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Subject: =?utf-8?Q?Boost=20the=20Production=20of=20AAV2=20in=20HEK293=20Fed=2DBatch=20Culture?=
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Learn More About our HEK293 Media Survey Panel & Fed-Batch Culture

View in your browser. (https://mailchi.mp/labroots/boost-the-production-of=
-aav2-in-hek293-fed-batch-culture?e=3D421d0bfc01)

https://www.irvinesci.com/

https://www.irvinesci.com/
https://www.irvinesci.com/custom-media-services/hek-media-survey-panel?utm=
_source=3Dlabroots&utm_medium=3Demail&utm_campaign=3Dhek293

**
Improve Viral Packaging and Efficiency with HEK293 Media Survey Panel Feed=
s
------------------------------------------------------------

** Development of a Feed Medium to Improve AAV Production in HEK293 Fed-Ba=
tch Culture
------------------------------------------------------------

Human embryonic kidney (HEK293) cells are the most commonly used cell line=
 to produce viral vectors for gene therapy. Due to the complexity of their=
 production and purification=2C as well as the therapeutic demand for high=
 dosages=2C viral vectors can be very expensive to produce.

Choosing the proper media in a scale-down model for each cell line and pro=
cess can improve yield and lower production costs. In this poster presenta=
tion=2C we address how the HEK293 Media Survey Panel (HMSP) helps cell and=
 gene therapy product manufacturers more quickly and efficiently discover=
 the optimal media as well as:

* How the HSMP Feed panel (https://www.irvinesci.com/custom-media-services=
/hek-media-survey-panel?utm_source=3Dlabroots&utm_medium=3Demail&utm_campa=
ign=3Dhek293) can help improve production yields of high-quality adeno-ass=
ociated viral vectors
* How the HMSP Feed panel can boost AAV2 viral genome titer
* How the HMSP Feed can improve viral packaging efficiency without comprom=
ising cell growth and health

Contact us (https://www.irvinesci.com/contact-us/custom-media-services-req=
uest?utm_source=3Dlabroots&utm_medium=3Demail&utm_campaign=3Dhek293)  for=
 more information about BalanCD HEK293 System (https://www.irvinesci.com/b=
ioproduction/balancd-hek293-system.html?utm_source=3Dlabroots&utm_medium=
=3Demail&utm_campaign=3Dhek293) .

Download Now (https://www.irvinesci.com/media/IrvineScientific/Resources/0=
/1/013525-aav-production-in-hek293-fed-batch-culture-esact2022.pdf?utm_sou=
rce=3Dlabroots&utm_medium=3Demail&utm_campaign=3Dhek293)

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        <title>Boost the Production of AAV2 in HEK293 Fed-Batch Culture</t=
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Learn More About our HEK293 Media Survey Panel &amp; Fed-Batch Culture<br>
<br>
<span style=3D"font-size:11px"><a href=3D"https://mailchi.mp/labroots/boos=
t-the-production-of-aav2-in-hek293-fed-batch-culture?e=3D421d0bfc01" target=
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&nbsp;</div>

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<h1 style=3D"margin: 9px 18px 0 18px !importan=
t;padding: 0;display: block;font-family: Arial=2C 'Helvetica Neue'=2C Helv=
etica=2C sans-serif;font-size: 26px;font-style: normal;font-weight: 900;li=
ne-height: 125%;letter-spacing: normal;text-align: left;color: #007ac2 !im=
portant;"><br>
<strong>Improve Viral Packaging and Efficiency with HEK293 Media Survey Pa=
nel Feeds</strong></h1>
<br>
&nbsp;
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=09=09=09=09

<h3 class=3D"null" style=3D"margin: 0 18px 9px=
 18px !important;padding: 0;display: block;font-family: Helvetica;font-siz=
e: 17px;font-style: normal;font-weight: bold;line-height: 125%;letter-spac=
ing: normal;text-align: left;color: #44697d !important;">Development of a=
 Feed Medium to Improve AAV Production in HEK293 Fed-Batch Culture
</h3>

</td>
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=09=09=09=09

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              =09
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                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
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<p style=3D"line-height: 150%;margin: 9px 18px=
 18px !important;padding: 0;-ms-text-size-adjust: 100%;-webkit-text-size-a=
djust: 100%;color: #696969;font-family: Arial=2C 'Helvetica Neue'=2C Helve=
tica=2C sans-serif;font-size: 13px;text-align: left;">Human embryonic kidn=
ey (HEK293) cells are the most commonly used cell line to produce viral ve=
ctors for gene therapy. Due to the complexity of their production and puri=
fication=2C as well as the therapeutic demand for high dosages=2C viral ve=
ctors can be very expensive to produce.</p><p style=3D"line-height: 150%;m=
argin: 9px 18px 18px !important;padding: 0;-ms-text-size-adjust: 100%;-web=
kit-text-size-adjust: 100%;color: #696969;font-family: Arial=2C 'Helvetica=
 Neue'=2C Helvetica=2C sans-serif;font-size: 13px;text-align: left;">

</p><p style=3D"line-height: 150%;margin: 9px 18px 18px !important;padding=
: 0;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #6969=
69;font-family: Arial=2C 'Helvetica Neue'=2C Helvetica=2C sans-serif;font-=
size: 13px;text-align: left;">Choosing the proper media in a scale-down mo=
del for each cell line and process can improve yield and lower production=
 costs. In this poster presentation=2C we address how the HEK293 Media Sur=
vey Panel (HMSP) helps cell and gene therapy product manufacturers more qu=
ickly and efficiently discover the optimal media as well as:</p><p style=
=3D"line-height: 150%;margin: 9px 18px 18px !important;padding: 0;-ms-text=
-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #696969;font-fami=
ly: Arial=2C 'Helvetica Neue'=2C Helvetica=2C sans-serif;font-size: 13px;t=
ext-align: left;">
</p><ul style=3D"margin-right: 18px;">
=09<li style=3D"-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;=
">How the <a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D=
6f39393ef38fb324428ff8c2c&id=3De9eeb6a40c&e=3D421d0bfc01" target=3D"_blan=
k" style=3D"word-wrap: break-word;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;color: #38b1d1;font-weight: normal;text-decoration: unde=
rline;"><strong>HSMP Feed panel</strong></a> can help improve production y=
ields of high-quality adeno-associated viral vectors</li>
=09<li style=3D"-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;=
">How the HMSP Feed panel can boost AAV2 viral genome titer</li>
=09<li style=3D"-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;=
">How the HMSP Feed can improve viral packaging efficiency without comprom=
ising cell growth and health</li>
</ul>

<p style=3D"line-height: 150%;margin: 9px 18px 18px !important;padding: 0;=
-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #696969;f=
ont-family: Arial=2C 'Helvetica Neue'=2C Helvetica=2C sans-serif;font-size=
: 13px;text-align: left;"><span style=3D"font-size:14px"><a href=3D"https:=
//labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb324428ff8c2c&i=
d=3Dfeccbadf8d&e=3D421d0bfc01" target=3D"_blank" style=3D"word-wrap: brea=
k-word;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #3=
8b1d1;font-weight: normal;text-decoration: underline;"><strong>Contact us<=
/strong></a>&nbsp;for more information about <a href=3D"https://labroots.u=
s7.list-manage.com/track/click?u=3D6f39393ef38fb324428ff8c2c&id=3Da6319d73=
3e&e=3D421d0bfc01" target=3D"_blank" style=3D"word-wrap: break-word;-ms-t=
ext-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #38b1d1;font-w=
eight: normal;text-decoration: underline;"><strong>BalanCD HEK293 System</=
strong></a>. </span><br>
&nbsp;</p>

</td>
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                </tbody></table>
=09=09=09=09

=09=09=09=09
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</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
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e: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;padding:=
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nner">
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ass=3D"mcnButtonContentContainer" style=3D"border-collapse: separate !impo=
rtant;border-radius: 7px;background-color: #0E8547;mso-table-lspace: 0pt;m=
so-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust:=
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0%;-webkit-text-size-adjust: 100%;padding-top: 13px !important;padding-rig=
ht: 25px !important;padding-bottom: 13px !important;padding-left: 25px !im=
portant;">
                                <a class=3D"mcnButton " title=3D"Download=
 Now" href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393=
ef38fb324428ff8c2c&id=3Da7966ebb91&e=3D421d0bfc01" target=3D"_blank" styl=
e=3D"font-weight: bold;letter-spacing: normal;line-height: 100%;text-align=
: center;text-decoration: none;color: #FFFFFF;word-wrap: break-word;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;">Download Now</a>
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</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnBoxedTextBlock" style=3D"min-width: 100%;border-collapse:=
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: 100%;-webkit-text-size-adjust: 100%;">
    
=09<tbody class=3D"mcnBoxedTextBlockOuter">
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dding=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"templateColumn" styl=
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or: #007ac2;border-top: 0;border-bottom: 0;">
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oterContainer" style=3D"padding-bottom: 9px;mso-table-lspace: 0pt;mso-tabl=
e-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;pa=
dding-top: 0 !important;padding-right: 0 !important;padding-left: 0 !impor=
tant;padding: 0 0 !important;"><table border=3D"0" cellpadding=3D"0" cells=
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t: 100%;-webkit-text-size-adjust: 100%;padding-right: 0 !important;padding=
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>
              =09
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=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
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<p style=3D"color: #FFFFFF;font-family: Helvetica;font-size: 11px;font-wei=
ght: normal;margin: 9px 18px 18px !important;padding: 0;-ms-text-size-adju=
st: 100%;-webkit-text-size-adjust: 100%;line-height: 125%;text-align: left=
;">=C2=A9 2022&nbsp;FUJIFILM Irvine Scientific and its logo are registered=
 trademarks of FUJIFILM Irvine Scientific=2C Inc. in various jurisdictions=
=2E All other trademarks are the property of their respective owners.<br>
&nbsp;</p>
</div>

=09=09=09=09
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