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Envelope-to: mykhaylo.dubrovka@saraya.co.in
Delivery-date: Thu, 26 Jan 2023 12:41:56 +0800
Message-ID: <1139808631086.1119371711477.1404958413.0.562338JL.2002@synd.ccsend.com>
Date: Wed, 25 Jan 2023 23:41:05 -0500 (EST)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
Subject: Supporting bispecific Checkpoint Inhibitor development
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View as Webpage Products Support Resources Insights About Us Supporting bis=
pecific Checkpoint Inhibitor developmentwith With the rise of bispecific dr=
ugs, there is a wave of research and development of dual-targeted based on =
PD-1 / PD-L1 and CTLA-4. Several researches have showed that anti-CTLA-4 in=
hibitors increase the expression of PD-L1 in some tumors and the combinatio=
n of anti-CTLA-4 inhibition and PD-(L)1 inhibition favors effector T cell r=
ecruitment in preclinical tumor models. At present, there are many bispecif=
ic drugs in the clinical validation stage, such as MEDI5752, MGD019, KN046 =
and AK104. And its indications also cover a variety of solid tumors. Overal=
l, these molecules potential new candidates to simultaneously block PD-1/PD=
-L1 and CTLA-4/B7 immune checkpoints pathway. hence mimicking the clinical =
effect of a dual immune checkpoint blockade. ACROBiosystems has specially l=
aunched a series of PD-(L)1 and CTLA-4 homodimer proteins, which are suitab=
le for antibody screening and functional verification, to support the resea=
rch and development of related targeted drugs. Assay Data CTLA-4 homodimer =
structure and purity verified by SELC-MALS SDS-PAGE and SEC-MALS evaluation=
 for structural homogeneity and purity. The purity of Human CTLA-4, His Tag=
 (Cat. No. CT4-H52H9) is more than 90% using SDS-PAGE under reducing and SE=
C-MALS. The molecular weight is 45-60 kDa verified by SEC-MALS. Neutralizin=
g antibody blocking assay Serial dilutions of Ipilimumab neutralizing antib=
ody (1:2 serial dilutions, from 40 =CE=BCg/mL to 0.019 =CE=BCg/mL) were add=
ed into Human B7-1, Fc Tag (Cat. No. B71-H5259): Biotinylated Human CTLA-4,=
 Fc,Avitag (Cat. No. CT4-H82F3) binding reactions. The assay was performed =
according to the above described protocol. Background was subtracted from d=
ata points before curve fitting. Protocol Quantitative Analysis of CTLA-4 x=
 OX40 Bispecific Antibody in Human Serum by Intact Assay Immobilized Human =
OX40 Protein, His Tag (MALS verified) (Cat. No. OX0-H5224) at 2 =CE=BCg/mL,=
 add increasing concentrations of CTLA-4 x OX40 bispecific antibody in 50% =
Human serum and then add Biotinylated Human CTLA-4, His, Avitag (Cat. No. C=
T4-H82E3) at 0.2 =CE=BCg/mL. Detection was performed using HRP-conjugated s=
treptavidin with sensitivity of 4 ng/mL (Intact assay, Routinely tested). P=
rotocol =E2=80=8A =E2=80=8A To receive the latest industry news and updates=
 from ACROBiosystems, =EF=BB=BFvisit our website & follow us on our social =
media!=EF=BB=BF Visit our Website       ACROBiosystems | 1 Innovation Way, =
Newark, DE 19711 Unsubscribe mykhaylo.dubrovka@saraya.co.in Update Profile =
| Our Privacy Policy | Constant Contact Data Notice Sent by acrobio.apac@ou=
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order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Georgia,Times New Roman,Times,serif; c=
olor: #2f3131; font-size: 14px; line-height: 1.2; display: block; word-wrap=
: break-word; padding: 10px 20px 10px 0px;" align=3D"center" valign=3D"top"=
><p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001m8WXW=
FK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBs14QR-L8qXQAyFBH9d-ATD-yqaU5=
2nYKlHdvuWwJgyrw-j7LxVWl5qmD7gsph1VeB-xrgfm4Mv7NE7oizd6O8LxrCIeuN-sLgeXm-gR=
aFRS4Ajv8vkt6D-LF9AbRYIPfaMCVW9pQsVODRyXHfzdzbQBx_8Rdzyn8lM6hSRDNezhneiKJXZ=
gf3wpMliRqrWFOnc9E46PQvBaVtfK0KXYEjSJUHVelPYb83dP_b-KVlBZCRdXZeJP-HUs-tj9zd=
FHnZbdtB3oFJ495ktzJG1Aww4s=3D&c=3D0KBLrftzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM=
7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLc=
bwUA=3D=3D" target=3D"_blank" style=3D"font-size: 13px; color: rgb(255, 255=
, 255); text-decoration: underline; font-family: Arial, Verdana, Helvetica,=
 sans-serif; font-weight: bold; font-style: normal;">About Us</a></p></td> =
</tr> </table> </td> </tr> </table> <table class=3D"layout layout--feature =
layout--1-column" style=3D"background-color: #c03e30; table-layout: fixed;"=
 width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D=
"#c03e30"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: =
100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Georgia,Times New Roman,Times,serif; c=
olor: #2f3131; font-size: 14px; line-height: 1.2; display: block; word-wrap=
: break-word; padding: 10px 20px;" align=3D"center" valign=3D"top"><h1 styl=
e=3D"text-align: center; font-family: Georgia,Times New Roman,Times,serif; =
color: #ffffff; font-size: 24px; font-weight: bold; margin: 0;" align=3D"ce=
nter"><span style=3D"font-size: 18px; color: rgb(255, 255, 255); font-weigh=
t: bold; font-family: Arial, Verdana, Helvetica, sans-serif;">Supporting bi=
specific Checkpoint Inhibitor developmentwith</span></h1></td> </tr> </tabl=
e> </td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"t=
able-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspac=
ing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: =
100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 2; text-align: left; font-family: Georgia,Times New Roman,=
Times,serif; color: #2f3131; font-size: 14px; display: block; word-wrap: br=
eak-word; padding: 10px 20px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif;">With the rise of bispecific drugs, there is a wave of rese=
arch and development of dual-targeted based on</span><a href=3D"https://r20=
.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dB=
s0W2-Esqm7J-9lHdsti9idTR15WKMeJiw1DfaGLpuMQ8A0vHrM7jnBmvzzf0v526qxvQNJNcviV=
wrAZ0RxM4Shzj4X7mOmuJxr2DMUDQTnnTemAKae_-6kRCeM1UevDByap_wgh_XITllTpb1Z_R9Q=
Hh3k4Y8-zAeqr5TIRGwLCkwX5PRJL30v2fcEKmlJToSte1KP353X9eSZt3I69l-bajKxVYfklRS=
4rRFgBQprNFvv2h3hwZ3M5LYS785OP2cI4-rq1w__Ki023QD_xOkgHQRoKjCxrzvg=3D=3D&c=
=3D0KBLrftzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0U=
FKTcwV-XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" target=3D"_blank" s=
tyle=3D"font-family: Arial, Verdana, Helvetica, sans-serif; color: #7CB9C0;=
 font-weight: normal; text-decoration: none; font-style: normal;"> </a><a h=
ref=3D"https://r20.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H9=
8fAvAPed68ZMnTx_dBs0W2-Esqm7J-9lHdsti9idTR15WKMeJiw1DfaGLpuMQ8A0vHrM7jnBmvz=
zf0v526qxvQNJNcviVwrAZ0RxM4Shzj4X7mOmuJxr2DMUDQTnnTemAKae_-6kRCeM1UevDByap_=
wgh_XITllTpb1Z_R9QHh3k4Y8-zAeqr5TIRGwLCkwX5PRJL30v2fcEKmlJToSte1KP353X9eSZt=
3I69l-bajKxVYfklRS4rRFgBQprNFvv2h3hwZ3M5LYS785OP2cI4-rq1w__Ki023QD_xOkgHQRo=
KjCxrzvg=3D=3D&c=3D0KBLrftzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=
=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" t=
arget=3D"_blank" style=3D"font-family: Arial, Verdana, Helvetica, sans-seri=
f; color: rgb(233, 76, 58); font-weight: normal; text-decoration: none; fon=
t-style: normal;">PD-1</a><span style=3D"font-family: Arial, Verdana, Helve=
tica, sans-serif;"> /</span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001m8=
WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBs0aQnoNWvZ_WG8JKQHlKkTGf7=
SKgd1BNXWaoEfCi30nY98ae5jwRtEoluo6RW1_8wQa_f_h_TmZ5GHuJYH7HxB9jzQsP9aqnzM1G=
NaI11cwux2IORnjm1-yhbvLbIj5Cu3lzEEO6NKB9q04v3r3yVMIPkyMzuJQ0u3MYcfswvszzpOS=
akcvHmJV04ehp5dGfn8Br9oX4kfKaUaOvW7D10qIMvMivSrGZYhZVt8mJIXWfgXn4KxLQFwOEsJ=
crq7ivwBZOIScaVm_wyk_7Er_WOt-kqrKi2qYN9Q=3D=3D&c=3D0KBLrftzK3WXlfcCMNWhW9Bz=
D-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3yQ4=
PTSsLu1d4woZjugLcbwUA=3D=3D" target=3D"_blank" style=3D"font-family: Arial,=
 Verdana, Helvetica, sans-serif; color: rgb(233, 76, 58); font-weight: norm=
al; text-decoration: none; font-style: normal;"> PD-L1</a><span style=3D"fo=
nt-family: Arial, Verdana, Helvetica, sans-serif; color: rgb(192, 0, 0);"> =
</span><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif;">=
and </span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV=
3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBsycXXjoqeE4bcvhS-dqO1WE-IIfG7xvPPNkH6yCOpR=
XhOUdGB0iUkBLhMYFhhIPABU6Ni_YIskI4oloH4Y9YhnhJfd8MHSvw6qiKt-cGa2kbpqydndC8m=
CVrD2RzAnerDKgHBgQNn1DmsUCOqvKKb0mAUQ8hgsD8eAdqNk2VmxO2UyYhuuneJzPxV2cAICxw=
vFYCWStiXT8kzB6NF_OXmRsUg3jYvvU8lgR2fekKlLYuwD3ea4r_G7PU8xodtLOvbf09Zf1YkHj=
NWG0u5n72GjRHWuN5AZCmJA=3D=3D&c=3D0KBLrftzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM=
7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLc=
bwUA=3D=3D" target=3D"_blank" style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif; color: rgb(233, 76, 58); font-weight: normal; text-decorati=
on: none; font-style: normal;">CTLA-4</a><span style=3D"font-family: Arial,=
 Verdana, Helvetica, sans-serif;">. </span></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif;">Several researches have showed that anti-CTLA-4 inhibitors=
 increase the expression of PD-L1 in some tumors and the combination of ant=
i-CTLA-4 inhibition and PD-(L)1 inhibition favors effector T cell recruitme=
nt in preclinical tumor models. </span></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif;">At present, there are many bispecific drugs in the clinica=
l validation stage, such as MEDI5752, MGD019, KN046 and AK104. And its indi=
cations also cover a variety of solid tumors. </span></p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif;">Overall, these molecules potential new candidates to simul=
taneously block PD-1/PD-L1 and CTLA-4/B7 immune checkpoints pathway. hence =
mimicking the clinical effect of a dual immune checkpoint blockade.</span><=
/p>
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif;">ACROBiosystems has specially launched a series of PD-(L)1 =
and CTLA-4 homodimer proteins, which are suitable for antibody screening an=
d functional verification, to support the research and development of relat=
ed targeted drugs.</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--he=
ading layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" borde=
r=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column colum=
n--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 center; font-family: Georgia,Times New Roman,Times,serif; color: #767676; =
font-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; p=
adding: 10px 20px;" align=3D"center" valign=3D"top"><h2 style=3D"text-align=
: center; font-family: Arial,Verdana,Helvetica,sans-serif; color: #606d78; =
font-size: 22px; font-weight: bold; margin: 0;" align=3D"center"><span styl=
e=3D"font-weight: bold; font-family: Arial, Verdana, Helvetica, sans-serif;=
 font-size: 16px; color: rgb(47, 47, 47);">Assay Data</span></h2></td> </tr=
> </table> </td> </tr> </table> <table class=3D"layout layout--1-column" st=
yle=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" =
cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D=
"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cen=
ter; margin: 0;" align=3D"center"><span style=3D"color: rgb(204, 53, 54); f=
ont-weight: bold; font-family: Arial, Verdana, Helvetica, sans-serif;">CTLA=
-4 homodimer structure and purity&#xa0;verified by SELC-MALS</span></p></td=
> </tr> </table> <table class=3D"image image--mobile-scale image--mobile-ce=
nter" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr>=
 <td class=3D"image_container" align=3D"center" valign=3D"top"> <a href=3D"=
https://r20.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPe=
d68ZMnTx_dBs2kyYUfVHa-9KsxC1oo4W7QdLBn1VuaPkUpthn0NPZZ_dhT-WNAW89DgCgjtjlJv=
brlrlh44412JYMGz0e-9Uux5qw7GJesk2szzOO_xoC8_dzI93ph1kR9gjbHgH-qhPYgYK28IdqK=
L-B3UROF3g0EEV4SzrCuvOfQHklbYeh8T0xuZVl3Rxj7EX55MZrdf3a2vmAZevZ0HuU2Bi-9HEd=
_bAlUldsd46VGRhCfwliJxR-iq4ty8AZwX4X6CFkT4sEzPjgfaQmN_HQ0MZGaQg7ht1B_h_SkJK=
zY50YBppbiwrdA3I3aIGUaKrH4gjUZSjwXsTEDlW7eOPLtAETe5Z4BQWp0mLlvcwA=3D=3D&c=
=3D0KBLrftzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0U=
FKTcwV-XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" data-trackable=3D"t=
rue"><img data-image-content class=3D"image_content" width=3D"499" src=3D"h=
ttps://files.constantcontact.com/5f3d0cf9401/a0437d55-464f-4ff5-ac07-737398=
9f4df3.png" alt=3D"" style=3D"display: block; height: auto; max-width: 100%=
;"></a> </td> </tr> </table> <table class=3D"text text--padding-vertical" w=
idth=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"tab=
le-layout: fixed;"> <tr> <td class=3D"text_content-cell content-padding-hor=
izontal" style=3D"text-align: left; font-family: Georgia,Times New Roman,Ti=
mes,serif; color: #767676; font-size: 14px; line-height: 1.2; display: bloc=
k; word-wrap: break-word; padding: 10px 20px;" align=3D"left" valign=3D"top=
"><p style=3D"margin: 0;"><span style=3D"font-size: 12px; color: gray; font=
-family: Arial, Verdana, Helvetica, sans-serif; font-style: italic;">SDS-PA=
GE and SEC-MALS evaluation for structural homogeneity and purity. The purit=
y of Human CTLA-4, His Tag (Cat. No. </span><a href=3D"https://r20.rs6.net/=
tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBswjkm53yg=
8du8u5baRBVsxZ3wkpvm_FqxIhvqk2SHrJXtTwvlQn8g_YKXwCoE8uuh73atDv7tnQ5oaja5M8I=
5JuAUx8kjFrRmB4Cl60lfENZtdRRSTtVZvS3_Uh0n6abvM7xiLKB5GR9hFvjwwDCPMf8b7TiB-n=
_vc0eW9fe0Ljjjkcfs_0v5fRtxCv-FHHWt6VzWQHBSYIMazLvqACbA1srXA94S14swLh5ewUqjt=
ZGZl6oGb8TLKRBrji2Ni_cRIpPmypW_LsL1z5Qk3mdBPbmy8JzYRXoCnouDYMFlz5dsFCdXgsed=
n4c_JhIHlz1WqIapVVVRtnr0cylIJSlqah0iQUYtW4x184HVhUi4hPpnfqRlWIIN4E=3D&c=3D0=
KBLrftzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTc=
wV-XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" target=3D"_blank" style=
=3D"font-size: 12px; color: rgb(192, 0, 0); font-family: Arial, Verdana, He=
lvetica, sans-serif; font-style: italic; font-weight: normal; text-decorati=
on: underline;">CT4-H52H9</a><span style=3D"font-size: 12px; color: gray; f=
ont-family: Arial, Verdana, Helvetica, sans-serif; font-style: italic;">) i=
s more than 90% using SDS-PAGE under reducing and SEC-MALS. The molecular w=
eight is 45-60 kDa verified by SEC-MALS.</span></p></td> </tr> </table> </t=
d> </tr> </table> <table class=3D"layout layout--1-column" style=3D"table-l=
ayout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D=
"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;"=
 align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cen=
ter; margin: 0;" align=3D"center"><span style=3D"color: rgb(204, 53, 54); f=
ont-weight: bold; font-family: Arial, Verdana, Helvetica, sans-serif;">Neut=
ralizing antibody blocking assay</span></p></td> </tr> </table> <table clas=
s=3D"image image--padding-vertical image--mobile-scale image--mobile-center=
" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td=
 class=3D"image_container content-padding-horizontal" align=3D"center" vali=
gn=3D"top" style=3D"padding: 10px 20px;"> <a href=3D"https://r20.rs6.net/tn=
.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBs2kyYUfVHa-=
9jaTiDN3v4ZTVEAHqhCt2aELxkBJRJJ4PFiccly5WExdAUZz8vD0PG4vcCKiIGOxmD7M9kLNOps=
PwQnxqQh2mql1HutmZQLD-0ZAZi5algJD64L2N3qUifnixwAEKxDkAlfFuDS8DhslDowl2UGz_C=
NRkfvvteKW5a4ICow1GrwAHqVydBhz095n_8iJi0u4U-XZ8aGpfaQbPH-NtTZ8vY-8sOXYsP7w6=
rnLSfQ_-FARAepQtkeCdD5x8MAmy1o3_SHRL_8tAF_8tneqr9M-QDsKW7hwelNKVijM-D57P0a3=
qGtj-kMZOJJX_DbDSks5i7r1QqL19Ollz-Su-VxT6-Q=3D=3D&c=3D0KBLrftzK3WXlfcCMNWhW=
9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3=
yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" data-trackable=3D"true"><img data-image-con=
tent class=3D"image_content" width=3D"411" src=3D"https://files.constantcon=
tact.com/5f3d0cf9401/fa2e7d2a-c1a7-45fd-8eb0-9bd8b9dbc436.jpg" alt=3D"" sty=
le=3D"display: block; height: auto; max-width: 100%;"></a> </td> </tr> </ta=
ble> </td> </tr> </table> <table class=3D"layout layout--1-column" style=3D=
"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellsp=
acing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width=
: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><sp=
an style=3D"font-size: 12px; color: gray; font-family: Arial, Verdana, Helv=
etica, sans-serif; font-style: italic;">Serial dilutions of Ipilimumab neut=
ralizing antibody (1:2 serial dilutions, from 40 &#x3bc;g/mL to 0.019 &#x3b=
c;g/mL) were added into Human B7-1, Fc Tag (Cat. No.</span><a href=3D"https=
://r20.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZM=
nTx_dBs6D1KPyK-4Pe6HsB32HmN9ZrVLwBOVVU1qLW_Zwj_Zoq3bZPQh5FSobQQX6iAtlAcZeL1=
6u7nB43cYsjIlVhijolomg2EIckCkruQaXHBXCqOzFf0Ya0bAZw9QsIgSQbm13HB7NE_SDTgx5X=
8hKKSY36LbCp9kGkzWxICQmfJE_NFDynML7ycseXzuf0G7SMWF7HgcCerWtnenK7NK9Agk18yns=
eA1Y1-4nilBMUzGZhc1_HD-XaX2KHxfMEugrtuIhGs0sWT6DlHL3PLfnS1oDOdjv8PXWArOqnWm=
_1qnfiKWYAnVQqN-HartgJLcRDGx9t_RSpJC7Bjdt3X1VjK9D2yUnC8R8aPw=3D=3D&c=3D0KBL=
rftzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-=
XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" target=3D"_blank" style=3D=
"font-size: 12px; font-family: Arial, Verdana, Helvetica, sans-serif; font-=
style: italic; color: #c03e30; font-weight: normal; text-decoration: underl=
ine;"> B71-H5259)</a><span style=3D"font-size: 12px; color: gray; font-fami=
ly: Arial, Verdana, Helvetica, sans-serif; font-style: italic;">: Biotinyla=
ted Human CTLA-4, Fc,Avitag (Cat. No. </span><a href=3D"https://r20.rs6.net=
/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBszmRj3Km=
I5vrRyzMPxUjSX0dGyxY8uiKAkoTIy54uVz7HT4Af5juEfieG-cD7nreXy1CfiyGG7GspXzT-8x=
x8gb0oYAH44En1zpmosnHuBMtXx8tdB7W3Ip6eTaCQslj5tnjirYTeoOAO6NwrUq3z__BX9vtYE=
vOuzNyc02Q7G7vMobmrGCG47WQzcLcgHSyX0QTHhsoS-Rqj-6yDmQuBDEnk99xroZtfZfTYgMBq=
vQukAp9BCyd08-L1PQh9tilc159FfBYh1C8wpn9DTkWlnuDBlVBJNnXlfK9jf73fUQ1s5EuBZ4U=
EV9PBjqpIuC73KC3dc97GYjViuGloQ7tnaQyYeWY0vpFfmaBR0CG7ZpT&c=3D0KBLrftzK3WXlf=
cCMNWhW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd2=
6HNzZx3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" target=3D"_blank" style=3D"font-size=
: 12px; color: rgb(192, 0, 0); font-family: Arial, Verdana, Helvetica, sans=
-serif; font-style: italic; font-weight: normal; text-decoration: underline=
;">CT4-H82F3</a><span style=3D"font-size: 12px; color: gray; font-family: A=
rial, Verdana, Helvetica, sans-serif; font-style: italic;">) binding reacti=
ons. The assay was performed according to the above described protocol. Bac=
kground was subtracted from data points before curve fitting.</span></p></t=
d> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-col=
umn" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=
=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" s=
tyle=3D"width: 100%;" align=3D"center" valign=3D"top"> <table class=3D"butt=
on button--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" =
cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"button_=
container content-padding-horizontal" align=3D"center" style=3D"padding: 10=
px 20px;">    <table class=3D"button_content-row" style=3D"width: inherit; =
border-radius: 5px; border-spacing: 0; background-color: #c03e30; border: n=
one;" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#c03e30">=
 <tr> <td class=3D"button_content-cell" style=3D"padding: 10px 40px;" align=
=3D"center"> <a class=3D"button_link" href=3D"https://r20.rs6.net/tn.jsp?f=
=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBs32QUFS53eXg8USHF=
izLgc6VEczuz7bYyThx3s8FhXKEkz0XA5YpYyEi43R88v6Io14SiqcVNWman0W5ToP9eWy0s5Qi=
WI32Uafh6cKBl2b1JF5LPC3EqZtZ8-qRfz6r22kBjlvCzvoG5Ctotn1Pp_ncwCXoDUbome6S7OP=
kjjNTskiNuOKFUE4YUS4sI4ZWLFVlH196QnPBeMjCIpbT-2RPs5EfYfmbviDuW_K8FCgHAYCLaA=
PuBepdj1RvBKe6PnWKmy4cpx6p_Kwhh1HaZLHeXZ2roTMBRyCqLChkclbXtBdpCA7Q02jf_B8Ih=
x5PEQQdAnaPe2jc&c=3D0KBLrftzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=
=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" d=
ata-trackable=3D"true" style=3D"font-family: Arial,Verdana,Helvetica,sans-s=
erif; color: #FFFFFF; font-size: 14px; word-wrap: break-word; font-weight: =
bold; text-decoration: none;">Protocol</a> </td> </tr> </table>    </td> </=
tr> </table>   </td> </tr> </table> <table class=3D"layout layout--1-column=
" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" styl=
e=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cen=
ter; margin: 0;" align=3D"center"><span style=3D"color: rgb(204, 53, 54); f=
ont-weight: bold; font-family: Arial, Verdana, Helvetica, sans-serif;">Quan=
titative Analysis of CTLA-4 x OX40 Bispecific Antibody in Human Serum by In=
tact Assay</span></p></td> </tr> </table> </td> </tr> </table> <table class=
=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" =
border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column =
column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"to=
p">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 20px;"> <a href=3D"https://r20=
.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dB=
s2kyYUfVHa-9R2W7lQxM3YUh_SNMhRsq3Do7oTOXenB-55GybdSqkH0SA_TIQF4i0vdPMwXM_PO=
JCu4qr-Pc5DG2k-GgMkuxG7rV7VetASv-2UGJySKPFa-A7q6o_RgasPAqGlInDdQ7gtl6FqPq1E=
WrCp2L_jZn-UUKfUCXKOXtNOspzibOK1-hqt1WjxEgulAf-ezx4_JW9i6Q5Ujq6l0zeZQjFxSmA=
WRykcOE1RtUXYLvCaDX91Lm_CvQDjown_mFd9L7pbvuZY9RYpulFIfdUApkoeUXr2kR35Pl1JdJ=
Z5E5lsEu3QEvTeZmZX7BEQiK5h0TB1tSeFI8d81qRuLdlWzJtfY74z8OidUUAX5u&c=3D0KBLrf=
tzK3WXlfcCMNWhW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XK=
v11Izfd26HNzZx3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" data-trackable=3D"true"><img=
 data-image-content class=3D"image_content" width=3D"434" src=3D"https://fi=
les.constantcontact.com/5f3d0cf9401/2885b5f2-adcb-4cb1-bc21-4d5d67ad4609.jp=
g" alt=3D"" style=3D"display: block; height: auto; max-width: 100%;"></a> <=
/td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-c=
olumn" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpaddi=
ng=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack"=
 style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"margin: 0;"><sp=
an style=3D"color: gray; font-size: 12px; font-family: Arial, Verdana, Helv=
etica, sans-serif; font-style: italic;">Immobilized Human OX40 Protein, His=
 Tag (MALS verified) (Cat. No.</span><a href=3D"https://r20.rs6.net/tn.jsp?=
f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBsycXXjoqeE4bfRzN=
p0rtKWW9J_RNwvSAiN_gD5S9qsnsWsL5F73rs5TsPhU8vdRd6t-ARaJLKaTjx2hdW1w137Nu3Sn=
_ZfiUY7MIq6U_WznXPcaQPKobKqCgsSMt4J7lZiaSry6coLEk9MeLZKGT5y8Vn42_4O1wY706u4=
G4TbEUK3QmqRPmNSO9gVTXsvpTU8nB5lESLAnXW1FEGKYxpTGv86Kc3-lj8vtLEuHqj9jVITOPi=
3KlNRxcgWCwzIMZbaLobhBaZfOgkbMnpsn5MbsK6cLsSm4TbXUJIuChvuL4EN5zR2KLtgFyGFqH=
CUL3CfOZJHdZgv5n5ItoAf0CAGo40WUzrSc9TBCqYGnBzDFm&c=3D0KBLrftzK3WXlfcCMNWhW9=
BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3y=
Q4PTSsLu1d4woZjugLcbwUA=3D=3D" target=3D"_blank" style=3D"color: rgb(192, 6=
2, 48); font-size: 12px; font-family: Arial, Verdana, Helvetica, sans-serif=
; font-style: italic; font-weight: normal; text-decoration: underline;">&#x=
a0;OX0-H5224</a><span style=3D"color: gray; font-size: 12px; font-family: A=
rial, Verdana, Helvetica, sans-serif; font-style: italic;">) at 2 &#x3bc;g/=
mL, add increasing concentrations of CTLA-4 x OX40 bispecific antibody in 5=
0% Human serum and then add Biotinylated Human CTLA-4, His, Avitag (Cat. No=
.&#xa0;</span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXS=
tnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dBszmRj3KmI5vrbhfnbMXS4uchiFlPnsHKn-LdkdL=
SXbpgkx1RJNz8zFjferfyXgUrL8MJyfRFU-dRmC-ObCAw7ZV_4N-n6UtGeoxHjf3Ltr367hUqjL=
tiPp9mKTiKp3Klr-HaCafZbf28scDKLP17MBD0uKUa4lKvvKRPolIr2pi771tXmGfDyx8oFkrhK=
_MI6TLUTW6X8-qptTcdtbxI3Mm2dFC0MP-ygg=3D=3D&c=3D0KBLrftzK3WXlfcCMNWhW9BzD-R=
BlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3yQ4PTS=
sLu1d4woZjugLcbwUA=3D=3D" target=3D"_blank" style=3D"color: gray; font-size=
: 12px; text-decoration: none; font-family: Arial, Verdana, Helvetica, sans=
-serif; font-style: italic; font-weight: normal;">CT4-H82E3</a><span style=
=3D"color: gray; font-size: 12px; font-family: Arial, Verdana, Helvetica, s=
ans-serif; font-style: italic;">) at 0.2 &#x3bc;g/mL. Detection was perform=
ed using HRP-conjugated streptavidin with sensitivity of 4 ng/mL (Intact as=
say, Routinely tested).</span></p></td> </tr> </table> </td> </tr> </table>=
 <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;" wi=
dth=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td cla=
ss=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center"=
 valign=3D"top"> <table class=3D"button button--padding-vertical" width=3D"=
100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layou=
t: fixed;"> <tr> <td class=3D"button_container content-padding-horizontal" =
align=3D"center" style=3D"padding: 10px 20px;">    <table class=3D"button_c=
ontent-row" style=3D"width: inherit; border-radius: 5px; border-spacing: 0;=
 background-color: #c03e30; border: none;" border=3D"0" cellpadding=3D"0" c=
ellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"button_content-cell=
" style=3D"padding: 10px 40px;" align=3D"center"> <a class=3D"button_link" =
href=3D"https://r20.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H=
98fAvAPed68ZMnTx_dBs32QUFS53eXg8USHFizLgc6VEczuz7bYyThx3s8FhXKEkz0XA5YpYyEi=
43R88v6Io14SiqcVNWman0W5ToP9eWy0s5QiWI32Uafh6cKBl2b1JF5LPC3EqZtZ8-qRfz6r22k=
BjlvCzvoG5Ctotn1Pp_ncwCXoDUbome6S7OPkjjNTskiNuOKFUE4YUS4sI4ZWLFVlH196QnPBeM=
jCIpbT-2RPs5EfYfmbviDuW_K8FCgHAYCLaAPuBepdj1RvBKe6PnWKmy4cpx6p_Kwhh1HaZLHeX=
Z2roTMBRyCqLChkclbXtBdpCA7Q02jQSoWyq5fyd6DTmoL_JK4v&c=3D0KBLrftzK3WXlfcCMNW=
hW9BzD-RBlEwdK3qIhcKIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZ=
x3yQ4PTSsLu1d4woZjugLcbwUA=3D=3D" data-trackable=3D"true" style=3D"font-fam=
ily: Arial,Verdana,Helvetica,sans-serif; color: #FFFFFF; font-size: 14px; w=
ord-wrap: break-word; font-weight: bold; text-decoration: none;">Protocol</=
a> </td> </tr> </table>    </td> </tr> </table>   </td> </tr> </table> <tab=
le class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=
=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center" v=
align=3D"top">
<table class=3D"divider divider--dashed" width=3D"100%" cellpadding=3D"0" c=
ellspacing=3D"0" border=3D"0"> <tr> <td class=3D"divider_container content-=
padding-horizontal" style=3D"padding: 10px 20px;" width=3D"100%" align=3D"c=
enter" valign=3D"top"> <table class=3D"divider_content-row" style=3D"height=
: 1px; width: 100%;" cellpadding=3D"0" cellspacing=3D"0" border=3D"0"> <tr>=
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px; border-bottom-style: dashed; border-bottom-color: #555556;" height=3D"1=
" align=3D"center" bgcolor=3D"transparent"> <img alt=3D"" width=3D"5" heigh=
t=3D"1" border=3D"0" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.consta=
ntcontact.com/letters/images/1101116784221/S.gif" style=3D"display: block; =
height: 1px; width: 5px;"> </td> </tr> </table> </td> </tr> </table> </td> =
</tr> </table> <table class=3D"layout layout--1-column" style=3D"table-layo=
ut: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"=
> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" al=
ign=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 20px;"> <a href=3D"https://r20=
.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dB=
szJQbUDxOd6VejN99M87n4LvuBXrBXlDFbiP0KsZHjYiAO_MRwtkdlG6y2GCuCboPm31KI0CyhR=
yYGIEeagN9cSVfPB0tO8sJRdTfo6zKxf6-wgNnFxLVSrYieaCisiXowSvvBvhJReay2Rym_TaWF=
tPAFu-j7dYteGhDq5RaUjL2WyzxxoxZiJRtZPrWmWBI0tWMXyFoNdfMXjpszC9mMtn0BIgNhQnn=
2dcRpiW1j_G9sDm2jSccBgXiNZGDa3oRNGYFDNY0d8wxMf6FN17sBQNvsrEbzPhjqFcmDD7PZGw=
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KIM7Sf9vvmqrggTQ=3D=3D&ch=3DL1mo0UFKTcwV-XKv11Izfd26HNzZx3yQ4PTSsLu1d4woZju=
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ock; height: auto; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> =
</table> <table class=3D"layout layout--1-column" style=3D"table-layout: fi=
xed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr>=
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"center" valign=3D"top"><div class=3D"spacer" style=3D"line-height: 15px; h=
eight: 15px;">&#x200a;</div></td> </tr> </table> <table class=3D"layout lay=
out--1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" c=
ellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scal=
e stack" style=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=
=3D"spacer" style=3D"line-height: 10px; height: 10px;">&#x200a;</div></td> =
</tr> </table> <table class=3D"layout layout--1-column" style=3D"table-layo=
ut: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"=
> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" al=
ign=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 20px;"> <a href=3D"https://r20=
.rs6.net/tn.jsp?f=3D001m8WXWFK57eL2WyXStnV3LZrnyIT7vd51H98fAvAPed68ZMnTx_dB=
s1WHOBvp0gBDpXXN3QkWNxI_9vheX5aX8FT4EwetAZq3_6_2wqZmhTMRLbTrmPLpaU6wCMBBEhK=
hrX6auyAmhzrPAfXHBjS22AZZwYxXyGzm-MgqFJMa_PI4RBWpOmefeAzyhtDMbJeVoRAGdJAD6v=
tF_rJhpcaTG38QOopsJlyNgVwfK-vRb_POp8mJxw27DxGnV06zycow0_1Hv0BZXtWvMyXtH-K3X=
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