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Envelope-to: tfujikawa@saraya.co.in
Delivery-date: Thu, 16 Mar 2023 14:43:16 +0800
Message-ID: <1139987464985.1119371711477.1205581575.0.530239JL.2002@synd.ccsend.com>
Date: Thu, 16 Mar 2023 02:42:28 -0400 (EDT)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: tfujikawa@saraya.co.in
Subject: =?utf-8?Q?=E3=80=90A-Synuclain_PFFs=E3=80=91Aneuro_?=
 =?utf-8?Q?New_Product_Available_Now?=
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View as Webpage =E2=80=8A Products Support Resources Insights About Us =E3=
=80=90A-Synuclain PFFs=E3=80=91Aneuro New Product Available Now Pre-formed =
Fibrils (PFFs) are a new approach to modeling neurodegeneration that is inc=
reasingly being used in related research. These PFFs are generated in vitro=
 and can mimic endogenous protein aggregation in animal and cellular models=
. As such, PFFs can create a model that is more closely aligned with the fe=
atures found in neurodegenerative diseases, including the 'seeding' and 'pr=
opagation' of associated pathogenic proteins. As the brand of ACROBiosystem=
s that focused on neuroscience, Aneuro provides a range of PFFs to help bui=
ld models of neurodegenerative diseases. Based on stable, quantifiable char=
acterization and validation of reproducible protocols, our structural featu=
res and mechanisms activity of PFFs in disease models are more clearly defi=
ned, allowing for their application in mechanistic research, scale drug scr=
eening and testing. Pre-formed Fibrils (PFFs) Product =E2=80=8A PFFs Produc=
t Features  Induced using high-purity (>95%) monomers  Low endotoxin, suita=
ble for in vivo experiments  Stable lead time, strict quality controls, and=
 cost-effective  Customized services offered =E2=80=8A =E2=80=8A PFFs Produ=
ct Verification Data =E2=98=85 l High purity of monomer verified by SDS-PAG=
E Alpha-Synuclein monomer on SDS-PAGE under reducing (R) condition. The gel=
 was stained overnight with Coomassie Blue. The purity of the protein is gr=
eater than 90%. =E2=80=8A =E2=98=85 Structural integrity of PFFs verified b=
y Electron Microscope Transmission electron microscopy (TEM) of alpha-synuc=
lein preformed fibrils (Cat. No. ALN-H51H4). Fibril structure is visible on=
 negative stain TEM images of ALN-H51H4 (Routinely tested). =E2=98=85  High=
 bioactivity of PFFs verified by ThT Assay Thioflavin T is a sensitive fluo=
rescence reporter of fibrils formulation that binds to beta sheet-rich stru=
ctures. The alpha synuclein pre-formed fibrils (Cat. No. ALN-H51H4) is able=
 to induce the aggregation of alpha synuclein monomers (Cat. No. ALN-H52H8)=
 (QC tested). Request for Protocol =E2=80=8A =E2=80=8A =E2=96=B6=E3=80=80 C=
lick here to learn more about Aneuro =E2=80=8A =EF=BB=BFTo receive the late=
st industry news and updates from ACROBiosystems, =EF=BB=BFvisit our websit=
e & follow us on our social media!=EF=BB=BF =E2=80=8A Visit our Website =E2=
=80=8A =E2=80=8A       ACROBiosystems | 1 Innovation Way, Newark, DE 19711 =
Unsubscribe tfujikawa@saraya.co.in Update Profile | Our Privacy Policy | Co=
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=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
 break-word; padding: 10px 40px 10px 0px;" align=3D"center" valign=3D"top">=
<p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001Et6Uc_=
Q0bAI5c_K7NnEAo6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hAiPzc0YBRVkhYpjEKvzPEINYgRhB=
aITFy9yVzoWWdtEygi8sPN2FKWDt_8DGVSDaI7CxMQ3v7cMsFAyhGwkQe883hDPbPWJZ8oxu3QO=
J9N7IimFByyKVyo_2qrVHk4PIXdd2751238-KwTWVqLQTXvPbre53CTGu6BJWDwntQU3hzGns-4=
bBjKLv4jeRn9rlqa29IkyO38QY9flp4lDLSkbqm25mrGVdSxvFm3eL8EMl816PMJxcdxdqTffNT=
G-lIn1esfweWZeNKGBqUU8Psw=3D&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9z=
fbqsT2O4IPCQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-G=
ASw=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 62, 48); text-decorat=
ion: underline; font-size: 13px; font-weight: bold;">About Us</a></p></td> =
</tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-column=
" style=3D"background-color: #c03e30; table-layout: fixed;" width=3D"100%" =
border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> =
<td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"=
center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: center; font-family: Arial,Verdana,Helvet=
ica,sans-serif; color: #3E3E3E; font-size: 14px; display: block; word-wrap:=
 break-word; padding: 10px 40px;" align=3D"center" valign=3D"top"><p style=
=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001Et6Uc_Q0bAI5c_=
K7NnEAo6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hKe8uYdBr7twfCnekzM0_osYKdIK2OdXtgVXX=
B9j1mX5RU7iWMugBXIFhWJeT-uUBiEaBwD0ZcYP0yHVuJsKlwbJjCwjlsXj5KBmjQsbvvIkY7gu=
N-2gBBWyiP1pdyJGLTyQmVitnktBe5ZrqqVB0vziflNjOwt9drwV3VgNZJWAYh4xwfFZqjNv5-G=
q_1UOtfU6BUJDpYchJBnGVDoiemjt6a8K8LMtkp6NjgokexJ81p1MspqAiJNcfYzkeVpNgsCbm-=
4IkKIPbkAB2EIfivgI7v6SPj-ATQYSp-SEnNrSTLGLoQqCKCahsf7JGOK9y26vWM9C6UxHJPzNF=
FtoVZo=3D&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9zfbqsT2O4IPCQ=3D=3D&=
ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-GASw=3D=3D" target=
=3D"_blank" style=3D"font-size: 20px; color: rgb(255, 255, 255); font-weigh=
t: bold; text-decoration: none;">&#x3010;A-Synuclain PFFs&#x3011;Aneuro New=
 Product Available Now</a></p></td> </tr> </table> </td> </tr> </table> <ta=
ble class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=
=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center" v=
align=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"font-size: 16px;">Pre-formed Fibrils=
 (PFFs) are a new approach to modeling neurodegeneration that is increasing=
ly being used in related research. These PFFs are generated in vitro and ca=
n mimic endogenous protein aggregation in animal and cellular models. As su=
ch, PFFs can create a model that is more closely aligned with the features =
found in neurodegenerative diseases, including the 'seeding' and 'propagati=
on' of associated pathogenic proteins. As the brand of ACROBiosystems that =
focused on neuroscience, </span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D0=
01Et6Uc_Q0bAI5c_K7NnEAo6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hIj7WHzJAUQYKu9PQJdtv=
afGlaii97LBC3SyfXHBEgeIzK3SnVgVtWxp_BLOtgysj3fT58zx5D6Yg1fwlao3MUHEsa8fC5DC=
iXYka3xXIsNEDyFF0f0Cz-tZSzS8p8PDjLja95B1z-7bG0lQdk8nDriwCLYXuUWHp8KItWJK2Mi=
hznY0Tt6q9Q3u3fDyoAO5T6OU75Tet3vrajaqky3JANqXzaxc5ymm9aPayl9vhYXEISl4uI7C0s=
m91_zOsZcD_sz1xdrO8W5_LpwgWdSfCXCU_JeFPKwjw5hQ-PFmLm0fgr9SghGfyKs=3D&c=3DJg=
O3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9zfbqsT2O4IPCQ=3D=3D&ch=3Dr3rfp641OLq=
Xp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-GASw=3D=3D" target=3D"_blank" style=
=3D"color: red; font-size: 16px; font-weight: bold; text-decoration: underl=
ine;">Aneuro</a><span style=3D"color: red; font-size: 16px;"> </span><span =
style=3D"font-size: 16px;">provides a range of PFFs to help build models of=
 neurodegenerative diseases. Based on stable, quantifiable characterization=
 and validation of reproducible protocols, our structural features and mech=
anisms activity of PFFs in disease models are more clearly defined, allowin=
g for their application in mechanistic research, scale drug screening and t=
esting.</span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"color: black; font-weight: bold; font-size: 16px;">Pre-formed Fibrils (PFF=
s) Product</span></p>
</td> </tr> </table> <table class=3D"image image--mobile-scale image--mobil=
e-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> =
<tr> <td class=3D"image_container" align=3D"center" valign=3D"top"> <a href=
=3D"https://r20.rs6.net/tn.jsp?f=3D001Et6Uc_Q0bAI5c_K7NnEAo6n52Cmpev31rci0A=
kYlqZ1SHvN0pIf3hIj7WHzJAUQYKu9PQJdtvafGlaii97LBC3SyfXHBEgeIzK3SnVgVtWxp_BLO=
tgysj3fT58zx5D6Yg1fwlao3MUHEsa8fC5DCiXYka3xXIsNEDyFF0f0Cz-tZSzS8p8PDjLja95B=
1z-7bG0lQdk8nDriwCLYXuUWHp8KItWJK2MihznY0Tt6q9Q3u3fDyoAO5T6OU75Tet3vrajaqky=
3JANqXzaxc5ymm9aPayl9vhYXEISl4uI7C0sm91_zOsZcD_sz1xdrO8W5_LpwgWdSfCXCU_JeFP=
Kwjw5hQ-PFmLm0fgr9SghGfyKs=3D&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9=
zfbqsT2O4IPCQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-=
GASw=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"image_=
content" width=3D"645" src=3D"https://files.constantcontact.com/5f3d0cf9401=
/fea35e3c-c62d-4fd3-b3d4-0aeaa2980682.png" alt=3D"" style=3D"display: block=
; height: auto; max-width: 100%;"></a> </td> </tr> </table> <table class=3D=
"text text--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0"=
 cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_c=
ontent-cell content-padding-horizontal" style=3D"text-align: left; font-fam=
ily: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: 14px; l=
ine-height: 1.2; display: block; word-wrap: break-word; padding: 10px 40px;=
" align=3D"left" valign=3D"top"><p style=3D"text-align: center; margin: 0;"=
 align=3D"center"><br></p></td> </tr> </table> </td> </tr> </table> <table =
class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"1=
00%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"co=
lumn column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=
=3D"top"><div class=3D"spacer" style=3D"line-height: 10px; height: 10px;">&=
#x200a;</div></td> </tr> </table> <table class=3D"layout layout--1-column" =
style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0=
" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=
=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; col=
or: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddin=
g: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-weight: bold; font-size: 16px;">PFFs Product Features</span></p>
<ul>
<li>
<span style=3D'color: rgb(192, 0, 0); font-family: Georgia, "Times New Roma=
n", Times, serif; font-size: 9px;'>&#xa0;</span><span style=3D"font-size: 1=
6px;">Induced using high-purity (&gt;95%) monomers</span>
</li>
<li>
<span style=3D'color: rgb(192, 0, 0); font-family: Georgia, "Times New Roma=
n", Times, serif; font-size: 9px;'>&#xa0;</span><span style=3D"font-size: 1=
6px;">Low endotoxin, suitable for in vivo experiments</span>
</li>
<li>
<span style=3D'color: rgb(192, 0, 0); font-family: Georgia, "Times New Roma=
n", Times, serif; font-size: 9px;'>&#xa0;</span><span style=3D"font-size: 1=
6px;">Stable lead time, strict quality controls, and cost-effective</span>
</li>
<li>
<span style=3D'color: rgb(192, 0, 0); font-family: Georgia, "Times New Roma=
n", Times, serif; font-size: 9px;'>&#xa0;</span><span style=3D"font-size: 1=
6px;">Customized services offered</span>
</li>
</ul>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D"spac=
er" style=3D"height: 30px; line-height: 30px;">&#x200a;</div></td> </tr> </=
table> <table class=3D"layout layout--1-column" style=3D"table-layout: fixe=
d;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <=
td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"c=
enter" valign=3D"top"><div class=3D"spacer" style=3D"line-height: 43px; hei=
ght: 43px;">&#x200a;</div></td> </tr> </table> <table class=3D"layout-margi=
n" style=3D"" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"=
0"> <tr> <td class=3D"layout-margin_cell" style=3D"padding: 0px 40px;" alig=
n=3D"center" valign=3D"top"> <table class=3D"layout-border layout-border--d=
ashed" style=3D"border: 3px dashed #cccccc;" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"layout-border_cell" st=
yle=3D"" align=3D"center" valign=3D"top">
<table class=3D"layout layout--coupon layout--1-column" style=3D"table-layo=
ut: fixed; background-color: #ffffff;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0" bgcolor=3D"#ffffff"> <tr> <td class=3D"column c=
olumn--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top=
">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cent=
er; margin: 0;" align=3D"center"><span style=3D"font-size: 19px; font-weigh=
t: bold;">PFFs Product Verification Data</span></p></td> </tr> </table> <ta=
ble class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" cellp=
adding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td cla=
ss=3D"text_content-cell content-padding-horizontal" style=3D"text-align: le=
ft; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-s=
ize: 14px; line-height: 1.2; display: block; word-wrap: break-word; padding=
: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><span s=
tyle=3D"font-weight: bold;">&#x2605; l</span><span style=3D'font-family: Ge=
orgia, "Times New Roman", Times, serif; font-weight: bold;'>&#xa0;</span><s=
pan style=3D"font-weight: bold;">High purity of monomer verified by SDS-PAG=
E</span></p></td> </tr> </table> <table class=3D"image image--padding-verti=
cal image--mobile-scale image--mobile-center" width=3D"100%" border=3D"0" c=
ellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"image_container conte=
nt-padding-horizontal" align=3D"center" valign=3D"top" style=3D"padding: 10=
px 20px;"> <a href=3D"https://r20.rs6.net/tn.jsp?f=3D001Et6Uc_Q0bAI5c_K7NnE=
Ao6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hPbxapyjtb8od1eBU00O4aP4J6rWEbaAUxHBY-iSRE=
xBcmPtFZS7-3UEVUKfWETvETzaslKi2LIAQMe3SyWYyYfx0jyexpzm84Q1Vj1QG8hUPla4Nghdm=
rEEr34Bf9uh4BCJ07D6Gq0a5tSogygt43sreR4q7VvoZG7gwk_s8Of35YnvS0QdyHf0nrsz54pH=
obu5uq-lz2GDcxHEHh0hKaFNzMgCxtgeMH5keQlxcUblltAsAEN7qba7TD828ud9X4pGtSjCEop=
64y8DOiljJntOY4LK9NXXIOb0D83ELLzQt6a7f3Cm6-ofs_EvzgBFcXWonKrAJ4CKyQFW_gRUjf=
Gbn0YkE44Vvw=3D=3D&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9zfbqsT2O4IP=
CQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-GASw=3D=3D"=
 data-trackable=3D"true"><img data-image-content class=3D"image_content" wi=
dth=3D"135" src=3D"https://files.constantcontact.com/5f3d0cf9401/a3feff8e-5=
44c-47f8-8c98-d8446ffd31c0.jpg" alt=3D"" style=3D"display: block; height: a=
uto; max-width: 100%;"></a> </td> </tr> </table> <table class=3D"text text-=
-padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacin=
g=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_content-cell=
 content-padding-horizontal" style=3D"line-height: 1.5; text-align: left; f=
ont-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: =
14px; display: block; word-wrap: break-word; padding: 10px 20px;" align=3D"=
left" valign=3D"top"><p style=3D"margin: 0;"><span style=3D"font-size: 12px=
;">Alpha-Synuclein monomer on SDS-PAGE under reducing (R) condition. The ge=
l was stained overnight with Coomassie Blue. The purity of the protein is g=
reater than 90%.</span></p></td> </tr> </table> <div class=3D"spacer" style=
=3D"line-height: 20px; height: 20px;">&#x200a;</div>
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><spa=
n style=3D"font-weight: bold;">&#x2605; Structural integrity of PFFs verifi=
ed by Electron Microscope</span></p></td> </tr> </table> <table class=3D"im=
age image--padding-vertical image--mobile-scale image--mobile-center" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=
=3D"image_container content-padding-horizontal" align=3D"center" valign=3D"=
top" style=3D"padding: 10px 20px;"> <a href=3D"https://r20.rs6.net/tn.jsp?f=
=3D001Et6Uc_Q0bAI5c_K7NnEAo6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hPbxapyjtb8od1eBU=
00O4aP4J6rWEbaAUxHBY-iSRExBcmPtFZS7-3UEVUKfWETvETzaslKi2LIAQMe3SyWYyYfx0jye=
xpzm84Q1Vj1QG8hUPla4NghdmrEEr34Bf9uh4BCJ07D6Gq0a5tSogygt43sreR4q7VvoZG7gwk_=
s8Of35YnvS0QdyHf0nrsz54pHobu5uq-lz2GDcxHEHh0hKaFNzMgCxtgeMH5keQlxcUblltAsAE=
N7qba7TD828ud9X4pGtSjCEop64y8DOiljJntOY4LK9NXXIOb0D83ELLzQt6a7f3Cm6-ofs_Evz=
gBFcXWonKrAJ4CKyQFW_gRUjfGbn0YkE44Vvw=3D=3D&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp=
_gimz0E7xnCFV9zfbqsT2O4IPCQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB8=
83p2jgcpaSIF2-GASw=3D=3D" data-trackable=3D"true"><img data-image-content c=
lass=3D"image_content" width=3D"329" src=3D"https://files.constantcontact.c=
om/5f3d0cf9401/a96bf8fa-2eb7-4fd0-af03-3f4c8e7e1fda.jpg" alt=3D"" style=3D"=
display: block; height: auto; max-width: 100%;"></a> </td> </tr> </table> <=
table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" cel=
lpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td c=
lass=3D"text_content-cell content-padding-horizontal" style=3D"line-height:=
 1.5; text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; display: block; word-wrap: break-word; paddi=
ng: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><span=
 style=3D"font-size: 12px;">Transmission electron microscopy (TEM) of alpha=
-synuclein preformed fibrils (Cat. No.</span><a href=3D"https://r20.rs6.net=
/tn.jsp?f=3D001Et6Uc_Q0bAI5c_K7NnEAo6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hPbxapyj=
tb8od1eBU00O4aP4J6rWEbaAUxHBY-iSRExBcmPtFZS7-3UEVUKfWETvETzaslKi2LIAQMe3SyW=
YyYfx0jyexpzm84Q1Vj1QG8hUPla4NghdmrEEr34Bf9uh4BCJ07D6Gq0a5tSogygt43sreR4q7V=
voZG7gwk_s8Of35YnvS0QdyHf0nrsz54pHobu5uq-lz2GDcxHEHh0hKaFNzMgCxtgeMH5keQlxc=
UblltAsAEN7qba7TD828ud9X4pGtSjCEop64y8DOiljJntOY4LK9NXXIOb0D83ELLzQt6a7f3Cm=
6-ofs_EvzgBFcXWonKrAJ4CKyQFW_gRUjfGbn0YkE44Vvw=3D=3D&c=3DJgO3xeDByxpSFGIay_=
FaRoiOxLp_gimz0E7xnCFV9zfbqsT2O4IPCQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uG=
hFdMyduB883p2jgcpaSIF2-GASw=3D=3D" target=3D"_blank" style=3D"font-size: 12=
px; text-decoration: underline; color: #4d4d4d; font-weight: bold;"> </a><a=
 href=3D"https://r20.rs6.net/tn.jsp?f=3D001Et6Uc_Q0bAI5c_K7NnEAo6n52Cmpev31=
rci0AkYlqZ1SHvN0pIf3hPbxapyjtb8od1eBU00O4aP4J6rWEbaAUxHBY-iSRExBcmPtFZS7-3U=
EVUKfWETvETzaslKi2LIAQMe3SyWYyYfx0jyexpzm84Q1Vj1QG8hUPla4NghdmrEEr34Bf9uh4B=
CJ07D6Gq0a5tSogygt43sreR4q7VvoZG7gwk_s8Of35YnvS0QdyHf0nrsz54pHobu5uq-lz2GDc=
xHEHh0hKaFNzMgCxtgeMH5keQlxcUblltAsAEN7qba7TD828ud9X4pGtSjCEop64y8DOiljJntO=
Y4LK9NXXIOb0D83ELLzQt6a7f3Cm6-ofs_EvzgBFcXWonKrAJ4CKyQFW_gRUjfGbn0YkE44Vvw=
=3D=3D&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9zfbqsT2O4IPCQ=3D=3D&ch=
=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-GASw=3D=3D" target=3D"=
_blank" style=3D"font-size: 12px; text-decoration: underline; color: rgb(19=
2, 62, 48); font-weight: bold;">ALN-H51H4</a><span style=3D"font-size: 12px=
;">). Fibril structure is visible on negative stain TEM images of ALN-H51H4=
 (Routinely tested).</span></p></td> </tr> </table> <table class=3D"text te=
xt--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspa=
cing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_content-c=
ell content-padding-horizontal" style=3D"text-align: left; font-family: Ari=
al,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: 14px; line-heig=
ht: 1.2; display: block; word-wrap: break-word; padding: 10px 20px;" align=
=3D"left" valign=3D"top"><p style=3D"margin: 0;"><span style=3D"font-weight=
: bold;">&#x2605; </span><span style=3D'font-family: Georgia, "Times New Ro=
man", Times, serif; font-weight: bold;'>&#xa0;</span><span style=3D"font-we=
ight: bold;">High bioactivity of PFFs verified by ThT Assay</span></p></td>=
 </tr> </table> <table class=3D"image image--padding-vertical image--mobile=
-scale image--mobile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" =
cellspacing=3D"0"> <tr> <td class=3D"image_container content-padding-horizo=
ntal" align=3D"center" valign=3D"top" style=3D"padding: 10px 20px;"> <a hre=
f=3D"https://r20.rs6.net/tn.jsp?f=3D001Et6Uc_Q0bAI5c_K7NnEAo6n52Cmpev31rci0=
AkYlqZ1SHvN0pIf3hPbxapyjtb8od1eBU00O4aP4J6rWEbaAUxHBY-iSRExBcmPtFZS7-3UEVUK=
fWETvETzaslKi2LIAQMe3SyWYyYfx0jyexpzm84Q1Vj1QG8hUPla4NghdmrEEr34Bf9uh4BCJ07=
D6Gq0a5tSogygt43sreR4q7VvoZG7gwk_s8Of35YnvS0QdyHf0nrsz54pHobu5uq-lz2GDcxHEH=
h0hKaFNzMgCxtgeMH5keQlxcUblltAsAEN7qba7TD828ud9X4pGtSjCEop64y8DOiljJntOY4LK=
9NXXIOb0D83ELLzQt6a7f3Cm6-ofs_EvzgBFcXWonKrAJ4CKyQFW_gRUjfGbn0YkE44Vvw=3D=
=3D&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9zfbqsT2O4IPCQ=3D=3D&ch=3Dr=
3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-GASw=3D=3D" data-trackable=
=3D"true"><img data-image-content class=3D"image_content" width=3D"471" src=
=3D"https://files.constantcontact.com/5f3d0cf9401/728bd321-506a-4b87-a6bb-f=
b35cc4aba07.jpg" alt=3D"" style=3D"display: block; height: auto; max-width:=
 100%;"></a> </td> </tr> </table> <table class=3D"text text--padding-vertic=
al" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=
=3D"table-layout: fixed;"> <tr> <td class=3D"text_content-cell content-padd=
ing-horizontal" style=3D"text-align: left; font-family: Arial,Verdana,Helve=
tica,sans-serif; color: #3E3E3E; font-size: 14px; line-height: 1.2; display=
: block; word-wrap: break-word; padding: 10px 20px;" align=3D"left" valign=
=3D"top"><p style=3D"margin: 0;"><span style=3D"font-size: 12px;">Thioflavi=
n T is a sensitive fluorescence reporter of fibrils formulation that binds =
to beta sheet-rich structures. The alpha synuclein pre-formed fibrils (Cat.=
 No.</span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001Et6Uc_Q0bAI5c_K7NnE=
Ao6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hPbxapyjtb8od1eBU00O4aP4J6rWEbaAUxHBY-iSRE=
xBcmPtFZS7-3UEVUKfWETvETzaslKi2LIAQMe3SyWYyYfx0jyexpzm84Q1Vj1QG8hUPla4Nghdm=
rEEr34Bf9uh4BCJ07D6Gq0a5tSogygt43sreR4q7VvoZG7gwk_s8Of35YnvS0QdyHf0nrsz54pH=
obu5uq-lz2GDcxHEHh0hKaFNzMgCxtgeMH5keQlxcUblltAsAEN7qba7TD828ud9X4pGtSjCEop=
64y8DOiljJntOY4LK9NXXIOb0D83ELLzQt6a7f3Cm6-ofs_EvzgBFcXWonKrAJ4CKyQFW_gRUjf=
Gbn0YkE44Vvw=3D=3D&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9zfbqsT2O4IP=
CQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-GASw=3D=3D"=
 target=3D"_blank" style=3D"font-size: 12px; text-decoration: underline; co=
lor: #4d4d4d; font-weight: bold;"> </a><a href=3D"https://r20.rs6.net/tn.js=
p?f=3D001Et6Uc_Q0bAI5c_K7NnEAo6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hPbxapyjtb8od1=
eBU00O4aP4J6rWEbaAUxHBY-iSRExBcmPtFZS7-3UEVUKfWETvETzaslKi2LIAQMe3SyWYyYfx0=
jyexpzm84Q1Vj1QG8hUPla4NghdmrEEr34Bf9uh4BCJ07D6Gq0a5tSogygt43sreR4q7VvoZG7g=
wk_s8Of35YnvS0QdyHf0nrsz54pHobu5uq-lz2GDcxHEHh0hKaFNzMgCxtgeMH5keQlxcUblltA=
sAEN7qba7TD828ud9X4pGtSjCEop64y8DOiljJntOY4LK9NXXIOb0D83ELLzQt6a7f3Cm6-ofs_=
EvzgBFcXWonKrAJ4CKyQFW_gRUjfGbn0YkE44Vvw=3D=3D&c=3DJgO3xeDByxpSFGIay_FaRoiO=
xLp_gimz0E7xnCFV9zfbqsT2O4IPCQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyd=
uB883p2jgcpaSIF2-GASw=3D=3D" target=3D"_blank" style=3D"font-size: 12px; te=
xt-decoration: underline; color: rgb(192, 62, 48); font-weight: bold;">ALN-=
H51H4</a><span style=3D"font-size: 12px;">) is able to induce the aggregati=
on of alpha synuclein monomers (Cat. No. </span><a href=3D"https://r20.rs6.=
net/tn.jsp?f=3D001Et6Uc_Q0bAI5c_K7NnEAo6n52Cmpev31rci0AkYlqZ1SHvN0pIf3hPbxa=
pyjtb8ojMIVm2TJeggTJLjV0OPVzKMZ9gtUGUveA6sUni-hEjm01KRn2jSrsjBPJDR1dOb8t6kp=
Hcvtw8QmKrH_xONWcFn1a_f_7me6aMDotdZH-1FI-0C-r_xZPAqyk4VDOg7ZEdqeLAFIOEiGAja=
ohWi7qx3MaoM-DneA-gQ9udkG8wWJLPbOeoI5gWn1ctqAD4aRMDzpphhN99SENfN5UyKZ102Hf-=
epw5U8eibjq7YmvUpi3THGLk7xz_UFMHHG_77fyznd0yniqw_MnFG312obJJYegxABYLS2Dx4rh=
TR5gBiyCIDYTKKQ4VC8hXjjpXNZ&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9zf=
bqsT2O4IPCQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-GA=
Sw=3D=3D" target=3D"_blank" style=3D"font-size: 12px; color: rgb(192, 0, 0)=
; font-weight: bold; text-decoration: underline;">ALN-H52H8</a><span style=
=3D"font-size: 12px;">) (QC tested).</span></p></td> </tr> </table>  <table=
 class=3D"button button--padding-vertical" width=3D"100%" border=3D"0" cell=
padding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td cl=
ass=3D"button_container content-padding-horizontal" align=3D"center" style=
=3D"padding: 10px 20px;">    <table class=3D"button_content-row" style=3D"b=
ackground-color: #c03e30; width: inherit; border-radius: 7px; border-spacin=
g: 0; border: none;" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcol=
or=3D"#c03e30"> <tr> <td class=3D"button_content-cell" style=3D"padding: 10=
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xapyjtb8oVOeBr_NLBzXhxNKqTk-7jF5pn9zeMWHYS0AfaxBg3ORNPTyTYTRnU00PcQUo8y5rDH=
be-Nh-sm_gwuECg0dkXjuohhHFOlkY_p2zotqQtEAJPeHdVbGerU9TRMBdtK-m9X58zBQVijfbX=
_UBwk4m-ZG1MYsenCsIuOGpqqDNJT9S_x9YLkoSM44yrzdWDhP-LW__YWUb5XgnSX1FBPxkRFQI=
tXG0lWibO7UriQLD0JlN-6k9Q7c-Va8gNjjyV6wxhdFGohH0dRNiV9Xe3opu9m6LxkHdJpYkl1w=
mggT4MtnRwnz-OZSmuWojkUQ1SI0R&c=3DJgO3xeDByxpSFGIay_FaRoiOxLp_gimz0E7xnCFV9=
zfbqsT2O4IPCQ=3D=3D&ch=3Dr3rfp641OLqXp179BOEdYEEI8uGhFdMyduB883p2jgcpaSIF2-=
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class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
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