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Envelope-to: daisuke@saraya.co.in
Delivery-date: Tue, 25 Apr 2023 09:27:08 +0800
Message-ID: <1140116956249.1119371711477.1237888709.0.512123JL.2002@synd.ccsend.com>
Date: Mon, 24 Apr 2023 21:26:20 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: daisuke@saraya.co.in
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xriHxJy7FMstGwKtlgCsaK_HUPEGUT8mmhFv4Zq64r7UmwhKuE4jXX5BBVbR9CnoCviVg2YO2T-=
heggz83wemBATth8xsc9nPWAAwvQ=3D=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbFoKw2ch0Epyu=
mMNAms4wj5J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4VNHCjWoCajYq=
ST4nbLYRg=3D=3D" target=3D"_blank" style=3D"font-size: 13px; text-decoratio=
n: underline; color: rgb(192, 62, 48); font-weight: bold;">&#x30ea;&#x30bd;=
&#x30fc;&#x30b9;</a></p></td> </tr> </table> </td>  <td class=3D"column col=
umn--4 scale stack" style=3D"width: 25%;" align=3D"center" valign=3D"middle=
">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
 break-word; padding: 10px 40px 10px 0px;" align=3D"center" valign=3D"top">=
<p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001J-Z8SA=
5Z-AkuurmtNijqIcDbICaG85lwDPXy9Id5w1FWGhiXTnhWx7J68K187Pb0xWENNfeNxyTT3IHAo=
BxJAeNDZobeDdjFazcTo74QuXwyO3dTNjY3s2d6PPq4ds3_wGB2ViHtuToa9_MJcJmheCDcya5P=
27dNXe9RWlcTxqjjAYT-dkSrBi074EWnx13VU3IEWqSvit36b6vTtOVXpHc8F3jsbLusufT04Dp=
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4wj5J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4VNHCjWoCajYqST4nbL=
YRg=3D=3D" target=3D"_blank" style=3D"font-size: 13px; color: rgb(192, 62, =
48); text-decoration: underline; font-weight: bold;">&#x30a4;&#x30f3;&#x30b=
5;&#x30a4;&#x30c8;</a></p></td> </tr> </table> </td> </tr> </table> <table =
class=3D"layout layout--1-column" style=3D"background-color: #c03e30; table=
-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"column column--1 scale stack"=
 style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1; text-align: center; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #3E3E3E; font-size: 14px; display: block; word-wrap: b=
reak-word; padding: 10px 40px;" align=3D"center" valign=3D"top"><p style=3D=
"text-align: center; margin: 0;" align=3D"center"><span style=3D"font-size:=
 19px; color: black; font-weight: bold;">&#x6297;&#x539f;&#x691c;&#x51fa;&#=
x7528;&#x306e;</span><span style=3D"font-size: 19px; color: black; font-fam=
ily: Calibri, Helvetica, Arial, sans-serif; font-weight: bold;">MHC</span><=
span style=3D"font-size: 19px; color: black; font-weight: bold;">&#x30e2;&#=
x30ce;&#x30de;&#x30fc;&#xff06;&#x30c6;&#x30c8;&#x30e9;&#x30de;&#x30fc;</spa=
n></p></td> </tr> </table> </td> </tr> </table> <table class=3D"layout layo=
ut--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale=
 stack" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><a hre=
f=3D"https://r20.rs6.net/tn.jsp?f=3D001J-Z8SA5Z-AkuurmtNijqIcDbICaG85lwDPXy=
9Id5w1FWGhiXTnhWx3Df4t1LyS06XXM5xPIfHqkFZGTPDuuhQqMwsKpHD642dgXjlnW1bGey2br=
ros3TjDGk-DKR91kySfASqz5BywzXje9qePUVPIu4h0Cutzk4vEDG-qCyGQQtT9gF9rpU-Uc6sW=
oJNa5u3oHQLlyMqKI9sPqi4GL0Klsv29oId1IyEWS5SvjnVdv7LU-63ZBUtWA8agA0fqKXJMxT0=
WqHFULjNn-PD-5BGzvirUfCYszZLSZ_U0aEb6xaurccgVJB_D-YnFZhJAfEs2XAgGGH-lUs4eh5=
24r3E0U1ljuNFb8JlKcHphNnwN25ZX9D3fzm5w=3D=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbFo=
Kw2ch0EpyumMNAms4wj5J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4VN=
HCjWoCajYqST4nbLYRg=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 62, 4=
8); text-decoration: underline; font-weight: bold;">&#x5929;&#x7136;&#x306e=
;MHC&#x8907;&#x5408;&#x4f53;</a>&#x304c;&#x30e2;&#x30ce;&#x30de;&#x30fc;&#x=
3068;&#x30c6;&#x30c8;&#x30e9;&#x30de;&#x30fc;&#x306e;&#x4e21;&#x65b9;&#x306=
7;&#x5229;&#x7528;&#x53ef;&#x80fd;&#x3067;&#x3059;&#x3002;&#x6297;&#x539f;&=
#x7279;&#x7570;&#x7684;&#x306a;&#x691c;&#x51fa;&#x306b;&#x306f;&#x3001;&#x5=
6db;&#x91cf;&#x4f53;&#x304c;T&#x7d30;&#x80de;&#x53d7;&#x5bb9;&#x4f53;&#xff0=
8;TCR&#xff09;&#x3068;&#x3088;&#x308a;&#x5b89;&#x5b9a;&#x306b;&#x7d50;&#x540=
8;&#x3059;&#x308b;&#x305f;&#x3081;&#x3001;&#x7d50;&#x5408;&#x8a66;&#x9a13;&=
#x3084;FACS&#x304c;&#x4f7f;&#x308f;&#x308c;&#x307e;&#x3059;&#x3002;&#x307e;=
&#x305f;&#x3001;&#x30da;&#x30d7;&#x30c1;&#x30c9;&#x3092;&#x542b;&#x307e;&#x=
306a;&#x3044;MHC&#x8907;&#x5408;&#x4f53;&#xff08;<a href=3D"https://r20.rs6.=
net/tn.jsp?f=3D001J-Z8SA5Z-AkuurmtNijqIcDbICaG85lwDPXy9Id5w1FWGhiXTnhWx3Df4=
t1LyS06XXM5xPIfHqkFZGTPDuuhQqMwsKpHD642dgXjlnW1bGey2brros3TjDGk-DKR91kySfAS=
qz5BywzXje9qePUVPIu4h0Cutzk4vEDG-qCyGQQtT9gF9rpU-Uc6sWoJNa5u3oHQLlyMqKI9sPq=
i4GL0Klsv29oId1IyEWS5SvjnVdv7LU-63ZBUtWA8agA0fqKXJMxT0WqHFULjNn-PD-5BGzvirU=
fCYszZLSZ_U0aEb6xaurccgVJB_D-YnFZhJAfEs2XAgGGH-lUs4eh524r3E0U1ljuNFb8JlKcHp=
hNnwN25ZX9D3fzm5w=3D=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbFoKw2ch0EpyumMNAms4wj5J=
226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4VNHCjWoCajYqST4nbLYRg=
=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 62, 48); text-decoration=
: underline; font-weight: bold;">&#x88fd;&#x54c1;&#x30ea;&#x30b9;&#x30c8;&#=
x306f;&#x3053;&#x3061;&#x3089;</a>&#xff09;&#x3082;&#x3054;&#x7528;&#x610f;&=
#x3067;&#x304d;&#x3001;&#x3044;&#x305a;&#x308c;&#x3082;&#x7570;&#x306a;&#x3=
08b;&#x86cd;&#x5149;&#x30e9;&#x30d9;&#x30eb;&#x3092;&#x4f7f;&#x7528;&#x3057=
;&#x3066;&#x304a;&#x308a;&#x307e;&#x3059;&#x3002;</p></td> </tr> </table> <=
/td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"table=
-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100=
%;" align=3D"center" valign=3D"top"><div class=3D"spacer" style=3D"line-hei=
ght: 10px; height: 10px;">&#x200a;</div></td> </tr> </table> <table class=
=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" =
border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column =
column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"to=
p"> <table class=3D"button button--padding-vertical" width=3D"100%" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> =
<tr> <td class=3D"button_container content-padding-horizontal" align=3D"cen=
ter" style=3D"padding: 10px 40px;">    <table class=3D"button_content-row" =
style=3D"background-color: #c03e30; width: inherit; border-radius: 7px; bor=
der-spacing: 0; border: none;" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"button_content-cell" style=3D=
"padding: 10px 15px;" align=3D"center"> <a class=3D"button_link" href=3D"ht=
tps://r20.rs6.net/tn.jsp?f=3D001J-Z8SA5Z-AkuurmtNijqIcDbICaG85lwDPXy9Id5w1F=
WGhiXTnhWx3Df4t1LyS06XXM5xPIfHqkFZGTPDuuhQqMwsKpHD642dgXjlnW1bGey2brros3TjD=
Gk-DKR91kySfASqz5BywzXje9qePUVPIu4h0Cutzk4vEDG-qCyGQQtT9gF9rpU-Uc6sWoJNa5u3=
oHQLlyMqKI9sPqi4GL0Klsv29oId1IyEWS5SvjnVdv7LU-63ZBUtWA8agA0fqKXJMxT0WqHFULj=
Nn-PD-5BGzvirUfCYszZLSZ_U0aEb6xaurccgVJB_D-YnFZhJAfEs2XAgGGH-lUs4eh524r3E0U=
1ljuNFb8JlKcHphNnwN25ZX9D3fzm5w=3D=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbFoKw2ch0E=
pyumMNAms4wj5J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4VNHCjWoCa=
jYqST4nbLYRg=3D=3D" data-trackable=3D"true" style=3D"color: #FFFFFF; font-f=
amily: Arial,Verdana,Helvetica,sans-serif; font-size: 16px; word-wrap: brea=
k-word; font-weight: bold; text-decoration: none;">&#x30ab;&#x30bf;&#x30ed;=
&#x30b0;&#x306f;&#x3053;&#x3061;&#x3089;&#x304b;&#x3089;</a> </td> </tr> </=
table>    </td> </tr> </table>   </td> </tr> </table> <table class=3D"layou=
t layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D=
"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1=
 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top"><div c=
lass=3D"spacer" style=3D"line-height: 10px; height: 10px;">&#x200a;</div></=
td> </tr> </table> <table class=3D"layout-margin" style=3D"" width=3D"100%"=
 border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"layout=
-margin_cell" style=3D"padding: 0px 40px;" align=3D"center" valign=3D"top">=
 <table class=3D"layout layout--2-column layout--divided" style=3D"table-la=
yout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"=
0"> <tr> <td class=3D"column column-border column--1 scale stack" style=3D"=
width: 50%; border: 1px solid #3e3e3e;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cent=
er; margin: 0;" align=3D"center"><span style=3D'font-size: 16px; font-weigh=
t: bold; color: rgb(0, 0, 0); font-family: "Arial Black", Gadget, sans-seri=
f;'>MHC&#x30c6;&#x30c8;&#x30e9;&#x30de;&#x30fc;</span></p></td> </tr> </tab=
le> <table class=3D"image image--padding-vertical image--mobile-scale image=
--mobile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0"> <tr> <td class=3D"image_container content-padding-horizontal" align=
=3D"center" valign=3D"top" style=3D"padding: 10px 20px;"> <a href=3D"https:=
//r20.rs6.net/tn.jsp?f=3D001J-Z8SA5Z-AkuurmtNijqIcDbICaG85lwDPXy9Id5w1FWGhi=
XTnhWx3Df4t1LyS06XXM5xPIfHqkFZGTPDuuhQqMwsKpHD642dgXjlnW1bGey2brros3TjDGk-D=
KR91kySfASqz5BywzXje9qePUVPIu4h0Cutzk4vEDG-qCyGQQtT9gF9rpU-Uc6sWoJNa5u3oHQL=
lyMqKI9sPqi4GL0Klsv29oId1IyEWS5SvjnVdv7LU-63ZBUtWA8agA0fqKXJMxT0WqHFULjNn-P=
D-5BGzvirUfCYszZLSZ_U0aEb6xaurccgVJB_D-YnFZhJAfEs2XAgGGH-lUs4eh524r3E0U1lju=
NFb8JlKcHphNnwN25ZX9D3fzm5w=3D=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbFoKw2ch0Epyum=
MNAms4wj5J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4VNHCjWoCajYqS=
T4nbLYRg=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"im=
age_content" width=3D"200" src=3D"https://files.constantcontact.com/5f3d0cf=
9401/b57b5f9b-b957-4b9f-8f58-e18821d4fcb2.jpg" alt=3D"" style=3D"display: b=
lock; height: auto; max-width: 100%;"></a> </td> </tr> </table> <table clas=
s=3D"text text--padding-vertical" width=3D"100%" border=3D"0" cellpadding=
=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"=
text_content-cell content-padding-horizontal" style=3D"text-align: left; fo=
nt-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: 1=
4px; line-height: 1.2; display: block; word-wrap: break-word; padding: 10px=
 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: center; margi=
n: 0;" align=3D"center"><span style=3D"color: rgb(26, 26, 26); font-size: 1=
0px;">MHC-peptide complex can stably bind to T cell receptor after tetramer=
ization.</span></p></td> </tr> </table> </td>  <td class=3D"column-divider =
scale stack" style=3D"height: 1px; line-height: 1px;" width=3D"20" align=3D=
"center" valign=3D"top"> <img alt=3D"" width=3D"20" height=3D"20" border=3D=
"0" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.constantcontact.com/let=
ters/images/1101116784221/S.gif"> </td>  <td class=3D"column column-border =
column--2 scale stack" style=3D"width: 50%; border: 1px solid #3e3e3e;" ali=
gn=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cent=
er; margin: 0;" align=3D"center"><span style=3D'font-size: 16px; font-weigh=
t: bold; color: rgb(0, 0, 0); font-family: "Arial Black", Gadget, sans-seri=
f;'>MHC&#x30e2;&#x30ce;&#x30de;&#x30fc;</span></p></td> </tr> </table> <tab=
le class=3D"image image--padding-vertical image--mobile-scale image--mobile=
-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <=
tr> <td class=3D"image_container content-padding-horizontal" align=3D"cente=
r" valign=3D"top" style=3D"padding: 10px 20px;"> <a href=3D"https://r20.rs6=
.net/tn.jsp?f=3D001J-Z8SA5Z-AkuurmtNijqIcDbICaG85lwDPXy9Id5w1FWGhiXTnhWx3Df=
4t1LyS06XXM5xPIfHqkFZGTPDuuhQqMwsKpHD642dgXjlnW1bGey2brros3TjDGk-DKR91kySfA=
Sqz5BywzXje9qePUVPIu4h0Cutzk4vEDG-qCyGQQtT9gF9rpU-Uc6sWoJNa5u3oHQLlyMqKI9sP=
qi4GL0Klsv29oId1IyEWS5SvjnVdv7LU-63ZBUtWA8agA0fqKXJMxT0WqHFULjNn-PD-5BGzvir=
UfCYszZLSZ_U0aEb6xaurccgVJB_D-YnFZhJAfEs2XAgGGH-lUs4eh524r3E0U1ljuNFb8JlKcH=
phNnwN25ZX9D3fzm5w=3D=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbFoKw2ch0EpyumMNAms4wj5=
J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4VNHCjWoCajYqST4nbLYRg=
=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"image_cont=
ent" width=3D"215" src=3D"https://files.constantcontact.com/5f3d0cf9401/96d=
e637c-f633-45c3-8808-9ecf8e908188.jpg" alt=3D"" style=3D"display: block; he=
ight: auto; max-width: 100%;"></a> </td> </tr> </table> <table class=3D"tex=
t text--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cel=
lspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_conte=
nt-cell content-padding-horizontal" style=3D"text-align: left; font-family:=
 Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: 14px; line-=
height: 1.2; display: block; word-wrap: break-word; padding: 10px 20px;" al=
ign=3D"left" valign=3D"top"><p style=3D"text-align: center; margin: 0;" ali=
gn=3D"center"><span style=3D"color: rgb(26, 26, 26); font-size: 10px;">MHC =
monomers have a low avidity and fast dissociation rates when binding to the=
 TCR.</span></p></td> </tr> </table> </td> </tr> </table>  </td> </tr> </ta=
ble> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;=
" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td=
 class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"cen=
ter" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;">&#x30a=
b;&#x30bf;&#x30ed;&#x30b0;&#x304b;&#x3089;&#x3054;&#x5e0c;&#x671b;&#x306e;&=
#x3082;&#x306e;&#x304c;&#x898b;&#x3064;&#x304b;&#x3089;&#x306a;&#x3044;&#x3=
04a;&#x5ba2;&#x69d8;&#x306e;&#x30cb;&#x30fc;&#x30ba;&#x3084;&#x30a2;&#x30d7=
;&#x30ea;&#x30b1;&#x30fc;&#x30b7;&#x30e7;&#x30f3;&#x3092;&#x8003;&#x616e;&#=
x3057;&#x3001;&#x5929;&#x7136;&#x306a;&#x30b3;&#x30f3;&#x30d5;&#x30a9;&#x30=
e1;&#x30fc;&#x30b7;&#x30e7;&#x30f3;&#x3092;&#x78ba;&#x4fdd;&#x3059;&#x308b;=
&#x305f;&#x3081;&#x306b;&#x3001;&#x5f53;&#x793e;&#x306f;HEK293&#x30d7;&#x30=
e9;&#x30c3;&#x30c8;&#x30d5;&#x30a9;&#x30fc;&#x30e0;&#x3092;&#x7528;&#x3044;=
&#x305f;<a href=3D"https://r20.rs6.net/tn.jsp?f=3D001J-Z8SA5Z-AkuurmtNijqIc=
DbICaG85lwDPXy9Id5w1FWGhiXTnhWx3Df4t1LyS06XXM5xPIfHqkFZGTPDuuhQqMwsKpHD642d=
gXjlnW1bGey2brros3TjDGk-DKR91kySfASqz5BywzXje9qePUVPIu4h0Cutzk4vEDG-qCyGQQt=
T9gF9rpU-Uc6sWoJNa5u3oHQLlyMqKI9sPqi4GL0Klsv29oId1IyEWS5SvjnVdv7LU-63ZBUtWA=
8agA0fqKXJMxT0WqHFULjNn-PD-5BGzvirUfCYszZLSZ_U0aEb6xaurccgVJB_D-YnFZhJAfEs2=
XAgGGH-lUs4eh524r3E0U1ljuNFb8JlKcHphNnwN25ZX9D3fzm5w=3D=3D&c=3DBWHzlokRgCtN=
WfsGfZ-f19jbFoKw2ch0EpyumMNAms4wj5J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-tou=
krtluH56LBd4VNHCjWoCajYqST4nbLYRg=3D=3D" target=3D"_blank" style=3D"color: =
rgb(192, 62, 48); text-decoration: underline; font-weight: bold;">MHC-&#x30=
da;&#x30d7;&#x30c1;&#x30c9;&#x8907;&#x5408;&#x4f53;&#x958b;&#x767a;&#x30b5;=
&#x30fc;&#x30d3;&#x30b9;</a>&#x3082;&#x63d0;&#x4f9b;&#x3057;&#x3066;&#x304a=
;&#x308a;&#x307e;&#x3059;&#x3002;</p></td> </tr> </table> </td> </tr> </tab=
le> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;"=
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class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"cent=
er" valign=3D"top"> <table class=3D"button button--padding-vertical" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-l=
ayout: fixed;"> <tr> <td class=3D"button_container content-padding-horizont=
al" align=3D"center" style=3D"padding: 10px 40px;">    <table class=3D"butt=
on_content-row" style=3D"background-color: #c03e30; width: inherit; border-=
radius: 7px; border-spacing: 0; border: none;" border=3D"0" cellpadding=3D"=
0" cellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"button_content-=
cell" style=3D"padding: 10px 15px;" align=3D"center"> <a class=3D"button_li=
nk" href=3D"https://r20.rs6.net/tn.jsp?f=3D001J-Z8SA5Z-AkuurmtNijqIcDbICaG8=
5lwDPXy9Id5w1FWGhiXTnhWx3Df4t1LyS06XXM5xPIfHqkFZGTPDuuhQqMwsKpHD642dgXjlnW1=
bGey2brros3TjDGk-DKR91kySfASqz5BywzXje9qePUVPIu4h0Cutzk4vEDG-qCyGQQtT9gF9rp=
U-Uc6sWoJNa5u3oHQLlyMqKI9sPqi4GL0Klsv29oId1IyEWS5SvjnVdv7LU-63ZBUtWA8agA0fq=
KXJMxT0WqHFULjNn-PD-5BGzvirUfCYszZLSZ_U0aEb6xaurccgVJB_D-YnFZhJAfEs2XAgGGH-=
lUs4eh524r3E0U1ljuNFb8JlKcHphNnwN25ZX9D3fzm5w=3D=3D&c=3DBWHzlokRgCtNWfsGfZ-=
f19jbFoKw2ch0EpyumMNAms4wj5J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH5=
6LBd4VNHCjWoCajYqST4nbLYRg=3D=3D" data-trackable=3D"true" style=3D"color: #=
FFFFFF; font-family: Arial,Verdana,Helvetica,sans-serif; font-size: 16px; w=
ord-wrap: break-word; font-weight: bold; text-decoration: none;">&#x304a;&#=
x554f;&#x3044;&#x5408;&#x308f;&#x305b;</a> </td> </tr> </table>    </td> </=
tr> </table>   </td> </tr> </table> <table class=3D"layout layout--1-column=
" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" styl=
e=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"divider divider--dashed" width=3D"100%" cellpadding=3D"0" c=
ellspacing=3D"0" border=3D"0"> <tr> <td class=3D"divider_container content-=
padding-horizontal" style=3D"padding: 10px 40px;" width=3D"100%" align=3D"c=
enter" valign=3D"top"> <table class=3D"divider_content-row" style=3D"height=
: 1px; width: 100%;" cellpadding=3D"0" cellspacing=3D"0" border=3D"0"> <tr>=
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px; border-bottom-style: dashed; border-bottom-color: #4d4d4d;" height=3D"1=
" align=3D"center" bgcolor=3D"transparent"> <img alt=3D"" width=3D"5" heigh=
t=3D"1" border=3D"0" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.consta=
ntcontact.com/letters/images/1101116784221/S.gif" style=3D"display: block; =
height: 1px; width: 5px;"> </td> </tr> </table> </td> </tr> </table> </td> =
</tr> </table> <table class=3D"layout layout--1-column" style=3D"table-layo=
ut: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"=
> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" al=
ign=3D"center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #3E3E3E; font-size: 14px; display: block; word-wrap: b=
reak-word; padding: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"t=
ext-align: center; margin: 0;" align=3D"center"><span style=3D"font-size: 1=
5px; color: black; font-weight: bold;">Our Workflow for Custom MHC Synthesi=
s&#xa0;</span><span style=3D'font-size: 16px; color: rgb(0, 0, 0); font-fam=
ily: "Arial Black", Gadget, sans-serif;'> &#x1f447;</span></p></td> </tr> <=
/table> </td> </tr> </table> <table class=3D"layout layout--1-column" style=
=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cel=
lspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"wi=
dth: 100%;" align=3D"center" valign=3D"top"><div class=3D"spacer" style=3D"=
line-height: 11px; height: 11px;">&#x200a;</div></td> </tr> </table> <table=
 class=3D"layout-margin" style=3D"" width=3D"100%" border=3D"0" cellpadding=
=3D"0" cellspacing=3D"0"> <tr> <td class=3D"layout-margin_cell" style=3D"pa=
dding: 0px 40px;" align=3D"center" valign=3D"top"> <table class=3D"layout l=
ayout--feature layout--1-column" style=3D"table-layout: fixed; background-c=
olor: #fef9f8;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0" bgcolor=3D"#fef9f8"> <tr> <td class=3D"column column--1 scale stack"=
 style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 2; text-align: left; font-family: Arial,Verdana,Helvetica,=
sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: bre=
ak-word; padding: 10px 20px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"font-size: 16px; color: black; font-=
family: Calibri, Helvetica, Arial, sans-serif; font-weight: bold;">01 Co-ex=
pressed monomer:&#xa0;</span><span style=3D"font-size: 16px; color: black; =
font-family: Calibri, Helvetica, Arial, sans-serif;">Biotinylated MHC class=
 I heavy chain and &#x3b2;2-microglobulin</span><span style=3D"font-size: 1=
6px; color: black;">&#xff08;</span><span style=3D"font-size: 16px; color: b=
lack; font-family: Calibri, Helvetica, Arial, sans-serif;">&#x3b2;2m</span>=
<span style=3D"font-size: 16px; color: black;">&#xff09;</span><span style=
=3D"font-size: 16px; color: black; font-family: Calibri, Helvetica, Arial, =
sans-serif;">are co-expressed in HEK293 systems to get the MHC class I mono=
mer(peptide free) by purified in vitro.</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 16px; color: black; font-=
family: Calibri, Helvetica, Arial, sans-serif; font-weight: bold;">02 Short=
 peptide loading:&#xa0;</span><span style=3D"font-size: 16px; color: black;=
 font-family: Calibri, Helvetica, Arial, sans-serif;">Monomer MHC class I-p=
eptide complex was obtained by co-incubation of MHC class I (peptide free) =
monomer with antigenic peptide.</span></p>
<p style=3D"margin: 0;"><span style=3D"font-size: 16px; color: black; font-=
family: Calibri, Helvetica, Arial, sans-serif; font-weight: bold;">03 Tetra=
merization:&#xa0;</span><span style=3D"font-size: 16px; color: black; font-=
family: Calibri, Helvetica, Arial, sans-serif;">Subsequently, MHC class I-p=
eptide complex monomers are linked by the addition of fluorochrome-labeled =
streptavidin.</span></p>
</td> </tr> </table> <table class=3D"image image--padding-vertical image--m=
obile-scale image--mobile-center" width=3D"100%" border=3D"0" cellpadding=
=3D"0" cellspacing=3D"0"> <tr> <td class=3D"image_container" align=3D"cente=
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rros3TjDGk-DKR91kySfASqz5BywzXje9qePUVPIu4h0Cutzk4vEDG-qCyGQQtT9gF9rpU-Uc6s=
WoJNa5u3oHQLlyMqKI9sPqi4GL0Klsv29oId1IyEWS5SvjnVdv7LU-63ZBUtWA8agA0fqKXJMxT=
0WqHFULjNn-PD-5BGzvirUfCYszZLSZ_U0aEb6xaurccgVJB_D-YnFZhJAfEs2XAgGGH-lUs4eh=
524r3E0U1ljuNFb8JlKcHphNnwN25ZX9D3fzm5w=3D=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbF=
oKw2ch0EpyumMNAms4wj5J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4V=
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e> </td> </tr> </table>  </td> </tr> </table> <table class=3D"layout layout=
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tack" style=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D"=
spacer" style=3D"line-height: 13px; height: 13px;">&#x200a;</div></td> </tr=
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fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <t=
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; height: 10px;">&#x200a;</div></td> </tr> </table> <table class=3D"layout-=
margin" style=3D"" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacin=
g=3D"0"> <tr> <td class=3D"layout-margin_cell" style=3D"padding: 0px 40px;"=
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er--dashed" style=3D"border: 3px dashed #cccccc;" width=3D"100%" border=3D"=
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l" style=3D"" align=3D"center" valign=3D"top">
<table class=3D"layout layout--coupon layout--2-column" style=3D"table-layo=
ut: fixed; background-color: #ffffff;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0" bgcolor=3D"#ffffff"> <tr> <td class=3D"column c=
olumn--1 scale stack" style=3D"width: 50%;" align=3D"center" valign=3D"top"=
>
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 10px 10px 20px;"> <a href=3D"h=
ttps://r20.rs6.net/tn.jsp?f=3D001J-Z8SA5Z-AkuurmtNijqIcDbICaG85lwDPXy9Id5w1=
FWGhiXTnhWx3Df4t1LyS06Y04X9wQSREk4FfypEPyCXXbgw04yxGlNmMWUCNUm_ypn_J89mVL-I=
1gzxxxEu9pw7bOwNloJ0kvxNR-SvuEA5vl_n66MqC4ypE7WCeyPq-WinwvhpjmiLxdj5JfvpP-I=
GHPCtyMNwZTEgwtG2SKPzeL0oSblfZLjn5qHUCw6ElQ5slwZYEv1h5zKj9kPPU2_sKXtv_7Ha4M=
VhHbM0LFcRH8z1FKVS2gXgjoBfjZL4uvsVCr7ivj2ryeHn7WZjI-U0c5Xi82vdm9ZsYw8NS3LSQ=
iAV3jLwD2VVCKz1SDLTvE=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbFoKw2ch0EpyumMNAms4wj5=
J226Bo-A=3D=3D&ch=3DOhr4GNgSbD_TICXTF-toukrtluH56LBd4VNHCjWoCajYqST4nbLYRg=
=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"image_cont=
ent" width=3D"200" src=3D"https://files.constantcontact.com/5f3d0cf9401/d88=
0e877-c3f4-49d7-90c2-c670074c4bf7.png" alt=3D"" style=3D"display: block; he=
ight: auto; max-width: 100%;"></a> </td> </tr> </table> <div class=3D"space=
r" style=3D"line-height: 10px; height: 10px;">&#x200a;</div>
</td>  <td class=3D"column column--2 scale stack" style=3D"width: 50%;" ali=
gn=3D"center" valign=3D"top">
<div class=3D"spacer" style=3D"line-height: 10px; height: 10px;">&#x200a;</=
div>
<div class=3D"spacer" style=3D"height: 30px; line-height: 30px;">&#x200a;</=
div>
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 20px 10px 10px;" align=3D"left" valign=3D"top"><p style=3D"margin=
: 0;"><span style=3D"font-size: 18px; font-weight: bold; font-family: Verda=
na, Geneva, sans-serif;">MHC</span><span style=3D"font-size: 18px; font-fam=
ily: Verdana, Geneva, sans-serif;">&#x88fd;&#x54c1;&#x306b;&#x3054;&#x8208;=
&#x5473;&#x3092;&#x304a;&#x6301;&#x3061;&#x306e;&#x65b9;&#x306f;&#x305c;&#x=
3072;&#x30d1;&#x30f3;&#x30d5;&#x30ec;&#x30c3;&#x30c8;&#x3092;&#x3054;&#x89a=
7;&#x304f;&#x3060;&#x3055;&#x3044;&#xff01;</span></p></td> </tr> </table>  =
<table class=3D"button button--padding-vertical" width=3D"100%" border=3D"0=
" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> =
<td class=3D"button_container content-padding-horizontal" align=3D"center" =
style=3D"padding: 10px 20px 10px 10px;">    <table class=3D"button_content-=
row" style=3D"background-color: #c03e30; width: inherit; border-radius: 7px=
; border-spacing: 0; border: none;" border=3D"0" cellpadding=3D"0" cellspac=
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-I1gzxxxEu9pw7bOwNloJ0kvxNR-SvuEA5vl_n66MqC4ypE7WCeyPq-WinwvhpjmiLxdj5JfvpP=
-IGHPCtyMNwZTEgwtG2SKPzeL0oSblfZLjn5qHUCw6ElQ5slwZYEv1h5zKj9kPPU2_sKXtv_7Ha=
4MVhHbM0LFcRH8z1FKVS2gXgjoBfjZL4uvsVCr7ivj2ryeHn7WZjI-U0c5Xi82vdm9ZsYw8NS3L=
SQiAV3jLwD2VVCKz1SDLTvE=3D&c=3DBWHzlokRgCtNWfsGfZ-f19jbFoKw2ch0EpyumMNAms4w=
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l,Verdana,Helvetica,sans-serif; font-size: 16px; word-wrap: break-word; fon=
t-weight: bold; text-decoration: none;">&#x30c0;&#x30a6;&#x30f3;&#x30ed;&#x=
30fc;&#x30c9;</a> </td> </tr> </table>    </td> </tr> </table>   </td> </tr=
> </table> </td> </tr> </table>  </td> </tr> </table> <table class=3D"layou=
t layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D=
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td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"table-=
layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
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llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
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