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Envelope-to: mykhaylo.dubrovka@saraya.co.in
Delivery-date: Thu, 24 Nov 2022 15:38:28 +0800
Message-ID: <1139552617262.1119371711477.1404958413.0.510234JL.2002@scheduler.constantcontact.com>
Date: Thu, 24 Nov 2022 02:37:38 -0500 (EST)
From: ACROBiosystems <apac@acrobiosystems.com>
Reply-To: apac@acrobiosystems.com
To: mykhaylo.dubrovka@saraya.co.in
Subject: =?utf-8?Q?=E3=80=90Newly_launched=E3=80=91A=CE=B242_protein_facilitat?=
 =?utf-8?Q?es_Alzheimer=E2=80=99s_disease_drug_development?=
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View as Webpage Products Support Resources Insights About Us [Newly launche=
d] A=CE=B242 protein facilitates Alzheimer=E2=80=99s disease drug developme=
nt News express For the treatment of Alzheimer's disease (AD), Biogen and E=
isai have jointly developed two A=CE=B2-targeting drugs, including aducanum=
ab, which was approved for marketing on June 7, 2021, and lecanemab, which =
recently met its primary endpoint and all key secondary endpoints in the Ph=
ase III Clarity AD clinical trial with highly statistically significant res=
ults.  =E2=80=8A Drugs targeting the A=CE=B2 pathway for AD treatment The f=
ormation of amyloid plaques by A=CE=B2 deposition is one of the main pathol=
ogical features of AD. Therapies that can selectively bind, neutralize and =
eliminate soluble and toxic A=CE=B2 amyloid aggregates are believed to help=
 delay the neurodegenerative process of AD. Including lecanemab that has be=
en marketed, there are currently 5 antibody drugs targeting A=CE=B2 pathway=
 for the treatment of AD.  =EF=BB=BF Advances in drugs targeting A=CE=B2 pa=
thway for AD treatment Although all of them bind to A=CE=B2, they target di=
fferent aggregation forms of A=CE=B2. Lecanemab targets soluble aggregates =
of A=CE=B2, including oligomers and protofibril, it has been shown to bind =
soluble protofibril 10-15 times more than aducanumab and gantenerumab, whic=
h also target A=CE=B2. Compared with insoluble aggregates, these soluble fi=
bril and plaques have higher neurotoxicity, which may be the main reason fo=
r lecanemab=E2=80=99s better clinical results in phase III. 5 Antibody drug=
s target different A=CE=B2 aggregation forms Aneuro's new product: A=CE=B24=
2 Aneuro recently launched recombinant A=CE=B242 protein=EF=BC=88Cat. No. A=
PP-H51H6=EF=BC=89, which has been showed to bind specifically to aducanumab=
 with high biological activity. Compared with synthetic peptides, our A=CE=
=B242 protein has natural conformation to facilitate the diagnosis and trea=
tment research of AD. Verification data  High purity=EF=BC=9E95% Human Abet=
a42, His Tag =EF=BC=88Cat. No. APP-H51H6=EF=BC=89 on SDS-PAGE under reducin=
g (R) condition. The gel was stained overnight with Coomassie Blue. The pur=
ity of the protein is greater than 95%. High bioactivity verified by bindin=
g to aducanumab Immobilized Human Abeta42, His Tag (Cat. No. APP-H51H6) at =
5 =CE=BCg/mL (100 =CE=BCL/well) can bind Aducanumab with a linear range of =
0.2-2 ng/mL (QC tested). Protocol =E2=96=BC Click to learn about our A=CE=
=B2 protein =E2=80=8A To receive the latest industry news and updates from =
ACROBiosystems, =EF=BB=BFvisit our website & follow us on our social media!=
=EF=BB=BF =E2=80=8A Visit our Website       ACROBiosystems | 1 Innovation W=
ay, Newark, DE 19711 Unsubscribe mykhaylo.dubrovka@saraya.co.in Update Prof=
ile | Our Privacy Policy | Constant Contact Data Notice Sent by apac@acrobi=
osystems.com
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<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
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<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-size: 19px; color: rgb(255, 255, 255); font-weight: bold; font-family=
: Arial, Verdana, Helvetica, sans-serif;">[Newly launched]</span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-size: 19px; color: rgb(255, 255, 255); font-weight: bold; font-family=
: Arial, Verdana, Helvetica, sans-serif;">A&#x3b2;42 protein facilitates Al=
zheimer&#x2019;s disease drug development</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--fe=
ature layout--1-column" style=3D"table-layout: fixed; background-color: #F1=
F1F1;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgco=
lor=3D"#F1F1F1"> <tr> <td class=3D"column column--1 scale stack" style=3D"w=
idth: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
 break-word; padding: 10px 40px;" align=3D"center" valign=3D"top"><h1 style=
=3D"text-align: left; font-family: Franklin Gothic Medium,Arial,Helvetica,s=
ans-serif; color: #3E3E3E; font-size: 24px; font-weight: bold; margin: 0;" =
align=3D"left"><span style=3D"color: rgb(192, 0, 0); font-family: Calibri, =
Helvetica, Arial, sans-serif; font-size: 17px;">News express</span></h1></t=
d> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-col=
umn" style=3D"background-color: #f1f1f1; table-layout: fixed;" width=3D"100=
%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#f1f1f1"> <t=
r> <td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=
=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 40px;"> <img data-image-conten=
t class=3D"image_content" width=3D"203" src=3D"https://files.constantcontac=
t.com/5f3d0cf9401/27c0cc18-8907-4ada-a292-a91457c47e4b.png" alt=3D"" style=
=3D"display: block; height: auto; max-width: 100%;"> </td> </tr> </table> <=
/td> </tr> </table> <table class=3D"layout layout--feature layout--1-column=
" style=3D"table-layout: fixed; background-color: #F1F1F1;" width=3D"100%" =
border=3D"0" cellpadding=3D"0" cellspacing=3D"0" bgcolor=3D"#F1F1F1"> <tr> =
<td class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"=
center" valign=3D"top">
<table class=3D"text text--feature text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: center; font-family: Arial,Verdana,Helvetica,sans-serif; co=
lor: #3E3E3E; font-size: 14px; line-height: 1.2; display: block; word-wrap:=
 break-word; padding: 10px 40px;" align=3D"center" valign=3D"top"><p style=
=3D"text-align: left; margin: 0;" align=3D"left"><span style=3D"color: rgb(=
16, 18, 20); font-family: Calibri, Helvetica, Arial, sans-serif;">For the t=
reatment of Alzheimer's disease (AD), Biogen and Eisai have jointly develop=
ed two A&#x3b2;-targeting drugs, including aducanumab, which was approved f=
or marketing on June 7, 2021, and lecanemab, which recently met its primary=
 endpoint and all key secondary endpoints in the Phase III Clarity AD clini=
cal trial with highly statistically significant results.&#xa0;</span></p></=
td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-co=
lumn" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpaddin=
g=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack" =
style=3D"width: 100%;" align=3D"center" valign=3D"top"><div class=3D"spacer=
" style=3D"line-height: 15px; height: 15px;">&#x200a;</div></td> </tr> </ta=
ble> <table class=3D"layout layout--1-column" style=3D"table-layout: fixed;=
" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td=
 class=3D"column column--1 scale stack" style=3D"width: 100%;" align=3D"cen=
ter" valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: b=
reak-word; padding: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"margin: 0;"><span style=3D"color: rgb(192, 0, 0); font-weight: =
bold; font-family: Calibri, Helvetica, Arial, sans-serif;">Drugs targeting =
the A&#x3b2; pathway for AD treatment</span></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(34, 34, 34); font-family:=
 Calibri, Helvetica, Arial, sans-serif;">The formation of amyloid plaques b=
y A&#x3b2; deposition is one of the main pathological features of AD. Thera=
pies that can selectively bind, neutralize and eliminate soluble and toxic =
A&#x3b2; amyloid aggregates are believed to help delay the neurodegenerativ=
e process of AD. </span><span style=3D"color: rgb(16, 18, 20); font-family:=
 Calibri, Helvetica, Arial, sans-serif;">Including lecanemab that has been =
marketed, there are currently 5 antibody drugs targeting A&#x3b2; pathway f=
or the treatment of AD.&#xa0;</span></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(16, 18, 20); font-family:=
 Calibri, Helvetica, Arial, sans-serif;"><span class=3D"ql-cursor">&#xfeff;=
</span></span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"color: rgb(16, 18, 20); font-family: Calibri, Helvetica, Arial, sans-serif=
; font-style: italic;">Advances in drugs targeting A&#x3b2; pathway for AD =
treatment</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 40px;"> <a href=3D"https://r20=
.rs6.net/tn.jsp?f=3D0012a1QjHQodXmwxulSlsZCvXJtvUBHhl5zEc1HJNyMbmbxlUoeNBMs=
ClCu13FWx0E8D_SuFeUeCNEh6U5-WFXg74ZeHB5Sw57AcG2kcRKnhxG9IaO2PxBs-r8QGOlfhC_=
s0ls8GYNwQUwa-VqSa52EWxHDtDHFoJE7mfE9WN4JDzbEjwvgRcj6yjTNTV_R7D70b7LbJCjLrT=
HiX0SLf9pi2vcGqjPXKtdAO_dyNhGtlcwy5xL3fLAbxzs_xapAuWTU7xk8GMqwEt8l-O1JdEMeN=
aFUQaggvtaCALctz5WSvVYs5KqLymr3shdHE8pScFSAt27z5rFYRsyZLSAneZLpVas1sVcwzai_=
l7Pv3jrE2Tc=3D&c=3DLGE7Qun9sEqBnD6XCHBZp2UYOQIXb0sq3nR36tPFiXyTDn6XQRqHyA=
=3D=3D&ch=3DeO8m8RGFMuSPuNs5hbLhvNaseCh0hKD5FUh6U-Frw7SKRgUWL5nIwg=3D=3D" d=
ata-trackable=3D"true"><img data-image-content class=3D"image_content" widt=
h=3D"597" src=3D"https://files.constantcontact.com/5f3d0cf9401/2088e687-444=
2-43a6-a0f4-0bd3cdc78a78.png" alt=3D"" style=3D"display: block; height: aut=
o; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </table> <table =
class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"1=
00%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"co=
lumn column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=
=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: b=
reak-word; padding: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"m=
argin: 0;"><span style=3D"color: rgb(16, 18, 20); font-family: Calibri, Hel=
vetica, Arial, sans-serif;">Although all of them bind to A&#x3b2;, they tar=
get different aggregation forms of A&#x3b2;. Lecanemab targets soluble aggr=
egates of A&#x3b2;, including oligomers and protofibril, it has been shown =
to bind soluble protofibril 10-15 times more than aducanumab and gantenerum=
ab, which also target A&#x3b2;. Compared with insoluble aggregates, these s=
oluble fibril and plaques have higher neurotoxicity, which may be the main =
reason for lecanemab&#x2019;s better clinical results in phase III.</span><=
/p></td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout-=
-1-column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellp=
adding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale st=
ack" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"image image--padding-vertical image--mobile-scale image--mo=
bile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"image_container content-padding-horizontal" align=3D"c=
enter" valign=3D"top" style=3D"padding: 10px 40px;"> <a href=3D"https://r20=
.rs6.net/tn.jsp?f=3D0012a1QjHQodXmwxulSlsZCvXJtvUBHhl5zEc1HJNyMbmbxlUoeNBMs=
ClCu13FWx0E8D_SuFeUeCNEh6U5-WFXg74ZeHB5Sw57AcG2kcRKnhxG9IaO2PxBs-r8QGOlfhC_=
s0ls8GYNwQUwa-VqSa52EWxHDtDHFoJE7mfE9WN4JDzbEjwvgRcj6yjTNTV_R7D70b7LbJCjLrT=
HiX0SLf9pi2vcGqjPXKtdAO_dyNhGtlcwy5xL3fLAbxzs_xapAuWTU7xk8GMqwEt8l-O1JdEMeN=
aFUQaggvtaCALctz5WSvVYs5KqLymr3shdHE8pScFSAt27z5rFYRsyZLSAneZLpVas1sVcwzai_=
l7Pv3jrE2Tc=3D&c=3DLGE7Qun9sEqBnD6XCHBZp2UYOQIXb0sq3nR36tPFiXyTDn6XQRqHyA=
=3D=3D&ch=3DeO8m8RGFMuSPuNs5hbLhvNaseCh0hKD5FUh6U-Frw7SKRgUWL5nIwg=3D=3D" d=
ata-trackable=3D"true"><img data-image-content class=3D"image_content" widt=
h=3D"473" src=3D"https://files.constantcontact.com/5f3d0cf9401/1e843211-74c=
0-4bce-98e2-dbd43d2e0e69.png" alt=3D"" style=3D"display: block; height: aut=
o; max-width: 100%;"></a> </td> </tr> </table> </td> </tr> </table> <table =
class=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"1=
00%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"co=
lumn column--1 scale stack" style=3D"width: 100%;" align=3D"center" valign=
=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,Helvetic=
a,sans-serif; color: #343332; font-size: 16px; display: block; word-wrap: b=
reak-word; padding: 10px 40px;" align=3D"left" valign=3D"top">
<p style=3D"text-align: center; margin: 0;" align=3D"center"><span style=3D=
"font-style: italic; font-family: Calibri, Helvetica, Arial, sans-serif; co=
lor: rgb(16, 18, 20);">5 Antibody drugs target different A&#x3b2; aggregati=
on forms</span></p>
<p style=3D"margin: 0;"><br></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(0, 0, 0); font-family: Ca=
libri, Helvetica, Arial, sans-serif; font-weight: bold;">Aneuro's new produ=
ct: A&#x3b2;42</span></p>
<p style=3D"margin: 0;"><span style=3D"color: rgb(16, 18, 20); font-family:=
 Calibri, Helvetica, Arial, sans-serif;">Aneuro recently launched recombina=
nt</span><span style=3D"color: rgb(0, 0, 0); font-family: Calibri, Helvetic=
a, Arial, sans-serif; text-decoration: underline;"> A&#x3b2;42 protein</spa=
n><span style=3D"color: rgb(0, 0, 0); text-decoration: underline;">&#xff08;=
</span><span style=3D"color: rgb(0, 0, 0); font-family: Calibri, Helvetica,=
 Arial, sans-serif; text-decoration: underline;">Cat. No. APP-H51H6</span><=
span style=3D"color: rgb(0, 0, 0); text-decoration: underline;">&#xff09;</s=
pan><span style=3D"color: rgb(16, 18, 20); font-family: Calibri, Helvetica,=
 Arial, sans-serif;">, which has been showed to bind specifically to aducan=
umab with high biological activity. Compared with synthetic peptides, our A=
&#x3b2;42 protein has natural conformation to facilitate the diagnosis and =
treatment research of AD.</span></p>
</td> </tr> </table> </td> </tr> </table> <table class=3D"layout layout--1-=
column" style=3D"table-layout: fixed;" width=3D"100%" border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0"> <tr> <td class=3D"column column--1 scale stack=
" style=3D"width: 100%;" align=3D"center" valign=3D"top">
<table class=3D"text text--article text--padding-vertical" width=3D"100%" b=
order=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixe=
d;"> <tr> <td class=3D"text_content-cell content-padding-horizontal" style=
=3D"text-align: left; font-family: Arial,Verdana,Helvetica,sans-serif; colo=
r: #343332; font-size: 16px; line-height: 1.2; display: block; word-wrap: b=
reak-word; padding: 10px 40px;" align=3D"left" valign=3D"top"><p style=3D"t=
ext-align: center; margin: 0;" align=3D"center"><span style=3D"font-weight:=
 bold; font-family: Calibri, Helvetica, Arial, sans-serif; color: rgb(0, 0,=
 0); font-size: 17px;">Verification data</span></p></td> </tr> </table> </t=
d> </tr> </table> <table class=3D"layout-margin" style=3D"" width=3D"100%" =
border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"layout-=
margin_cell" style=3D"padding: 0px 40px;" align=3D"center" valign=3D"top"> =
<table class=3D"layout layout--2-column layout--divided" style=3D"table-lay=
out: fixed;" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0=
"> <tr> <td class=3D"column column-border column--1 scale stack" style=3D"w=
idth: 45%; border: 1px solid #3e3e3e;" align=3D"center" valign=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 20px;" align=3D"left" valign=3D"top"><ul><li style=3D"font-size: =
16px;"><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif; f=
ont-weight: bold; font-size: 16px;">&#xa0;High purity&#xff1e;95%</span></li=
></ul></td> </tr> </table> <table class=3D"image image--mobile-scale image-=
-mobile-center" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0"> <tr> <td class=3D"image_container" align=3D"center" valign=3D"top">=
 <img data-image-content class=3D"image_content" width=3D"115" src=3D"https=
://files.constantcontact.com/5f3d0cf9401/91f890b9-c6cf-4572-824f-ee5176aa01=
19.jpg" alt=3D"" style=3D"display: block; height: auto; max-width: 100%;"> =
</td> </tr> </table> <table class=3D"text text--padding-vertical" width=3D"=
100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"table-layou=
t: fixed;"> <tr> <td class=3D"text_content-cell content-padding-horizontal"=
 style=3D"line-height: 1.5; text-align: left; font-family: Arial,Verdana,He=
lvetica,sans-serif; color: #3E3E3E; font-size: 14px; display: block; word-w=
rap: break-word; padding: 10px 20px;" align=3D"left" valign=3D"top"><p styl=
e=3D"margin: 0;"><span style=3D"font-family: Arial, Verdana, Helvetica, san=
s-serif;">Human Abeta42, His Tag </span><span style=3D"font-family: Arial, =
Verdana, Helvetica, sans-serif; color: rgb(85, 85, 85);">&#xff08;Cat. No. <=
/span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D0012a1QjHQodXmwxulSlsZCvXJt=
vUBHhl5zEc1HJNyMbmbxlUoeNBMsCvEk5krvsfjMxm9x3p3kqrgJxIlL777Mywza9DnOOuACtYn=
atFlJQ3_1m3I9NJBCdEhVbOKVw9Wox2qzlXv3p30_zwodXbLpCx8ztG7bCxFB0OACaVccCeqA3P=
5TPx9rpn5P7p2jdJ9pfk2v13j1bjXd2TOJY9B824ZlTGR4_7Yut0FiGtL9Uao-ToxtdjqegjzM8=
yyKWllUdfzZGySginkdCOHTBwkyG6IJVb8StJ_RRtdwWn_6PnTn73G09GA1FTiMcYGP73t-olJQ=
dedqMTZA5ROHn_LZ3qM7V6Ak4FP50ghAAMM6SxUOqcu2A-pyhQ=3D=3D&c=3DLGE7Qun9sEqBnD=
6XCHBZp2UYOQIXb0sq3nR36tPFiXyTDn6XQRqHyA=3D=3D&ch=3DeO8m8RGFMuSPuNs5hbLhvNa=
seCh0hKD5FUh6U-Frw7SKRgUWL5nIwg=3D=3D" target=3D"_blank" style=3D"font-fami=
ly: Arial, Verdana, Helvetica, sans-serif; color: rgb(192, 0, 0); font-weig=
ht: bold; text-decoration: underline;">APP-H51H6</a><span style=3D"font-fam=
ily: Arial, Verdana, Helvetica, sans-serif; color: rgb(85, 85, 85);">&#xff0=
9; </span><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif=
;">on SDS-PAGE under reducing (R) condition. The gel was stained overnight =
with Coomassie Blue. The purity of the protein is greater than 95%.</span><=
/p></td> </tr> </table> </td>  <td class=3D"column-divider scale stack" sty=
le=3D"height: 1px; line-height: 1px;" width=3D"20" align=3D"center" valign=
=3D"top"> <img alt=3D"" width=3D"20" height=3D"20" border=3D"0" hspace=3D"0=
" vspace=3D"0" src=3D"https://imgssl.constantcontact.com/letters/images/110=
1116784221/S.gif"> </td>  <td class=3D"column column-border column--2 scale=
 stack" style=3D"width: 55%; border: 1px solid #3e3e3e;" align=3D"center" v=
align=3D"top">
<table class=3D"text text--padding-vertical" width=3D"100%" border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" style=3D"table-layout: fixed;"> <tr> <td =
class=3D"text_content-cell content-padding-horizontal" style=3D"text-align:=
 left; font-family: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; fon=
t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
ing: 10px 20px;" align=3D"left" valign=3D"top"><ul><li style=3D"font-size: =
16px;"><span style=3D"font-family: Arial, Verdana, Helvetica, sans-serif; f=
ont-size: 16px; font-weight: bold;">High bioactivity verified by binding to=
 aducanumab</span></li></ul></td> </tr> </table> <table class=3D"image imag=
e--padding-vertical image--mobile-scale image--mobile-center" width=3D"100%=
" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"> <tr> <td class=3D"image=
_container" align=3D"center" valign=3D"top" style=3D"padding-top: 10px; pad=
ding-bottom: 10px;"> <img data-image-content class=3D"image_content" width=
=3D"288" src=3D"https://files.constantcontact.com/5f3d0cf9401/647079ca-a154=
-4d55-97ee-e8384f6adad8.jpg" alt=3D"" style=3D"display: block; height: auto=
; max-width: 100%;"> </td> </tr> </table> <table class=3D"text text--paddin=
g-vertical" width=3D"100%" border=3D"0" cellpadding=3D"0" cellspacing=3D"0"=
 style=3D"table-layout: fixed;"> <tr> <td class=3D"text_content-cell conten=
t-padding-horizontal" style=3D"line-height: 1.5; text-align: left; font-fam=
ily: Arial,Verdana,Helvetica,sans-serif; color: #3E3E3E; font-size: 14px; d=
isplay: block; word-wrap: break-word; padding: 10px 20px;" align=3D"left" v=
align=3D"top">
<p style=3D"margin: 0;"><span style=3D"color: black; font-family: Arial, Ve=
rdana, Helvetica, sans-serif;">Immobilized Human Abeta42, His Tag (Cat. No.=
 </span><a href=3D"https://r20.rs6.net/tn.jsp?f=3D0012a1QjHQodXmwxulSlsZCvX=
JtvUBHhl5zEc1HJNyMbmbxlUoeNBMsCvEk5krvsfjMxm9x3p3kqrgJxIlL777Mywza9DnOOuACt=
YnatFlJQ3_1m3I9NJBCdEhVbOKVw9Wox2qzlXv3p30_zwodXbLpCx8ztG7bCxFB0OACaVccCeqA=
3P5TPx9rpn5P7p2jdJ9pfk2v13j1bjXd2TOJY9B824ZlTGR4_7Yut0FiGtL9Uao-Toxtdjqegjz=
M8yyKWllUdfzZGySginkdCOHTBwkyG6IJVb8StJ_RRtdwWn_6PnTn73G09GA1FTiMcYGP73t-ol=
JQdedqMTZA5ROHn_LZ3qM7V6Ak4FP50ghAAMM6SxUOqcu2A-pyhQ=3D=3D&c=3DLGE7Qun9sEqB=
nD6XCHBZp2UYOQIXb0sq3nR36tPFiXyTDn6XQRqHyA=3D=3D&ch=3DeO8m8RGFMuSPuNs5hbLhv=
NaseCh0hKD5FUh6U-Frw7SKRgUWL5nIwg=3D=3D" target=3D"_blank" style=3D"color: =
rgb(192, 0, 0); font-family: Arial, Verdana, Helvetica, sans-serif; font-we=
ight: bold; text-decoration: underline;">APP-H51H6</a><span style=3D"color:=
 black; font-family: Arial, Verdana, Helvetica, sans-serif;">) at 5 &#x3bc;=
g/mL (100 &#x3bc;L/well) can bind Aducanumab with a linear range of 0.2-2 n=
g/mL (QC tested).</span></p>
<p style=3D"text-align: center; margin: 0;" align=3D"center"><a href=3D"htt=
ps://r20.rs6.net/tn.jsp?f=3D0012a1QjHQodXmwxulSlsZCvXJtvUBHhl5zEc1HJNyMbmbx=
lUoeNBMsCvEk5krvsfjMfChSnW3BXQaOMUwKWrc8iCc-rE--BP13n4PwumUHrfGdmWlmsofsFeC=
yoL5m4R5lRDwRah-L52joitqOFe2fpqkzE48IOQPUH-ZgFQhK26eI3f5_k_H55aRp5ygcmZqH1T=
G-3qF0pSauhxBKqe-kPfOY6VpclYGoDftLMFM23847U2c1hvJ1-d3ZhjWMtif8MHGiWzKrsiaBG=
fzl9UB4i3_kn_3KrVrFGW8LEYJQRqwC4DDPw_Vy50ckdI2RnP23KIff1YpNRdQ63xpFEYvQUWqx=
LRD5OIpvVFND5Bykg6zJDsJe76a5D6x5hDdaD6dL&c=3DLGE7Qun9sEqBnD6XCHBZp2UYOQIXb0=
sq3nR36tPFiXyTDn6XQRqHyA=3D=3D&ch=3DeO8m8RGFMuSPuNs5hbLhvNaseCh0hKD5FUh6U-F=
rw7SKRgUWL5nIwg=3D=3D" target=3D"_blank" style=3D"background-color: rgb(251=
, 224, 221); color: #4d4d4d; font-weight: bold; text-decoration: underline;=
">Protocol</a></p>
</td> </tr> </table> </td> </tr> </table>  </td> </tr> </table> <table clas=
s=3D"layout layout--1-column" style=3D"table-layout: fixed;" width=3D"100%"=
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t-size: 14px; line-height: 1.2; display: block; word-wrap: break-word; padd=
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n style=3D'font-size: 9px; color: red; font-family: Georgia, "Times New Rom=
an", Times, serif;'>&#x25bc;&#xa0;</span><a href=3D"https://r20.rs6.net/tn.=
jsp?f=3D0012a1QjHQodXmwxulSlsZCvXJtvUBHhl5zEc1HJNyMbmbxlUoeNBMsCpu4Fk9ADoJF=
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erif; text-decoration: underline; font-weight: bold;">Click to learn about =
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