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Message-ID: <1139574257089.1119371711477.1404958413.0.432003JL.2002@scheduler.constantcontact.com>
Date: Wed, 30 Nov 2022 20:06:29 -0500 (EST)
From: ACROBiosystems <apac@acrobiosystems.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
Subject: =?utf-8?Q?_Insights=EF=BC=9AFacilitating_Bispecific_Antibod?=
 =?utf-8?Q?y_Drug_Development_through_Quality_Control?=
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Bispecific Antibody View as Webpage Products Support Resources Insights Abo=
ut Us =E2=80=8A Facilitating Bispecific Antibody Drug Development through Q=
uality Control Bispecific antibodies(bsAbs) are a relatively new type of dr=
ug in the field of targeted therapeutics. By binding to both CD3 and a tumo=
r-associated antigen, these bsAbs bridge T cells and tumor cells together t=
o initiate tumor cell death, irrespective of T cell receptor specificity, c=
o-stimulation, or peptide antigen presentation. Furthermore, the activation=
 of T cells by CD3 bsAbs stimulates the secretion of a wide variety of cyto=
kines to recruit immune helper cells to further enhance the anti-tumor cell=
 effects. Current marketed bsAbs that have successfully received market app=
roval and their listed indication of use From the concept phase to clinical=
 trials, many companies around the world are accelerating their research an=
d development processes of these drugs, especially CD3-targeting bsAbs. Thi=
s means that quality control of bsAb drugs becomes even more critical, espe=
cially as a novel immunotherapeutic. A key reagent for these quality contro=
l studies are recombinant proteins. To support bsAb research and its releva=
nt quality control studies, ACROBiosystems strives to provide high-quality,=
 bioactive, and consistent recombinant proteins including CD3 and many othe=
rs. Read Full Texts =E2=80=8A Have you signed up in ACRO's websites? have c=
hance to get gift Yes No To receive the latest industry news and updates fr=
om ACROBiosystems, =EF=BB=BFvisit our website & follow us on our social med=
ia!=EF=BB=BF Visit our Website       ACROBiosystems | 1 Innovation Way, New=
ark, DE 19711 Unsubscribe mykhaylo.dubrovka@saraya.co.in Update Profile | O=
ur Privacy Policy | Constant Contact Data Notice Sent by apac@acrobiosystem=
s.com
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lign=3D"center" valign=3D"middle">
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oF0D2DIk4WNiCxbLpOVI8PT5jveJKhWxR_PA8Q1hV6wW5Hp9GkYATI0ck48eAbsaS4vpMJlwNCT=
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qPU21gMd_VH-_0Om8kkRamuEFqGB9VMy3vo1XmkP_b8P2hq5hKqlGHpchCvL7E8kTe8WFd1jBVb=
T1Za82FFxuBKmOi5nT31kWFj8b0iX3-tXq2eV9R-Jh2nVk6D1iW0tgcwdSQEO9G5oVfrzkLu8wV=
K7YE74FQq-Ba-FHON4pKW32vSs=3D&c=3DXTdzXNpxvAWIGY0ewly8rFD9eamtsCzvkDOUK3W-x=
YufDtnzfjouLA=3D=3D&ch=3DujA1qvimb7w2O5K1mj9rGmA_NnFx0JZ-G3anNlhRkyvryWXHaZ=
2UmA=3D=3D" target=3D"_blank" style=3D"font-size: 13px; color: rgb(255, 255=
, 255); text-decoration: underline; font-family: Arial, Verdana, Helvetica,=
 sans-serif; font-weight: bold; font-style: normal;">About Us</a></p></td> =
</tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-column=
" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" styl=
e=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D"spacer" st=
yle=3D"line-height: 15px; height: 15px;">&#x200a;</div></td> </tr> </table>=
 <table class=3D"layout layout--feature layout--1-column" style=3D"backgrou=
nd-color: #c03e30; table-layout: fixed;" width=3D"100%" border=3D"0" cellpa=
dding=3D"0" cellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"column=
 column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"t=
op">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Georgia,Times New Roman,Times,serif; c=
olor: #2f3131; font-size: 14px; line-height: 1.2; display: block; word-wrap=
: break-word; padding: 10px 20px;" align=3D"center" valign=3D"top">
<p style=3D"margin: 0;"><a href=3D"https://r20.rs6.net/tn.jsp?f=3D001vzA-Yo=
F0D2DIk4WNiCxbLpOVI8PT5jveJKhWxR_PA8Q1hV6wW5Hp9MiSujQsYmGg7Yy29RB5TMHK1ZqqA=
8jf-oHC1oeRY2okb77NrQrbbp9p_VU1XVKdgmbHMolANPmVk-RoxxBA7KT-vJ12yu217Sc2bCV3=
Rvw6U5NwgNzFLoVnXscbH36Cg5Wd2nHT_vjpQf8luFyDtoJ_QHJgfvp9rtNZM0IQwQY-g_266K8=
b5Xgdtt_OXqfZcr5BhrCud2grJJj9Z-kNdFdiUY1bVtkbFGDRUDBhsGnaZwm1kc4nqPU8S8vgxe=
OTLJM1ppMIs4OEeaHGt9ZUsk_4il-BIDpsYfZqmpwfttAB8xxNi21lj9vG1CmbE0dFLbMsXUaxj=
G0V&c=3DXTdzXNpxvAWIGY0ewly8rFD9eamtsCzvkDOUK3W-xYufDtnzfjouLA=3D=3D&ch=3Du=
jA1qvimb7w2O5K1mj9rGmA_NnFx0JZ-G3anNlhRkyvryWXHaZ2UmA=3D=3D" target=3D"_bla=
nk" style=3D"font-size: 18px; color: rgb(255, 255, 255); font-family: Arial=
, Verdana, Helvetica, sans-serif; font-weight: bold; text-decoration: none;=
 font-style: normal;">Facilitating Bispecific Antibody Drug Development thr=
ough</a></p>
<h1 style=3D"font-family: Georgia,Times New Roman,Times,serif; color: #ffff=
ff; font-size: 24px; font-weight: bold; margin: 0;"><a href=3D"https://r20.=
rs6.net/tn.jsp?f=3D001vzA-YoF0D2DIk4WNiCxbLpOVI8PT5jveJKhWxR_PA8Q1hV6wW5Hp9=
MiSujQsYmGg7Yy29RB5TMHK1ZqqA8jf-oHC1oeRY2okb77NrQrbbp9p_VU1XVKdgmbHMolANPmV=
k-RoxxBA7KT-vJ12yu217Sc2bCV3Rvw6U5NwgNzFLoVnXscbH36Cg5Wd2nHT_vjpQf8luFyDtoJ=
_QHJgfvp9rtNZM0IQwQY-g_266K8b5Xgdtt_OXqfZcr5BhrCud2grJJj9Z-kNdFdiUY1bVtkbFG=
DRUDBhsGnaZwm1kc4nqPU8S8vgxeOTLJM1ppMIs4OEeaHGt9ZUsk_4il-BIDpsYfZqmpwfttAB8=
xxNi21lj9vG1CmbE0dFLbMsXUaxjG0V&c=3DXTdzXNpxvAWIGY0ewly8rFD9eamtsCzvkDOUK3W=
-xYufDtnzfjouLA=3D=3D&ch=3DujA1qvimb7w2O5K1mj9rGmA_NnFx0JZ-G3anNlhRkyvryWXH=
aZ2UmA=3D=3D" target=3D"_blank" style=3D"font-size: 18px; color: rgb(255, 2=
55, 255); font-family: Arial, Verdana, Helvetica, sans-serif; font-weight: =
bold; text-decoration: none; font-style: normal;">Quality Control</a></h1>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 2; text-align: left; font-family: Georgia,Times New Roman,=
Times,serif; color: #2f3131; font-size: 14px; display: block; word-wrap: br=
eak-word; padding: 10px 20px;" align=3D"left" valign=3D"top"><p style=3D"te=
xt-align: justify; margin: 0;" align=3D"justify"><span style=3D"color: rgb(=
0, 0, 0); font-family: Arial, Verdana, Helvetica, sans-serif;">Bispecific a=
ntibodies(bsAbs) are a relatively new type of drug in the field of targeted=
 therapeutics. By binding to both CD3 and a tumor-associated antigen, these=
 bsAbs bridge T cells and tumor cells together to initiate tumor cell death=
, irrespective of T cell receptor specificity, co-stimulation, or peptide a=
ntigen presentation. Furthermore, the activation of T cells by CD3 bsAbs st=
imulates the secretion of a wide variety of cytokines to recruit immune hel=
per cells to further enhance the anti-tumor cell effects.</span></p></td> <=
/tr> </table> <table class=3D"text text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: left; font-family: Georgia,Times New Roman,Times,serif; col=
or: #767676; font-size: 14px; line-height: 1.2; display: block; word-wrap: =
break-word; padding: 10px 20px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"color: rgb(0, 0, 0); font-family: Arial, Verdana, Helvetica, sans-serif; f=
ont-style: italic;">Current marketed bsAbs that have successfully received =
market approval</span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"color: rgb(0, 0, 0); font-family: Arial, Verdana, Helvetica, sans-serif; f=
ont-style: italic;">and their listed indication of use</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--mobile-scale image--mobile-center" width=3D"10=
0%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"ima=
ge_container content-padding-horizontal" align=3D"center" valign=3D"top" st=
yle=3D"padding-left: 20px; padding-right: 20px;"> <a href=3D"https://r20.rs=
6.net/tn.jsp?f=3D001vzA-YoF0D2DIk4WNiCxbLpOVI8PT5jveJKhWxR_PA8Q1hV6wW5Hp9Mi=
SujQsYmGg7Yy29RB5TMHK1ZqqA8jf-oHC1oeRY2okb77NrQrbbp9p_VU1XVKdgmbHMolANPmVk-=
RoxxBA7KT-vJ12yu217Sc2bCV3Rvw6U5NwgNzFLoVnXscbH36Cg5Wd2nHT_vjpQf8luFyDtoJ_Q=
HJgfvp9rtNZM0IQwQY-g_266K8b5Xgdtt_OXqfZcr5BhrCud2grJJj9Z-kNdFdiUY1bVtkbFGDR=
UDBhsGnaZwm1kc4nqPU8S8vgxeOTLJM1ppMIs4OEeaHGt9ZUsk_4il-BIDpsYfZqmpwfttAB8xx=
Ni21lj9vG1CmbE0dFLaby_c4eQt7O&c=3DXTdzXNpxvAWIGY0ewly8rFD9eamtsCzvkDOUK3W-x=
YufDtnzfjouLA=3D=3D&ch=3DujA1qvimb7w2O5K1mj9rGmA_NnFx0JZ-G3anNlhRkyvryWXHaZ=
2UmA=3D=3D" data-trackable=3D"true"><img data-image-content class=3D"image_=
content" width=3D"560" src=3D"https://files.constantcontact.com/5f3d0cf9401=
/287a3385-2d16-421e-a449-a8eafecdf939.png" alt=3D"" style=3D"display: block=
; height: auto; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </t=
able> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed=
;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <t=
d class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"ce=
nter" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"line-height=
: 2; text-align: left; font-family: Georgia,Times New Roman,Times,serif; co=
lor: #767676; font-size: 14px; display: block; word-wrap: break-word; paddi=
ng: 10px 20px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: justify; margin: 0;" align=3D"justify"><span style=
=3D"color: rgb(0, 0, 0); font-family: Arial, Verdana, Helvetica, sans-serif=
;">From the concept phase to clinical trials, many companies around the wor=
ld are accelerating their research and development processes of these drugs=
, especially CD3-targeting bsAbs. This means that quality control of bsAb d=
rugs becomes even more critical, especially as a novel immunotherapeutic. A=
 key reagent for these quality control studies are recombinant proteins. To=
 support bsAb research and its relevant quality control studies, ACROBiosys=
tems strives to provide high-quality, bioactive, and consistent recombinant=
 proteins including CD3 and many others.</span></p>
<p style=3D"margin: 0;"><br></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top"> <table class=3D"b=
utton button--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D"=
0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"butt=
on_container content-padding-horizontal" align=3D"center" style=3D"padding:=
 10px 20px;">    <table class=3D"button_content-row" style=3D"width: inheri=
t; border-radius: 5px; border-spacing: 0; background-color: #c03e30; border=
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0"> <tr> <td class=3D"button_content-cell" style=3D"padding: 10px 40px;" al=
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?f=3D001vzA-YoF0D2DIk4WNiCxbLpOVI8PT5jveJKhWxR_PA8Q1hV6wW5Hp9MiSujQsYmGg7Yy=
29RB5TMHK1ZqqA8jf-oHC1oeRY2okb77NrQrbbp9p_VU1XVKdgmbHMolANPmVk-RoxxBA7KT-vJ=
12yu217Sc2bCV3Rvw6U5NwgNzFLoVnXscbH36Cg5Wd2nHT_vjpQf8luFyDtoJ_QHJgfvp9rtNZM=
0IQwQY-g_266K8b5Xgdtt_OXqfZcr5BhrCud2grJJj9Z-kNdFdiUY1bVtkbFGDRUDBhsGnaZwm1=
kc4nqPU8S8vgxeOTLJM1ppMIs4OEeaHGt9ZUsk_4il-BIDpsYfZqmpwfttAB8xxNi21lj9vG1Cm=
bE0dFLaby_c4eQt7O&c=3DXTdzXNpxvAWIGY0ewly8rFD9eamtsCzvkDOUK3W-xYufDtnzfjouL=
A=3D=3D&ch=3DujA1qvimb7w2O5K1mj9rGmA_NnFx0JZ-G3anNlhRkyvryWXHaZ2UmA=3D=3D" =
data-trackable=3D"true" style=3D"font-family: Arial,Verdana,Helvetica,sans-=
serif; color: #FFFFFF; font-size: 14px; word-wrap: break-word; font-weight:=
 bold; text-decoration: none;">Read Full Texts</a> </td> </tr> </table>    =
</td> </tr> </table>   </td> </tr> </table> <table class=3D"layout layout--=
1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpa=
dding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale sta=
ck" style=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D"sp=
acer" style=3D"line-height: 10px; height: 10px;">&#x200a;</div></td> </tr> =
</table> <table class=3D"layout layout--feature layout--1-column" style=3D"=
background-color: #c03e30; table-layout: fixed;" width=3D"100%" border=3D"0=
" cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=
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align=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Georgia,Times New Roman,Times,serif; c=
olor: #2f3131; font-size: 14px; line-height: 1.2; display: block; word-wrap=
: break-word; padding: 10px 20px;" align=3D"center" valign=3D"top"><p style=
=3D"margin: 0;"><span style=3D"font-size: 18px; font-family: Arial, Verdana=
, Helvetica, sans-serif; font-weight: bold; color: rgb(255, 255, 255);">Hav=
e you signed up in ACRO's websites?</span></p></td> </tr> </table> </td> </=
tr> </table> <table class=3D"layout layout--1-column" style=3D"table-layout=
: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> =
<tr> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" alig=
n=3D"center" valign=3D"top">
<table class=3D"block-wrapper" style=3D"table-layout: fixed;" width=3D"100%=
" cellpadding=3D"0" cellspacing=3D"0" border=3D"0"> <tr> <td class=3D"block=
-wrapper_cell" width=3D"100%" align=3D"center" valign=3D"top"> <table class=
=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"100%" =
border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column =
column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=3D"to=
p">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Georgia,Times New Roman,Times,serif; color: #767676; fo=
nt-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; pad=
ding: 10px 20px;" align=3D"left" valign=3D"top">have chance to get gift</td=
> </tr> </table>  <table class=3D"button button--padding-vertical" width=3D=
"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layo=
ut: fixed;"> <tr> <td class=3D"button_container content-padding-horizontal"=
 align=3D"center" style=3D"padding: 10px 20px;">    <table class=3D"button_=
content-row" style=3D"width: 100%; border-radius: 5px; border-spacing: 0; b=
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lspacing=3D"0" bgcolor=3D"#c03e30"> <tr> <td class=3D"button_content-cell" =
style=3D"padding: 10px 40px;" align=3D"center"> <a class=3D"button_link" hr=
ef=3D"https://r20.rs6.net/tn.jsp?f=3D001vzA-YoF0D2DIk4WNiCxbLpOVI8PT5jveJKh=
WxR_PA8Q1hV6wW5Hp9CKX65o-RXZzBFEN1cpSHP1zxm02Aabmv6pTFbuXj3M9CUHwhF-Qk7JK2B=
hrX-iSF48TURpS-wqoyVJNwXlW7E65HsZwTUyqwodmm0UZeyc0ZDLrAgzMNoFtfo3K1bVekM82c=
kVfSYCIWCw4DlsEJLSniqBwMCBhBgVZJs901NpfmM1GGUVP8wy7f5-_lbrONt1YqAad8_nX_pb5=
8bJvLtv3kID4_GTJa28MSoSoUx1zd57107SFIlje1xR9PaFyvepfwhXe6MjFU2ginh92IQvjl_J=
TbjtPwhJTQR55QLe7PYAOPa_QA1h3sh5XJ9yy00GwCMXXrcLJTDH3yZWs1C5o5ILePEoiL0FDiZ=
66T14VHAg3f_ZC_DjFMwxB54FvZBUro2OYRFWYxBuqQkEhvZeOSTAOwzCYgczK16AdDAqwrTxty=
8EHtoVWCq1BA-ovRiA7YZd_tjU-SbRnwxEkiBZo6wRtWImPVtwSM_Vu3BxM9t5xtntuS_oMQN9g=
jXai2o4Zt0WwuEMz8nkYvOMRgYTvqOqbACrY8Qp1uLo8_Lj6ztAbO0mb4tY=3D&c=3DXTdzXNpx=
vAWIGY0ewly8rFD9eamtsCzvkDOUK3W-xYufDtnzfjouLA=3D=3D&ch=3DujA1qvimb7w2O5K1m=
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button button--padding-vertical" width=3D"100%" border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td class=3D"but=
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: 10px 20px;">    <table class=3D"button_content-row" style=3D"width: 100%;=
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6QbHSAN_7NShdAh_xAeg6mjnOQU6s5-UK0nW-Nw6dfmd84SXJMWf1IhoB6VuMjUssSAFNEwT75z=
eEtODzzJ-QFU3fED7wKYhUXPhYhDgeL3nDhF1OtW4Kg_ITarcoDjbATe9j8afTM9PbpnbCMQ37F=
KlwlUH-ySXZ4e604MJaubhkkarrGvU820KSdr7QwKcoIM_6JkGmv2cQQr2hfjexmjKxG85WVIIH=
gcbJGL-EtOd4zw03uiiWlOOmqaAA8foiE3PoKmXIP7gBB8OFaMS_vB0jHBB0_0I3lteCBhG9GnA=
43ELNWMtT-hfRvQf_GcQb1UzZx0iodYn7u58JnGE2bj_OfMVQp1yEVkO5y73oxMwwpyKSn-GK8j=
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atSH41-EzoTmL5DHqySL_chhBUMka-sY6RRe_KNVtmuRZzrIxl48yl_vNb7S5-Lho-itBDZFkqj=
ZE9BSVQ3Le0KU9qOq1Y6akf2c=3D&c=3DXTdzXNpxvAWIGY0ewly8rFD9eamtsCzvkDOUK3W-xY=
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