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Envelope-to: mykhaylo.dubrovka@saraya.co.in
Delivery-date: Thu, 29 Dec 2022 13:45:52 +0800
Message-ID: <1139709913381.1119371711477.1404958413.0.500041JL.2002@scheduler.constantcontact.com>
Date: Thu, 29 Dec 2022 00:45:05 -0500 (EST)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
Subject: Anti-MMAE Antibodies for PK/PD Studies on ADCs
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View as Webpage Anti-MMAE Antibodies for PK/PD Studies on ADCs Given the co=
mplex structure of ADCs, which contain both large and small molecule compon=
ents, and the mixture of various DAR species in the dosing solution, the PK=
 of ADCs are expected to be complex, at least three different analytes are =
commonly required to characterize the PK properties of an ADC: antibody-dru=
g conjugated, total antibody, and unconjugated payload. Pharmacokinetic (PK=
) study is necessary for drug discovery and development process to help und=
erstand and predict the behavior of drugs and to link with the pharmacodyna=
mics or toxicological effects of drugs. Due to highly cytotoxic characteris=
tics, PK studies of the payloads used for ADCs are important in understandi=
ng the behavior of the payloads. =E2=80=8A ACROBiosystems has recently laun=
ched a serial of anti-MMAE antibodies with high affinity and specificity th=
at are designed for use in an ELISA environment, and can be applied in PK/P=
D studies of MMAE-ADCs, thereby greatly saving the time and costs. Related =
Products High-quality ADC target proteins =E2=80=8A Learn more Proteases fo=
r peptide linker Learn more ADC site-specific conjugation kits =E2=80=8A Le=
arn more >>>Click to learn more about ADCs related products and validation =
data Products Support Resources Insights About Us To receive the latest ind=
ustry news and updates from ACROBiosystems, =EF=BB=BFvisit our website & fo=
llow us on our social media!=EF=BB=BF Visit our Website       ACROBiosystem=
s | 1 Innovation Way, Newark, DE 19711 Unsubscribe mykhaylo.dubrovka@saraya=
.co.in Update Profile | Our Privacy Policy | Constant Contact Data Notice S=
ent by acrobio.apac@outlook.com
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/td> </tr> </table> <table class=3D"layout layout--feature layout--1-column=
" style=3D"background-color: #c03e30; table-layout: fixed;" width=3D"100%" =
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<td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"=
center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Georgia,Times New Roman,Times,serif; c=
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: break-word; padding: 10px 20px;" align=3D"center" valign=3D"top"><p style=
=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D"font-si=
ze: 18px; font-weight: bold; font-family: Arial, Verdana, Helvetica, sans-s=
erif; color: rgb(255, 255, 255);">Anti-MMAE Antibodies for PK/PD Studies on=
 ADCs</span></p></td> </tr> </table> </td> </tr> </table> <table class=3D"l=
ayout layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" borde=
r=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column colum=
n--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container" align=3D"center" valign=3D"top"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001aN26btIYZKVMeMrlw5caWwMZNYy8yv4hJRlN85K-5dMboa5JQ1tbyoPLE_=
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eight: auto; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </tabl=
e> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;" =
width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td c=
lass=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"cente=
r" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Georgia,Times New Roma=
n,Times,serif; color: #2f3131; font-size: 14px; display: block; word-wrap: =
break-word; padding: 10px 20px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helveti=
ca, sans-serif; color: rgb(0, 0, 0); font-weight: normal; font-size: 15px;"=
>G</span><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif;=
 color: rgb(0, 0, 0);">iven the complex structure of ADCs, which contain bo=
th large and small molecule components, and the mixture of various DAR spec=
ies in the dosing solution, the PK of ADCs are expected to be complex, at l=
east three different analytes are commonly required to characterize the PK =
properties of an ADC: antibody-drug conjugated, total antibody, and unconju=
gated payload. Pharmacokinetic (PK) study is necessary for drug discovery a=
nd development process to help understand and predict the behavior of drugs=
 and to link with the pharmacodynamics or toxicological effects of drugs.</=
span></p>
<p style=3D"text-align: justify; margin: 0;" align=3D"justify"><span style=
=3D"font-family: Arial, Verdana, Helvetica, sans-serif; color: rgb(0, 0, 0)=
;">Due to highly cytotoxic characteristics, PK studies of the payloads used=
 for ADCs are important in understanding the behavior of the payloads.</spa=
n></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D"spac=
er" style=3D"line-height: 10px; height: 10px;">&#x200a;</div></td> </tr> </=
table> <table class=3D"layout layout--2-column" style=3D"table-layout: fixe=
d;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <=
td class=3D"column column--1 scale stack" style=3D"width: 40%;" align=3D"ce=
nter" valign=3D"top">
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bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container" align=3D"center" valign=3D"top" style=
=3D"padding-top: 10px; padding-bottom: 10px;"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001aN26btIYZKVMeMrlw5caWwMZNYy8yv4hJRlN85K-5dMboa5JQ1tbyrsK_w=
-GqmkVlrdhxs7esvqmjqDjzWXr5X3sfs42nVFOigDNWqMdfAwAPAJD43cLAYZ0iTIrPHDyOllIG=
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9UH9IgElrlMKbDxjeVKfZ_xpGo-VPOf9lX3SLQoujoNDgY7y0y_M2R-VsA2aR9kl1X_LA2Ah--P=
uQsVBLnCRnwdsVsDkyU3Wp1X-fz79Dj9g-ZFLJ4F39FiklUzItS1oYzAjQh31lIp0-OIFdIGO_M=
YhY5e0eLNvTtwP1sK0viM27UYHebe45ZkWo2ZPv0FAeFP5uas64_mg7Z2M&c=3DMfwUQVzddCzi=
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n5XTj7tVbY2g20LBc3RHXhg58dyNRh4bg=3D=3D" data-trackable=3D"true"><img data-=
image-content class=3D"image_content" width=3D"154" src=3D"https://files.co=
nstantcontact.com/5f3d0cf9401/39e67d1c-73a3-42f2-85f1-a3e69331c4da.jpg" alt=
=3D"" style=3D"display: block; height: auto; max-width: 100%;"></a> </td> <=
/tr> </table> </td>  <td class=3D"column column--2 scale stack" style=3D"wi=
dth: 60%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: left; font-family: Georgia,Times New Roman,Times,serif; =
color: #767676; font-size: 14px; display: block; word-wrap: break-word; pad=
ding: 10px 20px 10px 10px;" align=3D"left" valign=3D"top"><p style=3D"margi=
n: 0;"><span style=3D"font-size: 15px; color: rgb(0, 0, 0); font-family: Ar=
ial, Verdana, Helvetica, sans-serif;">A</span><span style=3D"color: rgb(0, =
0, 0); font-family: Arial, Verdana, Helvetica, sans-serif;">CROBiosystems h=
as recently launched a serial of</span><span style=3D"color: rgb(233, 76, 5=
8); font-family: Arial, Verdana, Helvetica, sans-serif;"> </span><a href=3D=
"https://r20.rs6.net/tn.jsp?f=3D001aN26btIYZKVMeMrlw5caWwMZNYy8yv4hJRlN85K-=
5dMboa5JQ1tbyrsK_w-GqmkVlrdhxs7esvqmjqDjzWXr5X3sfs42nVFOigDNWqMdfAwAPAJD43c=
LAYZ0iTIrPHDyOllIGDASXGpFtoPbVoksTx-JllYm4Kx7zEkT0fBlaASmKXlqJadB_eZvnL5ACN=
eus19MvK0pTRXnge879UH9IgElrlMKbDxjeVKfZ_xpGo-VPOf9lX3SLQoujoNDgY7y0y_M2R-Vs=
A2aR9kl1X_LA2Ah--PuQsVBLnCRnwdsVsDkyU3Wp1X-fz79Dj9g-ZFLJ4F39FiklUzItS1oYzAj=
Qh31lIp0-OIFdIGO_MYhY5e0eLNvTtwP1sK0viM27UYHebe45ZkWo2ZPv0FAeFP5uas64_mg7Z2=
M&c=3DMfwUQVzddCziNCk6P-VVj7m7HM3x1LpQLiJapdiQ4JPlKM47PuucLA=3D=3D&ch=3Ddhm=
u6aGKE905at1FPxpyZn5XTj7tVbY2g20LBc3RHXhg58dyNRh4bg=3D=3D" target=3D"_blank=
" style=3D"color: rgb(233, 76, 58); font-family: Arial, Verdana, Helvetica,=
 sans-serif; text-decoration: underline; font-weight: bold; font-style: nor=
mal;">anti-MMAE antibodies</a><span style=3D"color: rgb(233, 76, 58); font-=
family: Arial, Verdana, Helvetica, sans-serif;"> </span><span style=3D"colo=
r: rgb(0, 0, 0); font-family: Arial, Verdana, Helvetica, sans-serif;">with =
high affinity and specificity that are designed for use in an ELISA environ=
ment, and can be applied in PK/PD studies of MMAE-ADCs, thereby greatly sav=
ing the time and costs.</span></p></td> </tr> </table> </td> </tr> </table>=
 <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;" wi=
dth=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td cla=
ss=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"center"=
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<table class=3D"divider divider--dashed" width=3D"100%" cellpadding=3D"0" c=
ellspacing=3D"0" border=3D"0"> <tr> <td class=3D"divider_container content-=
padding-horizontal" style=3D"padding: 10px 20px;" width=3D"100%" align=3D"c=
enter" valign=3D"top"> <table class=3D"divider_content-row" style=3D"height=
: 1px; width: 100%;" cellpadding=3D"0" cellspacing=3D"0" border=3D"0"> <tr>=
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px; border-bottom-style: dashed; border-bottom-color: #555556;" height=3D"1=
" align=3D"center" bgcolor=3D"transparent"> <img alt=3D"" width=3D"5" heigh=
t=3D"1" border=3D"0" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.consta=
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height: 1px; width: 5px;"> </td> </tr> </table> </td> </tr> </table> </td> =
</tr> </table> <table class=3D"layout layout--1-column" style=3D"table-layo=
ut: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"=
> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" al=
ign=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-align: cen=
ter; margin: 0;" align=3D"center"><span style=3D"font-weight: bold; font-si=
ze: 16px; color: rgb(3, 3, 3);">Related Products</span></p></td> </tr> </ta=
ble> </td> </tr> </table> <table class=3D"layout layout--3-column" style=3D=
"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellsp=
acing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width=
: 33.333333333333336%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 0px 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-a=
lign: center; margin: 0;" align=3D"center"><a href=3D"https://r20.rs6.net/t=
n.jsp?f=3D001aN26btIYZKVMeMrlw5caWwMZNYy8yv4hJRlN85K-5dMboa5JQ1tbyoPLE_4Nvf=
lwsiCq6gZmB2He92CRzY9yehLzvNxbLH13Lt5LeAs018WfYbElgdkEptA2VCEqO4-z0sKBGoEty=
zArwvM6s4f3K2KD5sApCckxqGBUi-fp5e2NW1HEQ4QLHN5yuzvj2zyA3dUGqhXUnNK4ZwqXn17q=
UEG67QMzorcfmjetP_F8ktKTYz79G_on2xgTsTbKFIYfnqnYzoLZd3jNBC2k48c61sDzC9AEsan=
PiCg1J6Qj6-fNaqzw8V85uuR-tKj6QjBdgPeTUPdGRS4zNNkve0KPpd7ch8QuRxr8ip6sCdUHHE=
fzVkj3HZt5X0-2QKQvYzig&c=3DMfwUQVzddCziNCk6P-VVj7m7HM3x1LpQLiJapdiQ4JPlKM47=
PuucLA=3D=3D&ch=3Ddhmu6aGKE905at1FPxpyZn5XTj7tVbY2g20LBc3RHXhg58dyNRh4bg=3D=
=3D" target=3D"_blank" style=3D"font-family: Arial, Verdana, Helvetica, san=
s-serif; color: rgb(47, 47, 47); font-weight: normal; text-decoration: unde=
rline; font-style: normal;">  High-quality ADC target proteins</a></p></td>=
 </tr> </table> <table class=3D"image image--padding-vertical image--mobile=
-scale image--mobile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" =
cellspacing=3D"0"> <tr> <td class=3D"image_container" align=3D"center" vali=
gn=3D"top" style=3D"padding-top: 10px; padding-bottom: 10px;"> <a href=3D"h=
ttps://r20.rs6.net/tn.jsp?f=3D001aN26btIYZKVMeMrlw5caWwMZNYy8yv4hJRlN85K-5d=
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c3RHXhg58dyNRh4bg=3D=3D" data-trackable=3D"true"><img data-image-content cl=
ass=3D"image_content" width=3D"185" src=3D"https://files.constantcontact.co=
m/5f3d0cf9401/69d7163a-cf16-44de-8fd0-c4747af8c45c.png" alt=3D"" style=3D"d=
isplay: block; height: auto; max-width: 100%;"></a> </td> </tr> </table> <d=
iv class=3D"spacer" style=3D"line-height: 22px; height: 22px;">&#x200a;</di=
v>
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 0px 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"text-a=
lign: center; margin: 0;" align=3D"center"><a href=3D"https://r20.rs6.net/t=
n.jsp?f=3D001aN26btIYZKVMeMrlw5caWwMZNYy8yv4hJRlN85K-5dMboa5JQ1tbyoPLE_4Nvf=
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fzVkj3HZt5X0-2QKQvYzig&c=3DMfwUQVzddCziNCk6P-VVj7m7HM3x1LpQLiJapdiQ4JPlKM47=
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=3D" target=3D"_blank" style=3D"font-family: Arial, Verdana, Helvetica, san=
s-serif; color: rgb(233, 76, 58); font-weight: normal; text-decoration: und=
erline; font-style: normal;">Learn more</a></p></td> </tr> </table> </td>  =
<td class=3D"column column--2 scale stack" style=3D"width: 31.6666666666666=
68%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px;" align=3D"left" valign=3D"top"><p style=3D"text-align: center; =
margin: 0;" align=3D"center"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001a=
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92CRzY9yehLzvNxbLH13Lt5LeAs018WfYbElgdkEptA2VCEqO4-z0sKBGoEtyzArwvM6s4f3K2K=
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etP_F8ktKTYz79G_on2xgTsTbKFIYfnqnYzoLZd3jNBC2k48c61sDzC9AEsanPiCg1J6Qj6-fNa=
qzw8V85uuR-tKj6QjBdgPeTUPdGRS4zNNkve0KPpd7ch8QuRxr8ip6sCdUHHEfzVkj3HZt5X5F2=
nH4p5Mmn&c=3DMfwUQVzddCziNCk6P-VVj7m7HM3x1LpQLiJapdiQ4JPlKM47PuucLA=3D=3D&c=
h=3Ddhmu6aGKE905at1FPxpyZn5XTj7tVbY2g20LBc3RHXhg58dyNRh4bg=3D=3D" target=3D=
"_blank" style=3D"font-family: Arial, Verdana, Helvetica, sans-serif; color=
: rgb(47, 47, 47); font-weight: normal; text-decoration: underline; font-st=
yle: normal;">  Proteases for peptide linker</a></p></td> </tr> </table> <t=
able class=3D"image image--padding-vertical image--mobile-scale image--mobi=
le-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0">=
 <tr> <td class=3D"image_container content-padding-horizontal" align=3D"cen=
ter" valign=3D"top" style=3D"padding: 10px;"> <a href=3D"https://r20.rs6.ne=
t/tn.jsp?f=3D001aN26btIYZKVMeMrlw5caWwMZNYy8yv4hJRlN85K-5dMboa5JQ1tbyoPLE_4=
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=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"image_cont=
ent" width=3D"170" src=3D"https://files.constantcontact.com/5f3d0cf9401/fae=
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ight: auto; max-width: 100%;"></a> </td> </tr> </table> <table class=3D"tex=
t text--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cel=
lspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_conte=
nt-cell content-padding-horizontal" style=3D"text-align: left; font-family:=
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=3D"left" valign=3D"top"><p style=3D"text-align: center; margin: 0;" align=
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caWwMZNYy8yv4hJRlN85K-5dMboa5JQ1tbyoPLE_4NvflwsiCq6gZmB2He92CRzY9yehLzvNxbL=
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QVzddCziNCk6P-VVj7m7HM3x1LpQLiJapdiQ4JPlKM47PuucLA=3D=3D&ch=3Ddhmu6aGKE905a=
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"font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: normal; c=
olor: rgb(233, 76, 58); text-decoration: underline; font-style: normal;">Le=
arn more</a></p></td> </tr> </table> </td>  <td class=3D"column column--3 s=
cale stack" style=3D"width: 35%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px 10px 0px;" align=3D"left" valign=3D"top"><p style=3D"text-a=
lign: center; margin: 0;" align=3D"center"><a href=3D"https://r20.rs6.net/t=
n.jsp?f=3D001aN26btIYZKVMeMrlw5caWwMZNYy8yv4hJRlN85K-5dMboa5JQ1tbyoPLE_4Nvf=
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fzVkj3HZt5X9wMekIifS3v&c=3DMfwUQVzddCziNCk6P-VVj7m7HM3x1LpQLiJapdiQ4JPlKM47=
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s-serif; color: rgb(47, 47, 47); font-weight: normal; text-decoration: unde=
rline; font-style: normal;">  ADC site-specific conjugation kits</a></p></t=
d> </tr> </table> <table class=3D"image image--mobile-scale image--mobile-c=
enter" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr=
> <td class=3D"image_container" align=3D"center" valign=3D"top"> <a href=3D=
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"display: block; height: auto; max-width: 100%;"></a> </td> </tr> </table> =
<div class=3D"spacer" style=3D"line-height: 10px; height: 10px;">&#x200a;</=
div>
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llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px 10px 0px;" align=3D"left" valign=3D"top"><p style=3D"text-a=
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