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Envelope-to: daisuke@saraya.co.in
Delivery-date: Thu, 09 Mar 2023 15:37:15 +0800
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Date: Thu, 9 Mar 2023 02:36:18 -0500 (EST)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: daisuke@saraya.co.in
Subject: =?utf-8?Q?A_new_target_for_the_treatme?=
 =?utf-8?Q?nt_of_colitis:_Integrin_=CE=B14/=CE=B27?=
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View as Webpage Products Support Resources Insights About Us A new target f=
or the treatment of colitis: Integrin =CE=B14/=CE=B27 Integrin is a class o=
f heterophilic cell adhesion molecules as the adhesion protein for cell-to-=
cell and cell-to-extracellular matrix (ECM) connections. It=E2=80=99s also =
a transmembrane heterodimer consists of 2 non-covalently associated transme=
mbrane glycoprotein subunits, called =CE=B1 and =CE=B2.   The interaction o=
f Integrin =CE=B14/=CE=B27 and MAdCAM-1 can affect the development of colit=
is so inhibiting Integrin =CE=B14/=CE=B27-MAdCAM-1 interaction through anti=
body drugs can reduce colitis inflammation develop. Product list 24 types o=
f Integrin Protein for immunization, antibody screening and functional veri=
fication of candidate drug applications Integrin-Related ligands Learn more=
 Validation of the data =E2=98=85=E3=80=80High Bioactivity-ELISA =E2=80=8A =
Immobilized anti-alpha4 unit,Human IgG4, kappa LC at 1 =CE=BCg/mL (100 =CE=
=BCL/well) can bind Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free=
 (Cat. No. IT7-H52W4) with a linear range of 8-31 ng/mL (QC tested).  =E2=
=80=8A =E2=98=85=E3=80=80High purity-SDS-PAGE, SEC-MALS Purityof Human Inte=
grin alpha 6 beta 4 Protein, His Tag&Tag Free (Cat. No. IN4-H52W3) was veri=
fied as> 95% by SDS-PAGE and greater than 90% by SEC-MALS =E2=80=8A =E2=98=
=85=E3=80=80High batch-to-batch Consistency =E2=80=8A Immobilized Human Fib=
ronectin at 2 =CE=BCg/mL (100 =CE=BCL/well) can bind Human ITGAV&ITGB1 Hete=
rodimer Protein, His Tag & Tag Free (Cat. No. IT1-H52E1) with a linear rang=
e of 0.02-0.313 =CE=BCg/mL. To receive the latest industry news and updates=
 from ACROBiosystems, =EF=BB=BFvisit our website & follow us on our social =
media!=EF=BB=BF =E2=80=8A Visit our Website       ACROBiosystems | 1 Innova=
tion Way, Newark, DE 19711 Unsubscribe daisuke@saraya.co.in Update Profile =
| Our Privacy Policy | Constant Contact Data Notice Sent by acrobio.apac@ou=
tlook.com
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e layout--1-column" style=3D"background-color: #c03e30; table-layout: fixed=
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ze: 20px; font-weight: bold; color: rgb(255, 255, 255);">A new target for t=
he treatment of colitis: Integrin &#x3b1;4/&#x3b2;7</span></p></td> </tr> <=
/table> </td> </tr> </table> <table class=3D"layout layout--feature layout-=
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<p style=3D"text-align: left; margin: 0;" align=3D"left">Integrin is a clas=
s of heterophilic cell adhesion molecules as the adhesion protein for cell-=
to-cell and cell-to-extracellular matrix (ECM) connections. It&#x2019;s als=
o a transmembrane heterodimer&#xa0;consists of 2 non-covalently associated =
transmembrane glycoprotein subunits, called &#x3b1; and &#x3b2;.</p>
<p style=3D"text-align: left; margin: 0;" align=3D"left">&#xa0;</p>
<p style=3D"text-align: left; margin: 0;" align=3D"left">The interaction of=
 Integrin &#x3b1;4/&#x3b2;7 and MAdCAM-1 can affect the development of coli=
tis so inhibiting Integrin &#x3b1;4/&#x3b2;7-MAdCAM-1 interaction through a=
ntibody drugs can reduce colitis inflammation develop.</p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
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span></h2>
<p style=3D"margin: 0;"><br></p>
<p style=3D"margin: 0;">24 types of Integrin Protein for immunization, anti=
body screening and functional verification of candidate drug applications</=
p>
</td> </tr> </table> <table class=3D"image image--padding-vertical image--m=
obile-scale image--mobile-center" width=3D"100%" border=3D"0" cellpadding=
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to; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </table> <table=
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dth=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td cla=
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</tr> </table>   </td> </tr> </table> <table class=3D"layout layout--1-colu=
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order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
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or: #3E3E3E; font-size: 20px; font-weight: bold; margin: 0;" align=3D"cente=
r"><span style=3D"font-size: 18px; color: rgb(192, 62, 48);">Validation of =
the data</span></h2>
<p style=3D"margin: 0;"><br></p>
<p style=3D"margin: 0;"><span style=3D"font-weight: bold;">&#x2605;&#x3000;=
High Bioactivity-ELISA</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--2-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
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<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container" align=3D"center" valign=3D"top" style=
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et/tn.jsp?f=3D001ekxQXmBQV0eJ1NzJk4gJkIPvc1ElPke9P6jsG48S3NCKKDnRQJn9lEUTnI=
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_IiEN8HGrMYu7jqLtuJdGoPVfOJT5Kot5-3rZflKFGT6o3APTGBiVcT-ekV_LHUncPRfE-1ZkJe=
HK3o0hP0Yr3-sEX8hji7qGJC5m4gTT3hVMN0MJahN3WBCMSZtqfLOo81rj4qKcO00Cdwl7usuJu=
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o; max-width: 100%;"></a> </td> </tr> </table> </td>  <td class=3D"column c=
olumn--2 scale stack" style=3D"width: 37.5%;" align=3D"center" valign=3D"to=
p">
<div class=3D"spacer" style=3D"line-height: 70px; height: 70px;">&#x200a;</=
div>
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; colo=
r: #343332; font-size: 16px; line-height: 1.2; display: block; word-wrap: b=
reak-word; padding: 10px 40px 10px 20px;" align=3D"left" valign=3D"top"><p =
style=3D"margin: 0;"><span style=3D"color: rgb(85, 85, 85); font-family: Ar=
ial, Verdana, Helvetica, sans-serif; font-size: 14px;">Immobilized anti-alp=
ha4 unit,Human IgG4, kappa LC at 1 &#x3bc;g/mL (100 &#x3bc;L/well) can bind=
 Human ITGA4&amp;ITGB7 Heterodimer Protein, His Tag&amp;Tag Free (</span><a=
 href=3D"https://r20.rs6.net/tn.jsp?f=3D001ekxQXmBQV0eJ1NzJk4gJkIPvc1ElPke9=
P6jsG48S3NCKKDnRQJn9lEUTnIG9nlSd_Tqlw9QniCiKLlhNpLFbR0A4gBK4infWoM1CMj6FLq0=
LLQihVkH-OZj3Y0vvUmbiIHOVK_IiEN8HGrMYu7jqLtuJdGoPVfOJT5Kot5-3rZflKFGT6o3APT=
GBiVcT-ekV_LHUncPRfE-1ZkJeHK3o0hP0Yr3-sEX8hji7qGJC5m4gTT3hVMN0MJahN3WBCMSZt=
qfLOo81rj4qKcO00Cdwl7usuJupR0dNt7ZhEdHbLz3bE_HAVrW7BQ9yoBpBWWzHgUCxRWOguVSG=
T22v7_kcUxdrC1lF9YSZusCvmvQLxEqXDeyltd7S8cq_5bkud8k8c3mnCJ2wEOVIBt4z82__-RQ=
9wXuQbSN1Dl_AofcROJKE2kRUtW3kOVJ9X52ATdBn&c=3DDiMy2E7IaBeWJOABMEk-ExJzVcKS6=
JipmxNlrdiP3Jxa6NlTg4jf3Q=3D=3D&ch=3Dbm5aDd3JL9tms387g4Z91uq0lw6bPKOWoxW5H6=
7KE2bhRR1MRcFnjA=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 62, 48);=
 font-family: Arial, Verdana, Helvetica, sans-serif; font-size: 14px; text-=
decoration: underline; font-weight: bold;">Cat. No. IT7-H52W4</a><span styl=
e=3D"color: rgb(85, 85, 85); font-family: Arial, Verdana, Helvetica, sans-s=
erif; font-size: 14px;">) with a linear range of 8-31 ng/mL (QC tested).&#x=
a0;</span></p></td> </tr> </table> </td> </tr> </table> <table class=3D"lay=
out layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column=
--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top"><di=
v class=3D"spacer" style=3D"height: 30px; line-height: 30px;">&#x200a;</div=
></td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"tab=
le-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacin=
g=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 10=
0%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><spa=
n style=3D"color: rgb(0, 0, 0); font-weight: bold; font-size: 16px;">&#x260=
5;&#x3000;High purity-SDS-PAGE, SEC-MALS</span></p></td> </tr> </table> </t=
d> </tr> </table> <table class=3D"layout layout--1-column" style=3D"table-l=
ayout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D=
"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;"=
 align=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container" align=3D"center" valign=3D"top" style=
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et/tn.jsp?f=3D001ekxQXmBQV0eJ1NzJk4gJkIPvc1ElPke9P6jsG48S3NCKKDnRQJn9lEUTnI=
G9nlSdCdJKsBd7xWn9xN5HiU0Rqtxz7eaS0vwqrSSQKHRdCfAo4N-nEsvjhmW4ETEFZN1EbK8ND=
BuT2yE2Z1RFLtbCY5FOSHfAuGeUBZAbgG647t2vCnCnAAprMKT5d04dQHwH6F6bsxpzTM5VDMlX=
vGELGpNmn2GGQf387N8WhohROxfV71BnQW2-hzeQ67vq9KDicFSmqRJbAaxBs6tGW7DHVfIc4DE=
occWSZtyfons1CDOaP-OnpTA9IiWu0XJJtcQeFLFfP3V2tosWzQaqKQpN1KgD6k-fkyRq7ONzSc=
N3cZ9wscA-jBkqLMSmAtOq2o-ggIUCIKUovnSlPDk8EXbTYInqwdTG_lMKjFZFoQKB_AyxJciTk=
W_unA=3D=3D&c=3DDiMy2E7IaBeWJOABMEk-ExJzVcKS6JipmxNlrdiP3Jxa6NlTg4jf3Q=3D=
=3D&ch=3Dbm5aDd3JL9tms387g4Z91uq0lw6bPKOWoxW5H67KE2bhRR1MRcFnjA=3D=3D" data=
-trackable=3D"true"><img data-image-content class=3D"image_content" width=
=3D"611" src=3D"https://files.constantcontact.com/5f3d0cf9401/1569c950-0f11=
-4f99-b373-0333a109fbde.png" alt=3D"" style=3D"display: block; height: auto=
; max-width: 100%;"></a> </td> </tr> </table> <table class=3D"text text--ar=
ticle text--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0"=
 cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_c=
ontent-cell content-padding-horizontal" style=3D"text-align: left; font-fam=
ily: Arial,Verdana,Helvetica,sans-serif; color: #343332; font-size: 16px; l=
ine-height: 1.2; display: block; word-wrap: break-word; padding: 10px 40px;=
" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><span style=3D"font=
-size: 14px; color: rgb(85, 85, 85); font-family: Arial, Verdana, Helvetica=
, sans-serif;">Purityof Human Integrin alpha 6 beta 4 Protein, His Tag&amp;=
Tag Free (</span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001ekxQXmBQV0eJ1=
NzJk4gJkIPvc1ElPke9P6jsG48S3NCKKDnRQJn9lEUTnIG9nlSdCdJKsBd7xWn9xN5HiU0Rqtxz=
7eaS0vwqrSSQKHRdCfAo4N-nEsvjhmW4ETEFZN1EbK8NDBuT2yE2Z1RFLtbCY5FOSHfAuGeUBZA=
bgG647t2vCnCnAAprMKT5d04dQHwH6F6bsxpzTM5VDMlXvGELGpNmn2GGQf387N8WhohROxfV71=
BnQW2-hzeQ67vq9KDicFSmqRJbAaxBs6tGW7DHVfIc4DEoccWSZtyfons1CDOaP-OnpTA9IiWu0=
XJJtcQeFLFfP3V2tosWzQaqKQpN1KgD6k-fkyRq7ONzScN3cZ9wscA-jBkqLMSmAtOq2o-ggIUC=
IKUovnSlPDk8EXbTYInqwdTG_lMKjFZFoQKB_AyxJciTkW_unA=3D=3D&c=3DDiMy2E7IaBeWJO=
ABMEk-ExJzVcKS6JipmxNlrdiP3Jxa6NlTg4jf3Q=3D=3D&ch=3Dbm5aDd3JL9tms387g4Z91uq=
0lw6bPKOWoxW5H67KE2bhRR1MRcFnjA=3D=3D" target=3D"_blank" style=3D"font-size=
: 14px; color: rgb(192, 62, 48); font-family: Arial, Verdana, Helvetica, sa=
ns-serif; font-weight: bold; text-decoration: underline;">Cat. No. IN4-H52W=
3</a><span style=3D"font-size: 14px; color: rgb(85, 85, 85); font-family: A=
rial, Verdana, Helvetica, sans-serif;">) was verified as&gt; 95% by SDS-PAG=
E and greater than 90% by SEC-MALS</span></p></td> </tr> </table> </td> </t=
r> </table> <table class=3D"layout layout--1-column" style=3D"table-layout:=
 fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <=
tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=
=3D"center" valign=3D"top"><div class=3D"spacer" style=3D"height: 30px; lin=
e-height: 30px;">&#x200a;</div></td> </tr> </table> <table class=3D"layout =
layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0=
" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 s=
cale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><spa=
n style=3D"font-size: 16px; color: rgb(0, 0, 0); font-weight: bold;">&#x260=
5;&#x3000;High batch-to-batch Consistency</span></p></td> </tr> </table> </=
td> </tr> </table> <table class=3D"layout layout--2-column" style=3D"table-=
layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 62.=
5%;" align=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container" align=3D"center" valign=3D"top" style=
=3D"padding-top: 10px; padding-bottom: 10px;"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001ekxQXmBQV0eJ1NzJk4gJkIPvc1ElPke9P6jsG48S3NCKKDnRQJn9lKSQkD=
_SZ7KZb4jM74lWXPT9jPciSia-aktjyd1BuGGkl3x9neO5aVhO2zZqAC3kG7BVEt9D0d7RdmEIk=
QLyZl4AwsdFcxHtmqM0xE4HKX_VFND2vO5KrzbR27Fv2Cgw4Xr61CdfdPj4ChHm9SzXLQB1oOgV=
Mj0l_aqOHtvACu5Ww8YrTdQSRhTGdgI7mANEGQSeKqFntLyni5ELOS7-YsanjA7zY0JeEmorKoH=
Sss2m-y3o-HhOrua0IKkmyjNiRWQ4W_CxsSGQ85fOlu5FibswmaMQYAxqcKoFhvvgSpV5H6ps8d=
8XHIN5a5FBcw3OnW2bIQ1q7rv64yHzG1GBRRRHmSudcOYX_FFftLBv9S5PQlDLF9rrL2KkJVfFh=
sw70mYCpQDzYtxe&c=3DDiMy2E7IaBeWJOABMEk-ExJzVcKS6JipmxNlrdiP3Jxa6NlTg4jf3Q=
=3D=3D&ch=3Dbm5aDd3JL9tms387g4Z91uq0lw6bPKOWoxW5H67KE2bhRR1MRcFnjA=3D=3D" d=
ata-trackable=3D"true"><img data-image-content class=3D"image_content" widt=
h=3D"419" src=3D"https://files.constantcontact.com/5f3d0cf9401/2d33ce20-5c2=
4-4037-9714-4a47a06781d9.png" alt=3D"" style=3D"display: block; height: aut=
o; max-width: 100%;"></a> </td> </tr> </table> </td>  <td class=3D"column c=
olumn--2 scale stack" style=3D"width: 37.5%;" align=3D"center" valign=3D"to=
p">
<div class=3D"spacer" style=3D"line-height: 70px; height: 70px;">&#x200a;</=
div>
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; colo=
r: #343332; font-size: 16px; line-height: 1.2; display: block; word-wrap: b=
reak-word; padding: 10px 40px 10px 20px;" align=3D"left" valign=3D"top"><p =
style=3D"margin: 0;"><span style=3D"font-size: 14px; color: rgb(85, 85, 85)=
; font-family: Arial, Verdana, Helvetica, sans-serif;">Immobilized Human Fi=
bronectin at 2 </span><span style=3D"font-size: 14px; color: rgb(85, 85, 85=
);">&#x3bc;</span><span style=3D"font-size: 14px; color: rgb(85, 85, 85); f=
ont-family: Arial, Verdana, Helvetica, sans-serif;">g/mL (100 </span><span =
style=3D"font-size: 14px; color: rgb(85, 85, 85);">&#x3bc;</span><span styl=
e=3D"font-size: 14px; color: rgb(85, 85, 85); font-family: Arial, Verdana, =
Helvetica, sans-serif;">L/well) can bind Human ITGAV&amp;ITGB1 Heterodimer =
Protein, His Tag &amp; Tag Free (</span><span style=3D"font-size: 14px; col=
or: rgb(192, 62, 48); font-family: Arial, Verdana, Helvetica, sans-serif; t=
ext-decoration: underline;">Cat. </span><a href=3D"https://r20.rs6.net/tn.j=
sp?f=3D001ekxQXmBQV0eJ1NzJk4gJkIPvc1ElPke9P6jsG48S3NCKKDnRQJn9lKSQkD_SZ7KZb=
4jM74lWXPT9jPciSia-aktjyd1BuGGkl3x9neO5aVhO2zZqAC3kG7BVEt9D0d7RdmEIkQLyZl4A=
wsdFcxHtmqM0xE4HKX_VFND2vO5KrzbR27Fv2Cgw4Xr61CdfdPj4ChHm9SzXLQB1oOgVMj0l_aq=
OHtvACu5Ww8YrTdQSRhTGdgI7mANEGQSeKqFntLyni5ELOS7-YsanjA7zY0JeEmorKoHSss2m-y=
3o-HhOrua0IKkmyjNiRWQ4W_CxsSGQ85fOlu5FibswmaMQYAxqcKoFhvvgSpV5H6ps8d8XHIN5a=
5FBcw3OnW2bIQ1q7rv64yHzG1GBRRRHmSudcOYX_FFftLBv9S5PQlDLF9rrL2KkJVfFhsw70mYC=
pQDzYtxe&c=3DDiMy2E7IaBeWJOABMEk-ExJzVcKS6JipmxNlrdiP3Jxa6NlTg4jf3Q=3D=3D&c=
h=3Dbm5aDd3JL9tms387g4Z91uq0lw6bPKOWoxW5H67KE2bhRR1MRcFnjA=3D=3D" target=3D=
"_blank" style=3D"font-size: 14px; color: rgb(192, 62, 48); font-family: Ar=
ial, Verdana, Helvetica, sans-serif; text-decoration: underline; font-weigh=
t: bold;">No.&#xa0;IT1-H52E1</a><span style=3D"font-size: 14px; color: rgb(=
85, 85, 85); font-family: Arial, Verdana, Helvetica, sans-serif;">) with a =
linear range of 0.02-0.313 </span><span style=3D"font-size: 14px; color: rg=
b(85, 85, 85);">&#x3bc;</span><span style=3D"font-size: 14px; color: rgb(85=
, 85, 85); font-family: Arial, Verdana, Helvetica, sans-serif;">g/mL.</span=
></p></td> </tr> </table> </td> </tr> </table> <table class=3D"layout layou=
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