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<h1 style="line-height: 100%;">Research</h1>
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<li><a href="../about/" class="heightLine-menu">What is Lactoferrin Lab?</a></li>
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<h2 class="concept-title">Great effect on your skin<br>
wrinkles due to an improvement in moisture,<br> texture and strenghtening of the skin</h2>
<p class="concept-lead mgr15">In a group of 20 subjects (9 males, 11 females) divided into a team drinking enteric tables containing lactoferrin and a team drinking tables not containing lactoferrin, a trial test was conducted measuring the effects on the skin in faces and hands during 3 months. After 2 months, the moisture levels, the texture and smoothness of the skin increased, improving the natural barrier of the skin and wrinkles becoming more shallow. Not only that, it was confirmed by interview questionnaire that there was also a positive effect on physical conditions such as fatigability and sleep.</p>
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<img src="images/2010_graph02.png" alt="Amount of moisture in face skin increases over time with Lactoferrin Lab." style="max-width: 350px; margin-right: 10%; margin-bottom: 30px;">
<img src="images/2010_graph03.png" alt="Lactoferrin Lab. provides high barrier results." style="max-width: 350px; margin-bottom: 30px;">
<img src="images/2010_graph04.png" alt="With Lactoferrin Lab. you will obtain an improved texture of your skin." style="max-width: 350px; margin-right: 10%; margin-bottom: 30px;">
<img src="images/2010_graph05.png" alt="Lactoferrin helps you in reducing wrinkles." style="max-width: 350px; margin-bottom: 30px;">
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<p class="concept-lead mgr15">Comparing with values obtained before the consumption of the test tablets, and up to 3 months of computation, the tables show the difference with a mean value ± standard error in the groups ingesting tablets containing lactoferrin (●) and without lactoferrin (○).<br>
The mean value of the 2 groups was compared by T-test, with a **p<0.01 judged as a significant difference.<br>
0.05 < P < 0.1 was selected as the p value to show.</p>
<p class="kome">※Presented at the 4th academic meeting of Japan Lactoferrin Society</p>
<p> </p>
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<img src="images/secret03_graph01.png" alt="In 1 month, about 2 times the amount of skin moisture." style="max-width: 400px; margin-right: 10%; margin-bottom: 30px;">
<img src="images/secret03_graph02.png" alt="Lactoferrin reaches deeply into the skin." style="max-width: 400px; margin-bottom: 30px;">
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<h2 class="concept-title">Gel containing lactoferrin<br> improve wrinkles by an average of 40%</h2>
<p class="concept-lead img-r"><img src="images/2012_img02.png" alt="Lactoferrin stimulates the switch to a beautiful skin." width="398">In order to keep a youthful skin without wrinkles, the work of "fibroblasts" that produce components for a beautiful skin such as hyaluronic acid are essential.<br>
However, when those "fibroblasts" are damaged due to corruption or ultraviolet rays, collagen and elastin are denatured and lose their resilience, hyaluronic acids are lost, moisture content decreases and wrinkles and sagging appears.<br>
When lactoferrin is applied to the skin, it stimulates the "fibroblats" dormant inside the skin, improving the firmness and elasticity of the skin, helping the disappearance of any wrinkles present.</p>
<p class="concept-lead img-r"><img src="images/2012_img01.jpg" alt="One month later, wrinkles are reduced." width="398">Eleven women in their 40s and 50s used a comestic gel containing 0.5% lactoferrin in the morning and evening for one month. Their skin moisture content improved and wrinkles dissapeared by an average of 40%.<br>
This demonstrates the effectiveness of a lactoferrin-containing gel as an anti-aging skin care.</p>
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<img src="images/2012_graph01.png" alt="Develop a stronger skin barrier that prevents water evaporation with lactoferrin." style="max-width: 300px; margin-right: 2%; margin-bottom: 30px;">
<img src="images/2012_graph02.png" alt="Improve hydration with Lactoferrin Lab." style="max-width: 300px; margin-right: 2%; margin-bottom: 30px;">
<img src="images/2012_graph03.png" alt="Shallower wrinkles are achieved with the use of lactoferrin." style="max-width: 300px; margin-bottom: 30px;">
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<p class="concept-lead">図 Fig. 1 Skin condition change before and after application (n=11, *p<0.05, ***p<0.001)<br>
with a mean value of 11 people on the amount of moisture evaporation, stratum hydration and wrinkle depth ± standard error.<br>
The mean value of the 2 groups was compared with the t-test, showing a significant difference when judged.</p>
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<h2 class="concept-title">The possibility of anti-aging at a gene level</h2>
<p class="concept-lead img-r cleafix"><img src="images/2013_img01.jpg" alt="Lactoferrin opens the posibility of anti-aging at a gene level." width="398">Lactoferrin helps the work of true fibroblasts. True fibroblasts are cells that create collage, hyaluronic acid and elastin, which are important for keeping the skin's elasticity. Due to aging, productivity of fibroblasts is reduced, causing wrinkles and sagging.<br>
Our studies lead to the conclusion that fibroblasts absorb the lactoferrin, promoting gene expression, and activating the cells.</p>
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<h2 class="concept-title">Works as twice as good as Vitamin C in<br> regards to sun related skin damage, comparable<br> to Tranexamic Acid even in small amounts</h2>
<p class="concept-lead img-r cleafix"><img src="images/2014_graph01.png" alt="Melanin production is reduced around 7 times with lactoferrin." width="398" style="margin-bottom: 40px;">When lactoferrin is applied to melanin-producing cells, it supresses melanin production, exceeding the beauty effect of vitamin C.<br><br> Among the melanocytes, there is a factor called MITF that controls the generation of melanin. As this factor increases,so does the production of melanin. Since lactoferrin prevents the generation of this factor, the production amount of melanin also decreases.<br> Also, lactoferrin at 0.5% concentration showed melanogenesis inhibitory effects as high as 2% in effective concentration of tranexamic acid, which is famous as a beauty component (experiment using three-dimensional culture skin as close as possible to human skin).</p>
<p class="concept-lead img-r cleafix"><img src="images/2014_graph02.png" alt="Lactoferrin at 0.5% concentration showed melanogenesis inhibitory effects as high as 2% in effective concentration of tranexamic acid." width="398">It can be said without a doubt that cosmetics containing lactoferrin proved to have an anti-aging efect comparable to skin-beautification cosmetics.</p>
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<h2 class="concept-title">Effective in decomposing the<br> already formed melanogenic factor</h2>
<p class="concept-lead img-r cleafix"><img src="images/2015_img01.jpg" alt="Lactoferrin does help reduce melanin production factors, a mechanism we presented in our follow-up report on skin beauty research in 2014." width="398">Lactoferrin does indeed help reduce melanin production factors, but this effect is not only reduces to the creation of new factors, but also promotes the descomposition of already existing melaninogenic ones.<br>
We clarified this mechanism and presented it in our follow-up report on skin beauty research in 2014.</p>
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