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Envelope-to: tfujikawa@saraya.co.in
Delivery-date: Fri, 09 Dec 2022 09:58:46 +0800
Message-ID: <1139606576732.1119371711477.1205581575.0.432054JL.2002@scheduler.constantcontact.com>
Date: Thu, 8 Dec 2022 20:57:56 -0500 (EST)
From: ACROBiosystems <apac@acrobiosystems.com>
Reply-To: apac@acrobiosystems.com
To: tfujikawa@saraya.co.in
Subject: =?utf-8?Q?Key_Biomarkers_for_Alzheimer=E2=80=B2s?=
 =?utf-8?Q?_Disease_and_Parkinson_Disease?=
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Tau&Syn View as Webpage Products Support Resources Insights About Us =E2=80=
=8A Key Biomarkers for Alzheimer=E2=80=B2s Disease and Parkinson Disease Al=
zheimer=E2=80=B2s disease (AD) and Parkinson disease (PD) are two of the mo=
st common neurodegenerative diseases. The diagnosis and treatment of neurod=
egenerative diseases are very difficult. The future research and developmen=
t of related biomarkers may bring hope for these patients. In AD, Tau prote=
in is involved in synaptic plasticity dysfunction caused by A=CE=B2, which =
aggravates memory impairment. Meanwhile, Tau protein can be involved in reg=
ulating the abnormal excitability of A=CE=B2 and Src family tyrosine kinase=
 fyn on neural network, and Tau protein is involved in axon transport dysfu=
nction caused by A=CE=B2. New therapeutic strategies for AD may include blo=
cking the A=CE=B2-induced increase in Tau-dependent NMDA receptor activity =
by reducing fyn levels in dendrites or directly targeting Tau. =E2=80=8A le=
arn more =E2=80=8A learn more Studies reported that =CE=B1-synuclein is the=
 most important protein in the pathogenesis of PD, because it is the main s=
tructural component of Lewy bodies. Many cases of inherited PD are caused b=
y mutations in the gene encoding =CE=B1-synuclein. Although the specific me=
chanism of action remains unclear, =CE=B1-synuclein may become a key biomar=
ker in the diagnosis and treatment of PD. =EF=BC=9E=EF=BC=9EPFFs, A Novel A=
pproach to Modeling Neurodegeneration To receive the latest industry news a=
nd updates from ACROBiosystems, =EF=BB=BFvisit our website & follow us on o=
ur social media!=EF=BB=BF Visit our Website       ACROBiosystems | 1 Innova=
tion Way, Newark, DE 19711 Unsubscribe tfujikawa@saraya.co.in Update Profil=
e | Our Privacy Policy | Constant Contact Data Notice Sent by apac@acrobios=
ystems.com
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8WbTATlvk7gLdZA0Zvp7FyNEAI=3D&c=3DWf_dIlEQIsjaVP1Ong56o0MlNywj4YMbxSMmpS6_z=
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, 255); text-decoration: underline; font-family: Arial, Verdana, Helvetica,=
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"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" styl=
e=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D"spacer" st=
yle=3D"line-height: 15px; height: 15px;">&#x200a;</div></td> </tr> </table>=
 <table class=3D"layout layout--feature layout--1-column" style=3D"backgrou=
nd-color: #c03e30; table-layout: fixed;" width=3D"100%" border=3D"0" cellpa=
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op">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
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=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D"font-si=
ze: 18px; font-weight: bold; font-family: Arial, Verdana, Helvetica, sans-s=
erif; color: rgb(255, 255, 255);">Key Biomarkers for Alzheimer&#x2032;s Dis=
ease and Parkinson Disease</span></p></td> </tr> </table> </td> </tr> </tab=
le> <table class=3D"layout layout--heading layout--1-column" style=3D"table=
-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"width: 100=
%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 1.5; text-align: center; font-family: Georgia,Times New Roman,Times,serif=
; color: #767676; font-size: 14px; display: block; word-wrap: break-word; p=
adding: 10px 20px;" align=3D"center" valign=3D"top"><h1 style=3D"text-align=
: left; font-family: Courier New,Courier,Lucida Sans Typewriter,Lucida Type=
writer,monospace; color: #2f3131; font-size: 20px; font-weight: bold; margi=
n: 0;" align=3D"left">
<span style=3D"font-size: 16px; color: rgb(16, 18, 20); font-family: Arial,=
 Verdana, Helvetica, sans-serif;">A</span><span style=3D"color: rgb(16, 18,=
 20); font-family: Arial, Verdana, Helvetica, sans-serif; font-size: 14px; =
font-weight: normal;">lzheimer&#x2032;s disease (AD) and Parkinson disease =
(PD) are two of the most common neurodegenerative diseases. The diagnosis a=
nd treatment of neurodegenerative diseases are very difficult. The future r=
esearch and development of related biomarkers may bring hope for these pati=
ents.</span>
</h1></td> </tr> </table> </td> </tr> </table> <table class=3D"layout layou=
t--2-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cel=
lpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale =
stack" style=3D"width: 62.5%;" align=3D"center" valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Georgia,Times New Roma=
n,Times,serif; color: #2f3131; font-size: 16px; display: block; word-wrap: =
break-word; padding: 10px 10px 10px 20px;" align=3D"left" valign=3D"top"><p=
 style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helvetica=
, sans-serif; color: rgb(16, 18, 20); font-weight: bold;">I</span><span sty=
le=3D"font-family: Arial, Verdana, Helvetica, sans-serif; color: rgb(16, 18=
, 20); font-size: 14px;">n AD, </span><a href=3D"https://r20.rs6.net/tn.jsp=
?f=3D001cb89Tz0hpJy1TjnjavaNeHvX44PgQTikDznFGtitJkwfRZRJ1_NRBMz51gomoek9rQL=
Z503xHrtIi1iSj3vkiO3_Gb7kDhUISAHtZgtjNQOJVd2RwtzQKEIwSTvOzE5NrWayDL7Fl1b7zo=
hQdAC98uvO38AKfLVC6hLK10tCl4-MtROW-5dcX-VlknFZYIE3Z0KoiB_ChTySppzQyoN3uWJq0=
iX-564GtHSyLZ5-pYKmBRpG2ET88nRdEMbgJcodCMSyL76C7DDDApPClTGLkMuhFWEClnSBUcva=
Dzvsz5inNdzcgge-EPQdyPzllc9ydO0j50CHqkE5BLJbVSonhA=3D=3D&c=3DWf_dIlEQIsjaVP=
1Ong56o0MlNywj4YMbxSMmpS6_zTz1txsazBbNmw=3D=3D&ch=3Dhko1D_26p96zkt5jZv1fmXv=
2QYU3XP5znWLBKuLVLp3pnQpZD0clLg=3D=3D" target=3D"_blank" style=3D"font-fami=
ly: Arial, Verdana, Helvetica, sans-serif; color: rgb(192, 0, 0); font-size=
: 14px; font-weight: normal; text-decoration: underline; font-style: normal=
;">Tau protein</a><span style=3D"font-family: Arial, Verdana, Helvetica, sa=
ns-serif; color: rgb(16, 18, 20); font-size: 14px;"> is involved in synapti=
c plasticity dysfunction caused by A&#x3b2;, which aggravates memory impair=
ment. Meanwhile, Tau protein can be involved in regulating the abnormal exc=
itability of A&#x3b2; and Src family tyrosine kinase fyn on neural network,=
 and Tau protein is involved in axon transport dysfunction caused by A&#x3b=
2;. New therapeutic strategies for AD may include blocking the A&#x3b2;-ind=
uced increase in Tau-dependent NMDA receptor activity by reducing fyn level=
s in dendrites or directly targeting Tau.</span></p></td> </tr> </table> </=
td>  <td class=3D"column column--2 scale stack" style=3D"width: 37.5%;" ali=
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=3D"column column--2 scale stack" style=3D"width: 57.5%;" align=3D"center" =
valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Georgia,Times New Roma=
n,Times,serif; color: #2f3131; font-size: 16px; display: block; word-wrap: =
break-word; padding: 10px 20px 10px 10px;" align=3D"left" valign=3D"top"><p=
 style=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helvetica=
, sans-serif; color: rgb(16, 18, 20); font-weight: bold;">S</span><span sty=
le=3D"font-family: Arial, Verdana, Helvetica, sans-serif; color: rgb(16, 18=
, 20); font-size: 14px;">tudies reported that </span><a href=3D"https://r20=
.rs6.net/tn.jsp?f=3D001cb89Tz0hpJy1TjnjavaNeHvX44PgQTikDznFGtitJkwfRZRJ1_NR=
BBHHpF1bAeZJzwCmisYhEK69YGNkX2wJKRz0yTVdz2ZmAE9qFTFEOS7SbVXDrW-6OCXfvby-es-=
pTDn_v7-12LrJ1-MJd29Cod674Sh7JjfPubEV3usYPkp1-hLWBwpPe8sLtYm9HgtWgliIdXR-y4=
npqT9bZEvq9rwx_hgxZLQ8I6ZAu1mdMSLA-J9aijiCesn80s14F6UTgsouv6bopR4aAPKy5WyjM=
ZnD4rioYAXfEolOfI5QLbYNqU0Q2CR6JF4vVsHX7dftjWWjhwXVzsnYIH_qbz8lGcLWduXvgkzk=
&c=3DWf_dIlEQIsjaVP1Ong56o0MlNywj4YMbxSMmpS6_zTz1txsazBbNmw=3D=3D&ch=3Dhko1=
D_26p96zkt5jZv1fmXv2QYU3XP5znWLBKuLVLp3pnQpZD0clLg=3D=3D" target=3D"_blank"=
 style=3D"font-family: Arial, Verdana, Helvetica, sans-serif; color: rgb(19=
2, 0, 0); font-size: 14px; font-weight: normal; text-decoration: underline;=
 font-style: normal;">&#x3b1;-synuclein</a><span style=3D"font-family: Aria=
l, Verdana, Helvetica, sans-serif; color: rgb(16, 18, 20); font-size: 14px;=
"> is the most important protein in the pathogenesis of PD, because it is t=
he main structural component of Lewy bodies. Many cases of inherited PD are=
 caused by mutations in the gene encoding &#x3b1;-synuclein. Although the s=
pecific mechanism of action remains unclear, &#x3b1;-synuclein may become a=
 key biomarker in the diagnosis </span><span style=3D"font-family: Arial, V=
erdana, Helvetica, sans-serif; font-size: 14px;">and treatment </span><span=
 style=3D"font-family: Arial, Verdana, Helvetica, sans-serif; color: rgb(16=
, 18, 20); font-size: 14px;">of PD.</span></p></td> </tr> </table> </td> </=
tr> </table> <table class=3D"layout layout--heading layout--1-column" style=
=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cel=
lspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" style=3D"wi=
dth: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
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font-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; p=
adding: 10px 20px;" align=3D"center" valign=3D"top"><h1 style=3D"font-famil=
y: Courier New,Courier,Lucida Sans Typewriter,Lucida Typewriter,monospace; =
color: #2f3131; font-size: 20px; font-weight: bold; margin: 0;"><a href=3D"=
https://r20.rs6.net/tn.jsp?f=3D001cb89Tz0hpJy1TjnjavaNeHvX44PgQTikDznFGtitJ=
kwfRZRJ1_NRBD4qYoBVz68kenwhzNIEeiQRrbABoJQNdi5PyEZMiWF35T47Qi8KkumVOiSdHzGC=
T_3hD3GXw8uUzem-60QeCEidANnafO6LOWHQ1B578vQnHWXyqrn4BFu0bCVpgoN1HPDH_ANMGfB=
Dmm-SnDgfsSfvHuClpECjMWVX181sOxcgJmSznJ69IMfzfA4ZhzLkHpRYPUEAqjOSd_K4zJb5kF=
VJGhehBQ8PgL9tXSUdB_wBoUfDz0g1aGWCb4IkoklTyAgxTh-KKR9pc2M-WLcwkS0Au8d0eMKOg=
KTLv3eRMe17mCQYALLNrDCB1-rlrkQjBg=3D=3D&c=3DWf_dIlEQIsjaVP1Ong56o0MlNywj4YM=
bxSMmpS6_zTz1txsazBbNmw=3D=3D&ch=3Dhko1D_26p96zkt5jZv1fmXv2QYU3XP5znWLBKuLV=
Lp3pnQpZD0clLg=3D=3D" target=3D"_blank" style=3D"font-weight: normal; color=
: rgb(192, 0, 0); font-family: Arial, Verdana, Helvetica, sans-serif; font-=
size: 14px; text-decoration: underline; font-style: normal;">&#xff1e;&#xff1=
e;PFFs, A Novel Approach to Modeling Neurodegeneration</a></h1></td> </tr> =
</table> </td> </tr> </table> <table class=3D"layout layout--1-column" styl=
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