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Subject: =?utf-8?Q?Enhance=20your=20oligo=20with=20a=20Locked=20Nucleic=20Acid=20probe=20or=20primer?=
From: =?utf-8?Q?LGC=2C=20Biosearch=20Technologies?= <newsletters@labroots.com>
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To: <mahmoud.shokry@saraya.world>
Date: Wed, 23 Mar 2022 14:02:18 +0000
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https://www.biosearchtech.com/ https://www.lgcgroup.com/

https://www.biosearchtech.com/products/custom-oligos/dna-probes/locked-nuc=
leic-acid-probes?utm_source=3Dlabroots.com&utm_medium=3Demail&utm_campaign=
=3Dgglobal22mar_npdlna&utm_content=3Dbanner

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 oligonucleotides (https://www.biosearchtech.com/products/custom-oligos/dn=
a-probes/locked-nucleic-acid-probes?utm_source=3Dlabroots.com&utm_medium=
=3Demail&utm_campaign=3Dgglobal22mar_npdlna&utm_content=3Dhyperlink) . LNA=
s are modified RNA bases in which the ribose is =E2=80=9Clocked=E2=80=9D w=
ith a methylene bridge=2C connecting the 2' oxygen atom to the 4' carbon a=
tom=2C fixing it in the C3'-endo conformation.

LNAs from LGC=2C Biosearch Technologies can be used in commercially availa=
ble products.

LNAs enable a shorter probe=2C which supports assay design for:
* Improved assay sensitivity

* Higher quenching efficiency (lower background)
* Greater signal-to-noise ratio

* Increased hybridisation specificity

* Targeting A-T rich sequences
* Better mismatch discrimination in SNP genotyping assays

In addition to offering LNA probes=2C Biosearch Technologies also synthesi=
ses custom oligos with internal LNA modifications.

Order now (https://www.biosearchtech.com/products/custom-oligos/dna-probes=
/locked-nucleic-acid-probes?utm_source=3Dlabroots.com&utm_medium=3Demail&u=
tm_campaign=3Dgglobal22mar_npdlna&utm_content=3Dcta)

Let's stay connected
https://twitter.com/lgcbiosearch https://www.facebook.com/LGCBiosearch/ ht=
tps://www.linkedin.com/company/lgc-biosearch-technologies/ https://www.ins=
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biosearchtech.com (https://www.biosearchtech.com)

Unit 1-2 Trident Industrial Estate=2C

Pindar Road=2C Hoddesdon=2C

Herts=2C EN11 0WZ=2C UK

*LNA is a registered trademark of QIAGEN Group.

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=09=09=09=09=09=09=09=09
=09=09=09=09=09=09=09=09<tr style=3D"">
=09=09=09=09=09=09=09=09=09<td pardot-region=3D"" style=3D"
                                                                    font-w=
eight: 400;
                                                                    font-f=
amily: Arial=2C
                                                                        Ca=
mbria=2C
                                                                        Ge=
orgia=2C
                                                                        He=
lvetica=2C
                                                                        sa=
ns-serif;
                                                                " class=3D=
""><p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{161}" paraid=3D"94=
774374"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=
=2CHelvetica=2Csans-serif;">Improve assay sensitivity and specificity with=
 <a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6f39393ef=
38fb324428ff8c2c&id=3D6790eac291&e=3Dc6feb6ce1a" style=3D"text-decoration=
:none;color:#00788a;" target=3D"_blank">Locked Nucleic Acid (LNA*) oligonu=
cleotides</a>. LNAs are modified RNA bases in which the ribose is =E2=80=
=9Clocked=E2=80=9D with a methylene bridge=2C connecting the 2' oxygen ato=
m to the 4' carbon atom=2C fixing it in the C3'-endo conformation.&nbsp;</=
span></span></p>

<p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{179}" paraid=3D"91845=
5396"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=2CH=
elvetica=2Csans-serif;">LNAs from LGC=2C Biosearch Technologies can be use=
d in commercially available products.&nbsp;</span></span></p>

<p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{185}" paraid=3D"32365=
7697"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=2CH=
elvetica=2Csans-serif;">LNAs enable a shorter probe=2C which supports assa=
y design for:&nbsp;</span></span></p>

<ul role=3D"list">
=09<li aria-setsize=3D"-1" data-aria-level=3D"2" data-aria-posinset=3D"1"=
 data-font=3D"Courier New" data-leveltext=3D"o" data-listid=3D"2" role=3D"=
listitem">
=09<p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{198}" paraid=3D"14=
62165993"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=
=2CHelvetica=2Csans-serif;">Higher quenching efficiency (lower background)=
&nbsp;</span></span></p>
=09</li>
=09<li aria-setsize=3D"-1" data-aria-level=3D"2" data-aria-posinset=3D"2"=
 data-font=3D"Courier New" data-leveltext=3D"o" data-listid=3D"2" role=3D"=
listitem">
=09<p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{205}" paraid=3D"20=
15420776"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=
=2CHelvetica=2Csans-serif;">Greater signal-to-noise ratio&nbsp;</span></sp=
an></p>
=09</li>
</ul>

<ul role=3D"list">
=09<li aria-setsize=3D"-1" data-aria-level=3D"1" data-aria-posinset=3D"2"=
 data-font=3D"Symbol" data-leveltext=3D"=EF=82=B7" data-listid=3D"2" role=
=3D"listitem">
=09<p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{212}" paraid=3D"19=
00311229"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=
=2CHelvetica=2Csans-serif;">Increased hybridisation specificity&nbsp;</spa=
n></span></p>
=09</li>
</ul>

<ul role=3D"list">
=09<li aria-setsize=3D"-1" data-aria-level=3D"1" data-aria-posinset=3D"1"=
 data-font=3D"Symbol" data-leveltext=3D"=EF=82=B7" data-listid=3D"2" role=
=3D"listitem">
=09<p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{219}" paraid=3D"21=
31224842"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=
=2CHelvetica=2Csans-serif;">Targeting A-T rich sequences&nbsp;</span></spa=
n></p>
=09</li>
=09<li aria-setsize=3D"-1" data-aria-level=3D"1" data-aria-posinset=3D"2"=
 data-font=3D"Symbol" data-leveltext=3D"=EF=82=B7" data-listid=3D"2" role=
=3D"listitem">
=09<p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{226}" paraid=3D"10=
71711484"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=
=2CHelvetica=2Csans-serif;">Better mismatch discrimination in SNP genotypi=
ng assays&nbsp;</span></span></p>
=09</li>
</ul>

<p paraeid=3D"{796943b1-08e1-42c7-8066-82d38395eb39}{233}" paraid=3D"76101=
1342"><span style=3D"font-size:14px;"><span style=3D"font-family:Arial=2CH=
elvetica=2Csans-serif;">In addition to offering LNA probes=2C Biosearch Te=
chnologies also synthesises custom oligos with internal LNA modifications.=
&nbsp;</span></span></p>
<br>&nbsp;

<table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" w=
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ns-serif;
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g=3D"0" style=3D"
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rder-collapse: separate !important;
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h=3D"350">
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               #6b1e74;
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       "><a href=3D"https://labroots.us7.list-manage.com/track/click?u=3D6=
f39393ef38fb324428ff8c2c&id=3Deaf535a14b&e=3Dc6feb6ce1a" pardot-region=3D=
"" style=3D"
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               color: #ffffff;
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&nbsp;</td>
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=09=09=09=09=09<tr pardot-repeatable=3D"" style=3D"" class=3D"">
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100%">&nbsp;</td>
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