관리-도구

편집 파일: 1663104928.M504929P21624.server.saraya-global.com,S=105647,W=107848:2,

Envelope-to: kibrahim@saraya.world
Delivery-date: Wed, 14 Sep 2022 05:35:28 +0800
Subject: =?utf-8?Q?Spatial=20Single=20Cell=20Characterization=20of=20Alzheimer=27s=20Disease=20in=20Mouse=20and=20Human=20Hippocampus?=
From: =?utf-8?Q?Labroots=20for=20NanoString?= <info@labroots.com>
Reply-To:  <us7-51097e609a-487e10314d@inbound.mailchimpapp.net>
To: <kibrahim@saraya.world>
Date: Tue, 13 Sep 2022 21:34:12 +0000
Message-ID: <6f39393ef38fb324428ff8c2c.24e951eba2.20220913213403.5349d28921.7bbe471c@mail98.atl11.rsgsv.net>
Feedback-ID: 18556591:18556591.223210:us7:mc
Precedence: bulk
Content-Type: multipart/alternative; boundary="_----------=_MCPart_889549204"
MIME-Version: 1.0

This is a multi-part message in MIME format

--_----------=_MCPart_889549204
Content-Type: text/plain; charset="utf-8"; format="fixed"
Content-Transfer-Encoding: quoted-printable

Free Webinar - Register Today!=C2=A0

View this email in your browser (https://mailchi.mp/labroots/interrogate-t=
umor-immune-interactions-in-aml-patients-receiving-immune-checkpoint-inhib=
itor-223210?e=3D24e951eba2)
https://www.labroots.com/ms/webinar/spatial-single-cell-characterization-a=
lzheimer-s-disease-mouse-human-hippocampus?campaign=3Dlremail
Register now (https://www.labroots.com/ms/webinar/spatial-single-cell-char=
acterization-alzheimer-s-disease-mouse-human-hippocampus?campaign=3Dlremai=
l)

** Spatial Single Cell Characterization of Alzheimer's Disease in Mouse an=
d Human Hippocampus
------------------------------------------------------------

September 27=2C 2022
https://www.labroots.com/intercall/add-to-calendar/Webinar/7595?start-date=
=3D20220927T100000&end-date=3D20220927T110000&TZID=3DAmerica/Los_Angeles 1=
0:00am (PDT)=2C 1:00pm (EDT)=2C
7:00pm (CEST)
Presented by:
https://www.labroots.com/ms/webinar/spatial-single-cell-characterization-a=
lzheimer-s-disease-mouse-human-hippocampus?campaign=3Dlremail
Vikram Devgan
Business Unit Lead-Spatial Genomics
https://www.labroots.com/ms/webinar/spatial-single-cell-characterization-a=
lzheimer-s-disease-mouse-human-hippocampus?campaign=3Dlremail
Miranda E. Orr
Assistant Professor=2C Gerontology and Geriatric Medicine=2C Wake Forest U=
niversity=2C School of Medicine

=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=
=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=
=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D

Abstract
Alzheimer=E2=80=99s disease is the most common cause of dementia and the s=
eventh leading cause of death in the United States. The accumulation of pr=
otein aggregates (i.e.=2C extracellular A=CE=B2 plaques and intracellular=
 tau-containing neurofibrillary tangles) constitute the biological hallmar=
ks of Alzheimer=E2=80=99s disease. Clinical trials enhancing the clearance=
 of A=CE=B2 and tau have failed to alter disease progression indicating di=
sease complexity beyond protein accumulation. Comprehending the cellular a=
nd molecular features of cells and their environments in Alzheimer=E2=80=
=99s disease is urgently needed to develop effective disease modifying the=
rapies. To uncover interactions between cells containing tau pathology and=
 their microenvironments=2C Dr. Orr=E2=80=99s team employed NanoString Geo=
Mx=C2=AE Digital Spatial Profiling (DSP). They performed a spatial-proteom=
ic analysis of postmortem brains from individuals with Alzheimer=E2=80=99s=
 disease neuropathology with or without dementia. Comparing the protein ex=
pression profiles in neurons
and their microenvironments led to identification of molecules differentia=
lly regulated in individuals resilient to dementia=2C despite the presence=
 of neuropathology. To gain mechanistic insights into the role of tau path=
ogenesis her team utilized CosMx^TM Spatial Molecular Imaging. Their spati=
al-transcriptomic analysis comparing a mouse model of tau neuropathology t=
o an age-matched control identified cellular population changes with spati=
ally-resolved gene expression differences across 42 cell types. The analys=
es further revealed a tau-dependent loss of three cellular niches involvin=
g neuronal=2C glia and vascular cells.

Learning Objectives
* Understand how Nanostring=E2=80=99s GeoMx DSP and CosMx SMI spatial plat=
forms were used to determine spatially resolved preotomic and transcriptom=
ic profiles of neurons and their microenvironments in Alzheimer=E2=80=99s=
 disease human and mouse tissue
* Learn how GeoMx DSP is able to subtype neuropathology in brain tissue wi=
th Alzheimer=E2=80=99s disease neuropathology.
* Learn how CosMx SMI is able to spatially resolve cellular and molecular=
 changes in response to tau protein toxicity

** Register now (https://www.labroots.com/ms/webinar/spatial-single-cell-c=
haracterization-alzheimer-s-disease-mouse-human-hippocampus?campaign=3Dlre=
mail)
** Share (http://www.facebook.com/sharer/sharer.php?u=3Dhttps%3A%2F%2Fmail=
chi.mp%2Flabroots%2Finterrogate-tumor-immune-interactions-in-aml-patients-=
receiving-immune-checkpoint-inhibitor-223210)
** Share (http://www.facebook.com/sharer/sharer.php?u=3Dhttps%3A%2F%2Fmail=
chi.mp%2Flabroots%2Finterrogate-tumor-immune-interactions-in-aml-patients-=
receiving-immune-checkpoint-inhibitor-223210)
** Tweet (http://twitter.com/intent/tweet?text=3DSpatial+Single+Cell+Chara=
cterization+of+Alzheimer%27s+Disease+in+Mouse+and+Human+Hippocampus: https=
%3A%2F%2Fmailchi.mp%2Flabroots%2Finterrogate-tumor-immune-interactions-in-=
aml-patients-receiving-immune-checkpoint-inhibitor-223210)
** Tweet (http://twitter.com/intent/tweet?text=3DSpatial+Single+Cell+Chara=
cterization+of+Alzheimer%27s+Disease+in+Mouse+and+Human+Hippocampus: https=
%3A%2F%2Fmailchi.mp%2Flabroots%2Finterrogate-tumor-immune-interactions-in-=
aml-patients-receiving-immune-checkpoint-inhibitor-223210)
** Share (http://www.linkedin.com/shareArticle?url=3Dhttps%3A%2F%2Fmailchi=
=2Emp%2Flabroots%2Finterrogate-tumor-immune-interactions-in-aml-patients-rec=
eiving-immune-checkpoint-inhibitor-223210&mini=3Dtrue&title=3DSpatial+Sing=
le+Cell+Characterization+of+Alzheimer%27s+Disease+in+Mouse+and+Human+Hippo=
campus)
** Share (http://www.linkedin.com/shareArticle?url=3Dhttps%3A%2F%2Fmailchi=
=2Emp%2Flabroots%2Finterrogate-tumor-immune-interactions-in-aml-patients-rec=
eiving-immune-checkpoint-inhibitor-223210&mini=3Dtrue&title=3DSpatial+Sing=
le+Cell+Characterization+of+Alzheimer%27s+Disease+in+Mouse+and+Human+Hippo=
campus)

Can't attend live? ** Click here (https://www.labroots.com/ms/webinar/spat=
ial-single-cell-characterization-alzheimer-s-disease-mouse-human-hippocamp=
us?campaign=3Dlremail)
to register and receive a link to the recorded webcast.

Webinars will be available for unlimited on-demand viewing after the live=
 event

** (https://www.labroots.com)

** (https://www.facebook.com/LabRootsInc)

** (https://twitter.com/labroots)

** (https://www.linkedin.com/company/labroots)

** (https://www.pinterest.com/labroots/)

** (https://www.instagram.com/labrootsinc/)

** (https://www.youtube.com/user/LabRoots)

** (http://blog.labroots.com)

Copyright =C2=A9 2008-2022 Labroots=2C Inc.  |  ** info@labroots.com (mail=
to:info@labroots.com)
|  ** labroots.com (http://www.labroots.com)
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
__________________________________________________________________________=
______________________________________

** Update your email preferences (https://labroots.com/profile/emails/kibrahim@saraya.world//)
or ** unsubscribe (https://labroots.com/profile/emails/kibrahim@saraya.world//)
from this list.** . (https://labroots.us7.list-manage.com/unsubscribe?u=3D=
6f39393ef38fb324428ff8c2c&id=3D70401679f9&e=3D24e951eba2&c=3D5349d28921)

Please read about reward eligibility and point distribution in our ** Term=
s and Conditions (https://www.labroots.com/terms-and-conditions#leaderboar=
d)
=2E
--_----------=_MCPart_889549204
Content-Type: text/html; charset="utf-8"
Content-Transfer-Encoding: quoted-printable

<!doctype html>
<html xmlns=3D"http://www.w3.org/1999/xhtml" xmlns:v=3D"urn:schemas-micros=
oft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office">
    <head>
        
        <meta charset=3D"UTF-8">
        <meta http-equiv=3D"X-UA-Compatible" content=3D"IE=3Dedge">
        <meta name=3D"viewport" content=3D"width=3Ddevice-width=2C initial=
-scale=3D1">
        <title>Spatial Single Cell Characterization of Alzheimer's Disease=
 in Mouse and Human Hippocampus</title>

}=09@media only screen and (max-width: 480px){
=09=09body=2Ctable=2Ctd=2Cp=2Ca=2Cli=2Cblockquote{
=09=09=09-webkit-text-size-adjust:none !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09body{
=09=09=09width:100% !important;
=09=09=09min-width:100% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.columnWrapper{
=09=09=09max-width:100% !important;
=09=09=09width:100% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnRetinaImage{
=09=09=09max-width:100% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnImage{
=09=09=09width:100% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnCartContainer=2C.mcnCaptionTopContent=2C.mcnRecContentContainer=
=2C.mcnCaptionBottomContent=2C.mcnTextContentContainer=2C.mcnBoxedTextCont=
entContainer=2C.mcnImageGroupContentContainer=2C.mcnCaptionLeftTextContent=
Container=2C.mcnCaptionRightTextContentContainer=2C.mcnCaptionLeftImageCon=
tentContainer=2C.mcnCaptionRightImageContentContainer=2C.mcnImageCardLeftT=
extContentContainer=2C.mcnImageCardRightTextContentContainer=2C.mcnImageCa=
rdLeftImageContentContainer=2C.mcnImageCardRightImageContentContainer{
=09=09=09max-width:100% !important;
=09=09=09width:100% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnBoxedTextContentContainer{
=09=09=09min-width:100% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnImageGroupContent{
=09=09=09padding:9px !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnCaptionLeftContentOuter .mcnTextContent=2C.mcnCaptionRightConten=
tOuter .mcnTextContent{
=09=09=09padding-top:9px !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnImageCardTopImageContent=2C.mcnCaptionBottomContent:last-child .=
mcnCaptionBottomImageContent=2C.mcnCaptionBlockInner .mcnCaptionTopContent=
:last-child .mcnTextContent{
=09=09=09padding-top:18px !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnImageCardBottomImageContent{
=09=09=09padding-bottom:9px !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnImageGroupBlockInner{
=09=09=09padding-top:0 !important;
=09=09=09padding-bottom:0 !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnImageGroupBlockOuter{
=09=09=09padding-top:9px !important;
=09=09=09padding-bottom:9px !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnTextContent=2C.mcnBoxedTextContentColumn{
=09=09=09padding-right:18px !important;
=09=09=09padding-left:18px !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnImageCardLeftImageContent=2C.mcnImageCardRightImageContent{
=09=09=09padding-right:18px !important;
=09=09=09padding-bottom:0 !important;
=09=09=09padding-left:18px !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcpreview-image-uploader{
=09=09=09display:none !important;
=09=09=09width:100% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09h1{
=09=09=09font-size:22px !important;
=09=09=09line-height:125% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09h2{
=09=09=09font-size:20px !important;
=09=09=09line-height:125% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09h3{
=09=09=09font-size:18px !important;
=09=09=09line-height:125% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09h4{
=09=09=09font-size:16px !important;
=09=09=09line-height:150% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09.mcnBoxedTextContentContainer .mcnTextContent=2C.mcnBoxedTextContent=
Container .mcnTextContent p{
=09=09=09font-size:14px !important;
=09=09=09line-height:150% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09#templatePreheader{
=09=09=09display:block !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09#templatePreheader .mcnTextContent=2C#templatePreheader .mcnTextCont=
ent p{
=09=09=09font-size:14px !important;
=09=09=09line-height:150% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09#templateHeader .mcnTextContent=2C#templateHeader .mcnTextContent p{
=09=09=09font-size:16px !important;
=09=09=09line-height:150% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09#templateBody .mcnTextContent=2C#templateBody .mcnTextContent p{
=09=09=09font-size:16px !important;
=09=09=09line-height:150% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09#templateColumns .columnContainer .mcnTextContent=2C#templateColumns=
 .columnContainer .mcnTextContent p{
=09=09=09font-size:16px !important;
=09=09=09line-height:150% !important;
=09=09}

}=09@media only screen and (max-width: 480px){
=09=09#templateFooter .mcnTextContent=2C#templateFooter .mcnTextContent p{
=09=09=09font-size:14px !important;
=09=09=09line-height:150% !important;
=09=09}

}</style></head>
    <body style=3D"height: 100%;margin: 0;padding: 0;width: 100%;-ms-text-=
size-adjust: 100%;-webkit-text-size-adjust: 100%;background-color: #FAFAFA=
;">
        
        <span class=3D"mcnPreviewText" style=
=3D"display:none; font-size:0px; line-height:0px; max-height:0px; max-widt=
h:0px; opacity:0; overflow:hidden; visibility:hidden; mso-hide:all;">Free=
 Webinar - Register Today!=C2=A0</span>
        
        <center>
            <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspa=
cing=3D"0" height=3D"100%" width=3D"100%" id=3D"bodyTable" style=3D"border=
-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-s=
ize-adjust: 100%;-webkit-text-size-adjust: 100%;height: 100%;margin: 0;pad=
ding: 0;width: 100%;background-color: #FAFAFA;">
                <tr>
                    <td align=3D"center" valign=3D"top" id=3D"bodyCell" st=
yle=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-te=
xt-size-adjust: 100%;height: 100%;margin: 0;padding: 10px;width: 100%;bord=
er-top: 0;">
                        
                        
                        <table border=3D"0" cellpadding=3D"0" cellspacing=
=3D"0" width=3D"100%" class=3D"templateContainer" style=3D"border-collapse=
: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;border: 0;max-width: 600px !importa=
nt;">
                            <tr>
                                <td valign=3D"top" id=3D"templatePreheader=
" style=3D"background:#fafafa none no-repeat center/cover;mso-line-height-=
rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;ba=
ckground-color: #fafafa;background-image: none;background-repeat: no-repea=
t;background-position: center;background-size: cover;border-top: 0;border-=
bottom: 0;padding-top: 9px;padding-bottom: 9px;"><table border=3D"0" cellp=
adding=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=
=3D"min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-ta=
ble-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;=
">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<a href=3D"https://mailchi.mp/labroots/interro=
gate-tumor-immune-interactions-in-aml-patients-receiving-immune-checkpoint=
-inhibitor-223210?e=3D24e951eba2" target=3D"_blank" style=3D"mso-line-height=
-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;c=
olor: #555555;font-weight: normal;text-decoration: underline;">View this e=
mail in your browser</a>
                        </td>
                    </tr>
                </tbody></table>
=09=09=09=09

=09=09=09=09
            </td>
        </tr>
    </tbody>
</table></td>
                            </tr>
                            <tr>
                                <td valign=3D"top" id=3D"templateHeader" s=
tyle=3D"background:#ffffff none no-repeat center/cover;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;backg=
round-color: #ffffff;background-image: none;background-repeat: no-repeat;b=
ackground-position: center;background-size: cover;border-top: 0;border-bot=
tom: 0;padding-top: 9px;padding-bottom: 0;"><table border=3D"0" cellpaddin=
g=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnDividerBlock" style=
=3D"min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-ta=
ble-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;=
table-layout: fixed !important;">
    <tbody class=3D"mcnDividerBlockOuter">
        <tr>
            <td class=3D"mcnDividerBlockInner" style=3D"min-width: 100%;pa=
dding: 3px 18px 0px;mso-line-height-rule: exactly;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;">
                <table class=3D"mcnDividerContent" border=3D"0" cellpaddin=
g=3D"0" cellspacing=3D"0" width=3D"100%" style=3D"min-width: 100%;border-c=
ollapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-siz=
e-adjust: 100%;-webkit-text-size-adjust: 100%;">
                    <tbody><tr>
                        <td style=3D"mso-line-height-rule: exactly;-ms-tex=
t-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                            <span></span>
                        </td>
                    </tr>
                </tbody></table>

            </td>
        </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnImageBlock" style=3D"min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnImageBlockOuter">
            <tr>
                <td valign=3D"top" style=3D"padding: 0px;mso-line-height-r=
ule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" c=
lass=3D"mcnImageBlockInner">
                    <table align=3D"left" width=3D"100%" border=3D"0" cell=
padding=3D"0" cellspacing=3D"0" class=3D"mcnImageContentContainer" style=
=3D"min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-ta=
ble-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;=
">
                        <tbody><tr>
                            <td class=3D"mcnImageContent" valign=3D"top" s=
tyle=3D"padding-right: 0px;padding-left: 0px;padding-top: 0;padding-bottom=
: 0;text-align: center;mso-line-height-rule: exactly;-ms-text-size-adjust:=
 100%;-webkit-text-size-adjust: 100%;">

</td>
                        </tr>
                    </tbody></table>
                </td>
            </tr>
    </tbody>
</table></td>
                            </tr>
                            <tr>
                                <td valign=3D"top" id=3D"templateBody" sty=
le=3D"background:#ffffff none no-repeat center/cover;mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;backgro=
und-color: #ffffff;background-image: none;background-repeat: no-repeat;bac=
kground-position: center;background-size: cover;border-top: 0;border-botto=
m: 0;padding-top: 9px;padding-bottom: 0;"><table border=3D"0" cellpadding=
=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnDividerBlock" style=3D=
"min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table=
-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;tab=
le-layout: fixed !important;">
    <tbody class=3D"mcnDividerBlockOuter">
        <tr>
            <td class=3D"mcnDividerBlockInner" style=3D"min-width: 100%;pa=
dding: 18px 18px 0px;mso-line-height-rule: exactly;-ms-text-size-adjust: 1=
00%;-webkit-text-size-adjust: 100%;">
                <table class=3D"mcnDividerContent" border=3D"0" cellpaddin=
g=3D"0" cellspacing=3D"0" width=3D"100%" style=3D"min-width: 100%;border-t=
op: 2px none #EAEAEA;border-collapse: collapse;mso-table-lspace: 0pt;mso-t=
able-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%=
;">
                    <tbody><tr>
                        <td style=3D"mso-line-height-rule: exactly;-ms-tex=
t-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                            <span></span>
                        </td>
                    </tr>
                </tbody></table>

            </td>
        </tr>
    </tbody>
</table></td>
                            </tr>
                            <tr>
                                <td valign=3D"top" id=3D"templateColumns"=
 style=3D"background:#ffffff none no-repeat center/cover;mso-line-height-r=
ule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;bac=
kground-color: #ffffff;background-image: none;background-repeat: no-repeat=
;background-position: center;background-size: cover;border-top: 0;border-b=
ottom: 2px solid #EAEAEA;padding-top: 0;padding-bottom: 9px;">
                                    
                                    <table align=3D"left" border=3D"0" cel=
lpadding=3D"0" cellspacing=3D"0" width=3D"300" class=3D"columnWrapper" sty=
le=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0p=
t;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                        <tr>
                                            <td valign=3D"top" class=3D"co=
lumnContainer" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust=
: 100%;-webkit-text-size-adjust: 100%;"><table border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnButtonBlock" style=3D"min=
-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rsp=
ace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnButtonBlockOuter">
        <tr>
            <td style=3D"padding-top: 0;padding-right: 18px;padding-bottom=
: 18px;padding-left: 18px;mso-line-height-rule: exactly;-ms-text-size-adju=
st: 100%;-webkit-text-size-adjust: 100%;" valign=3D"top" align=3D"left" cl=
ass=3D"mcnButtonBlockInner">
                <table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi=
dth=3D"100%" class=3D"mcnButtonContentContainer" style=3D"border-collapse:=
 separate !important;border-radius: 4px;background-color: #A3C849;mso-tabl=
e-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-tex=
t-size-adjust: 100%;">
                    <tbody>
                        <tr>
                            <td align=3D"center" valign=3D"middle" class=
=3D"mcnButtonContent" style=3D"font-family: Arial;font-size: 18px;padding:=
 18px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-tex=
t-size-adjust: 100%;">
                                <a class=3D"mcnButton " title=3D"Register=
 now" href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393=
ef38fb324428ff8c2c&id=3D16665ef89b&e=3D24e951eba2" target=3D"_blank" styl=
e=3D"font-weight: bold;letter-spacing: normal;line-height: 100%;text-align=
: center;text-decoration: none;color: #FFFFFF;mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;display: block=
;">Register now</a>
                            </td>
                        </tr>
                    </tbody>
                </table>
            </td>
        </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnTextBlock" style=3D"min-width: 100%;border-collapse: coll=
apse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<h1 style=3D"display: block;margin: 0;padding:=
 0;color: #333333;font-family: Helvetica;font-size: 24px;font-style: norma=
l;font-weight: normal;line-height: 125%;letter-spacing: normal;text-align:=
 left;"><span style=3D"font-size:24px">Spatial Single Cell Characterizatio=
n of Alzheimer's Disease in Mouse and Human Hippocampus</span></h1>

<p style=3D"text-align: left;margin: 10px 0;padding: 0;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color=
: #202020;font-family: Helvetica;font-size: 14px;line-height: 150%;"><br>
<span style=3D"font-size:16px"><strong><span style=3D"color:#A3C849">Septe=
mber 27=2C 2022</span></strong></span><br>
<span style=3D"font-size:15px"><a href=3D"https://labroots.us7.list-manage=
=2Ecom/track/click?u=3D6f39393ef38fb324428ff8c2c&id=3D74f25c3507&e=3D24e951eba2" target=3D"_blank" style=3D"mso-line-height-rule: exactly;-ms-text-si=
ze-adjust: 100%;-webkit-text-size-adjust: 100%;color: #1e8ae7;font-weight:=
 normal;text-decoration: underline;"><img data-file-id=3D"42943" height=3D=
"13" src=3D"https://gallery.mailchimp.com/6f39393ef38fb324428ff8c2c/images=
/b9d0b3b5-66ac-4b86-857f-08e5d0e67a46.png" style=3D"border: 0px;width: 20p=
x;height: 13px;margin: 0px;outline: none;text-decoration: none;-ms-interpo=
lation-mode: bicubic;" width=3D"20"></a>&nbsp;10:00am (PDT)=2C&nbsp;1:00pm=
 (EDT)=2C<br>
&nbsp; &nbsp; &nbsp; 7:00pm (CEST)</span></p>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

=09=09=09=09
            </td>
        </tr>
    </tbody>
</table></td>
                                        </tr>
                                    </table>
                                    
                                    <table align=3D"left" border=3D"0" cel=
lpadding=3D"0" cellspacing=3D"0" width=3D"300" class=3D"columnWrapper" sty=
le=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0p=
t;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                        <tr>
                                            <td valign=3D"top" class=3D"co=
lumnContainer" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust=
: 100%;-webkit-text-size-adjust: 100%;"><table border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D"min-w=
idth: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspac=
e: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<strong>Presented by:</strong>
                        </td>
                    </tr>
                </tbody></table>
=09=09=09=09

</td>
                        </tr>
                    </tbody></table>
                </td>
            </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnTextBlock" style=3D"min-width: 100%;border-collapse: coll=
apse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

=09=09=09=09
            </td>
        </tr>
    </tbody>
</table></td>
                                        </tr>
                                    </table>
                                    
                                </td>
                            </tr>
                            <tr>
                                <td valign=3D"top" id=3D"templateFooter" s=
tyle=3D"background:#ffffff none no-repeat center/cover;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;backg=
round-color: #ffffff;background-image: none;background-repeat: no-repeat;b=
ackground-position: center;background-size: cover;border-top: 0;border-bot=
tom: 0;padding-top: 9px;padding-bottom: 9px;"><table border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D=
"min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table=
-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<p style=3D"font-size: 14px;text-align: left;m=
argin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;color: #555555;font-family: Helveti=
ca;line-height: 150%;"><span style=3D"font-family:arial=2Chelvetica neue=
=2Chelvetica=2Csans-serif"><span style=3D"font-size:14px"><strong>Abstract=
</strong>&nbsp;<br>
Alzheimer=E2=80=99s disease is the most common cause of dementia and the s=
eventh leading cause of death in the United States. The accumulation of pr=
otein aggregates (i.e.=2C extracellular A=CE=B2 plaques and intracellular=
 tau-containing neurofibrillary tangles) constitute the biological hallmar=
ks of Alzheimer=E2=80=99s disease. Clinical trials enhancing the clearance=
 of A=CE=B2 and tau have failed to alter disease progression indicating di=
sease complexity beyond protein accumulation. Comprehending the cellular a=
nd molecular features of cells and their environments in Alzheimer=E2=80=
=99s disease is urgently needed to develop effective disease modifying the=
rapies. To uncover interactions between cells containing tau pathology and=
 their microenvironments=2C Dr. Orr=E2=80=99s team employed NanoString Geo=
Mx=C2=AE Digital Spatial Profiling (DSP). They performed a spatial-proteom=
ic analysis of postmortem brains from individuals with Alzheimer=E2=80=99s=
 disease neuropathology with or without dementia. Comparing the protein ex=
pression profiles in neurons and their microenvironments led to identifica=
tion of molecules differentially regulated in individuals resilient to dem=
entia=2C despite the presence of neuropathology. To gain mechanistic insig=
hts into the role of tau pathogenesis her team utilized CosMx<sup>TM</sup>=
&nbsp;Spatial Molecular Imaging. Their spatial-transcriptomic analysis com=
paring a mouse model of tau neuropathology to an age-matched control ident=
ified cellular population changes with spatially-resolved gene expression=
 differences across 42 cell types. The analyses further revealed a tau-dep=
endent loss of three cellular niches involving neuronal=2C glia and vascul=
ar cells.<br>
&nbsp;<br>
<strong>Learning Objectives</strong></span></span></p>

<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;"><span style=3D"font-family:arial=2Chelveti=
ca neue=2Chelvetica=2Csans-serif"><span style=3D"font-size:14px">Understan=
d how Nanostring=E2=80=99s GeoMx DSP and CosMx SMI spatial platforms were=
 used to determine spatially resolved preotomic and transcriptomic profile=
s of neurons and their microenvironments in Alzheimer=E2=80=99s disease hu=
man and mouse tissue</span></span></li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;"><span style=3D"font-family:arial=2Chelveti=
ca neue=2Chelvetica=2Csans-serif"><span style=3D"font-size:14px">Learn how=
 GeoMx DSP is able to subtype neuropathology in brain tissue with Alzheime=
r=E2=80=99s disease neuropathology.</span></span></li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;"><span style=3D"font-family:arial=2Chelveti=
ca neue=2Chelvetica=2Csans-serif"><span style=3D"font-size:14px">Learn how=
 CosMx SMI is able to spatially resolve cellular and molecular changes in=
 response to tau protein toxicity</span></span></li>
</ul>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

<table align=3D"left" border=3D"0"=
 cellpadding=3D"0" cellspacing=3D"0" style=3D"border-collapse: collapse;ms=
o-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webk=
it-text-size-adjust: 100%;">
                                            <tbody><tr>
                                                <td valign=3D"top" style=
=3D"padding-right: 9px;padding-bottom: 9px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" class=3D"mcnSha=
reContentItemContainer">
                                                    <table border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" width=3D"" class=3D"mcnShareContentItem"=
 style=3D"border-collapse: separate;mso-table-lspace: 0pt;mso-table-rspace=
: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                        <tbody><tr>
                                                            <td align=3D"l=
eft" valign=3D"middle" style=3D"padding-top: 5px;padding-right: 9px;paddin=
g-bottom: 5px;padding-left: 9px;mso-line-height-rule: exactly;-ms-text-siz=
e-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                                <table ali=
gn=3D"left" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"" st=
yle=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0=
pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                                    <tbody=
><tr>
                                                                        <t=
d align=3D"center" valign=3D"middle" width=3D"24" class=3D"mcnShareIconCon=
tent" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-w=
ebkit-text-size-adjust: 100%;">
                                                                         =
   <a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393=
ef38fb324428ff8c2c&id=3D6e2c7b146f&e=3D24e951eba2" target=3D"_blank" styl=
e=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text=
-size-adjust: 100%;"><img src=3D"https://cdn-images.mailchimp.com/icons/so=
cial-block-v2/outline-dark-facebook-48.png" alt=3D"Share" style=3D"display=
: block;border: 0;height: auto;outline: none;text-decoration: none;-ms-int=
erpolation-mode: bicubic;" height=3D"24" width=3D"24" class=3D""></a>
                                                                        </=
td>
                                                                        <t=
d align=3D"left" valign=3D"middle" class=3D"mcnShareTextContent" style=3D"=
padding-left: 5px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%=
;-webkit-text-size-adjust: 100%;">
                                                                         =
   <a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393=
ef38fb324428ff8c2c&id=3Df786cafb92&e=3D24e951eba2" target=3D"" style=3D"c=
olor: #202020;font-family: Arial;font-size: 12px;font-weight: normal;line-=
height: normal;text-align: center;text-decoration: none;mso-line-height-ru=
le: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">Sh=
are</a>
                                                                        </=
td>
                                                                    </tr>
                                                                </tbody></=
table>
                                                            </td>
                                                        </tr>
                                                    </tbody></table>
                                                </td>
                                            </tr>
                                        </tbody></table>

<table align=3D"left" border=3D"0"=
 cellpadding=3D"0" cellspacing=3D"0" style=3D"border-collapse: collapse;ms=
o-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webk=
it-text-size-adjust: 100%;">
                                            <tbody><tr>
                                                <td valign=3D"top" style=
=3D"padding-right: 9px;padding-bottom: 9px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" class=3D"mcnSha=
reContentItemContainer">
                                                    <table border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" width=3D"" class=3D"mcnShareContentItem"=
 style=3D"border-collapse: separate;mso-table-lspace: 0pt;mso-table-rspace=
: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                        <tbody><tr>
                                                            <td align=3D"l=
eft" valign=3D"middle" style=3D"padding-top: 5px;padding-right: 9px;paddin=
g-bottom: 5px;padding-left: 9px;mso-line-height-rule: exactly;-ms-text-siz=
e-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                                <table ali=
gn=3D"left" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"" st=
yle=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0=
pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                                    <tbody=
><tr>
                                                                        <t=
d align=3D"center" valign=3D"middle" width=3D"24" class=3D"mcnShareIconCon=
tent" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-w=
ebkit-text-size-adjust: 100%;">
                                                                         =
   <a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393=
ef38fb324428ff8c2c&id=3Dca65c00240&e=3D24e951eba2" target=3D"_blank" styl=
e=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text=
-size-adjust: 100%;"><img src=3D"https://cdn-images.mailchimp.com/icons/so=
cial-block-v2/outline-dark-twitter-48.png" alt=3D"Tweet" style=3D"display:=
 block;border: 0;height: auto;outline: none;text-decoration: none;-ms-inte=
rpolation-mode: bicubic;" height=3D"24" width=3D"24" class=3D""></a>
                                                                        </=
td>
                                                                        <t=
d align=3D"left" valign=3D"middle" class=3D"mcnShareTextContent" style=3D"=
padding-left: 5px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%=
;-webkit-text-size-adjust: 100%;">
                                                                         =
   <a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393=
ef38fb324428ff8c2c&id=3D2b7fcb9870&e=3D24e951eba2" target=3D"" style=3D"c=
olor: #202020;font-family: Arial;font-size: 12px;font-weight: normal;line-=
height: normal;text-align: center;text-decoration: none;mso-line-height-ru=
le: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">Tw=
eet</a>
                                                                        </=
td>
                                                                    </tr>
                                                                </tbody></=
table>
                                                            </td>
                                                        </tr>
                                                    </tbody></table>
                                                </td>
                                            </tr>
                                        </tbody></table>

<table align=3D"left" border=3D"0"=
 cellpadding=3D"0" cellspacing=3D"0" style=3D"border-collapse: collapse;ms=
o-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webk=
it-text-size-adjust: 100%;">
                                            <tbody><tr>
                                                <td valign=3D"top" style=
=3D"padding-right: 0;padding-bottom: 9px;mso-line-height-rule: exactly;-ms=
-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" class=3D"mcnShare=
ContentItemContainer">
                                                    <table border=3D"0" ce=
llpadding=3D"0" cellspacing=3D"0" width=3D"" class=3D"mcnShareContentItem"=
 style=3D"border-collapse: separate;mso-table-lspace: 0pt;mso-table-rspace=
: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                        <tbody><tr>
                                                            <td align=3D"l=
eft" valign=3D"middle" style=3D"padding-top: 5px;padding-right: 9px;paddin=
g-bottom: 5px;padding-left: 9px;mso-line-height-rule: exactly;-ms-text-siz=
e-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                                <table ali=
gn=3D"left" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"" st=
yle=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0=
pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                                    <tbody=
><tr>
                                                                        <t=
d align=3D"center" valign=3D"middle" width=3D"24" class=3D"mcnShareIconCon=
tent" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-w=
ebkit-text-size-adjust: 100%;">
                                                                         =
   <a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393=
ef38fb324428ff8c2c&id=3D8f238dc153&e=3D24e951eba2" target=3D"_blank" styl=
e=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text=
-size-adjust: 100%;"><img src=3D"https://cdn-images.mailchimp.com/icons/so=
cial-block-v2/outline-dark-linkedin-48.png" alt=3D"Share" style=3D"display=
: block;border: 0;height: auto;outline: none;text-decoration: none;-ms-int=
erpolation-mode: bicubic;" height=3D"24" width=3D"24" class=3D""></a>
                                                                        </=
td>
                                                                        <t=
d align=3D"left" valign=3D"middle" class=3D"mcnShareTextContent" style=3D"=
padding-left: 5px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%=
;-webkit-text-size-adjust: 100%;">
                                                                         =
   <a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393=
ef38fb324428ff8c2c&id=3D551e96bbd2&e=3D24e951eba2" target=3D"" style=3D"c=
olor: #202020;font-family: Arial;font-size: 12px;font-weight: normal;line-=
height: normal;text-align: center;text-decoration: none;mso-line-height-ru=
le: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">Sh=
are</a>
                                                                        </=
td>
                                                                    </tr>
                                                                </tbody></=
table>
                                                            </td>
                                                        </tr>
                                                    </tbody></table>
                                                </td>
                                            </tr>
                                        </tbody></table>

</td>
                            </tr>
                        </tbody></table>
                    </td>
                </tr>
            </tbody></table>
        </td>
    </tr>
</tbody></table>

</td>
            </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnTextBlock" style=3D"min-width: 100%;border-collapse: coll=
apse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<p style=3D"font-size: 14px;text-align: center=
;margin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-text-size-adj=
ust: 100%;-webkit-text-size-adjust: 100%;color: #555555;font-family: Helve=
tica;line-height: 150%;"><span style=3D"font-size:12px"><strong>Can't atte=
nd live?</strong><span style=3D"color:#366CF5"> </span><a href=3D"https://=
labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb324428ff8c2c&id=
=3D90d5a38744&e=3D24e951eba2" target=3D"_blank" style=3D"mso-line-height-=
rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;co=
lor: #1e8ae7;font-weight: normal;text-decoration: underline;"><span style=
=3D"color:#A3C849">Click here</span></a><span style=3D"color:#A3C849"> </s=
pan>to register and receive a link to the recorded webcast.<br>
<br>
Webinars will be available for unlimited on-demand viewing after the live=
 event</span></p>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

=09=09=09=09
            </td>
        </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnDividerBlock" style=3D"min-width: 100%;border-collapse: c=
ollapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust:=
 100%;-webkit-text-size-adjust: 100%;table-layout: fixed !important;">
    <tbody class=3D"mcnDividerBlockOuter">
        <tr>
            <td class=3D"mcnDividerBlockInner" style=3D"min-width: 100%;pa=
dding: 18px 18px 0px;mso-line-height-rule: exactly;-ms-text-size-adjust: 1=
00%;-webkit-text-size-adjust: 100%;">
                <table class=3D"mcnDividerContent" border=3D"0" cellpaddin=
g=3D"0" cellspacing=3D"0" width=3D"100%" style=3D"min-width: 100%;border-t=
op: 2px none #EAEAEA;border-collapse: collapse;mso-table-lspace: 0pt;mso-t=
able-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%=
;">
                    <tbody><tr>
                        <td style=3D"mso-line-height-rule: exactly;-ms-tex=
t-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                            <span></span>
                        </td>
                    </tr>
                </tbody></table>

            </td>
        </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnDividerBlock" style=3D"min-width: 100%;background-color:=
 #F2F2F2;border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace:=
 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;table-layou=
t: fixed !important;">
    <tbody class=3D"mcnDividerBlockOuter">
        <tr>
            <td class=3D"mcnDividerBlockInner" style=3D"min-width: 100%;pa=
dding: 3px 18px 0px;mso-line-height-rule: exactly;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;">
                <table class=3D"mcnDividerContent" border=3D"0" cellpaddin=
g=3D"0" cellspacing=3D"0" width=3D"100%" style=3D"min-width: 100%;border-t=
op: 2px none #EAEAEA;border-collapse: collapse;mso-table-lspace: 0pt;mso-t=
able-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%=
;">
                    <tbody><tr>
                        <td style=3D"mso-line-height-rule: exactly;-ms-tex=
t-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                            <span></span>
                        </td>
                    </tr>
                </tbody></table>

            </td>
        </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnCodeBlock" style=3D"border-collapse: collapse;mso-table-l=
space: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-s=
ize-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"mso-li=
ne-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjus=
t: 100%;">
                
<div class=3D"mcnTextContent" style=3D"word-break: break-word;color: #5555=
55;font-family: Helvetica;font-size: 12px;line-height: 150%;text-align: ce=
nter;">
<table width=3D"100%" bgcolor=3D"#ffffff" cellpadding=3D"0" cellspacing=3D=
"0" border=3D"0" id=3D"backgroundTable" st-sortable=3D"footer" style=3D"bo=
rder-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
   <tbody>
      <tr>
         <td style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust:=
 100%;-webkit-text-size-adjust: 100%;">
            <table style=3D"border-width: 0;border-collapse: collapse;mso-=
table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit=
-text-size-adjust: 100%;" width=3D"600" bgcolor=3D"#535353" cellpadding=3D=
"0" cellspacing=3D"0" border=3D"0" align=3D"center" class=3D"devicewidth">
               <tbody>
                  <tr>
                     <td width=3D"100%" style=3D"mso-line-height-rule: exa=
ctly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                        <table style=3D"border-width: 0;border-collapse: c=
ollapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust:=
 100%;-webkit-text-size-adjust: 100%;" bgcolor=3D"#535353" width=3D"600" c=
ellpadding=3D"0" cellspacing=3D"0" border=3D"0" align=3D"center" class=3D"=
devicewidth">
                           <tbody>
                              
                              <tr>
                                 <td height=3D"20" style=3D"font-size: 1px=
;line-height: 1px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%=
;-webkit-text-size-adjust: 100%;">&nbsp;</td>
                              </tr>
                              
                              <tr>
                                 <td style=3D"mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                    
                                    <table width=3D"400" align=3D"center"=
 border=3D"0" cellpadding=3D"0" cellspacing=3D"0" class=3D"devicewidth" st=
yle=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0=
pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                       <tbody>
                                          <tr>
                                             <td width=3D"122" height=3D"2=
8" align=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-a=
djust: 100%;-webkit-text-size-adjust: 100%;">
                                                <div class=3D"imgpop">
                                                   <a target=3D"_blank" hr=
ef=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb32=
4428ff8c2c&id=3D96ea3ab1bf&e=3D24e951eba2" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #1e8ae7;font-weight: normal;text-decoration: underline;">
                                                   <img src=3D"https://gal=
lery.mailchimp.com/6f39393ef38fb324428ff8c2c/images/5f1a4891-b804-49dc-963=
5-7775e875cdce.png" alt=3D"" border=3D"0" width=3D"122" height=3D"28" styl=
e=3D"display: block;border: none;outline: none;text-decoration: none;heigh=
t: auto !important;-ms-interpolation-mode: bicubic;">
                                                   </a>
                                                </div>
                                             </td>
                                             <td align=3D"left" width=3D"1=
" style=3D"font-size: 1px;line-height: 1px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">&nbsp;</td>
                                             <td width=3D"28" height=3D"28=
" align=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-ad=
just: 100%;-webkit-text-size-adjust: 100%;">
                                                <div class=3D"imgpop">
                                                   <a target=3D"_blank" hr=
ef=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb32=
4428ff8c2c&id=3D1e8962a08a&e=3D24e951eba2" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #1e8ae7;font-weight: normal;text-decoration: underline;">
                                                   <img src=3D"https://gal=
lery.mailchimp.com/744b2c895ca6228a12e586fc3/images/de1646f1-d522-435e-844=
2-6b3d7514941d.png" alt=3D"" border=3D"0" width=3D"28" height=3D"28" style=
=3D"display: block;border: none;outline: none;text-decoration: none;height=
: auto !important;-ms-interpolation-mode: bicubic;">
                                                   </a>
                                                </div>
                                             </td>
                                             <td align=3D"left" width=3D"1=
" style=3D"font-size: 1px;line-height: 1px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">&nbsp;</td>
                                             <td width=3D"28" height=3D"28=
" align=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-ad=
just: 100%;-webkit-text-size-adjust: 100%;">
                                                <div class=3D"imgpop">
                                                   <a target=3D"_blank" hr=
ef=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb32=
4428ff8c2c&id=3De63c9016ff&e=3D24e951eba2" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #1e8ae7;font-weight: normal;text-decoration: underline;">
                                                   <img src=3D"https://gal=
lery.mailchimp.com/744b2c895ca6228a12e586fc3/images/14b1a8cf-7178-4fc4-933=
5-d5d1a13b546a.png" alt=3D"" border=3D"0" width=3D"28" height=3D"28" style=
=3D"display: block;border: none;outline: none;text-decoration: none;height=
: auto !important;-ms-interpolation-mode: bicubic;">
                                                   </a>
                                                </div>
                                             </td>
                                             <td align=3D"left" width=3D"1=
" style=3D"font-size: 1px;line-height: 1px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">&nbsp;</td>
                                             <td width=3D"28" height=3D"28=
" align=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-ad=
just: 100%;-webkit-text-size-adjust: 100%;">
                                                <div class=3D"imgpop">
                                                   <a target=3D"_blank" hr=
ef=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb32=
4428ff8c2c&id=3D358197780a&e=3D24e951eba2" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #1e8ae7;font-weight: normal;text-decoration: underline;">
                                                   <img src=3D"https://gal=
lery.mailchimp.com/744b2c895ca6228a12e586fc3/images/e08f426e-e924-409e-815=
5-429f07987870.png" alt=3D"" border=3D"0" width=3D"28" height=3D"28" style=
=3D"display: block;border: none;outline: none;text-decoration: none;height=
: auto !important;-ms-interpolation-mode: bicubic;">
                                                   </a>
                                                </div>
                                             </td>
                                             <td align=3D"left" width=3D"1=
" style=3D"font-size: 1px;line-height: 1px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">&nbsp;</td>   =
                                          <td width=3D"28" height=3D"28" a=
lign=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;">
                                                <div class=3D"imgpop">
                                                   <a target=3D"_blank" hr=
ef=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb32=
4428ff8c2c&id=3D5750409b9d&e=3D24e951eba2" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #1e8ae7;font-weight: normal;text-decoration: underline;">
                                                   <img src=3D"https://gal=
lery.mailchimp.com/744b2c895ca6228a12e586fc3/images/dc96c933-ffc0-43cb-9f6=
0-458833338585.png" alt=3D"" border=3D"0" width=3D"28" height=3D"28" style=
=3D"display: block;border: none;outline: none;text-decoration: none;height=
: auto !important;-ms-interpolation-mode: bicubic;">
                                                   </a>
                                                </div>
                                             </td>
                                             <td align=3D"left" width=3D"1=
" style=3D"font-size: 1px;line-height: 1px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">&nbsp;</td>
                                             <td width=3D"28" height=3D"28=
" align=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-ad=
just: 100%;-webkit-text-size-adjust: 100%;">
                                                <div class=3D"imgpop">
                                                   <a target=3D"_blank" hr=
ef=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb32=
4428ff8c2c&id=3D975bb5fcda&e=3D24e951eba2" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #1e8ae7;font-weight: normal;text-decoration: underline;">
                                                   <img src=3D"https://gal=
lery.mailchimp.com/744b2c895ca6228a12e586fc3/images/a3f39659-7e46-4247-81f=
b-e41e8ed05844.png" alt=3D"" border=3D"0" width=3D"28" height=3D"28" style=
=3D"display: block;border: none;outline: none;text-decoration: none;height=
: auto !important;-ms-interpolation-mode: bicubic;">
                                                   </a>
                                                </div>
                                             </td>
                                             <td align=3D"left" width=3D"1=
" style=3D"font-size: 1px;line-height: 1px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">&nbsp;</td>
                                             <td width=3D"28" height=3D"28=
" align=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-ad=
just: 100%;-webkit-text-size-adjust: 100%;">
                                                <div class=3D"imgpop">
                                                   <a target=3D"_blank" hr=
ef=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb32=
4428ff8c2c&id=3D42748f122f&e=3D24e951eba2" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #1e8ae7;font-weight: normal;text-decoration: underline;">
                                                   <img src=3D"https://gal=
lery.mailchimp.com/744b2c895ca6228a12e586fc3/images/8bb9bca7-0795-4f31-a85=
5-1f6e20235cf1.png" alt=3D"" border=3D"0" width=3D"28" height=3D"28" style=
=3D"display: block;border: none;outline: none;text-decoration: none;height=
: auto !important;-ms-interpolation-mode: bicubic;">
                                                   </a>
                                                </div>
                                             </td>
                                             <td align=3D"left" width=3D"1=
" style=3D"font-size: 1px;line-height: 1px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">&nbsp;</td>
                                             <td width=3D"28" height=3D"28=
" align=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-ad=
just: 100%;-webkit-text-size-adjust: 100%;">
                                                <div class=3D"imgpop">
                                                   <a target=3D"_blank" hr=
ef=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef38fb32=
4428ff8c2c&id=3D7558e2ced2&e=3D24e951eba2" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #1e8ae7;font-weight: normal;text-decoration: underline;">
                                                   <img src=3D"https://gal=
lery.mailchimp.com/744b2c895ca6228a12e586fc3/images/b6cf0cd9-7096-4fc1-a4c=
4-1b2d0730de4f.png" alt=3D"" border=3D"0" width=3D"28" height=3D"28" style=
=3D"display: block;border: none;outline: none;text-decoration: none;height=
: auto !important;-ms-interpolation-mode: bicubic;">
                                                   </a>
                                                </div>
                                             </td>
                                          </tr>
                                       </tbody>
                                    </table>
                                             =
                        </td>
                              </tr>
                                                         =
   <tr>
                                 <td height=3D"10" style=3D"font-size: 1px=
;line-height: 1px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%=
;-webkit-text-size-adjust: 100%;">&nbsp;</td>
                              </tr>
                              
                           </tbody>
                        </table>
                        <table bgcolor=3D"#535353" width=3D"600" cellpaddi=
ng=3D"0" cellspacing=3D"0" border=3D"0" align=3D"center" class=3D"devicewi=
dth" style=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rs=
pace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                           <tbody>
                           <tr>
                           <td style=3D"font-family: Helvetica=2C arial=2C=
 sans-serif;font-size: 9px;color: #ffffff;text-align: center;line-height:=
 16px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-tex=
t-size-adjust: 100%;">
=09=09=09=09=09=09=09</td>
=09=09=09=09=09=09=09<td style=3D"font-family: Helvetica=2C arial=2C sans-=
serif;font-size: 9px;color: #C0C0C0;text-align: center;line-height: 16px;m=
so-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-=
adjust: 100%;">
                           Copyright =C2=A9 2008-2022 Labroots=2C&nbsp;Inc=
=2E &nbsp;|&nbsp;&nbsp;<a href=3D"mailto:info@labroots.com" style=3D"color:=
 #B0BC22;text-decoration: none;mso-line-height-rule: exactly;-ms-text-size=
-adjust: 100%;-webkit-text-size-adjust: 100%;font-weight: normal;">info@la=
broots.com</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href=3D"https://labroots.us7.lis=
t-manage.com/track/click?u=3D6f39393ef38fb324428ff8c2c&id=3Dc3e5816625&e=
=3D24e951eba2" style=3D"color: #B0BC22;text-decoration: none;mso-line-hei=
ght-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100=
%;font-weight: normal;">labroots.com</a>&nbsp;&nbsp;
                           </td>
                           </tr>
                        </tbody>
                        </table>
                     </td>
                  </tr>

<tr>
    <td style=3D"font-family: Helvetica=2C arial=2C sans-serif;font-size:=
 9px;color: #C0C0C0;text-align: center;line-height: 16px;mso-line-height-r=
ule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">

<a style=3D"color: #B0BC22;text-decoration: none;mso-line-heig=
ht-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%=
;font-weight: normal;" href=3D"https://labroots.us7.list-manage.com/track/=
click?u=3D6f39393ef38fb324428ff8c2c&id=3D299f5646de&e=3D24e951eba2">Updat=
e your email preferences</a> or <a style=3D"color: #B0BC22;text-decoration=
: none;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-te=
xt-size-adjust: 100%;font-weight: normal;" href=3D"https://labroots.us7.li=
st-manage.com/track/click?u=3D6f39393ef38fb324428ff8c2c&id=3D0d2c54ea0d&e=
=3D24e951eba2">unsubscribe</a> from this list.<a href=3D"https://labroots=
=2Eus7.list-manage.com/unsubscribe?u=3D6f39393ef38fb324428ff8c2c&id=3D704016=
79f9&e=3D24e951eba2&c=3D5349d28921" style=3D"mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #1e8ae7;fo=
nt-weight: normal;text-decoration: underline;">.</a>
=09=09<br>Please read about reward eligibility and point distribution in&n=
bsp;our&nbsp;<a style=3D"color: #B0BC22;text-decoration: none;mso-line-hei=
ght-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100=
%;font-weight: normal;" href=3D"https://labroots.us7.list-manage.com/track=
/click?u=3D6f39393ef38fb324428ff8c2c&id=3D49fea147ed&e=3D24e951eba2">Term=
s&nbsp;and&nbsp;Conditions</a>.

</td>
</tr>

</tbody>
            </table>
         </td>
      </tr>
   </tbody>
</table>
</div>

            </td>
        </tr>
    </tbody>
</table></td>
                            </tr>
                        </table>
                        
                        
                    </td>
                </tr>
            </table>
        </center>
    <img src=3D"https://labroots.us7.list-manage.com/track/open.php?u=3D6f=
39393ef38fb324428ff8c2c&id=3D5349d28921&e=3D24e951eba2" height=3D"1" widt=
h=3D"1" alt=3D""></body>
</html>
--_----------=_MCPart_889549204--