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Subject: =?utf-8?Q?Spatial=20Single=20Cell=20Characterization=20of=20Alzheimer=27s=20Disease=20in=20Mouse=20and=20Human=20Hippocampus?=
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Free Webinar - Register Today!=C2=A0

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umor-immune-interactions-in-aml-patients-receiving-immune-checkpoint-inhib=
itor-222234?e=3D6670ee6f6b)
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Register now (https://www.labroots.com/ms/webinar/spatial-single-cell-char=
acterization-alzheimer-s-disease-mouse-human-hippocampus?campaign=3Dlremai=
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** Spatial Single Cell Characterization of Alzheimer's Disease in Mouse an=
d Human Hippocampus
------------------------------------------------------------

September 27=2C 2022
https://www.labroots.com/intercall/add-to-calendar/Webinar/7595?start-date=
=3D20220927T100000&end-date=3D20220927T110000&TZID=3DAmerica/Los_Angeles 1=
0:00am (PDT)=2C 1:00pm (EDT)=2C
7:00pm (CEST)
Presented by:
https://www.labroots.com/ms/webinar/spatial-single-cell-characterization-a=
lzheimer-s-disease-mouse-human-hippocampus?campaign=3Dlremail
Vikram Devgan
Business Unit Lead-Spatial Genomics
https://www.labroots.com/ms/webinar/spatial-single-cell-characterization-a=
lzheimer-s-disease-mouse-human-hippocampus?campaign=3Dlremail
Miranda E. Orr
Assistant Professor=2C Gerontology and Geriatric Medicine=2C Wake Forest U=
niversity=2C School of Medicine

=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=
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=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D

Abstract
Alzheimer=E2=80=99s disease is the most common cause of dementia and the s=
eventh leading cause of death in the United States. The accumulation of pr=
otein aggregates (i.e.=2C extracellular A=CE=B2 plaques and intracellular=
 tau-containing neurofibrillary tangles) constitute the biological hallmar=
ks of Alzheimer=E2=80=99s disease. Clinical trials enhancing the clearance=
 of A=CE=B2 and tau have failed to alter disease progression indicating di=
sease complexity beyond protein accumulation. Comprehending the cellular a=
nd molecular features of cells and their environments in Alzheimer=E2=80=
=99s disease is urgently needed to develop effective disease modifying the=
rapies. To uncover interactions between cells containing tau pathology and=
 their microenvironments=2C Dr. Orr=E2=80=99s team employed NanoString Geo=
Mx=C2=AE Digital Spatial Profiling (DSP). They performed a spatial-proteom=
ic analysis of postmortem brains from individuals with Alzheimer=E2=80=99s=
 disease neuropathology with or without dementia. Comparing the protein ex=
pression profiles in neurons
and their microenvironments led to identification of molecules differentia=
lly regulated in individuals resilient to dementia=2C despite the presence=
 of neuropathology. To gain mechanistic insights into the role of tau path=
ogenesis her team utilized CosMx^TM Spatial Molecular Imaging. Their spati=
al-transcriptomic analysis comparing a mouse model of tau neuropathology t=
o an age-matched control identified cellular population changes with spati=
ally-resolved gene expression differences across 42 cell types. The analys=
es further revealed a tau-dependent loss of three cellular niches involvin=
g neuronal=2C glia and vascular cells.

Learning Objectives
* Understand how Nanostring=E2=80=99s GeoMx DSP and CosMx SMI spatial plat=
forms were used to determine spatially resolved preotomic and transcriptom=
ic profiles of neurons and their microenvironments in Alzheimer=E2=80=99s=
 disease human and mouse tissue
* Learn how GeoMx DSP is able to subtype neuropathology in brain tissue wi=
th Alzheimer=E2=80=99s disease neuropathology.
* Learn how CosMx SMI is able to spatially resolve cellular and molecular=
 changes in response to tau protein toxicity

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              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
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<h1 style=3D"display: block;margin: 0;padding:=
 0;color: #333333;font-family: Helvetica;font-size: 24px;font-style: norma=
l;font-weight: normal;line-height: 125%;letter-spacing: normal;text-align:=
 left;"><span style=3D"font-size:24px">Spatial Single Cell Characterizatio=
n of Alzheimer's Disease in Mouse and Human Hippocampus</span></h1>

<p style=3D"text-align: left;margin: 10px 0;padding: 0;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color=
: #202020;font-family: Helvetica;font-size: 14px;line-height: 150%;"><br>
<span style=3D"font-size:16px"><strong><span style=3D"color:#A3C849">Septe=
mber 27=2C 2022</span></strong></span><br>
<span style=3D"font-size:15px"><a href=3D"https://labroots.us7.list-manage=
=2Ecom/track/click?u=3D6f39393ef38fb324428ff8c2c&id=3De42d2fa05e&e=3D6670ee6f6b" target=3D"_blank" style=3D"mso-line-height-rule: exactly;-ms-text-si=
ze-adjust: 100%;-webkit-text-size-adjust: 100%;color: #1e8ae7;font-weight:=
 normal;text-decoration: underline;"><img data-file-id=3D"42943" height=3D=
"13" src=3D"https://gallery.mailchimp.com/6f39393ef38fb324428ff8c2c/images=
/b9d0b3b5-66ac-4b86-857f-08e5d0e67a46.png" style=3D"border: 0px;width: 20p=
x;height: 13px;margin: 0px;outline: none;text-decoration: none;-ms-interpo=
lation-mode: bicubic;" width=3D"20"></a>&nbsp;10:00am (PDT)=2C&nbsp;1:00pm=
 (EDT)=2C<br>
&nbsp; &nbsp; &nbsp; 7:00pm (CEST)</span></p>

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=09=09=09=09

=09=09=09=09
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</table></td>
                                        </tr>
                                    </table>
                                    
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lpadding=3D"0" cellspacing=3D"0" width=3D"300" class=3D"columnWrapper" sty=
le=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0p=
t;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                        <tr>
                                            <td valign=3D"top" class=3D"co=
lumnContainer" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust=
: 100%;-webkit-text-size-adjust: 100%;"><table border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D"min-w=
idth: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspac=
e: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
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<strong>Presented by:</strong>
                        </td>
                    </tr>
                </tbody></table>
=09=09=09=09

</td>
                        </tr>
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                </td>
            </tr>
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</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnTextBlock" style=3D"min-width: 100%;border-collapse: coll=
apse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

=09=09=09=09
            </td>
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    </tbody>
</table></td>
                                        </tr>
                                    </table>
                                    
                                </td>
                            </tr>
                            <tr>
                                <td valign=3D"top" id=3D"templateFooter" s=
tyle=3D"background:#ffffff none no-repeat center/cover;mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;backg=
round-color: #ffffff;background-image: none;background-repeat: no-repeat;b=
ackground-position: center;background-size: cover;border-top: 0;border-bot=
tom: 0;padding-top: 9px;padding-bottom: 9px;"><table border=3D"0" cellpadd=
ing=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D=
"min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table=
-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09
=09=09=09
=09=09=09=09
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;" width=3D"100%" class=3D"mcnTextContent=
Container">
                    <tbody><tr>

<p style=3D"font-size: 14px;text-align: left;m=
argin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;color: #555555;font-family: Helveti=
ca;line-height: 150%;"><span style=3D"font-family:arial=2Chelvetica neue=
=2Chelvetica=2Csans-serif"><span style=3D"font-size:14px"><strong>Abstract=
</strong>&nbsp;<br>
Alzheimer=E2=80=99s disease is the most common cause of dementia and the s=
eventh leading cause of death in the United States. The accumulation of pr=
otein aggregates (i.e.=2C extracellular A=CE=B2 plaques and intracellular=
 tau-containing neurofibrillary tangles) constitute the biological hallmar=
ks of Alzheimer=E2=80=99s disease. Clinical trials enhancing the clearance=
 of A=CE=B2 and tau have failed to alter disease progression indicating di=
sease complexity beyond protein accumulation. Comprehending the cellular a=
nd molecular features of cells and their environments in Alzheimer=E2=80=
=99s disease is urgently needed to develop effective disease modifying the=
rapies. To uncover interactions between cells containing tau pathology and=
 their microenvironments=2C Dr. Orr=E2=80=99s team employed NanoString Geo=
Mx=C2=AE Digital Spatial Profiling (DSP). They performed a spatial-proteom=
ic analysis of postmortem brains from individuals with Alzheimer=E2=80=99s=
 disease neuropathology with or without dementia. Comparing the protein ex=
pression profiles in neurons and their microenvironments led to identifica=
tion of molecules differentially regulated in individuals resilient to dem=
entia=2C despite the presence of neuropathology. To gain mechanistic insig=
hts into the role of tau pathogenesis her team utilized CosMx<sup>TM</sup>=
&nbsp;Spatial Molecular Imaging. Their spatial-transcriptomic analysis com=
paring a mouse model of tau neuropathology to an age-matched control ident=
ified cellular population changes with spatially-resolved gene expression=
 differences across 42 cell types. The analyses further revealed a tau-dep=
endent loss of three cellular niches involving neuronal=2C glia and vascul=
ar cells.<br>
&nbsp;<br>
<strong>Learning Objectives</strong></span></span></p>

<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;"><span style=3D"font-family:arial=2Chelveti=
ca neue=2Chelvetica=2Csans-serif"><span style=3D"font-size:14px">Understan=
d how Nanostring=E2=80=99s GeoMx DSP and CosMx SMI spatial platforms were=
 used to determine spatially resolved preotomic and transcriptomic profile=
s of neurons and their microenvironments in Alzheimer=E2=80=99s disease hu=
man and mouse tissue</span></span></li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;"><span style=3D"font-family:arial=2Chelveti=
ca neue=2Chelvetica=2Csans-serif"><span style=3D"font-size:14px">Learn how=
 GeoMx DSP is able to subtype neuropathology in brain tissue with Alzheime=
r=E2=80=99s disease neuropathology.</span></span></li>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;"><span style=3D"font-family:arial=2Chelveti=
ca neue=2Chelvetica=2Csans-serif"><span style=3D"font-size:14px">Learn how=
 CosMx SMI is able to spatially resolve cellular and molecular changes in=
 response to tau protein toxicity</span></span></li>
</ul>

</td>
                    </tr>
                </tbody></table>
=09=09=09=09

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it-text-size-adjust: 100%;">
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e-adjust: 100%;-webkit-text-size-adjust: 100%;">
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gn=3D"left" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"" st=
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it-text-size-adjust: 100%;">
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e-adjust: 100%;-webkit-text-size-adjust: 100%;">
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gn=3D"left" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"" st=
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eet</a>
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