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Subject: =?utf-8?Q?Sign=20Up=3A=20Producing=20human=20IgG=20Fc=20antibodies=20in=20yeasts=20=2D=20Methanol=2Dfree=20expression=20in=20Pichia=20pastoris?=
From: =?utf-8?Q?Labroots=20for=20Eppendorf?= <info@labroots.com>
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To: <gerald.wahome@saraya.world>
Date: Wed, 19 Oct 2022 18:03:38 +0000
Message-ID: <6f39393ef38fb324428ff8c2c.421d0bfc01.20221019180327.fda622b3ff.a077630b@mail92.sea21.rsgsv.net>
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Free Webinar - Register Today

View this email in your browser (https://mailchi.mp/labroots/viral-evoluti=
on-and-implications-on-hiv-and-sars-cov-227050?e=3D421d0bfc01)
https://www.labroots.com/ms/webinar/producing-human-igg-fc-antibodies-yeas=
ts-methanol-free-expression-pichia-pastoris?campaign=3Dlremail
Register for Free (https://www.labroots.com/ms/webinar/producing-human-igg=
-fc-antibodies-yeasts-methanol-free-expression-pichia-pastoris?campaign=3D=
lremail)

** Producing human IgG Fc antibodies in yeasts - Methanol-free expression=
 in Pichia pastoris
------------------------------------------------------------

November 03=2C 2022
https://www.labroots.com/intercall/add-to-calendar/Webinar/7644?start-date=
=3D20221103T070000&end-date=3D20221103T080000&TZID=3DAmerica/Los_Angeles7:=
00am (PST)=2C 10:00am (EST)=2C
3:00pm (CET)
Presented by:
https://www.labroots.com/ms/webinar/producing-human-igg-fc-antibodies-yeas=
ts-methanol-free-expression-pichia-pastoris?campaign=3Dlremail
Ying Yang
Senior Research Scientist=2C Bioprocess

=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=
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=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D

Abstract:
Nowadays=2C therapeutic monoclonal antibodies (mAb) are predominantly prod=
uced with mammalian cell culture systems such as those using Chinese hamst=
er ovary (CHO) cells. Efforts are underway to reduce the costs of this pro=
cess to meet the increasing global demand in biopharmaceuticals; meanwhile=
 cheaper and faster expression systems are being investigated as alternati=
ves. The yeast Pichia pastoris has become a substantial workhorse for reco=
mbinant protein production. However=2C the N-linked glycosylation in P. pa=
storis=2C namely high mannose glycosylation=2C is significantly different=
 from that in CHO or other mammalian cells including human cells. In this=
 webinar=2C we will show=2C how we constructed a SuperMan5 strain of P. pa=
storis using the Pichia GlycoSwitch=C2=AE technology to successfully produ=
ce a more mammalian-like immunoglobulin fragment IgG Fc. This showcases th=
e potential of P. pastoris as a next generation mAb production platform. I=
mportantly=2C we will highlight the benefits of working with a
methanol-independent promoter. Most P. pastoris promoters used for protein=
 expression are derived from genes in the methanol metabolism pathway=2C c=
reating safety concerns due to the flammable nature of methanol especially=
 at large scale. Here=2C a fed-batch SuperMan5 P. pastoris fermentation wa=
s carried out in which methanol induction=2C as well as its affiliated saf=
ety risks=2C was eliminated. The 3 L bench scale bioprocess demonstrates t=
he feasibility of using P. pastoris for IgG Fc production in a methanol-in=
dependent environment=2C providing insight for future industrial mAb produ=
ction seeking a safe and cost-effective approach to compete with mammalian=
 cell culture.

Learning Objectives
* Learn=2C how to run a methanol-free=2C bench-scale P. pastoris fermentat=
ion
* Learn=2C how to work with a Pichia GlycoSwitch System for IgG Fc product=
ion with in-situ mammalian-like glycosylation
* Learn=2C how to set up a bioprocess for Pichia fermentation

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              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
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<h1 style=3D"display: block;margin: 0;padding:=
 0;color: #333333;font-family: Helvetica;font-size: 24px;font-style: norma=
l;font-weight: normal;line-height: 125%;letter-spacing: normal;text-align:=
 left;"><span style=3D"font-size:26px">Producing human IgG Fc antibodies i=
n yeasts - Methanol-free expression in&nbsp;<i>Pichia pastoris</i></span><=
/h1>
&nbsp;

<p style=3D"text-align: left;margin: 10px 0;padding: 0;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color=
: #202020;font-family: Helvetica;font-size: 14px;line-height: 150%;"><span=
 style=3D"color:#0667AB"><strong>November 03=2C 2022</strong></span><br>
<a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef3=
8fb324428ff8c2c&id=3Dc5077f9f7e&e=3D421d0bfc01" target=3D"_blank" style=
=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;color: #1e8ae7;font-weight: normal;text-decoration: unde=
rline;"><img data-file-id=3D"42943" height=3D"13" src=3D"https://gallery.m=
ailchimp.com/6f39393ef38fb324428ff8c2c/images/b9d0b3b5-66ac-4b86-857f-08e5=
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tline: none;text-decoration: none;-ms-interpolation-mode: bicubic;" width=
=3D"20"></a>7:00am (PST)=2C&nbsp;10:00am (EST)=2C<br>
&nbsp; &nbsp; &nbsp;3:00pm (CET)</p>

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=09=09=09=09

=09=09=09=09
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lpadding=3D"0" cellspacing=3D"0" width=3D"300" class=3D"columnWrapper" sty=
le=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0p=
t;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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lumnContainer" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust=
: 100%;-webkit-text-size-adjust: 100%;"><table border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D"min-w=
idth: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspac=
e: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
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<strong>Presented by:</strong>
                        </td>
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=09=09=09=09

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00%" class=3D"mcnTextBlock" style=3D"min-width: 100%;border-collapse: coll=
apse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;">
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            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<span style=3D"color:#0467AB"><span style=3D"f=
ont-size:13px"><strong>Ying Yang</strong></span></span><br>
<span style=3D"font-size:13px">Senior Research Scientist=2C Bioprocess</sp=
an><br>
<span style=3D"display:none">&nbsp;</span><span style=3D"display:none">&nb=
sp;</span>
                        </td>
                    </tr>
                </tbody></table>
=09=09=09=09

=09=09=09=09
            </td>
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</table></td>
                                        </tr>
                                    </table>
                                    
                                </td>
                            </tr>
                            <tr>
                                <td valign=3D"top" id=3D"templateFooter" s=
tyle=3D"background:#ffffff none no-repeat center/cover;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;backg=
round-color: #ffffff;background-image: none;background-repeat: no-repeat;b=
ackground-position: center;background-size: cover;border-top: 0;border-bot=
tom: 0;padding-top: 9px;padding-bottom: 9px;"><table border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D=
"min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table=
-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<p style=3D"font-size: 14px;text-align: left;m=
argin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;color: #555555;font-family: Helveti=
ca;line-height: 150%;"><strong>Abstract:</strong></p>
Nowadays=2C therapeutic monoclonal antibodies (mAb) are predominantly prod=
uced with mammalian cell culture systems such as those using Chinese hamst=
er ovary (CHO) cells. Efforts are underway to reduce the costs of this pro=
cess to meet the increasing global demand in biopharmaceuticals; meanwhile=
 cheaper and faster expression systems are being investigated as alternati=
ves. The yeast&nbsp;<em>Pichia pastoris</em>&nbsp;has become a substantial=
 workhorse for recombinant protein production. However=2C the N-linked gly=
cosylation in&nbsp;<em>P. pastoris</em>=2C namely high mannose glycosylati=
on=2C is significantly different from that in CHO or other mammalian cells=
 including human cells. In this webinar=2C we will show=2C how we construc=
ted a SuperMan5 strain of&nbsp;<em>P. pastoris</em>&nbsp;using the Pichia=
 GlycoSwitch=C2=AE&nbsp;technology to successfully produce a more mammalia=
n-like immunoglobulin fragment IgG Fc. This showcases the potential of&nbs=
p;<em>P. pastoris</em>&nbsp;as a next generation mAb production platform.=
 Importantly=2C we will highlight the benefits of working with a methanol-=
independent promoter. Most&nbsp;<em>P. pastoris</em>&nbsp;promoters used f=
or protein expression are derived from genes in the methanol metabolism pa=
thway=2C creating safety concerns due to the flammable nature of methanol=
 especially at large scale. Here=2C a fed-batch SuperMan5&nbsp;<em>P. past=
oris</em>&nbsp;fermentation was carried out in which methanol induction=2C=
 as well as its affiliated safety risks=2C was eliminated. The 3 L bench s=
cale bioprocess demonstrates the feasibility of using&nbsp;<em>P. pastoris=
</em>&nbsp;for IgG Fc production in a methanol-independent environment=2C=
 providing insight for future industrial mAb production seeking a safe and=
 cost-effective approach to compete with mammalian cell culture.<br>
&nbsp;<br>
<strong>Learning Objectives</strong>

<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Learn=2C how to run a methanol-free=2C ben=
ch-scale&nbsp;<em>P. pastoris</em>&nbsp;fermentation</li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Learn=2C how to work with a Pichia GlycoSw=
itch System for IgG Fc production with in-situ mammalian-like glycosylatio=
n</li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Learn=2C how to set up a bioprocess for&nb=
sp;<em>Pichia&nbsp;</em>fermentation</li>
</ul>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

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o-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webk=
it-text-size-adjust: 100%;">
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=3D"padding-right: 9px;padding-bottom: 9px;mso-line-height-rule: exactly;-=
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