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Subject: =?utf-8?Q?Advances=20and=20Challenges=20in=20Targeting=20Kinases=20in=20Cancer=20Therapeutics?=
From: =?utf-8?Q?Labroots=20for=20BPS=20Bioscience?= <info@labroots.com>
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To: <omougy@saraya.world>
Date: Tue,  6 Sep 2022 14:34:53 +0000
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Free Webinar - Register Today!=C2=A0

View this email in your browser (https://mailchi.mp/labroots/advances-and-=
challenges-in-targeting-kinases-in-cancer-therapeutics-222262?e=3D93eddcbc4e=
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cancer-therapeutics?campaign=3Dlremail
Register now (https://www.labroots.com/ms/webinar/advances-challenges-targ=
eting-kinases-cancer-therapeutics?campaign=3Dlremail)

** Advances and Challenges in Targeting Kinases in Cancer Therapeutics
------------------------------------------------------------

September 15=2C 2022
https://www.labroots.com/intercall/add-to-calendar/Webinar/7545?start-date=
=3D20220915T090000&end-date=3D20220915T100000&TZID=3DAmerica/Los_Angeles9:=
00am (PDT)=2C 12:00pm (EDT)=2C
6:00pm (CEST)
Presented by:
https://www.labroots.com/ms/webinar/advances-challenges-targeting-kinases-=
cancer-therapeutics?campaign=3Dlremail
Aishath Shanaz Naeem
Postdoctoral Fellow=2C Dana Farber Institute at Harvard
https://www.labroots.com/ms/webinar/advances-challenges-targeting-kinases-=
cancer-therapeutics?campaign=3Dlremail
Veronique Baron
Scientific Applications Manager=2C BPS Bioscience

=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=
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=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D

Abstract
Tyrosine kinases=2C a ubiquitous and diverse family of enzymes=2C are of c=
onsiderable clinical interest because they directly contribute to the deve=
lopment of cancer. A growing number of tyrosine kinase inhibitors are in c=
linical use with many more in development.

Bruton's tyrosine kinase (BTK) is a receptor-type tyrosine kinase critical=
 for B cell maturation. It is encoded by the BTK gene=2C located on the X=
 chromosome. Mutations in BTK cause a primary immunodeficiency phenotype l=
inked to the failure of pre-B cells to mature (a disease termed Bruton's a=
gammaglobulinemia). Due to its control of B cell proliferation and surviva=
l=2C aberrant activity of BTK leads to B cell tumorigenicity. Several BTK=
 inhibitors are used for the clinical treatment of various forms of lympho=
ma=2C including chronic lymphocytic leukemia (CLL). Covalent BTK inhibitor=
s (BTKis) have led to an unprecedented improvement in CLL outcomes. Howeve=
r=2C disease progression on covalent BTKis=2C driven by histologic transfo=
rmation or selective expansion of BTK-mutated CLL clones=2C remains a majo=
r challenge.

Dr. Aishath's talk will focus on:
* Targeting BTK in CLL
* Comparative analysis of covalent and non-covalent BTK inhibitors
* Resistance mechanisms to BTK inhibitors

Dr. Baron will speak about:
* Tools to study kinases
* CRISPR/Cas9 Human Kinase Knockout Lentivirus Library
* Unique assays to study JAK inhibitors
* Off-the-shelf cell-based reporter systems

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              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
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<h1 style=3D"display: block;margin: 0;padding:=
 0;color: #333333;font-family: Helvetica;font-size: 24px;font-style: norma=
l;font-weight: normal;line-height: 125%;letter-spacing: normal;text-align:=
 left;"><span style=3D"font-size:23px">Advances and Challenges in Targetin=
g Kinases in Cancer Therapeutics</span></h1>
&nbsp;

<p style=3D"text-align: left;margin: 10px 0;padding: 0;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color=
: #202020;font-family: Helvetica;font-size: 14px;line-height: 150%;"><span=
 style=3D"color:#114D59"><span style=3D"font-size:14px"><strong>September=
 15=2C 2022</strong></span></span><br>
<a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef3=
8fb324428ff8c2c&id=3D232154c2ac&e=3D93eddcbc4e" target=3D"_blank" style=
=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;color: #1e8ae7;font-weight: normal;text-decoration: unde=
rline;"><img data-file-id=3D"42943" height=3D"13" src=3D"https://gallery.m=
ailchimp.com/6f39393ef38fb324428ff8c2c/images/b9d0b3b5-66ac-4b86-857f-08e5=
d0e67a46.png" style=3D"border: 0px;width: 20px;height: 13px;margin: 0px;ou=
tline: none;text-decoration: none;-ms-interpolation-mode: bicubic;" width=
=3D"20"></a>9:00am (PDT)=2C 12:00pm (EDT)=2C<br>
&nbsp; &nbsp; &nbsp; 6:00pm (CEST)</p>

</td>
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=09=09=09=09

=09=09=09=09
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lpadding=3D"0" cellspacing=3D"0" width=3D"300" class=3D"columnWrapper" sty=
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t;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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lumnContainer" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust=
: 100%;-webkit-text-size-adjust: 100%;"><table border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D"min-w=
idth: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspac=
e: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<strong>Presented by:</strong>
                        </td>
                    </tr>
                </tbody></table>
=09=09=09=09

</td>
                        </tr>
                    </tbody></table>
                </td>
            </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnTextBlock" style=3D"min-width: 100%;border-collapse: coll=
apse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

</td>
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=09=09=09=09

=09=09=09=09
            </td>
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    </tbody>
</table></td>
                                        </tr>
                                    </table>
                                    
                                </td>
                            </tr>
                            <tr>
                                <td valign=3D"top" id=3D"templateFooter" s=
tyle=3D"background:#ffffff none no-repeat center/cover;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;backg=
round-color: #ffffff;background-image: none;background-repeat: no-repeat;b=
ackground-position: center;background-size: cover;border-top: 0;border-bot=
tom: 0;padding-top: 9px;padding-bottom: 9px;"><table border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D=
"min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table=
-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<p style=3D"font-size: 14px;text-align: left;m=
argin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;color: #555555;font-family: Helveti=
ca;line-height: 150%;"><strong>Abstract</strong></p>

<div>Tyrosine kinases=2C a ubiquitous and diverse family of enzymes=2C are=
 of considerable clinical interest because they directly contribute to the=
 development of cancer. A growing number of tyrosine kinase inhibitors are=
 in clinical use with many more in development.</div>

<div>Bruton's tyrosine kinase (BTK) is a receptor-type tyrosine kinase cri=
tical for B cell maturation. It is encoded by the BTK gene=2C located on t=
he X chromosome. Mutations in BTK cause a primary immunodeficiency phenoty=
pe linked to the failure of pre-B cells to mature (a disease termed Bruton=
's agammaglobulinemia). Due to its control of B cell proliferation and sur=
vival=2C aberrant activity of BTK leads to B cell tumorigenicity. Several=
 BTK inhibitors are used for the clinical treatment of various forms of ly=
mphoma=2C including chronic lymphocytic leukemia (CLL). Covalent BTK inhib=
itors (BTKis) have led to an unprecedented improvement in CLL outcomes. Ho=
wever=2C disease progression on covalent BTKis=2C driven by histologic tra=
nsformation or selective expansion of BTK-mutated CLL clones=2C remains a=
 major challenge.</div>

<div><strong>Dr. Aishath's talk will focus on:</strong></div>

<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Targeting BTK in CLL</li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Comparative analysis of covalent and non-c=
ovalent BTK inhibitors</li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Resistance mechanisms to BTK inhibitors</l=
i>
</ul>

<div><strong>Dr. Baron will speak about:</strong></div>

<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Tools to study kinases</li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">CRISPR/Cas9 Human Kinase Knockout Lentivir=
us Library</li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Unique assays to study JAK inhibitors</li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">Off-the-shelf cell-based reporter systems<=
/li>
</ul>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

<table align=3D"left" border=3D"0"=
 cellpadding=3D"0" cellspacing=3D"0" style=3D"border-collapse: collapse;ms=
o-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webk=
it-text-size-adjust: 100%;">
                                            <tbody><tr>
                                                <td valign=3D"top" style=
=3D"padding-right: 9px;padding-bottom: 9px;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" class=3D"mcnSha=
reContentItemContainer">
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llpadding=3D"0" cellspacing=3D"0" width=3D"" class=3D"mcnShareContentItem"=
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: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                        <tbody><tr>
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eft" valign=3D"middle" style=3D"padding-top: 5px;padding-right: 9px;paddin=
g-bottom: 5px;padding-left: 9px;mso-line-height-rule: exactly;-ms-text-siz=
e-adjust: 100%;-webkit-text-size-adjust: 100%;">
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gn=3D"left" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"" st=
yle=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0=
pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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are</a>
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e-adjust: 100%;-webkit-text-size-adjust: 100%;">
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gn=3D"left" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"" st=
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pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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eet</a>
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" align=3D"center" style=3D"mso-line-height-rule: exactly;-ms-text-size-ad=
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