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Envelope-to: mykhaylo.dubrovka@saraya.co.in
Delivery-date: Thu, 15 Dec 2022 15:36:19 +0800
Message-ID: <1139646211807.1119371711477.1404958413.0.450232JL.2002@scheduler.constantcontact.com>
Date: Thu, 15 Dec 2022 02:35:23 -0500 (EST)
From: ACROBiosystems <acrobio.apac@outlook.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
Subject: Large-scale Characterization of Drug Candidates Against
 Transmembrane Receptors using HT-SPR
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View as Webpage Products Support Resources Insights About Us =E2=80=8A Larg=
e-scale Characterization of Drug Candidates Against Transmembrane Receptors=
 using HT-SPR We know that membrane protein, a class of proteins that are e=
mbedded in the phospholipid bilayer of cell membranes to enable extracellul=
ar and intracellular spanning, occupies a place in the field of 'non-pharma=
cological' therapeutics. Many human diseases may be associated with abnorma=
l receptor function, and the multifunctional nature of receptors makes them=
 ideal targets for drug action. However, multi-pass receptors are structura=
lly complex and often expressed at extremely low levels in the host cell. T=
he use of high-quality, full-length transmembrane receptors is therefore es=
sential for the accurate characterization of drug candidates. High-throughp=
ut surface plasmon resonance (HT-SPR) is a powerful technique that is trans=
forming the characterization workflow, enabling greater breadth and depth o=
f information on up to thousands of drug candidates. Three membrane recepto=
r formats used for large-scale characterization of antibody candidates Here=
, ACROBiosystem and carterra collaborated to demonstrate a powerful techniq=
ue for exploring the binding of drug candidates to membrane receptors using=
 HT-SPR. Following the membrane receptor evaluations to confirm purity, str=
ucture, and bioactivity, HT-SPR can be performed with confidence to screen =
drug candidates. And the HT-SPR scale characterization technique is effecti=
ve in reducing activity loss and the characterization method can be applied=
 to any drug form, thus making possible the scale characterization of thous=
ands of drug candidates across membrane receptors. Read Full Texts Download=
 the PDF =E2=80=8A To receive the latest industry news and updates from ACR=
OBiosystems, =EF=BB=BFvisit our website & follow us on our social media!=EF=
=BB=BF Visit our Website       ACROBiosystems | 1 Innovation Way, Newark, D=
E 19711 Unsubscribe mykhaylo.dubrovka@saraya.co.in Update Profile | Our Pri=
vacy Policy | Constant Contact Data Notice Sent by acrobio.apac@outlook.com
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7fsQeFcgffLHvMyW4OweBCeliA=3D&c=3DhPsxv19I9LYnkMRgmHc1K7J0qD-ld8nnIV5EHToiM=
bdgi0ACsk2Y5A=3D=3D&ch=3D-X42H-Eg46SYqbZbj8Umw_DvEia0_oWfg157n6RbrKFBsfYZ_R=
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ns-serif; font-weight: bold; font-style: normal;">About Us</a></p></td> </t=
r> </table> </td> </tr> </table> <table class=3D"layout layout--1-column" s=
tyle=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0"=
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<table class=3D"layout layout--feature layout--1-column" style=3D"backgroun=
d-color: #c03e30; table-layout: fixed;" width=3D"100%" border=3D"0" cellpad=
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p">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Georgia,Times New Roman,Times,serif; c=
olor: #2f3131; font-size: 14px; line-height: 1.2; display: block; word-wrap=
: break-word; padding: 10px 20px;" align=3D"center" valign=3D"top"><p style=
=3D"text-align: center; margin: 0;" align=3D"center"><a href=3D"https://r20=
.rs6.net/tn.jsp?f=3D001s9E-lW_lP1ZQhmBC9wVjEMjksuQRHnWXOVGre2sPrke0444fJgnS=
RioTOo6RedUTzNIITuAz3lnhQ4MihLPhCrawVJc44a-06DSAsfkm-G0PYBcFkC9MOd3kzPXS5TD=
qk6Tosdiwt9B_CRCkpCuQP3bhqkGZ_IrwtGUnrN8Q8rwHkij1Z1VOwmbBXU1Kwl3Qh6Vo9G4MKV=
iRYIOJ_hwsfx5O5GaG8l_4_pPsrTaTiFpfLnJlVddfrRvxgk3eMNY53mQPpo9na9vgvjkgRpzv9=
NbyEV1jJzTGEioqaCTVO6_8pH8TGKpIiW6wkPIk1knN8TPrlOyqtIg_m5p0ceEKiVZa6CXGSCYJ=
o0GRxqlNCIw=3D&c=3DhPsxv19I9LYnkMRgmHc1K7J0qD-ld8nnIV5EHToiMbdgi0ACsk2Y5A=
=3D=3D&ch=3D-X42H-Eg46SYqbZbj8Umw_DvEia0_oWfg157n6RbrKFBsfYZ_RxiRg=3D=3D" t=
arget=3D"_blank" style=3D"font-size: 18px; color: rgb(255, 255, 255); font-=
weight: bold; font-family: Arial, Verdana, Helvetica, sans-serif; text-deco=
ration: none; font-style: normal;">Large-scale Characterization of Drug Can=
didates Against Transmembrane Receptors using HT-SPR</a></p></td> </tr> </t=
able> </td> </tr> </table> <table class=3D"layout-margin" style=3D"" width=
=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=
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"top"> <table class=3D"layout layout--feature layout--1-column" style=3D"ta=
ble-layout: fixed; background-color: #fef7f7;" width=3D"100%" border=3D"0" =
cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#fef7f7"> <tr> <td class=3D"=
column column--1 scale stack" style=3D"width: 100%;" align=3D"center" valig=
n=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container" align=3D"center" valign=3D"top" style=
=3D"padding-top: 10px; padding-bottom: 10px;"> <a href=3D"https://r20.rs6.n=
et/tn.jsp?f=3D001s9E-lW_lP1ZQhmBC9wVjEMjksuQRHnWXOVGre2sPrke0444fJgnSRioTOo=
6RedUTzNIITuAz3lnhQ4MihLPhCrawVJc44a-06DSAsfkm-G0PYBcFkC9MOd3kzPXS5TDqk6Tos=
diwt9B_CRCkpCuQP3bhqkGZ_IrwtGUnrN8Q8rwHkij1Z1VOwmbBXU1Kwl3Qh6Vo9G4MKViRYIOJ=
_hwsfx5O5GaG8l_4_pPsrTaTiFpfLnJlVddfrRvxgk3eMNY53mQPpo9na9vgvjkgRpzv9NbyEV1=
jJzTGEioqaCTVO6_8pH8TGKpIiW6wkPIk1knN8TPrlOyqtIg_m5p0ceEKiVZa6CXGSCYJo0GRxq=
lNCIw=3D&c=3DhPsxv19I9LYnkMRgmHc1K7J0qD-ld8nnIV5EHToiMbdgi0ACsk2Y5A=3D=3D&c=
h=3D-X42H-Eg46SYqbZbj8Umw_DvEia0_oWfg157n6RbrKFBsfYZ_RxiRg=3D=3D" data-trac=
kable=3D"true"><img data-image-content class=3D"image_content" width=3D"388=
" src=3D"https://files.constantcontact.com/5f3d0cf9401/bf5b98fe-a2da-45b1-a=
7da-2a2542e4e9d8.png" alt=3D"" style=3D"display: block; height: auto; max-w=
idth: 100%;"></a> </td> </tr> </table> <table class=3D"text text--feature t=
ext--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cellsp=
acing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_content-=
cell content-padding-horizontal" style=3D"line-height: 2; text-align: left;=
 font-family: Georgia,Times New Roman,Times,serif; color: #2f3131; font-siz=
e: 14px; display: block; word-wrap: break-word; padding: 10px 20px;" align=
=3D"left" valign=3D"top"><p style=3D"text-align: justify; margin: 0;" align=
=3D"justify"><span style=3D"font-family: Arial, Verdana, Helvetica, sans-se=
rif;">We know that membrane protein, a class of proteins that are embedded =
in the phospholipid bilayer of cell membranes to enable extracellular and i=
ntracellular spanning, occupies a place in the field of 'non-pharmacologica=
l' therapeutics. Many human diseases may be associated with abnormal recept=
or function, and the multifunctional nature of receptors makes them ideal t=
argets for drug action. However, multi-pass receptors are structurally comp=
lex and often expressed at extremely low levels in the host cell. The use o=
f high-quality, full-length transmembrane receptors is therefore essential =
for the accurate characterization of drug candidates. High-throughput surfa=
ce plasmon resonance (HT-SPR) is a powerful technique that is transforming =
the characterization workflow, enabling greater breadth and depth of inform=
ation on up to thousands of drug candidates.</span></p></td> </tr> </table>=
 <table class=3D"image image--padding-vertical image--mobile-scale image--m=
obile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"=
0"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"=
center" valign=3D"top" style=3D"padding: 10px 20px;"> <a href=3D"https://r2=
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h=3D"474" src=3D"https://files.constantcontact.com/5f3d0cf9401/35323def-eae=
1-44a3-b992-f85dff9700f0.png" alt=3D"" style=3D"display: block; height: aut=
o; max-width: 100%;"></a> </td> </tr> </table> <table class=3D"text text--p=
adding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"text_content-cell =
content-padding-horizontal" style=3D"text-align: left; font-family: Georgia=
,Times New Roman,Times,serif; color: #767676; font-size: 14px; line-height:=
 1.2; display: block; word-wrap: break-word; padding: 10px 20px;" align=3D"=
left" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-family: Arial, Verdana, Helvetica, sans-serif; font-style: italic;">T=
hree membrane receptor formats used for large-scale characterization of ant=
ibody candidates</span></p>
<p style=3D"margin: 0;"><br></p>
</td> </tr> </table> </td> </tr> </table>  </td> </tr> </table> <table clas=
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eight: 1px; width: 100%;" cellpadding=3D"0" cellspacing=3D"0" border=3D"0">=
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th: 1px; border-bottom-style: dashed; border-bottom-color: #555556;" height=
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onstantcontact.com/letters/images/1101116784221/S.gif" style=3D"display: bl=
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/td> </tr> </table> <table class=3D"layout layout--1-column" style=3D"table=
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<table class=3D"image image--float-left scale image--mobile-scale image--mo=
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ale stack" align=3D"left" valign=3D"" style=3D"padding-top: 0px; padding-bo=
ttom: 0px;"> <a href=3D"https://r20.rs6.net/tn.jsp?f=3D001s9E-lW_lP1ZQhmBC9=
wVjEMjksuQRHnWXOVGre2sPrke0444fJgnSRioTOo6RedUT6sNS6RQFaUJy6hV0rOheMQHBiXrW=
p_J3TdioC_7DFlOb0Cog1wzcJekarqtTMyVLK3dLm5gTkFiBKxputpL6rOua74S2ELXW38Qk-iN=
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tyle=3D"color: #c03e30; font-weight: normal; text-decoration: underline; fo=
nt-style: normal;"><img data-image-content class=3D"image_content" width=3D=
"221" src=3D"https://files.constantcontact.com/5f3d0cf9401/c1dcba5a-f041-44=
cf-85bb-8e38cb05b0f0.png" alt=3D"" style=3D"display: block; height: auto; m=
ax-width: 100%;"></a> </td> <td class=3D"image_spacer hide" width=3D"15" he=
ight=3D"1" align=3D"center" valign=3D"top" style=3D"height: 1px; line-heigh=
t: 1px; padding: 0px;"> <img alt=3D"" width=3D"15" height=3D"1" border=3D"0=
" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.constantcontact.com/lette=
rs/images/sys/S.gif"> </td> </tr> <tr> <td class=3D"image_spacer_bottom hid=
e" height=3D"5" align=3D"center" valign=3D"top" style=3D"height: 5px; line-=
height: 1px; padding: 0px;"> <img alt=3D"" width=3D"1" height=3D"5" border=
=3D"0" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.constantcontact.com/=
letters/images/sys/S.gif"> </td> <td class=3D"image_spacer hide" width=3D"5=
" height=3D"5" align=3D"center" valign=3D"top" style=3D"height: 1px; line-h=
eight: 1px; padding: 0px;"> <img alt=3D"" width=3D"5" height=3D"1" border=
=3D"0" hspace=3D"0" vspace=3D"0" src=3D"https://imgssl.constantcontact.com/=
letters/images/sys/S.gif"> </td> </tr> </table> <p style=3D"margin: 0;"><sp=
an style=3D"font-size: 14px; font-family: Arial, Verdana, Helvetica, sans-s=
erif;"> Here, </span><span style=3D"font-size: 14px; font-family: Arial, Ve=
rdana, Helvetica, sans-serif; font-style: italic; font-weight: bold;">ACROB=
iosystem</span><span style=3D"font-size: 14px; font-family: Arial, Verdana,=
 Helvetica, sans-serif;"> and </span><span style=3D"font-size: 14px; font-f=
amily: Arial, Verdana, Helvetica, sans-serif; color: rgb(16, 18, 20); font-=
style: italic; font-weight: bold;">carterra</span><span style=3D"font-size:=
 14px; font-family: Arial, Verdana, Helvetica, sans-serif; color: rgb(16, 1=
8, 20);"> collaborated to demonstrate</span><span style=3D"font-size: 14px;=
 font-family: Arial, Verdana, Helvetica, sans-serif;"> a powerful technique=
 for exploring the binding of drug candidates to membrane receptors using H=
T-SPR. </span><span style=3D"font-size: 14px; font-family: Arial, Verdana, =
Helvetica, sans-serif; color: rgb(16, 18, 20);">Following the membrane rece=
ptor evaluations to confirm purity, structure, and bioactivity, HT-SPR can =
be performed with confidence to screen drug candidates. </span><span style=
=3D"font-size: 14px; font-family: Arial, Verdana, Helvetica, sans-serif;">A=
nd the HT-SPR scale characterization technique is effective in reducing act=
ivity loss and the characterization method can be applied to any drug form,=
 thus making possible the scale characterization of thousands of drug candi=
dates across membrane receptors. </span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--2-=
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