr7_mh9EVKIU1lZosFBVAI1S41pog_XMNipJkw0=
xUNWFCHfHLypXJHNEUC_sw1X2PeJAeWxtBSzI5OlkIrHOFGReF0U3jaUH0WcLFaM8PGxR4gSI95=
EhQnwgBBTukIdhPENaf57BPRCX-MEkn8e18GBtxDR4fAAswiy5UcehOTGIxpU=3D&c=3DQuY-0b=
nbmMfLnvkD9KftThHRtv5XrgW0eBSDsqT-57_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHF=
pPpR5K31wi7jcsDESyxchOephznLsYbJk7AJ7kw=3D=3D" target=3D"_blank" style=3D"c=
olor: black; font-weight: bold; text-decoration: underline;">AGLink&#x2122;=
 ADC site-specific conjugation kits</a></p></td> </tr> </table> <table clas=
s=3D"image image--padding-vertical image--mobile-scale image--mobile-center=
" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td=
 class=3D"image_container" align=3D"center" valign=3D"top" style=3D"padding=
-top: 10px; padding-bottom: 10px;"> <a href=3D"https://r20.rs6.net/tn.jsp?f=
=3D001RDJMZZRlUw4oEbU27xIPFW1pzf6VgJ1I6-BTnN-aAjcCfByujZSkduJSnacvGICHHBSK-=
ZRdb3s_4IbY71-e_32RBX_jjipy-rZJoxZbIemNISMtTFoGS2L2gtHZPVamiEw8vdU8hYPiEEW3=
5pRN38EmQ_B4lSE7UV8yfEDRnQBIhxk-bDPw_mg6ukhCwYmbxbg-7SF_L_6vFP4x04uGQ6Du6Pe=
fGr7_mh9EVKIU1lZosFBVAI1S41pog_XMNipJkw0xUNWFCHfHLypXJHNEUC_sw1X2PeJAeWxtBS=
zI5OlkIrHOFGReF0U3jaUH0WcLFaM8PGxR4gSI95EhQnwgBBTukIdhPENaf57BPRCX-MEkn8e18=
GBtxDR4fAAswiy5UcehOTGIxpU=3D&c=3DQuY-0bnbmMfLnvkD9KftThHRtv5XrgW0eBSDsqT-5=
7_f6yBm-9E8hA=3D=3D&ch=3Dl2GseYKEVLZNkHFpPpR5K31wi7jcsDESyxchOephznLsYbJk7A=
J7kw=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"image_=
content" width=3D"176" src=3D"https://files.constantcontact.com/5f3d0cf9401=
/5c933c2c-dd3f-4eeb-804e-99204b545660.png" alt=3D"" style=3D"display: block=
; height: auto; max-width: 100%;"></a> </td> </tr> </table> </td>  <td clas=
s=3D"column column--3 scale stack" style=3D"width: 33%;" align=3D"center" v=
align=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px 10px 0px;" align=3D"left" valign=3D"top"><p style=3D"margin:=
 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001RDJMZZRlUw4oEbU27xIPFW1pz=
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